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403 条记录 (耗时 0.125 秒)

    Interleukin-19
    52.
    发明授权
    Interleukin-19 有权
    白细胞介素-19多肽及其变体

    公开(公告)号：US06583270B2

    公开(公告)日：2003-06-24

    申请号：US09386380

    申请日：1999-08-31

    申请人： Craig A. Rosen ,  Joseph J. Kenny

    发明人： Craig A. Rosen ,  Joseph J. Kenny

    IPC分类号： C07K1454

    CPC分类号： C07K14/54 ,  A61K38/00 ,  Y02A50/41

    摘要： The present invention concerns a novel human cytokine. In particular, isolated nucleic acid molecules are provided encoding interleukin-19 (IL-19). IL-19 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further concerns therapeutic methods for modulating cytokine production.

    摘要翻译： 本发明涉及一种新的人细胞因子。 特别地，提供编码白细胞介素-19（IL-19）的分离的核酸分子。 还提供了IL-19多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及调节细胞因子产生的治疗方法。

    Polynucleotides encoding interleukin-19
    53.
    发明授权
    Polynucleotides encoding interleukin-19 失效
    编码白细胞介素-19的多核苷酸

    公开(公告)号：US5985614A

    公开(公告)日：1999-11-16

    申请号：US921382

    申请日：1997-08-29

    申请人： Craig A. Rosen ,  Joseph J. Kenny

    发明人： Craig A. Rosen ,  Joseph J. Kenny

    IPC分类号： A61K38/00 ,  C07K14/54 ,  C12N15/24 ,  C12P21/04 ,  C12N15/64 ,  C12N5/10

    CPC分类号： C07K14/54 ,  A61K38/00

    摘要： The present invention concerns a novel human cytokine. In particular, isolated nucleic acid molecules are provided encoding interleukin-19 (IL-19). IL-19 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further concerns therapeutic methods for modulating cytokine production.

    摘要翻译： 本发明涉及一种新的人细胞因子。 特别地，提供编码白细胞介素-19（IL-19）的分离的核酸分子。 还提供了IL-19多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及调节细胞因子产生的治疗方法。

    Tumor necrosis factor-gamma
    54.
    发明授权
    Tumor necrosis factor-gamma 有权
    抗肿瘤坏死因子-γ的抗体

    公开(公告)号：US07820798B2

    公开(公告)日：2010-10-26

    申请号：US11837082

    申请日：2007-08-10

    申请人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen ,  Jun Zhang

    发明人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen ,  Jun Zhang

    IPC分类号： C07K16/28 ,  C07K16/18 ,  C07K16/22 ,  C07K16/46 ,  C12N5/00 ,  G01N33/53

    CPC分类号： A61K51/08 ,  C07K16/241 ,  Y10S930/144

    摘要： Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.

    摘要翻译： 公开了人类TNF-γ-α和TNF-γ-β多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽抑制细胞生长的方法，例如在肿瘤或癌症中，用于促进伤口愈合，提供抗感染，诱导炎症活性和刺激某些细胞类型的生长以治疗疾病， 示例再狭窄。 还公开了用于检测TNF-γ-α和TNF-γ-β核酸序列中的突变或TNF-γ-α和/或TNF-γ-β多肽的过表达的诊断方法。 还公开了抗这些多肽的拮抗剂及其作为治疗性恶病质，败血性休克，脑疟疾，炎症，关节炎和移植排斥的治疗剂的用途。

    Tumor necrosis factor-gamma
    56.
    发明授权
    Tumor necrosis factor-gamma 有权

    公开(公告)号：US07597886B2

    公开(公告)日：2009-10-06

    申请号：US09899059

    申请日：2001-07-06

    申请人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen ,  Jun Zhang

    发明人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen ,  Jun Zhang

    IPC分类号： A61K39/395 ,  C07K14/525

    CPC分类号： A61K31/713 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/525 ,  C07K14/70575 ,  C07K16/241 ,  Y02A50/412 ,  Y10S930/144

    摘要： Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.

    Methods and compositions for treating metabolic bone diseases relating to human endokine alpha
    57.
    发明授权
    Methods and compositions for treating metabolic bone diseases relating to human endokine alpha 失效

    公开(公告)号：US07087225B2

    公开(公告)日：2006-08-08

    申请号：US10218547

    申请日：2002-08-15

    申请人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen ,  Bernadetta Nardelli

    发明人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen ,  Bernadetta Nardelli

    IPC分类号： A61K45/00 ,  A61K38/19 ,  C07K14/715

    CPC分类号： C07K14/5255 ,  A61K38/00

    摘要： The present invention concerns methods for diagnosis and treatment of metabolic bone diseases and disorders using a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular the invention provides methods of using the Endokine alpha protein and/or homomultimeric and/or heteromultimeric polypeptide complexes containing Endokine alpha, in the diagnosis, prognosis and treatment of metabolic bone diseases and disorders. Also provided by the invention are methods of using the Endokine alpha protein and/or homomultimeric and/or heteromultimeric polypeptide complexes containing Endokine alpha, in the diagnosis, prognosis and treatment of diseases and/or disorders associated with aberrant osteoclast development and/or activity. The present invention also provides isolated polynucleotides encoding polypeptides of the invention, antibodies thereto, and agonists and antagonists thereof, for use in the diagnosis, prognosis and treatment of metabolic bone diseases and disorders.

    Neutrokine-alpha polypeptides
    59.
    发明授权
    Neutrokine-alpha polypeptides 有权
    中枢神经素α多肽

    公开(公告)号：US06812327B1

    公开(公告)日：2004-11-02

    申请号：US09507968

    申请日：2000-02-22

    申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

    发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

    IPC分类号： A61K3816

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

    摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地提供编码人Neutrokine-α和/或Neutrokine-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 Neutrokine-α和/或Neutrokine-αSV激动剂和Neutrokine-α和/或Neutrokine-αSV活性的拮抗剂。 也生产相同。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Monoclonal antibodies to membrane neutrokine-&agr;
    60.
    发明授权
    Monoclonal antibodies to membrane neutrokine-&agr; 有权
    膜中性粒细胞α的单克隆抗体

    公开(公告)号：US06635482B1

    公开(公告)日：2003-10-21

    申请号：US09589286

    申请日：2000-06-08

    申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

    发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

    IPC分类号： C12N506

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

    摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。