-
51.发明授权Halogen-substituted amino dicarboxylic acid derivatives as medicaments for treating cardiovascular diseases 失效卤素取代的氨基二羧酸衍生物作为治疗心血管疾病的药物公开(公告)号：US07067694B2
公开(公告)日：2006-06-27
申请号：US10469180
申请日：2002-02-18
申请人： Michael Härter , Michael G. Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
发明人： Michael Härter , Michael G. Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
IPC分类号： C07C63/00
CPC分类号： C07C229/38 , A61K31/197
摘要： Compounds of the general formula (I) wherein R1 represents halogen, R2 and R3 represent H or halogen, and R4 represents C3-8-cycloalkyl or optionally substituted phenyl, pharamceutical compositions containing such materials, and methods of using such materials in the treatment of various diseases are disclosed and claimed.
摘要翻译： 其中R 1表示卤素，R 2和R 3的通式（I）的化合物表示H或卤素，R“ 4表示C 3-8 - 环烷基或任选取代的苯基，含有这些材料的pharamceutical组合物，以及使用这些材料用于治疗各种疾病的方法。
-
公开(公告)号：US5122610A
公开(公告)日：1992-06-16
申请号：US467719
申请日：1990-01-19
IPC分类号： A61K38/55 , A61P5/38 , A61P9/00 , A61P9/12 , C07C323/65 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/08 , C07K5/10 , C07K7/02 , C07K14/81
CPC分类号： C07K5/0227 , C07K5/0205 , C07K7/02 , Y02P20/55
摘要： Renin-inhibiting aminomethyl peptides of the formula ##STR1## in which A is H, an alkyl radical, a sulphony radical or an amino-protecting group,B, D, E and F each independently is a direct bond or an amino-organo-carbonyl group,R.sup.1 is an optionally substituted alkyl or aryl radical,R.sup.2 is H, alyl or acyl,R.sup.3 is H, alkyl, aryl or acyl, andR.sup.4 is alkyl, alkoxy, aryl or amino, and physiologically acceptable salts thereof.
-
公开(公告)号：US20140113900A1
公开(公告)日：2014-04-24
申请号：US14115871
申请日：2012-05-02
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Alexander Straub , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Alexander Straub , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li
IPC分类号： C07D487/04 , A61K31/5025 , A61K45/06 , A61K31/53
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/53 , A61K45/06
摘要： The present application relates to novel substituted imidazopyridazines, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的咪唑并哒嗪，其制备方法，其单独或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防心血管疾病。
-
公开(公告)号：US08609727B2
公开(公告)日：2013-12-17
申请号：US12083814
申请日：2006-10-17
申请人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr , Dieter Lang
发明人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr , Dieter Lang
CPC分类号： C07C65/28
摘要： The present application relates to novel dicarboxylic acid derivatives, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型二羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病，特别是用于治疗和/或预防疾病的药物的用途。 预防心血管疾病。
-
55.发明申请RING-FUSED 4-AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES 失效环状4-氨基亚氨基嘧啶并用作可溶性冠状动脉疾病的刺激物公开(公告)号：US20130172372A1
公开(公告)日：2013-07-04
申请号：US13704980
申请日：2011-07-05
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li
IPC分类号： A61K31/519 , C07D491/20 , A61K45/06 , C07D471/04
CPC分类号： A61K31/519 , A61K45/06 , C07D471/04 , C07D491/20 , C07D519/00
摘要： The present application relates to novel fused 4-aminopyrimidines, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型融合的4-氨基嘧啶，其制备方法，单独或组合用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或治疗的药物的用途 预防疾病，特别是用于治疗和/或预防心血管疾病。
-
公开(公告)号：US08324222B2
公开(公告)日：2012-12-04
申请号：US12086784
申请日：2006-12-08
申请人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
发明人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
IPC分类号： C07D491/04 , A61K31/519 , A61P9/00
CPC分类号： C07D491/04
摘要： The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
摘要翻译： 本申请涉及新的循环取代的呋喃嘧啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于 治疗和/或预防心血管疾病。
-
公开(公告)号：US08183246B2
公开(公告)日：2012-05-22
申请号：US12086783
申请日：2006-12-08
申请人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
发明人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
IPC分类号： A01N43/90 , A61K31/519 , C07D491/00 , C07D495/00
CPC分类号： C07D491/04
摘要： The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
摘要翻译： 本申请涉及新颖的非循环取代的呋喃嘧啶衍生物，其生产方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于 治疗和/或预防心血管疾病。
-
公开(公告)号：US06939990B2
公开(公告)日：2005-09-06
申请号：US10469557
申请日：2002-02-18
申请人： Michael Härter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
发明人： Michael Härter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61P1/16 , A61K31/195 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/08 , A61P15/08 , A61P15/10 , A61P15/12 , A61P25/04 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/06 , A61P29/00 , A61P29/02 , A61P43/00 , C07B61/00 , C07C227/02 , C07C229/38 , C07C253/30 , C07C255/54 , C07C63/00
CPC分类号： C07C229/38 , C07C2601/14
摘要： The invention relates to compounds of the general formula (I) wherein R1 represents H, halogen, or OCF3; R2 and R3 each represents H or halogen; R4 represents C1-6-alkyl, C3-8-cycloalkyl, CF3, OCF3, F, Cl, OMe, or optionally substituted phenyl; V represents O, CH2O, OCF2, or O—C1-6-alkyl-O; and W represents CH2 or CH2CH2. A process for making such compounds, pharmaceutical compositions containing them, and methods of treatment of various conditions using them are also disclosed and claimed.
