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    Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same
    57.
    发明授权
    Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same 有权
    用于可植入装置的涂层，包括生物可侵蚀的聚酯及其制造方法

    公开(公告)号：US08192752B2

    公开(公告)日：2012-06-05

    申请号：US10719516

    申请日：2003-11-21

    申请人： Yiwen Tang ,  Stephen D. Pacetti

    发明人： Yiwen Tang ,  Stephen D. Pacetti

    IPC分类号： A61F2/00

    CPC分类号： A61L31/16 ,  A61F2/86 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/606 ,  A61L2420/08 ,  C08L67/04

    摘要： A medical article comprising an implantable substrate having a coating is disclosed, the coating comprising a biologically erodable polymer having the glass transition temperature below about −50° C. The biologically erodable polymer can be blended with a polymeric additive which either has the glass transition temperature of about −50° C. or higher, or a degree of crystallinity greater than that of the first polymer.

    摘要翻译： 公开了包含具有涂层的可植入基材的医疗制品，所述涂层包含玻璃化转变温度低于约-50℃的生物侵蚀性聚合物。可生物侵蚀的聚合物可与聚合物添加剂共混，所述聚合物添加剂具有玻璃化转变温度 约-50℃或更高，或结晶度大于第一聚合物的结晶度。

    Purification of polymers for coating applications
    59.
    发明授权
    Purification of polymers for coating applications 有权
    用于涂料应用的聚合物的纯化

    公开(公告)号：US07985441B1

    公开(公告)日：2011-07-26

    申请号：US11418697

    申请日：2006-05-04

    申请人： Yiwen Tang ,  Stephen D. Pacetti ,  Qing Lin ,  Ni Ding

    发明人： Yiwen Tang ,  Stephen D. Pacetti ,  Qing Lin ,  Ni Ding

    IPC分类号： B05D3/00 ,  C08F6/28

    CPC分类号： C08F6/005 ,  A61L31/10 ,  A61L2420/02 ,  C08L27/20 ,  C08L27/16

    摘要： Various embodiments of methods and devices for coating stents are described herein. Among these embodiments are methods of manufacturing an implantable medical device by purifying a polymer with a fluid capable of swelling the polymer, and subsequently coating a device with the purified polymer or fabricating a device from the purified polymer. A preferred polymer is poly(vinylidene fluoride-co-hexafluoropropylene).

    摘要翻译： 本文描述了用于涂覆支架的方法和装置的各种实施例。 在这些实施方案中，通过用能够使聚合物膨胀的流体纯化聚合物，随后用纯化的聚合物涂覆装置或从纯化的聚合物制造装置来制造可植入医疗装置的方法。 优选的聚合物是聚（偏二氟乙烯 - 共 - 六氟丙烯）。

    Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices
    60.
    发明申请
    Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices 审中-公开
    提供可植入式设备的疏水性药物的控制释放的可生物降解的聚合材料

    公开(公告)号：US20090110713A1

    公开(公告)日：2009-04-30

    申请号：US11982160

    申请日：2007-10-31

    申请人： Florencia Lim ,  Michael H. Ngo ,  Yiwen Tang ,  Syed F.A. Hossainy ,  Mikael O. Trollsas

    发明人： Florencia Lim ,  Michael H. Ngo ,  Yiwen Tang ,  Syed F.A. Hossainy ,  Mikael O. Trollsas

    IPC分类号： A61F2/82 ,  C08L5/00 ,  C08L5/06 ,  C08L3/00 ,  C08L1/00 ,  C08G63/00 ,  C08G63/08 ,  A61K47/30 ,  A61K31/4353

    CPC分类号： C08G63/08 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/602 ,  C08L67/04

    摘要： The present invention is directed to polymeric materials (e.g., coatings) comprising biodegradable copolymers and implantable devices (e.g., drug-delivery stents) formed of such materials. The biodegradable copolymers are derived from at least two relatively polar monomers and at least one relatively nonpolar monomer. Incorporation of at least one relatively nonpolar monomer into the copolymer improves controlled release of a hydrophobic drug from the polymeric material by increasing the copolymer's miscibility with and permeability to the hydrophobic drug. The polymeric materials can also contain at least one biocompatible moiety, at least one non-fouling moiety, at least one biobeneficial material, at least one bioactive agent, or a combination thereof. The polymeric materials are designed to improve the mechanical, physical and biological properties of implantable devices formed thereof.

    摘要翻译： 本发明涉及包含由这种材料形成的可生物降解的共聚物和可植入装置（例如药物递送支架）的聚合物材料（例如包衣）。 可生物降解的共聚物衍生自至少两种相对极性的单体和至少一种相对非极性的单体。 将至少一种相对非极性的单体掺入共聚物中，通过增加共聚物与疏水性药物的混溶性和渗透性，可以改善疏水性药物从聚合物材料的受控释放。 聚合物材料还可含有至少一种生物相容部分，至少一种非结垢部分，至少一种生物有益材料，至少一种生物活性剂或其组合。 聚合材料被设计成改善由其形成的可植入装置的机械，物理和生物学特性。