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    Methods of treating microbial infections
    51.
    发明授权
    Methods of treating microbial infections 失效
    治疗微生物感染的方法

    公开(公告)号：US5668167A

    公开(公告)日：1997-09-16

    申请号：US477876

    申请日：1995-06-07

    申请人： Richard R. Tidwell ,  James E. Hall ,  David W. Boykin ,  Christine C. Dykstra ,  John Perfect ,  Byron L. Blagburn

    发明人： Richard R. Tidwell ,  James E. Hall ,  David W. Boykin ,  Christine C. Dykstra ,  John Perfect ,  Byron L. Blagburn

    IPC分类号： A61K31/40 ,  A61K31/403 ,  A61K31/415 ,  A61K31/4178 ,  A61K31/505 ,  A61P11/00 ,  A61P31/00 ,  C07D209/86 ,  C07D209/88 ,  C07D403/14

    CPC分类号： C07D403/14 ,  A61K31/403 ,  A61K31/4178 ,  C07D209/88

    摘要： The present invention provides methods for treating Cryptococcus neoformans, Cryptosporidium parvum, and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a compound of Formula I: ##STR1## wherein: X is located in the para or meta positions and is loweralkyl, loweralkoxy, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, alkylaryl, halogen, or ##STR2## wherein: each R.sub.2 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.2 groups together represent C.sub.2 -C.sub.10 alkylene, or two R.sub.2 groups together represent ##STR3## wherein m is from 1-3 and R.sub.4 is H, ##STR4## or --CONHR.sub.5 NR.sub.6 R.sub.7, whereinR.sub.5 is loweralkyl, R.sub.6 and R.sub.7 are each independently selected from the group consisting of H and lower alkyl; each R.sub.8 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl, or two R.sub.8 groups together represent C.sub.2 -C.sub.10 alkylene; R.sub.9 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl;R.sub.3 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl;R.sub.1 is H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, alkylaryl, or halogen; or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供了在需要这种治疗的受试者中治疗隐球菌新隐球蛋白，小隐孢子虫和白色念珠菌的方法。 所述方法包括向受试者施用式I化合物：其中：X位于对位或间位，且为低级烷基，低级烷氧基，烷氧基烷基，羟烷基，氨基烷基，烷基氨基烷基，环烷基，芳基，烷基芳基， 卤素或其中：每个R 2独立地选自H，低级烷基，烷氧基烷基，羟基烷基，氨基烷基，烷基氨基烷基，环烷基，芳基或烷芳基，或两个R 2基团一起表示C 2 -C 10亚烷基或两个R 2 基团一起表示，其中m为1-3，R4为H，IMA或-CONHR5NR6R7，其中R5为低级烷基，R6和R7各自独立地选自H和低级烷基; 每个R 8独立地选自H，低级烷基，烷氧基烷基，羟基烷基，氨基烷基，烷基氨基烷基，环烷基，芳基或烷基芳基，或两个R 8基团一起表示C 2 -C 10亚烷基; R9是H，羟基，低级烷基，烷氧基烷基，羟基烷基，氨基烷基，烷基氨基烷基，环烷基，芳基或烷基芳基; R3是H，羟基，低级烷基，烷氧基烷基，羟基烷基，氨基烷基，烷基氨基烷基，环烷基，芳基或烷基芳基; R1是H，低级烷基，烷氧基烷基，羟基烷基，氨基烷基，烷基氨基烷基，环烷基，芳基，烷基芳基或卤素; 或其药学上可接受的盐。

    Soluble anionic polymerization initiators and method of preparing same
    53.
    发明授权
    Soluble anionic polymerization initiators and method of preparing same 失效
    可溶性阴离子聚合引发剂及其制备方法

    公开(公告)号：US5578542A

    公开(公告)日：1996-11-26

    申请号：US220629

    申请日：1994-03-30

    申请人： David F. Lawson ,  James E. Hall ,  Yoichi Ozawa

    发明人： David F. Lawson ,  James E. Hall ,  Yoichi Ozawa

    IPC分类号： C08F4/48 ,  C07D295/22 ,  C08C19/44 ,  C08F4/00 ,  C08F4/06 ,  C08F4/08 ,  C08F36/04 ,  C08F236/04 ,  C07D295/00 ,  C07D487/08