摘要翻译： 本发明涉及通式（I）的化合物，其中R 1表示H，卤素或OCF 3 N; R 2和R 3各自表示H或卤素; R 4表示C 1-6 - 烷基，C 3-8 - 环烷基，CF 3 - ， - F，Cl，OMe或任选取代的苯基; V表示O，CH 2 O，OCF 2或O-C 1-6烷基-O; W表示CH 2或CH 2 CH 2。 还公开并要求保护这些化合物的方法，含有它们的药物组合物，以及使用它们处理各种条件的方法。
-
59.发明授权Side-chain halogenated amino dicarboxylic acid derivatives as medicaments for treating cardiovascular diseases 失效侧链卤代氨基二羧酸衍生物作为治疗心血管疾病的药物公开(公告)号：US06939989B2
公开(公告)日：2005-09-06
申请号：US10469178
申请日：2002-02-22
申请人： Michael Härter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
发明人： Michael Härter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61P1/16 , A61K31/197 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/08 , A61P15/10 , A61P25/00 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/26 , A61P25/30 , A61P27/06 , C07B61/00 , C07C227/02 , C07C229/38 , C07C63/00
CPC分类号： C07C229/38
摘要： Compounds of the general formula (I) wherein R1 represents halogen, R2 represent H or halogen, and R3 represents C3-8-cycloalkyl, C3-8-cycloalkenyl, or optionally substituted phenyl, pharmaceutical compositions containing such material, and methods of using such materials in the treatment of various diseases are disclosed and claimed.
摘要翻译： 通式（I）的化合物，其中R 1表示卤素，R 2表示H或卤素，R 3表示C 1 -C 6烷基， 3-8环 - 环烷基，C 3-8 - 环烯基或任选取代的苯基，含有这些材料的药物组合物，以及使用这些材料治疗各种疾病的方法被公开， 声称。
-
公开(公告)号：US4818748A
公开(公告)日：1989-04-04
申请号：US22710
申请日：1987-03-06
IPC分类号： C07K14/81 , A61K38/00 , A61K38/55 , A61P9/12 , C07C67/00 , C07C223/06 , C07C229/22 , C07C231/00 , C07C233/36 , C07C233/43 , C07C237/02 , C07C237/06 , C07C237/12 , C07C237/22 , C07C239/00 , C07C253/00 , C07C255/58 , C07C255/59 , C07C269/00 , C07C273/10 , C07C301/00 , C07C303/30 , C07C303/40 , C07C311/00 , C07D233/54 , C07D249/08 , C07D521/00 , C07K20060101 , C07K1/00 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/08 , C07K5/10 , C07K7/02 , A61K37/02 , C07K7/06
CPC分类号： C07D233/64 , C07D231/12 , C07D233/56 , C07D249/08 , C07K5/0227 , C07C2103/18 , Y10S530/86
摘要： Anti-hypertensive compounds of the formula ##STR1## in which A represents hydrogen, C.sub.1 -C.sub.8 -alkyl, C.sub.7 -C.sub.14 -aralkyl, phenylsulphonyl, tolylsulphonyl or C.sub.1 -C.sub.8 -alkylsulfphonyl, or represents an aminoprotective group,B represents a direct bond, or represents sarcosyl, or represents a group of the formula ##STR2## D represents a direct bond, or represents a group of the formula ##STR3## wherein X represents methylene, ethylene or sulphur,E, G, J, K, L and M independently have the same meanings as B,R.sup.1 is an optionally substituted phenyl radical, andQ is a hydroxy, alkoxy or amino group, or a physiologically acceptable salt thereof.
摘要翻译： 其中A表示氢，C 1 -C 8 - 烷基，C 7 -C 14 - 芳烷基，苯基磺酰基，甲苯磺酰基或C 1 -C 8 - 烷基磺酰基，或表示氨基保护基的式（I）的抗高血压化合物，B表示 或直接键合，或表示肌氨酰基，或表示下式的基团：D表示直接键，或表示下式的基团：其中X表示亚甲基，亚乙基或硫，E，G，J，K， L和M独立地具有与B相同的含义，R 1是任选取代的苯基，Q是羟基，烷氧基或氨基或其生理上可接受的盐。
-
-
-
-
-
-
-
-
-
搜索结果
170 条记录 (耗时 0.072 秒)
