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    Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    53.
    发明授权
    Gonadotropin-releasing hormone receptor antagonists and methods relating thereto 有权
    促性腺激素释放激素受体拮抗剂及其相关方法

    公开(公告)号：US06740656B2

    公开(公告)日：2004-05-25

    申请号：US10211993

    申请日：2002-08-02

    申请人： Joseph Pontillo ,  Chen Chen

    发明人： Joseph Pontillo ,  Chen Chen

    IPC分类号： C07D49804

    CPC分类号： C07D513/04

    摘要： GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, R1, R2, R3a, R3b, R4, R5, R6, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

    摘要翻译： 公开了GnRH受体拮抗剂，其可用于治疗男性和女性中各种性激素相关病症。 本发明的化合物具有以下结构：其中A，R1，R2，R3a，R3b，R4，R5，R6和n如本文所定义，包括其立体异构体，前药和药学上可接受的盐。 还公开了含有本发明化合物与药学上可接受的载体组合的组合物，以及涉及其在有需要的受试者中拮抗促性腺激素释放激素的方法。

    CRF antagonistic quino-and quinazolines
    54.
    发明授权
    CRF antagonistic quino-and quinazolines 有权
    CRF对抗喹诺酮和喹唑啉

    公开(公告)号：US06610678B2

    公开(公告)日：2003-08-26

    申请号：US10266662

    申请日：2002-10-08

    申请人： Charles Huang ,  Keith M. Wilcoxen ,  Chen Chen ,  Mustapha Haddach ,  James R. McCarthy

    发明人： Charles Huang ,  Keith M. Wilcoxen ,  Chen Chen ,  Mustapha Haddach ,  James R. McCarthy

    IPC分类号： A61K3133

    CPC分类号： C07D215/233 ,  C07D215/12 ,  C07D215/36 ,  C07D215/42 ,  C07D239/94 ,  C07D401/04

    摘要： This invention concerns compounds of formula including the stereoisomers and the pharmaceutically acceptable acid addition salt forms thereof, wherein R1 is C1-6alkyl, NR6R7, OR6 or SR7; R2 is hydrogen, C1-6alkyl, C1-6alkyloxy or C1-6alkylthio; R3 is Ar1 or Het1; R4 and R5 are each independently selected from hydrogen, halo, C1-6alkyl, C1-6alkyloxy, trifluoromethyl, cyano, nitro, amino, and mono- or di(C1-6alkyl)amino; R6 is hydrogen, C1-6alkyl, C1-6alkylsulfonyl, C1-6alkylsulfoxy or C1-6alkylthio; R7 is hydrogen, C1-8alkyl, mono- or di(C3-6cyclo-alkyl)methyl, C3-6cycloalkyl, C3-6alkenyl, hydroxyC1-6alkyl, C1-6alkylcarbonyloxy-C1-6alkyl or C1-6alkyloxyC1-6alkyl; R6 is C1-8alkyl, mono- or di(C3-6cycloalkyl)-methyl, Ar2CH2, C1-6alkyloxyC1-6alkyl, hydroxyC1-6alkyl, C3-6alkenyl, thienylmethyl, furanylmethyl, C1-6alkylthioC1-6alkyl, mono- or di(C1-6alkyl)aminoC1-6alkyl, di(C1-6alkyl)amino, C1-6alkylcarbonylC1-6alkyl; or R6 and R7 taken together with the nitrogen atom to which they are attached may form a pyrrolidinyl, piperidinyl, homopiperidinyl or morpholinyl group, optionally substituted with C1-6alkyl or C1-6alkyloxyC1-6alkyl; and Ar1 and Ar2 are each optionally substituted phenyl; and Het1 is optionally substituted pyridinyl; having CRF receptor antagonistic properties; pharmaceutical compositions containing such compounds as active ingredients; methods of treating disorders related to hypersecretion of CRF such as depression, anxiety, substance abuse, by administering an effective amount of a compound of formula (I).

