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公开(公告)号：US07060801B2
公开(公告)日：2006-06-13
申请号：US10922101
申请日：2004-08-20
IPC分类号： C07K16/00 , G01N33/356 , G01N33/53
CPC分类号： C07K14/475 , A61K38/00 , C07K2317/92
摘要： The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity. Also provided are diagnostic and therapeutic uses of huXAG-1. huXAG-2 and huXAG-3.
摘要翻译： 本发明涉及作为新型人生长因子的huXAG-1，huXAG-2和huXAG-3蛋白。 特别地，提供编码huXAG-1，huXAG-2和huXAG-3蛋白的分离的核酸分子。 还提供huXAG-1，huXAG-2和huXAG-3多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定huXAG-1，huXAG-2或huXAG-3活性的激动剂和拮抗剂的筛选方法。 还提供了huXAG-1的诊断和治疗用途。 huXAG-2和huXAG-3。
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公开(公告)号：US06818412B2
公开(公告)日：2004-11-16
申请号：US10078337
申请日：2002-02-21
IPC分类号： G01N33567
CPC分类号： C07K14/475 , A61K38/00 , C07K2317/92
摘要： The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity. Also provided are diagnostic and therapeutic uses of huXAG-1. huXAG-2 and huXAG-3.
摘要翻译： 本发明涉及作为新型人生长因子的huXAG-1，huXAG-2和huXAG-3蛋白。 特别地，提供编码huXAG-1，huXAG-2和huXAG-3蛋白的分离的核酸分子。 还提供huXAG-1，huXAG-2和huXAG-3多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定huXAG-1，huXAG-2或huXAG-3活性的激动剂和拮抗剂的筛选方法。 还提供了huXAG-1的诊断和治疗用途。 huXAG-2和huXAG-3。
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公开(公告)号：US20090005301A1
公开(公告)日：2009-01-01
申请号：US11759448
申请日：2007-06-07
申请人： Jian Ni , Reinhard Ebner , David W. LaFleur , Paul A. Moore , Henrik S. Olsen , Craig A. Rosen , Steven M. Ruben , Daniel R. Soppet , Paul E. Young , Yanggu Shi , Kimberly A. Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie L. Fischer , Ann M. Ferrie , Ping Fan , Ping Feng , Gregory A. Endress , Patrick J. Dillon , Kenneth C. Carter , Laurie A. Brewer , Guo-Liang Yu , Zhizhen Zeng , John M. Greene
发明人： Jian Ni , Reinhard Ebner , David W. LaFleur , Paul A. Moore , Henrik S. Olsen , Craig A. Rosen , Steven M. Ruben , Daniel R. Soppet , Paul E. Young , Yanggu Shi , Kimberly A. Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie L. Fischer , Ann M. Ferrie , Ping Fan , Ping Feng , Gregory A. Endress , Patrick J. Dillon , Kenneth C. Carter , Laurie A. Brewer , Guo-Liang Yu , Zhizhen Zeng , John M. Greene
IPC分类号： C07K14/47 , C12N15/12 , C12N15/85 , C07K16/18 , C12Q1/68 , A61K38/14 , A61K31/7088 , G01N33/68 , C12P21/02 , C12N15/00 , C12N5/10
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US06171816B2
公开(公告)日：2001-01-09
申请号：US08916576
申请日：1997-08-22
IPC分类号： C12N1500
CPC分类号： C07K14/475 , A61K38/00 , C07K2317/92
摘要： The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity. Also provided are diagnostic and therapeutic uses of huXAG-1. huXAG-2 and huXAG-3.
摘要翻译： 本发明涉及作为新型人生长因子的huXAG-1，huXAG-2和huXAG-3蛋白。 特别地，提供编码huXAG-1，huXAG-2和huXAG-3蛋白的分离的核酸分子。 还提供huXAG-1，huXAG-2和huXAG-3多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定huXAG-1，huXAG-2或huXAG-3活性的激动剂和拮抗剂的筛选方法。 还提供了huXAG-1的诊断和治疗用途。 huXAG-2和huXAG-3。
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公开(公告)号：US20100239564A1
公开(公告)日：2010-09-23
申请号：US12567317
申请日：2009-09-25
IPC分类号： A61K39/395 , C07H21/00 , C12N15/74 , C07K14/00 , C07K7/06 , C07K7/08 , C12N1/21 , C07K16/18 , A61K38/18 , C12Q1/68 , G01N33/53 , G01N33/567 , A61P35/00
CPC分类号： C07K14/475 , A61K38/00 , C07K2317/92
摘要： The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity. Also provided are diagnostic and therapeutic uses of huXAG-1. huXAG-2 and huXAG-3.
