-
公开(公告)号：US06448230B1
公开(公告)日：2002-09-10
申请号：US09152060
申请日：1998-09-11
申请人： Steven M. Ruben , Craig A. Rosen , Zhizhen Zeng
发明人： Steven M. Ruben , Craig A. Rosen , Zhizhen Zeng
IPC分类号： A61K3800
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
-
公开(公告)号：US07838636B1
公开(公告)日：2010-11-23
申请号：US11760578
申请日：2007-06-08
申请人： Steven M. Ruben , Craig A. Rosen , Ying-Fei Wei
发明人： Steven M. Ruben , Craig A. Rosen , Ying-Fei Wei
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
-
公开(公告)号：US06416984B1
公开(公告)日：2002-07-09
申请号：US08468024
申请日：1995-06-06
申请人： William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen
发明人： William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen
IPC分类号： C12N900
CPC分类号： C07K14/47 , Y10T436/143333
摘要： The invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.
摘要翻译： 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA（RNA），以及通过重组技术生产此类蛋白质的方法。 人类DNA修复蛋白hMLH1已被映射到染色体3，而hMLH2已被映射到染色体2，并且hMLH3已经被定位到染色体7上.DNA修复蛋白的多核苷酸序列可用于治疗和诊断治疗 遗传易感性癌症。
-
公开(公告)号：US06372456B1
公开(公告)日：2002-04-16
申请号：US09177304
申请日：1998-10-23
申请人： Ying-Fei Wei , Steven M. Ruben , Craig A. Rosen
发明人： Ying-Fei Wei , Steven M. Ruben , Craig A. Rosen
IPC分类号： C12N1519
CPC分类号： C07K16/24 , A61K38/00 , C07K14/522
摘要： The present invention relates to a novel CK(&agr;-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK&agr;-6 protein. CK&agr;-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK&agr;-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.
摘要翻译： 本发明涉及一种新的CK（α-6蛋白，其是α趋化因子家族的成员，特别是编码人CKalpha-6蛋白的分离的核酸分子，也提供了CKalpha-6多肽 本发明还涉及用于鉴定CKalpha-6活性的激动剂和拮抗剂的筛选方法，还提供了用于检测CNS和免疫系统相关疾病的诊断方法以及用于治疗CNS和 免疫系统相关疾病。
-
公开(公告)号：US06979443B2
公开(公告)日：2005-12-27
申请号：US10086882
申请日：2002-03-04
申请人： Ying-Fei Wei , Steven M. Ruben , Craig A. Rosen
发明人： Ying-Fei Wei , Steven M. Ruben , Craig A. Rosen
IPC分类号： A61K38/00 , C07K14/52 , C07K16/24 , C12N5/06 , C12N15/12 , C12N15/19 , G01N33/53 , G01N33/537 , G01N33/543 , A61K38/19 , C12N5/10 , C12N15/63
CPC分类号： C07K16/24 , A61K38/00 , C07K14/522
摘要： The present invention relates to a novel CKα-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-6 protein. CKα-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CKα-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.
摘要翻译： 本发明涉及作为α趋化因子家族成员的新型CKalpha-6蛋白。 特别地，提供编码人CKalpha-6蛋白的分离的核酸分子。 还提供了CKalpha-6多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及鉴定CKalpha-6活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测CNS和免疫系统相关疾病的诊断方法以及用于治疗CNS和免疫系统相关疾病的治疗方法。
-
公开(公告)号：US06610477B1
公开(公告)日：2003-08-26
申请号：US08465679
申请日：1995-06-06
申请人： William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen , Bert Vogelstein , Kenneth W. Kinzler , Nicholas C. Nicolaides , Nickolas Papadopoulos
发明人： William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen , Bert Vogelstein , Kenneth W. Kinzler , Nicholas C. Nicolaides , Nickolas Papadopoulos
IPC分类号： C12Q168
CPC分类号： C07K14/47 , Y10T436/143333
摘要： The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.
摘要翻译： 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA（RNA），以及通过重组技术生产此类蛋白质的方法。 人类DNA修复蛋白hMLH1已被映射到染色体3，而hMLH2已被映射到染色体2，并且hMLH3已经被定位到染色体7上.DNA修复蛋白的多核苷酸序列可用于治疗和诊断治疗 遗传易感性癌症。
-
公开(公告)号：US07217529B2
公开(公告)日：2007-05-15
申请号：US11081021
申请日：2005-03-16
申请人： Ying-Fei Wei , Steven M. Ruben , Craig A. Rosen
发明人： Ying-Fei Wei , Steven M. Ruben , Craig A. Rosen
CPC分类号： C07K16/24 , A61K38/00 , C07K14/522
摘要： The present invention relates to a novel CKα-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-6 protein. CKα-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CKα-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.
摘要翻译： 本发明涉及作为α趋化因子家族成员的新型CKalpha-6蛋白。 特别地，提供编码人CKalpha-6蛋白的分离的核酸分子。 还提供了CKalpha-6多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及鉴定CKalpha-6活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测CNS和免疫系统相关疾病的诊断方法以及用于治疗CNS和免疫系统相关疾病的治疗方法。
-
58.发明授权Polynucleotides encoding a protein kinase C inhibitor protein and methods of using these polynucleotides 失效编码蛋白激酶C抑制蛋白的多核苷酸和使用这些多核苷酸的方法公开(公告)号：US07335489B2
公开(公告)日：2008-02-26
申请号：US10453478
申请日：2003-06-04
申请人： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
发明人： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
摘要： Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
摘要翻译： 公开了编码这种多肽的人多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了将这些多肽用于治疗目的的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗剂的用途。 还公开了用于检测利用序列和多肽的疾病的诊断方法。
-
公开(公告)号：US20090197278A9
公开(公告)日：2009-08-06
申请号：US12036846
申请日：2008-02-25
申请人： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
发明人： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
摘要： Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
摘要翻译： 公开了编码此类多肽的人多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了将这些多肽用于治疗目的的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗剂的用途。 还公开了用于检测利用序列和多肽的疾病的诊断方法。
-
公开(公告)号：US20080227110A1
公开(公告)日：2008-09-18
申请号：US12036846
申请日：2008-02-25
申请人： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
发明人： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
摘要： Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
摘要翻译： 公开了编码这种多肽的人多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了将这些多肽用于治疗目的的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗剂的用途。 还公开了用于检测利用序列和多肽的疾病的诊断方法。
-
-
-
-
-
-
-
-
-
搜索结果
403 条记录 (耗时 0.08 秒)