    摘要翻译： 本发明涉及包括其立​​体异构体及其药学上可接受的酸加成盐形式的化合物，其中R 1是C 1-6烷基，NR 6 R 7，OR 6或SR 7; R2是氢，C1-6烷基，C1-6烷氧基或C1-6烷硫基; R3是Ar1或Het1; R 4和R 5各自独立地选自氢，卤素，C 1-6烷基，C 1-6烷氧基，三氟甲基，氰基，硝基，氨基和单或二（C 1-6烷基）氨基; R6是氢，C1-6烷基，C1-6烷基磺酰基，C1-6烷基亚磺酰基或C1-6烷硫基; R 7是氢，C 1-8烷基，一或二（C 3-6环烷基）甲基，C 3-6环烷基，C 3-6烯基，羟基C 1-6烷基，C 1-6烷基羰氧基-C 1-6烷基或C 1-6烷氧基C 1-6烷基; R 6是C 1-8烷基，单或二（C 3-6环烷基） - 甲基，Ar 2 CH 2，C 1-6烷氧基C 1-6烷基，羟基C 1-6烷基，C 3-6烯基，噻吩基甲基，呋喃基甲基，C 1-6烷硫基C 1-6烷基，单或二 1-6烷基）氨基C 1-6烷基，二（C 1-6烷基）氨基，C 1-6烷基羰基C 1-6烷基; 或R6和R7与它们所连接的氮原子一起可以形成任选被C 1-6烷基或C 1-6烷氧基C 1-6烷基取代的吡咯烷基，哌啶基，高哌啶基或吗啉基; Ar 1和Ar 2各自为任意取代的苯基; Het1是任选取代的吡啶基; 具有CRF受体拮抗特性; 含有这些化合物作为活性成分的药物组合物; 通过施用有效的方法治疗与CRF分泌过高有关的疾病，如抑郁症，焦虑症，药物滥用

    Neck pillow
    55.
    外观设计
    Neck pillow 有权

    公开(公告)号：USD1038644S1

    公开(公告)日：2024-08-13

    申请号：US29847001

    申请日：2022-07-20

    申请人： Chen Chen

    设计人： Chen Chen

    摘要： FIG. 1 is a front and top perspective view of a neck pillow, showing my new design;
    FIG. 2 is a rear and bottom perspective view thereof;
    FIG. 3 is a front elevation view thereof;
    FIG. 4 is a rear elevation view thereof;
    FIG. 5 is a left side elevation view thereof;
    FIG. 6 is a right side elevation view thereof;
    FIG. 7 is a top plan view thereof; and,
    FIG. 8 is a bottom plan view thereof.
    The broken lines in the figures illustrate portions of the neck pillow that form no part of the claimed design.

    Probe assembly for process vessels
    56.
    发明授权
    Probe assembly for process vessels 有权

    公开(公告)号：US11588958B2

    公开(公告)日：2023-02-21

    申请号：US17493530

    申请日：2021-10-04

    申请人： Chen Chen ,  William Cote ,  Paul Ream

    发明人： Chen Chen ,  William Cote ,  Paul Ream

    IPC分类号： G03B11/04 ,  H04N5/225 ,  F27D21/02

    摘要： A probe assembly for a process vessel for viewing the inside of the vessel, the probe assembly includes an elongated bracket, an elongated frame, an ICPC unit, and a camera unit. The elongated bracket has a front face and a rear face, the elongated bracket having an upper portion and a lower portion, the lower portion has a first aperture. The elongated frame has a proximal end and a distal end, the distal end of the elongated frame is coupled to the upper portion of the front face of the bracket. The ICPC unit includes a housing that has a front wall, a rear wall, and side wall extended between the front wall and the rear wall, the front wall has a second aperture, the rear wall has a third aperture. The ICPC unit further includes an actuator enclosed in the housing and an elongated tube operably coupled to the actuator, the tube extends through the second aperture and the first aperture away from the rear face of the bracket, the actuator configured to reciprocate the tube between an extended position and a retracted position. The camera unit includes a camera enclosure housing a camera, wherein the actuation member is configured to reciprocate the camera unit between the engage mode and stand-by mode, in the engage mode, the lens' hood is within the tube of the ICPC unit, and in the stand-by mode, the camera unit is away from the ICPC unit towards the proximal end of the elongated frame.

