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    Diagnostic methods involving human growth factor huXAG-1
    52.
    发明授权
    Diagnostic methods involving human growth factor huXAG-1 有权
    涉及人类生长因子huXAG-1的诊断方法

    公开(公告)号：US07611846B2

    公开(公告)日：2009-11-03

    申请号：US11368664

    申请日：2006-03-07

    申请人： Guo-Liang Yu ,  Patrick J. Dillon ,  Reinhard Ebner ,  Gregory A. Endress

    发明人： Guo-Liang Yu ,  Patrick J. Dillon ,  Reinhard Ebner ,  Gregory A. Endress

    IPC分类号： G01N33/53 ,  C07K16/00 ,  A61K38/27

    CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K2317/92

    摘要： The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity. Also provided are diagnostic and therapeutic uses of huXAG-1, huXAG-2 and huXAG-3.

    摘要翻译： 本发明涉及作为新型人生长因子的huXAG-1，huXAG-2和huXAG-3蛋白。 特别地，提供编码huXAG-1，huXAG-2和huXAG-3蛋白的分离的核酸分子。 还提供huXAG-1，huXAG-2和huXAG-3多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定huXAG-1，huXAG-2或huXAG-3活性的激动剂和拮抗剂的筛选方法。 还提供了huXAG-1，huXAG-2和huXAG-3的诊断和治疗用途。

    Human Neuronal Attachment Factor-1
    53.
    发明申请
    Human Neuronal Attachment Factor-1 失效
    人类神经元附着因子-1

    公开(公告)号：US20090208974A1

    公开(公告)日：2009-08-20

    申请号：US12364360

    申请日：2009-02-02

    申请人： Gregg Hastings ,  Patrick J. Dillon

    发明人： Gregg Hastings ,  Patrick J. Dillon

    IPC分类号： G01N33/53

    CPC分类号： C07K14/47 ,  A61K38/00 ,  Y02A50/411

    摘要： A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating spinal cord injuries and damage to peripheral nerves by promoting neural-cell adhesion and neurite extension, inhibiting tumor metastases and tumor angiogenesis, and stimulating wound repair. Antagonists are also disclosed which may be utilized to prevent malaria. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

    摘要翻译： 公开了一种编码这种蛋白质的人类F-脊椎样蛋白样蛋白和DNA（RNA）以及通过重组技术产生这种蛋白质的方法。 还公开了通过促进神经细胞粘附和神经突延伸，抑制肿瘤转移和肿瘤血管发生以及刺激伤口修复来利用这种多肽来治疗脊髓损伤和损伤周围神经的方法。 还公开了可用于预防疟疾的拮抗剂。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

    Fibroblast Growth Factor-14
    54.
    发明申请
    Fibroblast Growth Factor-14 审中-公开
    成纤维细胞生长因子-14

    公开(公告)号：US20090029916A1

    公开(公告)日：2009-01-29

    申请号：US11968702

    申请日：2008-01-03

    申请人： John M. Greene ,  Patrick J. Dillon

    发明人： John M. Greene ,  Patrick J. Dillon

    IPC分类号： C07K14/475 ,  C12N15/11 ,  C12N15/85 ,  C12P21/02 ,  C12N5/10 ,  A61K38/18 ,  C07K16/00 ,  A61K31/7088 ,  C12Q1/02 ,  C12Q1/68

    CPC分类号： C07K14/50 ,  A61K38/00 ,  C12N2799/026

    摘要： Disclosed is a human Fibroblast growth factor-14 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage due to associated with stroke and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate angiogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

    摘要翻译： 公开了人成纤维细胞生长因子-14多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 还公开了利用这种多肽促进伤口愈合的方法，例如作为烧伤和溃疡的结果，以防止与中风相关的神经元损伤并促进神经元生长，并防止皮肤老化和脱发，刺激血管发生，中胚层 诱导早期胚胎和肢体再生。 还公开了抗这些多肽的拮抗剂及其作为预防异常细胞增殖，高血管疾病和上皮细胞增殖的治疗剂的用途。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

    Fibroblast growth factor 14
    55.
    发明授权
    Fibroblast growth factor 14 失效
    成纤维细胞生长因子14

    公开(公告)号：US06787640B2

    公开(公告)日：2004-09-07

    申请号：US08462159

    申请日：1995-06-05

    申请人： John M. Greene ,  Patrick J. Dillon

    发明人： John M. Greene ,  Patrick J. Dillon

    IPC分类号： C07H2100

    CPC分类号： C07K14/50 ,  A61K38/00 ,  C12N2799/026

    摘要： Disclosed is a human Fibroblast growth factor-14 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage due to associated with stroke and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate angiogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

    摘要翻译： 公开了人成纤维细胞生长因子-14多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 还公开了利用这种多肽促进伤口愈合的方法，例如作为烧伤和溃疡的结果，以防止与中风相关的神经元损伤并促进神经元生长，并防止皮肤老化和脱发，刺激血管发生，中胚层 诱导早期胚胎和肢体再生。 还公开了抗这些多肽的拮抗剂及其作为预防异常细胞增殖，高血管疾病和上皮细胞增殖的治疗剂的用途。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

    Fibroblast growth factor-14
    58.
    发明授权
    Fibroblast growth factor-14 失效
    成纤维细胞生长因子-14

    公开(公告)号：US07338934B2

    公开(公告)日：2008-03-04

    申请号：US10787879

    申请日：2004-02-27

    申请人： John M. Greene ,  Patrick J. Dillon

    发明人： John M. Greene ,  Patrick J. Dillon

    IPC分类号： C07H14/475 ,  A61K38/18 ,  C07K14/50

    CPC分类号： C07K14/50 ,  A61K38/00 ,  C12N2799/026

    摘要： Disclosed is a human Fibroblast growth factor-14 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage due to associated with stroke and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate angiogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

    摘要翻译： 公开了人成纤维细胞生长因子-14多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 还公开了利用这种多肽促进伤口愈合的方法，例如作为烧伤和溃疡的结果，以防止与中风相关的神经元损伤并促进神经元生长，并防止皮肤老化和脱发，刺激血管发生，中胚层 诱导早期胚胎和肢体再生。 还公开了抗这些多肽的拮抗剂及其作为预防异常细胞增殖，高血管疾病和上皮细胞增殖的治疗剂的用途。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

    Human growth factors
    60.
    发明授权
    Human growth factors 失效
    人类生长因子

    公开(公告)号：US06818412B2

    公开(公告)日：2004-11-16

    申请号：US10078337

    申请日：2002-02-21

    申请人： Guo-Liang Yu ,  Patrick J. Dillon ,  Reinhard Ebner ,  Gregory A. Endress

    发明人： Guo-Liang Yu ,  Patrick J. Dillon ,  Reinhard Ebner ,  Gregory A. Endress

    IPC分类号： G01N33567

    CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K2317/92

    摘要： The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity. Also provided are diagnostic and therapeutic uses of huXAG-1. huXAG-2 and huXAG-3.

    摘要翻译： 本发明涉及作为新型人生长因子的huXAG-1，huXAG-2和huXAG-3蛋白。 特别地，提供编码huXAG-1，huXAG-2和huXAG-3蛋白的分离的核酸分子。 还提供huXAG-1，huXAG-2和huXAG-3多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定huXAG-1，huXAG-2或huXAG-3活性的激动剂和拮抗剂的筛选方法。 还提供了huXAG-1的诊断和治疗用途。 huXAG-2和huXAG-3。