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95 条记录 (耗时 0.038 秒)

    Affinity small molecules for the EPO receptor
    1.
    发明授权
    Affinity small molecules for the EPO receptor 有权
    EPO受体的亲和小分子

    公开(公告)号：US07037902B2

    公开(公告)日：2006-05-02

    申请号：US10613754

    申请日：2003-07-02

    申请人： Lennart Olsson ,  Tatjana Naranda

    发明人： Lennart Olsson ,  Tatjana Naranda

    IPC分类号： C07K14/505

    CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K38/17 ,  A61K45/06 ,  C07K14/71 ,  G01N33/566 ,  G01N33/746 ,  G01N2500/00 ,  A61K2300/00

    摘要： Compounds are provided that complex with the modulating domain of erythropoietin receptor (EPO-R) for use with EPO-R to determine the presence of EPO-R, the ability of other molecules to bind to the modulating domain in competitive assays and to induce a signal by EPO-R into a cell when bound by the subject compounds in a physiological environment. The compounds are characterized by having a six-membered heterocyclic ring comprising at least one nitrogen atom and include substituted triazolopyrimidine, pyridazinone, pyridine and piperidine.

    摘要翻译： 提供了与EPO-R一起使用的促红细胞生成素受体（EPO-R）的调节结构域复合物以确定EPO-R的存在，其它分子在竞争性测定中结合调节结构域的能力并诱导 当在生理环境中被受试化合物结合时，EPO-R被信号传导到细胞中。 该化合物的特征在于具有包含至少一个氮原子的六元杂环，并且包括取代的三唑并嘧啶，哒嗪酮，吡啶和哌啶。

    Receptor derived peptides as modulators of receptor activity
    2.
    发明授权
    Receptor derived peptides as modulators of receptor activity 失效
    受体衍生肽作为受体活性的调节剂

    公开(公告)号：US06333031B1

    公开(公告)日：2001-12-25

    申请号：US09028937

    申请日：1998-02-24

    申请人： Lennart Olsson ,  Tatjana Naranda

    发明人： Lennart Olsson ,  Tatjana Naranda

    IPC分类号： C07K700

    CPC分类号： C07K14/705 ,  C07K14/62 ,  C07K14/70539 ,  C07K14/71 ,  C07K14/7153 ,  C07K14/7155 ,  C07K14/72 ,  C07K2319/00 ,  C07K2319/74 ,  C07K2319/75

    摘要： Oligopeptides having an amino acid sequence corresponding to a receptor's extracellular domain, and having sequence similarity to regulatory peptides from MHC class I antigens, enhance or replace the physiological response of ligand binding to the corresponding receptor. The oligopeptides are used in diagnosis and therapy of diseases that involve inadequate or inappropriate receptor response as well as in the screening of drug candidates that affect surface expression of receptors. Also useful for drug screening is a modified receptor molecule, where the sequence corresponding to the regulatory peptide is modified or deleted.

    摘要翻译： 具有对应于受体细胞外结构域的氨基酸序列并且与来自MHC I类抗原的调节肽具有序列相似性的寡肽增强或替代与相应受体结合的配体的生理反应。 寡肽用于诊断和治疗涉及不充分或不恰当的受体反应以及影响受体表面表达的药物候选物的疾病。 也可用于药物筛选是修饰的受体分子，其中对应于调节肽的序列被修饰或缺失。

    Arrangements for Facilitating Assembly, Service and Maintenance of Image-Changing Signboards
    3.
    发明申请
    Arrangements for Facilitating Assembly, Service and Maintenance of Image-Changing Signboards 有权
    促进图像更改招牌的装配，维修和维护的安排

    公开(公告)号：US20080163525A1

    公开(公告)日：2008-07-10

    申请号：US11883095

    申请日：2006-01-18

    申请人： Lennart Olsson ,  Hans-Lvar Olsson

    发明人： Lennart Olsson ,  Hans-Lvar Olsson

    IPC分类号： G09F11/02

    CPC分类号： G09F11/025 ,  Y10T74/18528

    摘要： An image-changing signboard comprising an upper and a lower horizontal frame member (12, 14) having a substantially U-shaped cross-section. A plurality of vertical bar-shaped display elements having a triangular cross-section are rotatably mounted in the upper and lower frame members. Individual gear units (26, 32) are mounted in one (12) of the horizontal frame members for rotating a respective display element (18). A drive motor (20) is connected to a common drive shaft (24) for simultaneously rotating respective gear units (26, 32). A plurality of gear units (26, 32) are mounted on a common mounting plate (22) so as to form a drive module, which is slidably mounted on tracks (40) in one (12) of the U-shaped horizontal frame members and which form a bottom plate bridging the gap between the legs of the frame member (12) and facing the signboard display.

    摘要翻译： 一种图像改变招牌，包括具有基本上U形横截面的上和下水平框架构件（12,14）。 具有三角形横截面的多个垂直条形显示元件可旋转地安装在上框架构件和下框架构件中。 单个齿轮单元（26,32）安装在一个（12）水平框架构件中，用于旋转相应的显示元件（18）。 驱动马达（20）连接到公共驱动轴（24），用于同时旋转各个减速器（26,32）。 多个齿轮单元（26,32）安装在公共安装板（22）上，以形成驱动模块，该驱动模块可滑动地安装在一个（12）的U形水平框架构件中的轨道（40）上 并且其形成桥接框架构件（12）的腿之间的间隙并面向招牌显示器的底板。

    Bonnet bumpstop for a vehicle
    4.
    发明申请
    Bonnet bumpstop for a vehicle 有权
    Bonnet bumpstop为车辆

    公开(公告)号：US20070236048A1

    公开(公告)日：2007-10-11

    申请号：US11731959

    申请日：2007-04-02

    申请人： Mattias Wallman ,  Lennart Olsson ,  Anders Fredriksson

    发明人： Mattias Wallman ,  Lennart Olsson ,  Anders Fredriksson

    IPC分类号： B60J7/00

    CPC分类号： B60R21/38

    摘要： A bonnet bumpstop for use on an automotive vehicle is formed with a first component having a support part for supporting a bonnet on the vehicle in the vertical direction during normal operation when the bonnet is closed against the automotive frame, a second component attachable to the vehicle frame, and a member interconnecting the first and second components to each other. When the bonnet bumpstop incurs a force greater than a predetermined value, such as a force transmitted from a bonnet to the bonnet bumpstop, the bonnet bumpstop is collapsible by substantially instantaneous neutralizing of the interconnection between the first component and the second component. At least a part of the first component, including said support part, is then freed to be move relative to the second component so as to allow the bonnet to move downwardly in case of an impact between an object and the bonnet.

    摘要翻译： 在机动车辆上使用的发动机挡块形成有第一部件，所述第一部件具有支撑部件，用于在正常操作期间在发动机罩关闭汽车机架时在垂直方向上支撑发动机罩上的发动机罩，可附接到车辆的第二部件 框架和将第一和第二部件彼此互连的部件。 当发动机罩撞击停止引起大于预定值的力（例如从发动机罩传递到发动机罩撞击挡块的力）时，通过基本上瞬时中和第一部件和第二部件之间的互连，发动机罩撞击停止可折叠。 然后，包括所述支撑部分的第一部件的至少一部分然后被释放以相对于第二部件移动，以便在物体和阀盖之间的冲击的情况下允许发动机罩向下移动。