    Wireless communications system and precoding method
    57.
    发明授权
    Wireless communications system and precoding method 有权
    无线通信系统和预编码方法

    公开(公告)号：US09325390B2

    公开(公告)日：2016-04-26

    申请号：US13126677

    申请日：2009-11-04

    申请人： Ming Ding ,  Renmao Liu ,  Yingyu Zhang ,  Lei Huang ,  Chen Chen ,  Guolin Sun

    发明人： Ming Ding ,  Renmao Liu ,  Yingyu Zhang ,  Lei Huang ,  Chen Chen ,  Guolin Sun

    IPC分类号： H04B7/06 ,  H04B7/02 ,  H04B7/08 ,  H04L1/06 ,  H04L25/03 ,  H04B7/04 ,  H04L1/00 ,  H04L5/00

    CPC分类号： H04B7/024 ,  H04B7/0413 ,  H04B7/0486 ,  H04B7/0632 ,  H04B7/0634 ,  H04B7/0639 ,  H04B7/086 ,  H04L1/0026 ,  H04L1/0029 ,  H04L1/0675 ,  H04L5/0023 ,  H04L5/0035 ,  H04L25/03343 ,  H04L25/03866 ,  H04L2025/03426 ,  H04L2025/03808

    摘要： The present invention provides a precoding method for use in a wireless communications system. According to the precoding method of the present invention, a serving base station and cooperative communication base stations employ an identical precoding matrix so as to weight transmission signals and then transmit them. The weighting stands for multiplication of results of overall precoding or each layer precoding process by weight values at the serving base station and the cooperative communication base stations. A user device corresponding to the serving base station and the cooperative communication base stations receives a signal which is obtained by an operation in which the serving base station and the cooperative communication base stations perform an identical precoding process and additively combine results of overall precoding or each layer precoding process with one another. The user device feeds back information which includes (i) precoding matrix information for the serving base station and the cooperative communication base stations, (ii) weight vector information for either overall precoding or layer precoding, and (iii) a quantized value of channel quality. This feedback information is thus advantageous in that its signaling information amount is small.

    摘要翻译： 本发明提供一种在无线通信系统中使用的预编码方法。 根据本发明的预编码方法，服务基站和协作通信基站采用相同的预编码矩阵，以便对传输信号进行加权，然后发送它们。 加权表示在服务基站和协作通信基站处通过加权值对总预编码或每层预编码处理的结果进行乘法。 对应于服务基站和协作通信基站的用户设备接收通过其中服务基站和协作通信基站执行相同的预编码处理的操作而获得的信号，并且相加地组合整体预编码或每个 层预编码过程。 用户装置反馈信息，其包括（i）用于服务基站和协作通信基站的预编码矩阵信息，（ii）用于总体预编码或层预编码的加权矢量信息，以及（iii）信道质量的量化值 。 因此，该反馈信息的信令信息量小。

    Implantable blood pump with integrated controller
    58.
    发明授权
    Implantable blood pump with integrated controller 有权
    带集成控制器的植入式血液泵

    公开(公告)号：US09308305B2

    公开(公告)日：2016-04-12

    申请号：US14308177

    申请日：2014-06-18

    申请人： Keming Chen ,  Chen Chen ,  Frank Lin

    发明人： Keming Chen ,  Chen Chen ,  Frank Lin

    IPC分类号： A61N1/362 ,  A61M1/12 ,  A61M1/10

    CPC分类号： A61M1/122 ,  A61M1/101 ,  A61M1/1015 ,  A61M1/1031 ,  A61M1/1086 ,  A61M1/127

    摘要： An implantable blood pump includes motor control circuitry and power electronics circuitry integrated within the implantable pump body. The motor control circuitry and power electronics circuitry is configured to energize and control motor windings to rotate the pump rotor and impeller. Additional control circuitry and power electronics circuitry may be integrated within the pump housing to energize and control magnetic bearings of a magnetic levitation pump. A percutaneous cable coupled between the implantable blood pump and an extracorporeal monitor includes a reduced number of leads to provide power and control signals to the implantable blood pump. Wireless communication between the extracorporeal monitor and the integrated power electronics and control circuitry facilitates the use of a percutaneous cable with as few as two leads for providing power to the implantable pump.

    摘要翻译： 可植入血液泵包括集成在可植入泵体内的马达控制电路和电力电子电路。 电动机控制电路和电力电子电路被配置为激励和控制电动机绕组以使泵转子和叶轮旋转。 附加的控制电路和电力电子电路可以集成在泵壳体内以激励和控制磁悬浮泵的磁轴承。 耦合在可植入血液泵和体外监测器之间的经皮电缆包括减少数量的引线以向可植入血液泵提供功率和控制信号。 体外监测器和集成电力电子和控制电路之间的无线通信有助于使用具有少至两个引线的经皮电缆，以向可植入泵提供电力。

