公开(公告)号：US20080302638A1

公开(公告)日：2008-12-11

申请号：US12097486

申请日：2006-10-27

申请人： Jonny Malmberg ,  Lennart Olsson

发明人： Jonny Malmberg ,  Lennart Olsson

IPC分类号： B65G21/18

CPC分类号： B65G21/18 ,  B65G2201/0202 ,  B65G2207/24

摘要： A supporting installation for supporting a number of turns extending helically one above the other in a belt pile and included in an at least partly self-supporting conveyor belt (2), comprising an inner supporting structure (8) which, together with an inner chain (5) supported by and movable along the same, defines an inner channel (12), in which one or more inner bearing elements (14) are arranged. Outer supporting structure (9) which, together with an outer chain (6) supported by and movable along the same, defines an outer channel (13), in which one or more outer bearing elements (15) are arranged. The installation is characterised in that each chain (5; 6) comprises abutment surfaces which form a radially outer side wall (23) of the inner channel (12) and the outer channel (13) respectively, and that the outer bearing elements (15) are arranged for transfer of radially inward forces from the outer chain (6) to the outer supporting structure (9).

摘要翻译： 一种用于支撑多个匝的支撑装置，包括一个至少部分自支撑的输送带（2）中的螺旋形螺旋形并且包括在至少部分自支撑的传送带（2）中，包括内部支撑结构（8），内部支撑结构 （5）由其支撑并可沿其移动，限定了内部通道（12），其中布置有一个或多个内部轴承元件（14）。 外支撑结构（9）与外链（6）一起支撑并沿其移动，限定了外通道（13），其中布置有一个或多个外轴承元件（15）。 该装置的特征在于，每个链条（5; 6）包括分别形成内部通道（12）和外部通道（13）的径向外侧壁（23）的邻接表面，并且外部轴承元件（15） ）被布置用于将径向向内的力从外链（6）传递到外支撑结构（9）。

公开(公告)号：US07144539B2

公开(公告)日：2006-12-05

申请号：US10115071

申请日：2002-04-04

申请人： Lennart Olsson

发明人： Lennart Olsson

IPC分类号： B29C59/00 ,  B29C43/02 ,  H01L21/302

CPC分类号： B82Y10/00 ,  B29C43/021 ,  B29C43/10 ,  B29C43/3642 ,  B29C59/022 ,  B29C59/026 ,  B29C2059/023 ,  B29C2791/006 ,  B82Y40/00 ,  G03F7/0002 ,  G11B7/263

摘要： An imprint process comprises the step of aligning a substrate, supported on a first support member, with a template, supported on a second support member. The substrate has at least one essentially plane surface provided with a moldable film. The template has at least one essentially plane surface provided with a relief pattern. The relief pattern is adapted to interact with the moldable film. The process further comprises the step of arranging a sealing gasket between the template and the second support member, such that a pressure cavity is defined by the second support member, the template and the sealing gasket. The process also comprises the step of applying a static gas pressure to the pressure cavity, in order to provide a pressure between the template and the substrate. The pressure is sufficient to form a pattern in the moldable film. An imprint device is also disclosed.

公开(公告)号：USD525403S1

公开(公告)日：2006-07-18

申请号：US29194413

申请日：2003-11-24

申请人： Stig Olsson ,  Lennart Olsson

设计人： Stig Olsson ,  Lennart Olsson

公开(公告)号：US07037902B2

公开(公告)日：2006-05-02

申请号：US10613754

申请日：2003-07-02

申请人： Lennart Olsson ,  Tatjana Naranda

发明人： Lennart Olsson ,  Tatjana Naranda

IPC分类号： C07K14/505

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K38/17 ,  A61K45/06 ,  C07K14/71 ,  G01N33/566 ,  G01N33/746 ,  G01N2500/00 ,  A61K2300/00

摘要： Compounds are provided that complex with the modulating domain of erythropoietin receptor (EPO-R) for use with EPO-R to determine the presence of EPO-R, the ability of other molecules to bind to the modulating domain in competitive assays and to induce a signal by EPO-R into a cell when bound by the subject compounds in a physiological environment. The compounds are characterized by having a six-membered heterocyclic ring comprising at least one nitrogen atom and include substituted triazolopyrimidine, pyridazinone, pyridine and piperidine.

