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公开(公告)号：US06627741B2
公开(公告)日：2003-09-30
申请号：US10012542
申请日：2001-12-12
申请人： Steven M. Ruben , Jian Ni , Craig A. Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel R. Soppet , Laurie A. Brewer , Gregory A. Endress , Kenneth C. Carter , Michael Mucenski , Reinhard Ebner , David W. LaFleur , Henrik Olsen , Yanggu Shi , Paul A. Moore , George Komatsoulis
发明人： Steven M. Ruben , Jian Ni , Craig A. Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel R. Soppet , Laurie A. Brewer , Gregory A. Endress , Kenneth C. Carter , Michael Mucenski , Reinhard Ebner , David W. LaFleur , Henrik Olsen , Yanggu Shi , Paul A. Moore , George Komatsoulis
IPC分类号： C07K1624
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/47 , G01N2500/20
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US20090305991A1
公开(公告)日：2009-12-10
申请号：US12538668
申请日：2009-08-10
申请人： Daniel R. Soppet , Paul A. Moore , Yanggu Shi , Steven M. Ruben , Craig A. Rosen , David W. LaFleur , Henrik Olsen , Reinhard Ebner , Kimberly Florence , Paul Young , George Komatsoulis , Jian Ni
发明人： Daniel R. Soppet , Paul A. Moore , Yanggu Shi , Steven M. Ruben , Craig A. Rosen , David W. LaFleur , Henrik Olsen , Reinhard Ebner , Kimberly Florence , Paul Young , George Komatsoulis , Jian Ni
IPC分类号： A61K38/16 , C12N15/11 , C12N15/00 , C12N15/87 , C12N5/06 , C12N1/21 , C07K14/435 , C07K16/18 , C12P21/02 , C12Q1/68 , C12Q1/02 , G01N33/566
摘要： The present invention relates to 33 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及33种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US06475753B1
公开(公告)日：2002-11-05
申请号：US09461325
申请日：1999-12-14
申请人： Steven M. Ruben , Jian Ni , Craig A. Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel R. Soppet , Laurie A. Brewer , Gregory A. Endress , Kenneth C. Carter , Michael Mucenski , Reinhard Ebner , David W. Lafleur , Henrik Olsen , Yanggu Shi , Paul A. Moore , George Komatsoulis
发明人： Steven M. Ruben , Jian Ni , Craig A. Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel R. Soppet , Laurie A. Brewer , Gregory A. Endress , Kenneth C. Carter , Michael Mucenski , Reinhard Ebner , David W. Lafleur , Henrik Olsen , Yanggu Shi , Paul A. Moore , George Komatsoulis
IPC分类号： C12P2102
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/47 , G01N2500/20
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US06476195B1
公开(公告)日：2002-11-05
申请号：US09489847
申请日：2000-01-24
申请人： George Komatsoulis , Craig A. Rosen , Steven M. Ruben , Roxanne D. Duan , Paul A. Moore , Yanggu Shi , David W. LaFleur , Ying-Fei Wei , Jian Ni , Kimberly A. Florence , Paul Young , Laurie A. Brewer , Daniel R. Soppet , Gregory A. Endress , Reinhard Ebner , Henrik Olsen , Michael Mucenski
发明人： George Komatsoulis , Craig A. Rosen , Steven M. Ruben , Roxanne D. Duan , Paul A. Moore , Yanggu Shi , David W. LaFleur , Ying-Fei Wei , Jian Ni , Kimberly A. Florence , Paul Young , Laurie A. Brewer , Daniel R. Soppet , Gregory A. Endress , Reinhard Ebner , Henrik Olsen , Michael Mucenski
IPC分类号： C07K500
摘要： The present invention relates to novel human secreted protein (HNFGF20). Polypeptides of the invention are duseful in dianosis and treatment of disorders affecting the immune system.