    Heat dissipation system
    59.
    发明授权
    Heat dissipation system 有权
    散热系统

    公开(公告)号：US08848363B2

    公开(公告)日：2014-09-30

    申请号：US13152410

    申请日：2011-06-03

    申请人： Chen Chen ,  Hong-Zhi Sun ,  Yang Li

    发明人： Chen Chen ,  Hong-Zhi Sun ,  Yang Li

    IPC分类号： G06F1/20 ,  H05K7/20

    CPC分类号： G06F1/20

    摘要： A heat dissipation system includes a computer case having a base plate and a back plate perpendicularly to the base plate, a motherboard on the base plate adjacent to the back plate, and a mass storage device beside the motherboard. The motherboard has a heat sink and a first fan on the heat sink. The base plate has a second fan beside the motherboard. The second fan is adjacent to the back plate. The mass storage device is away from the back plate. The first fan rotates in such a manner that airflow is drawn into the computer case, flows through the heat sink and is exhausted out of the computer case. The second fan rotates in such a manner that airflow is drawn into the computer case, flows through the mass storage device and is exhausted out of the computer case.

    摘要翻译： 散热系统包括具有基板和垂直于基板的背板的计算机外壳，与底板相邻的基板上的主板和主板旁边的大容量存储装置。 主板上有散热片和散热片上的第一个风扇。 基板在主板旁边有一个第二个风扇。 第二个风扇与背板相邻。 大容量存储装置远离背板。 第一风扇以这样的方式旋转，使得气流被吸入计算机外壳中，流过散热器并被排出计算机外壳。 第二风扇以这样的方式旋转，使得气流被吸入计算机外壳中，流过大容量存储装置并被排出计算机外壳。

    Method for switching radio resource control state, base station, and user equipment
    60.
    发明授权
    Method for switching radio resource control state, base station, and user equipment 有权
    切换无线电资源控制状态，基站和用户设备的方法

    公开(公告)号：US08565192B2

    公开(公告)日：2013-10-22

    申请号：US12933615

    申请日：2009-03-19

    申请人： Lei Huang ,  Renmao Liu ,  Yongming Liang ,  Ming Ding ,  Chen Chen

    发明人： Lei Huang ,  Renmao Liu ,  Yongming Liang ,  Ming Ding ,  Chen Chen

    IPC分类号： H04W4/00 ,  H04M11/00

    CPC分类号： H04W72/005

    摘要： The present invention provides: a method for switching an RRC state; an eNB; and a UE. The eNB (104) of the present invention includes: a sending/receiving unit (1040) for carrying out data communication with one or more MBMS•UEs in a cell; a calculation unit (1042) for calculating the number of RRC connections currently available in a system; an execution determination unit (1044) for determining whether or not a switchover of an RRC state of the one or more MBMS•UEs is necessary, on the basis of the number of RRC connections currently available in the system and a threshold value of the number of RRC connections; a request unit (1046) for transmitting, via the sending/receiving unit (1040), a measurement report request to all of the one or more MBMS•UEs in the cell, in a case where the execution determination unit (1044) determines that the switchover of the RRC state of the MBMS•UE(s) is necessary; and an accurate value determination unit (1048) for (i) determining an accurate reference measurement threshold value with respect to a parameter on the basis of the threshold value of the number of the RRC connections and data of a measured parameter, received via the sending/receiving unit (1040) from each of the one or more MBMS•UEs, and (ii) transmitting, via the sending/receiving unit (1040), the accurate reference measurement threshold value to all of the one or more MBMS•UEs in the cell.

    摘要翻译： 本发明提供一种切换RRC状态的方法， 一个eNB; 和UE。 本发明的eNB（104）包括：发送/接收单元（1040），用于与小区中的一个或多个MBMS.UE进行数据通信; 计算单元（1042），用于计算系统当前可用的RRC连接数; 执行确定单元，用于根据当前在系统中可用的RRC连接的数量和数量的阈值来确定是否需要对一个或多个MBMS.UE的RRC状态进行切换 的RRC连接; 在所述执行确定单元（1044）确定所述单元（1044）的情况下，经由所述发送/接收单元（1040）向所述小区中的所有一个或多个MBMS.UE发送测量报告请求的请求单元（1046） MBMS.UE的RRC状态的切换是必要的; 以及准确值确定单元（1048），用于（i）基于所述RRC连接的数量的阈值和经由所述发送器接收的测量参数的数据来确定关于参数的精确参考测量阈值 /接收单元（1040），并且（ii）经由发送/接收单元（1040）将准确的参考测量阈值发送到所有一个或多个MBMS.UE中的所有一个或多个MBMS.UE 细胞。