摘要翻译： 提供了与EPO-R一起使用的促红细胞生成素受体（EPO-R）的调节结构域复合物以确定EPO-R的存在，其它分子在竞争性测定中结合调节结构域的能力并诱导 当在生理环境中被受试化合物结合时，EPO-R被信号传导到细胞中。 该化合物的特征在于具有包含至少一个氮原子的六元杂环，并且包括取代的三唑并嘧啶，哒嗪酮，吡啶和哌啶。

公开(公告)号：US06346390B1

公开(公告)日：2002-02-12

申请号：US08788820

申请日：1997-01-23

申请人： Lennart Olsson ,  Tatajna Navrenda

发明人： Lennart Olsson ,  Tatajna Navrenda

IPC分类号： G01N33566

CPC分类号： C07K14/705 ,  C07K14/62 ,  C07K14/70539 ,  C07K14/71 ,  C07K14/7153 ,  C07K14/7155 ,  C07K14/72 ,  C07K2319/00 ,  C07K2319/74 ,  C07K2319/75

摘要： Oligopeptides having an amino acid sequence corresponding to a receptor's extracellular domain, and having sequence similarity to regulatory peptides from MHC class I antigens, enhance the physiological response of ligand binding to the corresponding receptor. The oligopeptides are used in diagnosis and therapy of diseases that involve inadequate or inappropriate receptor response as well as in the screening of drug candidates that affect surface expression of receptors. Also useful for drug screening is a modified receptor molecule, where the sequence corresponding to the regulatory peptide is modified or deleted.

摘要翻译： 具有对应于受体细胞外结构域的氨基酸序列并且与来自MHC I类抗原的调节肽具有序列相似性的寡肽增强配体结合相应受体的生理反应。 寡肽用于诊断和治疗涉及不充分或不恰当的受体反应以及影响受体表面表达的药物候选物的疾病。 也可用于药物筛选是修饰的受体分子，其中对应于调节肽的序列被修饰或缺失。

公开(公告)号：US6098792A

公开(公告)日：2000-08-08

申请号：US313641

申请日：1999-05-18

申请人： Lennart Olsson

发明人： Lennart Olsson

IPC分类号： B65G15/52 ,  B65G17/08 ,  B65G17/06

CPC分类号： B65G17/086 ,  B65G2201/02

摘要： A conveyor belt comprises a plurality of interconnected elements (1, 2), which are successively arranged in the longitudinal direction of the conveyor belt. The elements are movable relative to each other at least about axes (3) which extend transversely of the longitudinal direction of the conveyor belt and in parallel with the plane of the conveyor belt. The elements (1, 2) are alternatively of a first type and a second type. Each element (1) of the first type has the form of an inversely U-shaped beam extended transversely of the longitudinal direction of the conveyor belt. This beam has flanges (6) and a web (7) interconnecting the flanges as well as a plurality of openings (8), spaced apart along the beam, in each border area between the web (7) and the respective flanges (6). Each element (2) of the second type has lugs (5), which are locked against complete withdrawal from the neighboring openings (8) in each of the two adjoining elements (1) of the first type.

摘要翻译： 传送带包括多个相互连接的元件（1,2），它们沿传送带的纵向依次布置。 这些元件可相对于至少围绕传送带的纵向方向横向延伸且与传送带平面平行的轴线（3）相对移动。 元件（1,2）可选地是第一类型和第二类型。 第一类型的每个元件（1）具有沿着输送带的纵向方向横向延伸的反向U形梁的形式。 该梁具有在腹板（7）和相应的凸缘（6）之间的每个边界区域中具有凸缘（6）和互连凸缘的腹板（7）以及沿着梁隔开的多个开口（8） 。 第二类型的每个元件（2）具有凸耳（5），其被锁定以防止从第一类型的两个相邻元件（1）中的每一个中的相邻开口（8）完全退出。

