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公开(公告)号：US5945309A
公开(公告)日：1999-08-31
申请号：US820825
申请日：1997-03-19
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
IPC分类号： C07K14/475 , C12N1/21 , C07K14/435 , C12N5/10
CPC分类号： C07K14/475 , C07K2319/00
摘要： The invention relates to Cytostatin III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及细胞抑制素III多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US5849286A
公开(公告)日：1998-12-15
申请号：US464604
申请日：1995-06-05
申请人： Jian Ni , Reiner Gentz , Mark D. Adams
发明人： Jian Ni , Reiner Gentz , Mark D. Adams
CPC分类号： C12N9/93 , C12Y603/02019 , A61K38/00
摘要： Human UCE 7, UCE 8 and UCE 9 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods of utilizing such polypeptide for the treatment of the proliferation of malignant cells. Antagonists against such polypeptides and their uses as a therapeutic to treat Alzheimer's disease, atrophying skeletal muscle, African swine fever virus and apoptotic cell death are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in UCE 7, 8 and 9 nucleic acid sequences and the concentration of polypeptides encoded by such sequences.
摘要翻译： 公开了人类UCE 7，UCE 8和UCE 9多肽和编码这些多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽来治疗恶性细胞增殖的方法。 还公开了抗这种多肽的拮抗剂及其作为治疗性阿尔茨海默氏病，萎缩性骨骼肌，非洲猪瘟病毒和凋亡性细胞死亡的治疗剂的用途。 还公开了用于检测与UCE 7,8和9核酸序列中的突变相关的疾病的诊断测定以及由这些序列编码的多肽的浓度。
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公开(公告)号：US5844081A
公开(公告)日：1998-12-01
申请号：US470298
申请日：1995-06-06
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12
CPC分类号： C07K14/475 , A61K38/00
摘要： A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other metastases.
摘要翻译： 公开了人类细胞抑素I多肽和编码这种多肽的DNA以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其他转移的方法。
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公开(公告)号：US5284933A
公开(公告)日：1994-02-08
申请号：US158962
申请日：1988-02-22
IPC分类号： C12N15/09 , A61K38/00 , C07K1/22 , C07K14/00 , C07K14/52 , C07K14/555 , C07K14/57 , C07K19/00 , C12N1/20 , C12N1/21 , C12N15/62 , C12N15/70 , C12P21/02 , C12R1/19 , C07K13/00
CPC分类号： C07K14/57 , C12N15/62 , C12N15/70 , A61K38/00 , C07K2319/00 , C07K2319/21 , C07K2319/50 , C07K2319/75
摘要： Fusion proteins and a process for their purification by means of metal chelate affinity chromatography on NTA resins are provided by this invention.
摘要翻译： 本发明提供融合蛋白及其通过NTA树脂上金属螯合亲和层析纯化的方法。
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公开(公告)号：US08003386B1
公开(公告)日：2011-08-23
申请号：US09006352
申请日：1998-01-13
申请人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven M. Ruben , Jian Ni , Ping Feng
发明人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven M. Ruben , Jian Ni , Ping Feng
CPC分类号： C07K14/70578
摘要： The present invention relates to novel Tumor Necorsis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译： 本发明涉及新型肿瘤坏死因子受体蛋白。 特别地，提供编码人TNFR-6α＆-6＆bgr的分离的核酸分子; 蛋白质。 TNFR-6α＆-6＆bgr; 还提供多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定TNFR-6α和-6β的激动剂和拮抗剂的筛选方法。 活动。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。
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公开(公告)号：US20080096821A1
公开(公告)日：2008-04-24
申请号：US11955013
申请日：2007-12-12
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz
IPC分类号： A61K38/00 , A61P43/00 , C07H21/04 , C07K16/00 , C12N15/00 , C12N5/04 , C12P21/04 , G01N33/53
CPC分类号： G01N33/57415 , A61K38/00 , C07K14/475
摘要： The invention relates to cytostatin II growth modulatory polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及细胞抑素II生长调节性多肽，编码多肽的多核苷酸，特别是通过表达多核苷酸产生多肽的方法，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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57.发明申请公开(公告)号：US20050026179A1
公开(公告)日：2005-02-03
申请号：US10820136
申请日：2004-04-08
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz
CPC分类号： C07K14/4702
摘要： The invention relates to hESF I, II and III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及hESF I，II和III多肽，编码多肽的多核苷酸，特别是通过表达多核苷酸产生多肽的方法，以及多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US06413726B1
公开(公告)日：2002-07-02
申请号：US09734036
申请日：2000-12-12
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
IPC分类号： G01N3350
CPC分类号： C07K14/475 , C07K2319/00
摘要： The invention relates to Cytostatin III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及细胞抑制素III多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US06294164B1
公开(公告)日：2001-09-25
申请号：US09407891
申请日：1999-09-29
申请人： Jiar Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
发明人： Jiar Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
IPC分类号： A61K3819
CPC分类号： C07K14/52 , A61K38/00 , Y10S514/885
摘要： A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating viral infections, inflammation, neoplasia and damage from superoxide radicals. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译： 公开了一种编码这种多肽的人类天然杀伤细胞增强因子C和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽预防和/或治疗病毒感染，炎症，瘤形成和超氧自由基损伤的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。
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公开(公告)号：US06287812B1
公开(公告)日：2001-09-11
申请号：US09361737
申请日：1999-07-28
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： C12N1512
CPC分类号： C07K14/475 , A61K38/00
摘要： A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other matastases.
摘要翻译： 公开了人类细胞抑素I多肽和编码这种多肽的DNA以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其它母细胞瘤的方法。
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