摘要翻译： 本发明涉及新型人分泌蛋白（HNFGF20）。 本发明的多肽对于影响免疫系统的紊乱的脓毒症和治疗是有益的。
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公开(公告)号：US06534631B1
公开(公告)日：2003-03-18
申请号：US09482273
申请日：2000-01-13
申请人： Steven M. Ruben , George Komatsoulis , Roxanne D. Duan , Craig A. Rosen , Paul A. Moore , Yanggu Shi , David W. LaFleur , Reinhard Ebner , Henrik Olsen , Laurie A. Brewer , Kimberly A. Florence , Paul Young , Michael Mucenski , Gregory A. Endress , Daniel R. Soppet
发明人： Steven M. Ruben , George Komatsoulis , Roxanne D. Duan , Craig A. Rosen , Paul A. Moore , Yanggu Shi , David W. LaFleur , Reinhard Ebner , Henrik Olsen , Laurie A. Brewer , Kimberly A. Florence , Paul Young , Michael Mucenski , Gregory A. Endress , Daniel R. Soppet
IPC分类号： C07K1100
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/47 , G01N2500/20
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号：US20090082264A1
公开(公告)日：2009-03-26
申请号：US11735351
申请日：2007-04-13
申请人： Carrie L. Fischer , Craig A. Rosen , Daniel R. Soppet , Steven M. Ruben , Hla Kyaw , Yi Li , Zhizhen Zeng , David W. LaFleur , Paul A. Moore , Yanggu Shi , Henrik Olsen , Reinhard Ebner , Charles E. Birse
发明人： Carrie L. Fischer , Craig A. Rosen , Daniel R. Soppet , Steven M. Ruben , Hla Kyaw , Yi Li , Zhizhen Zeng , David W. LaFleur , Paul A. Moore , Yanggu Shi , Henrik Olsen , Reinhard Ebner , Charles E. Birse
IPC分类号： A61K38/00 , C12N15/11 , C12N15/00 , C12N15/87 , C12N5/06 , C12Q1/68 , G01N33/566 , A61P43/00 , C12Q1/02 , A61K31/70 , C07K14/00 , C07K16/18 , C12P21/04
CPC分类号： A01C23/024 , A61K38/00 , C07K14/47 , C12N9/00 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/5047 , G01N33/505 , G01N33/5058 , G01N33/5091 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20050239099A1
公开(公告)日：2005-10-27
申请号：US10963903
申请日：2004-10-14
申请人： Steven Ruben , Jian Ni , Reinhard Ebner , Craig Rosen , Yanggu Shi , Charles Birse , Kimberly Florence , George Komatsoulis , David LaFleur , Paul Moore , Henrik Olsen , Paul Young
发明人： Steven Ruben , Jian Ni , Reinhard Ebner , Craig Rosen , Yanggu Shi , Charles Birse , Kimberly Florence , George Komatsoulis , David LaFleur , Paul Moore , Henrik Olsen , Paul Young
IPC分类号： G01N33/50 , A61K31/711 , A61K38/00 , A61K48/00 , A61P9/00 , A61P17/00 , A61P19/02 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07H21/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/09 , C12P21/02 , C12Q1/00 , C12Q1/02 , C12Q1/68 , C12Q1/6883 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： C07K14/47 , C12Q1/00 , C12Q1/6883
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20080051338A1
公开(公告)日：2008-02-28
申请号：US11777133
申请日：2007-07-12
申请人： George Komatsoulis , Craig Rosen , Steven Ruben , Roxanne Duan , Paul Moore , Yanggu Shi , David LaFleur , Ying-Fei Wei , Jian Ni , Kimberly Florence , Paul Young , Laurie Brewer , Daniel Soppet , Gregory Endress , Reinhard Ebner , Henrik Olsen , Michael Mucenski
发明人： George Komatsoulis , Craig Rosen , Steven Ruben , Roxanne Duan , Paul Moore , Yanggu Shi , David LaFleur , Ying-Fei Wei , Jian Ni , Kimberly Florence , Paul Young , Laurie Brewer , Daniel Soppet , Gregory Endress , Reinhard Ebner , Henrik Olsen , Michael Mucenski
IPC分类号： A61K31/70 , A61K38/00 , C07K14/00 , C07K16/18 , C12N15/00 , C12N15/11 , C12N15/87 , C12N5/06 , C12P21/04 , C12Q1/68 , G01N33/53
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20070020724A1
公开(公告)日：2007-01-25
申请号：US10886642
申请日：2004-07-09
申请人： Steven Ruben , Jian Ni , Craig Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel Soppet , Laurie Brewer , Gregory Endress , Kenneth Carter , Michael Mucenski , Reinhard Ebner , David LaFleur , Henrik Olsen , Yanggu Shi , Paul Moore , George Komatsoulis
发明人： Steven Ruben , Jian Ni , Craig Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel Soppet , Laurie Brewer , Gregory Endress , Kenneth Carter , Michael Mucenski , Reinhard Ebner , David LaFleur , Henrik Olsen , Yanggu Shi , Paul Moore , George Komatsoulis
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20060079670A1
公开(公告)日：2006-04-13
申请号：US11229769
申请日：2005-09-20
申请人： George Komatsoulis , Craig Rosen , Steven Ruben , Roxanne Duan , Paul Moore , Yanggu Shi , David LaFleur , Ying-Fei Wei , Jian Ni , Kimberly Florence , Paul Young , Laurie Brewer , Daniel Soppet , Gregory Endress , Reinhard Ebner , Henrik Olsen , Michael Mucenski
发明人： George Komatsoulis , Craig Rosen , Steven Ruben , Roxanne Duan , Paul Moore , Yanggu Shi , David LaFleur , Ying-Fei Wei , Jian Ni , Kimberly Florence , Paul Young , Laurie Brewer , Daniel Soppet , Gregory Endress , Reinhard Ebner , Henrik Olsen , Michael Mucenski
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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