摘要翻译： 本发明涉及作为新型人生长因子的huXAG-1，huXAG-2和huXAG-3蛋白。 特别地，提供编码huXAG-1，huXAG-2和huXAG-3蛋白的分离的核酸分子。 还提供huXAG-1，huXAG-2和huXAG-3多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定huXAG-1，huXAG-2或huXAG-3活性的激动剂和拮抗剂的筛选方法。 还提供了huXAG-1的诊断和治疗用途。 huXAG-2和huXAG-3。
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公开(公告)号：US07611846B2
公开(公告)日：2009-11-03
申请号：US11368664
申请日：2006-03-07
CPC分类号： C07K14/475 , A61K38/00 , C07K2317/92
摘要： The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity. Also provided are diagnostic and therapeutic uses of huXAG-1, huXAG-2 and huXAG-3.
摘要翻译： 本发明涉及作为新型人生长因子的huXAG-1，huXAG-2和huXAG-3蛋白。 特别地，提供编码huXAG-1，huXAG-2和huXAG-3蛋白的分离的核酸分子。 还提供huXAG-1，huXAG-2和huXAG-3多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定huXAG-1，huXAG-2或huXAG-3活性的激动剂和拮抗剂的筛选方法。 还提供了huXAG-1，huXAG-2和huXAG-3的诊断和治疗用途。
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公开(公告)号：US06525174B1
公开(公告)日：2003-02-25
申请号：US09205258
申请日：1998-12-04
申请人： Paul Young , John M. Greene , Ann M. Ferrie , Steven M. Ruben , Craig A. Rosen , Jing-Shan Hu , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , Charles Florence , Kimberly Florence , David W. Lafleur , Jian Ni , Ping Fan , Ying-Fei Wei , Carrie L. Fischer , Daniel R. Soppet , Yi Li , Zhizhen Zeng , Hla Kyaw , Guo-Liang Yu , Ping Feng , Patrick J. Dillon , Gregory A. Endress , Kenneth C. Carter
发明人： Paul Young , John M. Greene , Ann M. Ferrie , Steven M. Ruben , Craig A. Rosen , Jing-Shan Hu , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , Charles Florence , Kimberly Florence , David W. Lafleur , Jian Ni , Ping Fan , Ying-Fei Wei , Carrie L. Fischer , Daniel R. Soppet , Yi Li , Zhizhen Zeng , Hla Kyaw , Guo-Liang Yu , Ping Feng , Patrick J. Dillon , Gregory A. Endress , Kenneth C. Carter
IPC分类号： C07K1447
CPC分类号： G01N33/68 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N15/11 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US06531447B1
公开(公告)日：2003-03-11
申请号：US09690454
申请日：2000-10-18
申请人： Steven M. Ruben , Craig A. Rosen , Kenneth C. Carter , Patrick J. Dillon , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng
发明人： Steven M. Ruben , Craig A. Rosen , Kenneth C. Carter , Patrick J. Dillon , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng
IPC分类号： C07K1400
CPC分类号： C07K14/47 , A61K38/00 , C07K14/525 , G01N2500/04
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US06420526B1
公开(公告)日：2002-07-16
申请号：US09149476
申请日：1998-09-08
申请人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel P. Soppet , Kenneth C. Carter , Daniel R. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. Lafleur , Yi Li , Zhizhen Zeng , Hla Kyaw
发明人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel P. Soppet , Kenneth C. Carter , Daniel R. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. Lafleur , Yi Li , Zhizhen Zeng , Hla Kyaw
IPC分类号： C12Q168
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US20120122762A1
公开(公告)日：2012-05-17
申请号：US13359199
申请日：2012-01-26
申请人： Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
发明人： Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
IPC分类号： A61K38/17 , C12N15/63 , C07K14/435 , C07K16/18 , G01N33/53 , C12Q1/68 , C12P21/00 , G01N33/68 , C12N15/85 , C12N15/70 , C12N1/21 , C12N5/10 , A61P7/00 , A61P35/00 , A61P13/12 , A61P9/00 , A61P11/00 , A61P17/02 , A61P25/00 , A61P5/00 , A61P15/00 , A61P31/00 , A61P1/00 , C12N15/12
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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