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公开(公告)号：US20250019865A1
公开(公告)日：2025-01-16
申请号：US18748161
申请日：2024-06-20
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Grant Michael Gonzalez , Holly M. Golecki , Kwanwoo Shin , Josue A. Goss
Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.
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公开(公告)号：US20240182868A1
公开(公告)日：2024-06-06
申请号：US18439694
申请日：2024-02-12
Applicant: President and Fellows of Harvard College
Inventor： Donald E. Ingber , Kevin Kit Parker , Geraldine A. Hamilton , Anthony Bahinski
Abstract: Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.
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公开(公告)号：US20230243812A1
公开(公告)日：2023-08-03
申请号：US18096629
申请日：2023-01-13
Applicant: President and Fellows of Harvard College
Inventor： Gilyong Lee , Sung-Jin Park , Kevin Kit Parker , Andre G. Kleber
IPC: G01N33/50
CPC classification number: G01N33/5088 , G01N33/5061
Abstract: Engineered cardiac tissue structures and methods for forming the engineered cardiac tissue structures are provided herein. An example engineered cardiac tissue structure includes a support having a first side and a first engineered cardiac tissue layer disposed at the first side of the support. The first engineered cardiac tissue layer can include a geometrically insulated cardiac tissue node. Another example engineered cardiac tissue structure includes a support, a first engineered cardiac tissue layer, and a second engineered cardiac tissue layer. Excitation and contraction of the first engineered cardiac tissue layer bends the support and strains the second engineered cardiac tissue layer inducing excitation and contraction of the second engineered cardiac tissue layer. The excitation and contraction of the second engineered cardiac tissue layer bends the support and strains the first engineered cardiac tissue layer inducing excitation and contraction of the first engineered cardiac tissue layer thereby producing antagonistic cyclic contractions.
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公开(公告)号：US11629318B2
公开(公告)日：2023-04-18
申请号：US16757133
申请日：2018-10-19
Applicant: President and Fellows of Harvard College
Inventor： Benjamin D. Pope , Kevin Kit Parker
Abstract: The present invention provides methods and systems which accommodate 3-dimensional adipocyte expansion to produce, e.g., mature adipocytes and synthetic adipose tissue with cellular properties of mature adult organisms, including cell size and cytoarchitecture, and the use of such methods and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications.
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公开(公告)号：US20220136136A1
公开(公告)日：2022-05-05
申请号：US17501005
申请日：2021-10-14
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Grant Michael Gonzalez , Holly M. Golecki , Kwanwoo Shin , Josue A. Goss
Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.
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Patent Agency Ranking
公开(公告)号：US20210371782A1
公开(公告)日：2021-12-02
申请号：US16322507
申请日：2017-08-04
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Janna C. Nawroth , Lisa Scudder
Abstract: The present invention provides methods for optically micropatterning hydrogels, which may be used for, e.g., regenerative medicine, synthetic or cultured foods, and in devices suitable for use in high throughput drug screening assays.
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公开(公告)号：US20210324539A1
公开(公告)日：2021-10-21
申请号：US17262318
申请日：2019-07-26
Applicant: President and Fellows of Harvard College
Inventor： Luca Cera , Kevin Kit Parker
Abstract: The present invention provides methods for preparing an alpha-keratin solution comprising alpha-keratin protofibrils and intermediate filaments in liquid crystal phase and uses thereof for fabricating, e.g., shape-memory polymeric fibers, yarns, threads, fabrics, structures and objects.
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公开(公告)号：US20210205076A1
公开(公告)日：2021-07-08
申请号：US17102495
申请日：2020-11-24
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Andrew K. Capulli , Josue A. Goss
Abstract: The present invention provides engineered valves, tubular structures, and sheets comprising oriented polymeric fibers, e.g., nanofibers, methods of fabricating such structures, and methods of use of such structures as, for example, patches, grafts and valves, e.g., cardiac valves.
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公开(公告)号：US20200171322A1
公开(公告)日：2020-06-04
申请号：US16689178
申请日：2019-11-20
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker
Abstract: Photosensitive cardiac rhythm modulation structures and systems are described. A genetically-engineered tissue comprising a population of pacing cells expressing a photosensitive membrane transport mechanism that is responsive to light of a particular wavelength(s) combined with one or more of a light source, a power generator, and a sensor provides pacemaker and/or defibrillator function to a subject. The systems further provide in vitro model systems for electrophysiological studies.
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公开(公告)号：US10519569B2
公开(公告)日：2019-12-31
申请号：US14763620
申请日：2014-02-13
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Grant Michael Gonzalez , Holly M. Golecki , Kwanwoo Shin , Josue Adrian Goss
Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.
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