    CPC分类号： C08C19/44 ,  C07D295/22 ,  C08F36/04 ,  Y10T152/10495

    摘要： An acyclic alkane soluble anionic polymerization initiator includes a mixture of from about 90 to about 10 parts by weight of a lithio amine having the general formula A.sub.1 Li and from about 10 to about 90 parts by weight of at least one other lithio amine having the general formula A.sub.2 Li. A.sub.1 and A.sub.2 are selected from the dialkyl, alkyl, cycloalkyl and dicycloalkyl amine radicals and cyclic amine radicals. There is also provided a method of forming a mixture of anionic polymerization initiators, a functionalized polymer and a method of forming a functionalized polymer.

    摘要翻译： 无环烷烃可溶性阴离子聚合引发剂包括约90至约10重量份的具有通式A1Li的锂二胺和约10至约90重量份的至少一种其它具有通式 A2Li。 A1和A2选自二烷基，烷基，环烷基和二环烷基胺基和环胺基。 还提供了形成阴离子聚合引发剂，官能化聚合物和形成官能化聚合物的方法的混合物的方法。

    Thermoformable blends of multiblock polymer compositions with polystyrene
    56.
    发明授权
    Thermoformable blends of multiblock polymer compositions with polystyrene 失效
    多嵌段聚合物组合物与聚苯乙烯的可热成型共混物

    公开(公告)号：US5089558A

    公开(公告)日：1992-02-18

    申请号：US646485

    申请日：1991-01-28

    申请人： James E. Hall ,  Daniel F. Graves

    发明人： James E. Hall ,  Daniel F. Graves

    IPC分类号： C08L25/02 ,  C08L53/02

    CPC分类号： C08L25/02 ,  C08L53/02 ,  C08L2205/02

    摘要： A polymer composition for use in making thermoformed products which comprises a blend of: (1) 20 to 75% by weight of a polyvinylaromatic resin, (2) 20 to 75% by weight of S.sub.1 -(B/S.sub.2).sub.n type block copolymer wherein S.sub.1 and S.sub.2 are vinylaromatic block polymers, B is a diene block polymer, (B/S.sub.2) represents a tapered or non-tapered block copolymer and the S.sub.1 block is 5 to 20% by weight of the block copolymer, (S.sub.1 +S.sub.2) is 65 to 95% by weight of the block copolymer, and the total block styrene content of the block copolymer ranges between 35 and 80% by weight, and (3) 0.5 to 10% by weight a diene-vinylaromatic block copolymer (B'-S') containing 10-60% by weight of the vinylaromatic polymer block.

    摘要翻译： 一种用于制造热成型产品的聚合物组合物，其包含以下混合物：（1）20至75重量％的聚乙烯基芳族树脂，（2）20至75重量％的S1-（B / S2）n型嵌段共聚物 其中S1和S2是乙烯基芳族嵌段聚合物，B是二烯嵌段聚合物，（B / S2）表示锥形或非渐变嵌段共聚物，S1嵌段是嵌段共聚物的5〜20重量％（S1 + S2 ）为嵌段共聚物的65〜95重量％，嵌段共聚物的总嵌段苯乙烯含量为35〜80重量％，（3）0.5〜10重量％的二烯 - 乙烯基芳族嵌段共聚物（B '-S'），其含有10-60重量％的乙烯基芳族聚合物嵌段。

    Thermoplastic elastomer blends of alpha-olefin polymers and hydrogenated medium and high vinyl butadiene polymers
    58.
    发明授权
    Thermoplastic elastomer blends of alpha-olefin polymers and hydrogenated medium and high vinyl butadiene polymers 失效
    α-烯烃聚合物和氢化介质和高乙烯基丁二烯聚合物的热塑性弹性体共混物

    公开(公告)号：US4226952A

    公开(公告)日：1980-10-07

    申请号：US68281

    申请日：1979-08-20

    申请人： Adel F. Halasa ,  David W. Carlson ,  James E. Hall

    发明人： Adel F. Halasa ,  David W. Carlson ,  James E. Hall

    IPC分类号： C08L23/00 ,  C08L7/00 ,  C08L9/00 ,  C08L21/00 ,  C08L23/02 ,  C08L23/06 ,  C08L23/12 ,  C08L23/16 ,  C08L29/00 ,  C08L29/02 ,  C08L47/00 ,  C08L101/00 ,  C08F8/04

