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51.发明申请Systems and methods for selecting aesthetic settings for use in displaying advertisements over a network 审中-公开用于选择用于通过网络显示广告的美学设置的系统和方法公开(公告)号：US20080177588A1
公开(公告)日：2008-07-24
申请号：US11656709
申请日：2007-01-23
申请人： Martin Abbott , Michael Fisher
发明人： Martin Abbott , Michael Fisher
IPC分类号： G06F9/46
CPC分类号： G06Q30/02
摘要： Systems and methods are provided for selecting aesthetic settings that increase, and preferably optimize, the yield (e.g., click-through rate) of advertisements displayed over a network (e.g., within internet web pages).
摘要翻译： 提供的系统和方法用于选择增加并优选地优化通过网络（例如，在因特网网页内）显示的广告的收益（例如，点击率）的美学设置。
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52.发明申请Gas delivery configurations, foam control systems, and bag molding methods and articles for collapsible bag vessels and bioreactors 审中-公开气体输送配置，泡沫控制系统和用于可折叠袋容器和生物反应器的袋成型方法和制品公开(公告)号：US20080068920A1
公开(公告)日：2008-03-20
申请号：US11818901
申请日：2007-06-15
申请人： Parrish Galliher , Geoffrey Hodge , Michael Fisher
发明人： Parrish Galliher , Geoffrey Hodge , Michael Fisher
CPC分类号： B65D33/02 , B01F3/04106 , B01F13/0827 , B01F15/00831 , B01F15/0085 , B01F2215/0073 , B29C45/16 , B29K2023/0633 , B29L2031/7128 , C12M23/14 , C12M29/06 , C12M41/02
摘要： Systems for containing and manipulating fluids including systems and methods involving supported collapsible bags that may be used as reactors for performing chemical, biochemical and/or biological reactions contained therein are provided. Generally, a series of improvements and features for fluid containment systems such as gas delivery configurations, foam control systems and bag molding methods and articles for supported collapsible bag vessels and bioreactors are provided. For instance, in one aspect, fluids contained in a vessel can be sparged, e.g., such that a fluid is directed into a container of the vessel, and in some cases, the sparging can be controlled by rapidly activating or altering the degree of sparging as needed. Multiple spargers may be used in some cases. In another aspect, the vessel includes a seamless collapsible bag. In some cases, the collapsible bag may be injected, blown, or spin cast molded. In yet another aspect, the vessel includes a device which can reduce the foam produced or contained within the vessel. Sensors and/or controllers may optionally be used to monitor and/or control foaming.
摘要翻译： 提供了用于容纳和操纵流体的系统，包括可用作用于执行其中包含的化学，生物化学和/或生物反应的反应器的负载可折叠袋的系统和方法。 通常，提供了用于流体容纳系统的一系列改进和特征，例如气体输送配置，泡沫控制系统和袋成型方法以及用于支撑的可折叠袋容器和生物反应器的制品。 例如，在一个方面，容器中包含的流体可以被喷射，例如使得流体被引导到容器的容器中，并且在一些情况下，可以通过快速激活或改变喷射程度来控制喷射 如所须。 在某些情况下可能会使用多种喷射器。 在另一方面，容器包括无缝的可折叠袋。 在一些情况下，可折叠袋可以被注入，吹塑或旋转铸塑。 在另一方面，容器包括可以减少容器内产生或容纳的泡沫的装置。 传感器和/或控制器可以可选地用于监测和/或控制发泡。
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53.发明申请公开(公告)号：US20060293339A1
公开(公告)日：2006-12-28
申请号：US10550641
申请日：2004-03-19
申请人： Prasun Chakravarty , Michael Fisher , William Parsons , Jun Liang , Bishan Zhou
发明人： Prasun Chakravarty , Michael Fisher , William Parsons , Jun Liang , Bishan Zhou
IPC分类号： A61K31/506 , A61K31/4965 , A61K31/497 , A61K31/455 , A61K31/4439 , C07D403/02 , A61K31/5377 , C07D413/02
CPC分类号： C07D213/26 , C07D213/55 , C07D213/56 , C07D239/26 , C07D401/04 , C07D403/04
摘要： Biaryl substituted pyridine, pyrimidine and pyrazine compounds are sodium channel blockers useful for the treatment of pain. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds.
摘要翻译： 双芳基取代的吡啶，嘧啶和吡嗪化合物是可用于治疗疼痛的钠通道阻滞剂。 药物组合物包含单独的或与一种或多种治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。 治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，癫痫，肠易激综合征，抑郁症，焦虑症，多发性硬化症和双相 包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。
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公开(公告)号：US20060183897A1
公开(公告)日：2006-08-17
申请号：US10549790
申请日：2004-03-12
申请人： Prasun Chakravarty , Michael Fisher , Brenda Palucki , Min Park , William Parsons , Bishan Zhou , James Carey , Douglas Frantz , Michael Kress , Damian Weaver
发明人： Prasun Chakravarty , Michael Fisher , Brenda Palucki , Min Park , William Parsons , Bishan Zhou , James Carey , Douglas Frantz , Michael Kress , Damian Weaver
IPC分类号： C07D417/02 , C07D403/02 , C07D413/02
CPC分类号： C07D249/08 , C07D249/10
摘要： Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.
