摘要:
The small (&ggr;) subunit of human Transcription Factor IIA and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for regulating gene-specific and global transcription. Antagonists against such polypeptide and their use to inhibit transcription are also disclosed.
摘要:
Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
摘要:
Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
摘要:
Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
摘要:
The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
摘要:
A zero-IF receiver for an FM signal comprises quadrature-mixers (2,3) to which the input signal is applied and which mix the received carrier down to zero frequency. The signals appearing at the mixer outputs (11,12) are fed to a differentiate, multiply and subtract demodulator (22,23,25,27,31) via capacitors (17,19) which block the d.c. components of the signals, thereby preventing amplifier saturation effects, etc. This d.c.-blocking would, unless steps were taken to prevent it, result in distortion of the output signal appearing at an output terminal (32). This distortion is prevented by providing an amplitude divider (33) in the output signal path. The signal fed to the divider control input (48) is derived from the output signals of the blocking capacitors by squaring them by means of multipliers (37,40), adding the results together in an adder (43) and applying the adder output signal to the control input (48) both directly and via a low-pass filter (46) the cut-off frequency of which is equal to that of the high-pass filters (15,16) of which the blocking capacitors effectively form part.
摘要:
A bicycle safety apparatus for stabilizing a bicycle when the front wheel of the bicycle is elevated above the ground which includes rollers or wheels that are mounted on the ends of rigid arms that extend outwardly and rearwardly from the back wheel of the bicycle. The rollers or wheels are maintained in spaced apart relationship with the axis of the rollers or wheels being in approximately the same horizontal plane as the rear axle of the bicycle, when both wheels of the bicycle are in contact with the ground. The rollers or wheels of the safety apparatus are substantially smaller than the wheels of the bicycle such that when the front end of the bicycle is elevated, a three point contact is made by the rear wheel of the bicycle and the spaced apart rollers or wheels to stabilize the bicycle and prevent it from tipping over backwards.
摘要:
A transmitter has a power amplifier (40) to amplify an input signal having amplitude modulation, a supply voltage controller (10) to control a supply voltage of the power amplifier (40) according to the envelope, a sensor (R1) for sensing a modulation of a current drawn by the power amplifier (40), a delay detector (20) for detecting a delay of the controlled supply voltage relative to the sensed current, and a delay adjuster (30) for compensating the relative delay according to the detected delay. By sensing a current drawn, the delay detected can include any delay contributed by the power amplifier (40) up to that point, and yet avoid the more complex circuitry needed to derive the delay from an output of the power amplifier. Thus the distortion and out of band emissions caused by differential delays can be reduced more effectively.
摘要:
A receiver having a variable bit slicer for detecting bits in a demodulated signal, comprises a demodulator (14) for deriving a demodulated bit rate signal, means (36) for storing a plurality of threshold values, each of the threshold values being selectively adjustable, means (28, 38) for selecting the threshold value for comparison with the current bit signal (Sn) in response to a sequence of N bits (where N is at least 2) (Bn-1, Bn-2) received prior to the current bit (Bn) and means (38, 40) for using the current bit to update the selected threshold value.Also disclosed is a method of dc offset correction.
摘要翻译:具有用于检测解调信号中的比特的可变比特限制器的接收机包括用于导出解调比特率信号的解调器(14),用于存储多个阈值的装置(36),每个阈值可选择性地调整, 用于响应于N位序列(其中N至少为2),选择用于与当前位信号(S SUB n N)进行比较的阈值的装置(28,38)(B< 在当前位(B SUB)之前接收的n-1,b-n-2)和用于使用当前位的装置(38,40) 更新所选择的阈值。 还公开了一种直流偏移校正的方法。
摘要:
A polyphase receiver comprises an RF front end (10 to 28) for receiving a wanted data signal modulated on a carrier signal and for producing quadrature related low IF signals, an image rejection filter formed by a polyphase filter (30) for filtering the quadrature related low IF signals, soft limiting means (36,38) for compressing the dynamic range of the filtered quadrature related IF signals and a signal demodulator (41) for recovering the data signal. The soft limiting means (36,38) has a characteristic which is substantially linear at signal levels 10 dB below a predetermined minimum wanted signal level, moves into compression for higher signal levels and hard limits at substantially 10 dB above the desired receiver sensitivity which avoids degrading the sensitivity of the receiver.