公开(公告)号：US5853999A

公开(公告)日：1998-12-29

申请号：US473656

申请日：1995-06-07

申请人： Lennart Olsson ,  Robert S. Goodenow ,  Avram Goldstein

发明人： Lennart Olsson ,  Robert S. Goodenow ,  Avram Goldstein

IPC分类号： G01N33/566 ,  A61K38/00 ,  A61P43/00 ,  C07K14/485 ,  C07K14/49 ,  C07K14/65 ,  C07K14/705 ,  C07K14/72 ,  C07K14/74 ,  C07K14/79 ,  C07K16/28 ,  G01N33/53 ,  C07K5/10 ,  C07K7/06 ,  C07K14/00

CPC分类号： C07K14/70571 ,  C07K14/485 ,  C07K14/49 ,  C07K14/65 ,  C07K14/705 ,  C07K14/70539 ,  C07K14/72 ,  C07K14/79 ,  C07K16/2833 ,  A61K38/00 ,  C07K2317/77 ,  Y10S530/868

摘要： Methods and compositions are provided for regulating surface membrane receptor responses by modulating interaction between MHC Class I antigen and the surface membrane receptor. Various techniques may be employed for enhancing or reducing the interaction between the MHC Class I antigen and surface membrane receptor (e.g., enhancing surface expression of the MHC Class I antigen or employing agents which affect interaction between MHC Class I antigen and surface receptors). The aggregative characteristics of oligopeptides which act as agents in affecting interaction between MHC Class I antigen and surface receptors may be employed in a screening assay for determining drugs which affect interaction between Class I antigen and surface receptors. Active peptide aggregative characteristics may also be employed in a method of administration of effectors of surface receptor response modulation.

摘要翻译： 提供了通过调节MHC I类抗原与表面膜受体之间的相互作用来调节表面膜受体反应的方法和组合物。 可以使用各种技术来增强或减少MHC I类抗原和表面膜受体之间的相互作用（例如，增强MHC I类抗原的表面表达或使用影响MHC I类抗原和表面受体之间相互作用的试剂）。 作为影响MHC I类抗原和表面受体之间相互作用的药剂的寡肽的聚集特征可用于确定影响I类抗原和表面受体之间相互作用的药物的筛选试验。 活性肽聚集特性也可用于施用表面受体反应调节剂的方法。

公开(公告)号：US5019497A

公开(公告)日：1991-05-28

申请号：US215056

申请日：1988-07-05

申请人： Lennart Olsson

发明人： Lennart Olsson

IPC分类号： C07K16/30

CPC分类号： C07K16/3023 ,  Y10S435/948 ,  Y10S435/975 ,  Y10S436/808 ,  Y10S436/813 ,  Y10S530/808 ,  Y10S530/828 ,  Y10S530/848 ,  Y10S530/864 ,  Y10S530/866

摘要： Methods and compositions are provided for detecting antigens having a specific epitope associated with squamous lung carcinoma. The antigen may be found at lesion sites or in the blood as indicative of the squamous lung carcinoma.Specific antibodies may be used for the detection of the antigen and in therapy.The mouse hybridoma 43-9F producing IgM monoclonal antibody 43-9F and SLC cell RH-SLC-L11 were deposited at The PHLS Centre for Applied Microbiology and Research, Porton Down, Salisbury, U.K. on Jan. 31, 1985 and given Accession Nos. 85013101 and 85061403, respectively.

摘要翻译： 提供了用于检测具有与鳞状肺癌相关的特异性表位的抗原的方法和组合物。 抗原可以在病变部位或血液中发现，指示鳞状肺癌。 特异性抗体可以用于检测抗原和治疗。 1985年1月31日，将产生IgM单克隆抗体43-9F和SLC细胞RH-SLC-L11的小鼠杂交瘤43-9F保藏在1985年1月31日在英国索尔兹伯里的Porton Down的PHLS中心应用微生物与研究中心， 85013101和85061403。