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公开(公告)号：USD520410S1
公开(公告)日：2006-05-09
申请号：US29172121
申请日：2002-12-06
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公开(公告)号：US20060020006A1
公开(公告)日：2006-01-26
申请号：US10985592
申请日：2004-11-10
申请人： Min Park , Prasun Chakravarty , Bishan Zhou , Edward Gonzalez , Hyun Ok , Brenda Palucki , William Parsons , Rosemary Sisco , Michael Fisher , Louis Zuegner
发明人： Min Park , Prasun Chakravarty , Bishan Zhou , Edward Gonzalez , Hyun Ok , Brenda Palucki , William Parsons , Rosemary Sisco , Michael Fisher , Louis Zuegner
IPC分类号： A61K31/4196 , C07D403/02
CPC分类号： C07D249/10 , C07D403/10
摘要： Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.
摘要翻译： 由式I，II或III表示的取代的三唑化合物或其药学上可接受的盐。 药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。 治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，偏头痛，头痛，偏头痛，癫痫，肠易激综合征，糖尿病 神经病，多发性硬化症，躁狂抑郁症和双相性精神障碍，包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。 施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体组合施用。
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公开(公告)号：US09969965B2
公开(公告)日：2018-05-15
申请号：US13978726
申请日：2012-01-11
申请人： Colin Tuohey , Ted Deloggio , Thomas Erdenberger , Kenneth P. Clapp , Richard Damren , Parrish M. Galliher , Patrick Guertin , Jiyoung Lee , Michael Fisher
发明人： Colin Tuohey , Ted Deloggio , Thomas Erdenberger , Kenneth P. Clapp , Richard Damren , Parrish M. Galliher , Patrick Guertin , Jiyoung Lee , Michael Fisher
摘要： Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear/scalability/performance basis and also from a validation and regulatory basis. In summary, the 10L bioreactor system disclosed provides for “linear scalability” by using the same or substantially simulating the same vessel geometry, gas sparging system, impeller shape and type, polymer composition of the flexible bag/components, process control system, and shear rates as larger 50-5000 L systems.
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公开(公告)号：US09499781B2
公开(公告)日：2016-11-22
申请号：US13434345
申请日：2012-03-29
申请人： Richard Damren , Colin Touhey , Thomas Erdenberger , Michael Fisher , Geoffrey L. Hodge , Patrick M. Guertin , Parrish M. Galliher
发明人： Richard Damren , Colin Touhey , Thomas Erdenberger , Michael Fisher , Geoffrey L. Hodge , Patrick M. Guertin , Parrish M. Galliher
CPC分类号： C12M29/26 , B01D5/0042 , B01D5/0093 , B01D46/4263 , B01D53/265 , C12M23/28 , C12M29/04 , C12M41/12
摘要： Disclosed herein is a system and method for condensing moisture in a moist gas stream entering a bioreactor or leaving a bioreactor, forming a dry gas stream for entering or leaving the bioreactor.
摘要翻译： 本文公开了一种用于冷凝进入生物反应器或离开生物反应器的湿气流中的水分的系统和方法，形成用于进入或离开生物反应器的干燥气流。
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公开(公告)号：US09320914B2
公开(公告)日：2016-04-26
申请号：US12041405
申请日：2008-03-03
CPC分类号： A61N5/0622 , A61N5/0601 , A61N2005/0612 , A61N2005/063 , A61N2005/0659 , A61N2005/0662 , A61N2005/0663 , A61N2005/067
摘要： Endoscopic delivery of Red/NIR light to the Substantia Nigra to treat Parkinson's Disease in order to raise the energy levels in the substantia nigra.
摘要翻译： 将红/ NIR光内窥镜递送给黑质黑质以治疗帕金森病，以提高黑质中的能量水平。
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公开(公告)号：US09109193B2
公开(公告)日：2015-08-18
申请号：US12124039
申请日：2008-05-20
CPC分类号： C12M29/10 , B01D29/13 , C12M23/14 , C12M23/26 , C12M23/48 , C12M27/02 , C12M27/20 , C12M29/00 , C12M29/18 , C12M47/10
摘要： Systems and methods for containing and manipulating liquids, including vessels and unit operations or components of cell culture, cell containment, bioreactor, and/or pharmaceutical manufacturing systems, are provided. In certain embodiments, such vessels and unit operations are directed to continuous perfusion reactor or bioreactor systems and may include one or more disposable components. For instance, in one aspect, a system includes an apparatus in the form of a bioreactor for harvesting cells which produce one or more products. The apparatus may include a disposable, collapsible bag adapted for containing a liquid, the collapsible bag in fluid communication with a liquid-solids (e.g., cell) separation device. For example, an outlet of the collapsible bag may be connected to an inlet of the separation device, and an outlet of the separation device may be connected to an inlet of the collapsible bag for recycle. Accordingly, after separating the cells from the liquid in the separation device, the cells can be flowed back into the collapsible bag where they can be re-harvested. Meanwhile, product contained in the liquid can be collected in a separate container. The efficiency of product formation in such a system may be enhanced by using mixing systems described herein.
摘要翻译： 提供了用于容纳和操纵液体的系统和方法，包括容器和单元操作或细胞培养物，细胞容纳物，生物反应器和/或药物制造系统的组分。 在某些实施方案中，这样的容器和单元操作涉及连续灌注反应器或生物反应器系统，并且可以包括一个或多个一次性组件。 例如，一方面，系统包括生物反应器形式的装置，用于收集产生一种或多种产品的细胞。 该装置可以包括适于容纳液体的一次性可折叠袋，该可折叠袋与液体 - 固体（例如，池）分离装置流体连通。 例如，可折叠袋的出口可以连接到分离装置的入口，并且分离装置的出口可以连接到可折叠袋的入口以用于再循环。 因此，在分离装置中的液体分离细胞后，细胞可以流回到可收缩的袋子中，在那里它们可以被再次收获。 同时，包含在液体中的产品可以收集在单独的容器中。 通过使用本文所述的混合系统可以提高这种系统中产物形成的效率。
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