    CPC分类号： C08L9/00 ,  C08L23/02 ,  C08L15/00 ,  C08L23/06 ,  C08L23/10 ,  C08L23/12 ,  C08L23/16

    摘要： Thermoplastic elastomer blends of alpha-olefin polymers and copolymers, such as polypropylene, polyethylene, etc., having a melting point of at least 90.degree. C. with hydrogenated butadiene medium and high vinyl polymers have good physical properties such as low brittle point, good impact resistance at low temperatures, minimum creep at high temperatures, and good elongation. The blends can be repeatedly processed and still maintain good physical properties. The amount of alpha-olefin polymer or copolymer in the blend may range from about 10 percent to about 60 percent with the amount of the hydrogenated polybutadiene correspondingly ranging from about 90 percent to about 40 percent based on the combined weight of the two components. The blends are mixed at temperatures at least as high as the melting point of the alpha-olefin polymer or copolymer. These blends have excellent ozone resistance and aging properties, as well as excellent paint adhesion.

    摘要翻译： 与氢化丁二烯介质和高乙烯基聚合物具有至少90℃的熔点的α-烯烃聚合物和共聚物如聚丙烯，聚乙烯等的热塑性弹性体共混物具有良好的物理性能，例如低脆性，良好 低温下的耐冲击性，高温下的蠕变最小，伸长率好。 混合物可以重复处理，并且仍然保持良好的物理性能。 共混物中α-烯烃聚合物或共聚物的量可以在约10％至约60％的范围内，基于两种组分的组合重量，氢化聚丁二烯的量相应地范围为约90％至约40％。 共混物在至少与α-烯烃聚合物或共聚物的熔点一样高的温度下混合。 这些共混物具有优异的耐臭氧性和老化性能，以及优异的油漆附着力。

    Method of directing grafting by controlling the location of high vinyl segments in a polymer
    60.
    发明授权
    Method of directing grafting by controlling the location of high vinyl segments in a polymer 有权
    通过控制聚合物中高乙烯基链段的位置来引导接枝的方法

    公开(公告)号：US07560509B2

    公开(公告)日：2009-07-14

    申请号：US11617850

    申请日：2006-12-29

    申请人： James E. Hall

    发明人： James E. Hall

    IPC分类号： C08F287/00 ,  C08F2/38 ,  C08L53/00

    CPC分类号： C08F279/02 ,  C08F297/02 ,  C08F297/04 ,  C08L51/003 ,  C08L51/04 ,  C08L53/02 ,  C08L55/02 ,  Y10S525/942 ,  C08L2666/02 ,  C08L2666/04

    摘要： A method of producing an engineered plastic selected from the group consisting of high impact polystyrene, styrene-maleic anhydride copolymer, methylmethacrylate-butadiene-styrene copolymer, transparent impact polystyrene, and acrylonitrile butadiene styrene copolymer is provided. The method comprises the steps of: (a) adding a polymer containing at least one high vinyl segment having a 1,2-vinyl bond content of greater than 45% to a solvent comprising at least one vinyl monomer; (b) optionally adding at least one additional inert solvent; (c) optionally adding additives selected from the group consisting of extender oils, modifiers, and antioxidants; and (d) initiating polymerization of the at least one vinyl monomer by the use of an initiator and/or heat, wherein the presence of the at least one high vinyl segment in the polymer allows direction of the grafting site during preparation of the engineered plastic.

    摘要翻译： 提供了选自高抗冲聚苯乙烯，苯乙烯 - 马来酸酐共聚物，甲基丙烯酸甲酯 - 丁二烯 - 苯乙烯共聚物，透明抗冲聚苯乙烯和丙烯腈 - 丁二烯苯乙烯共聚物的工程塑料的制造方法。 该方法包括以下步骤：（a）向包含至少一种乙烯基单体的溶剂中加入含有至少一个1,2-乙烯基键含量大于45％的高乙烯基链段的聚合物; （b）任选地加入至少一种另外的惰性溶剂; （c）任选地添加选自由增量油，改性剂和抗氧化剂组成的组的添加剂; 和（d）通过使用引发剂和/或加热引发至少一种乙烯基单体的聚合，其中聚合物中至少一个高乙烯基链段的存在允许在制备工程塑料期间接枝位点的方向 。