公开(公告)号：US4668629A

公开(公告)日：1987-05-26

申请号：US599201

申请日：1984-04-09

申请人： Henry S. Kaplan ,  Lennart Olsson

发明人： Henry S. Kaplan ,  Lennart Olsson

IPC分类号： A61K39/395 ,  C07K16/00 ,  C12N5/16 ,  C12N5/00 ,  C12N15/00

CPC分类号： C12N5/163 ,  A61K39/395 ,  C07K16/00

摘要： Human monoclonal antibody compositions, human-human monoclonal hybridoma cells, human myeloma cells, human antibody genes and their uses. Human myeloma cells are developed for fusing with immunized lymphoid cells to provide stable human-human hybridoma strains producing complete monoclonal antibodies for a predefined antigen. From a myeloma cell line, rapidly growing 8-azaguanine resistant HAT sensitive cells are selected. The selected myeloma cells are crossed with immunized lymphoid cells and the resulting cell mixture grown under controlled selective conditions. After expansion of the desired hybridoma cells, the monoclonal antibodies may be harvested. The hybridomas serve as a source for messenger RNA for light and heavy chains which may be used for production of light and heavy chain immunoglobulin proteins through hybrid DNA techniques.

摘要翻译： 人单克隆抗体组合物，人 - 人单克隆杂交瘤细胞，人骨髓瘤细胞，人抗体基因及其用途。 开发人类骨髓瘤细胞用于与免疫淋巴细胞融合以提供稳定的人 - 人杂交瘤菌株，其产生预定抗原的完整单克隆抗体。 从骨髓瘤细胞系中，选择快速生长的8-氮鸟嘌呤抗性HAT敏感细胞。 将所选择的骨髓瘤细胞与免疫淋巴细胞杂交，并将所得细胞混合物在对照选择条件下生长。 在所需杂交瘤细胞扩增后，可以收获单克隆抗体。 杂交瘤作为轻链和重链的信使RNA的来源，可用于通过杂交DNA技术生产轻链和重链免疫球蛋白。

公开(公告)号：US4603776A

公开(公告)日：1986-08-05

申请号：US554346

申请日：1983-11-22

申请人： Lennart Olsson

发明人： Lennart Olsson

IPC分类号： B65G15/40 ,  B65G15/02 ,  B65G15/42 ,  B65G15/48 ,  B65G15/52 ,  B65G17/06 ,  B65G17/08 ,  B65G21/18

CPC分类号： B65G21/18 ,  B65G17/064 ,  B65G17/086 ,  B65G2201/02

摘要： A conveyor belt, which is adapted in endless condition to follow through part of its length a path comprising a number of superposed, helically extending turns, comprises link means which are articulated with one another and are relatively adjustable and comprise a bottom part and spacing members arranged at the longitudinal edges of said bottom part and constituting the two sides of the belt, said spacing members being adapted with their upper edge portions to bear against the lower edge portions of the overlying turn of the conveyor belt in order to permit this to carry the underlying belt turn, at least part of the spacing members being adapted with their upper edge portions to engage shoulders at the lower edge portions of the spacing members of the overlying turn of the conveyor belt so as to prevent lateral displacement of the belt turns. The spacing members are through part of their length fixedly connected to the longitudinal edges of the bottom part while the remaining part is movable relative to the bottom part and provided with a flange which is inclined downwards in inward direction, said flanges constituting the shoulders with which the upper edge portions of the spacing members are adapted to engage in order to prevent lateral displacement of the belt turns.

摘要翻译： 一种传送带，其适于环境状态以跟随其长度的一部分，包括多个重叠的螺旋形延伸的匝的路径包括彼此铰接并且相对可调并包括底部和间隔构件的连接装置 布置在所述底部的纵向边缘并且构成带的两侧，所述间隔构件适于其上边缘部分抵靠传送带的上转圈的下边缘部分，以允许其携带 下面的带子转动，至少一部分间隔部件与它们的上边缘部分适配，以在传送带的上翻转圈的间隔部件的下边缘部分处接合肩部，以防止皮带匝的横向位移。 间隔构件的一部分长度固定地连接到底部的纵向边缘，而剩余部分可相对于底部移动并且设置有向内倾斜的凸缘，所述凸缘构成肩部 间隔构件的上边缘部分适于接合，以防止带匝的横向位移。