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公开(公告)号：US06448221B1
公开(公告)日：2002-09-10
申请号：US09506855
申请日：2000-02-17
IPC分类号： C07K100
CPC分类号： A61K38/1709
摘要： The present invention relates to polynucleotide and polypeptide molecules for use as inhibitors in hemostasis and immune function. Such inhibitors are members of the family of proteins bearing a collagen-like domain and a globular domain. The inhibitors are useful for promoting blood flow in the vasculature by reducing thrombogenic and complement activity. The inhibitors are also useful for pacifying collagenous surfaces and modulating wound healing.
摘要翻译： 本发明涉及用作止血和免疫功能抑制剂的多核苷酸和多肽分子。 这种抑制剂是具有胶原样结构域和球状结构域的蛋白家族的成员。 抑制剂可用于通过降低血栓形成和补体活性来促进脉管系统中的血液流动。 抑制剂也可用于平缓胶原表面和调节伤口愈合。
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公开(公告)号：US06403783B1
公开(公告)日：2002-06-11
申请号：US09493565
申请日：2000-01-18
IPC分类号： C07H2104
CPC分类号： C07K14/4703 , C07K14/4748
摘要： Studies indicate that mutations in tumor suppressor genes occur early in the process of carcinogenesis, and that these mutations are correlated with a subsequent development of cancer. The detection of such alterations would provide useful molecular markers for diagnosis, surveillance, early tumor identification and intervention, and prognosis. A novel human gene, designated as “Zsig62,” resides within a region of chromosome 16q that is associated with prostate and breast cancer, and that appears to contain tumor suppressor genes. Like a tumor suppressor gene, the Zsig62 gene is expressed in particular normal tissues, but not in tumors derived from those tissues.
摘要翻译： 研究表明，肿瘤抑制基因突变在致癌过程的早期发生，这些突变与随后的癌症发展相关。 这种改变的检测将为诊断，监测，早期肿瘤鉴定和干预以及预后提供有用的分子标记。 称为“Zsig62”的新型人类基因位于与前列腺和乳腺癌相关的染色体16q的区域中，并且似乎含有肿瘤抑制基因。 像肿瘤抑制基因一样，Zsig62基因在特定的正常组织中表达，但不是来源于那些组织的肿瘤。
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公开(公告)号：US06300093B1
公开(公告)日：2001-10-09
申请号：US08811481
申请日：1997-03-05
申请人： Wayne Kindsvogel , Laura J. Jelinek , Paul O. Sheppard , William A. Hagopian , James M. LaGasse
发明人： Wayne Kindsvogel , Laura J. Jelinek , Paul O. Sheppard , William A. Hagopian , James M. LaGasse
IPC分类号： C12P2106
CPC分类号： C07K14/4713 , A61K38/00 , C12N9/16
摘要： A mammalian islet cell antigen polypeptide involved in the development of insulin-dependent diabetes mellitus (IDDM) is disclosed. This islet cell antigen polypeptide, 1851, was found to contain regions of homology to the protein tyrosine phosphatase family. Methods for diagnosis and treatment, including use in immunoprecipitation assays and the induction of immune tolerance using the recombinant mammalian polypeptides and antibodies specific to mammalian islet cell antigen 1851 polypeptides are presented.
摘要翻译： 公开了涉及胰岛素依赖性糖尿病（IDDM）发展的哺乳动物胰岛细胞抗原多肽。 该胰岛细胞抗原多肽1851被发现含有与蛋白酪氨酸磷酸酶家族同源的区域。 提出了用于诊断和治疗的方法，包括在免疫沉淀测定中的应用和使用重组哺乳动物多肽和对哺乳动物胰岛细胞抗原1851多肽特异的抗体诱导免疫耐受。
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公开(公告)号：US5989866A
公开(公告)日：1999-11-23
申请号：US951822
申请日：1997-10-16
申请人： Theresa A. Deisher , Darrell C. Conklin , Fenella Raymond , Thomas R. Bukowski , Susan D. Holderman , Birgit Hansen , Paul O. Sheppard
发明人： Theresa A. Deisher , Darrell C. Conklin , Fenella Raymond , Thomas R. Bukowski , Susan D. Holderman , Birgit Hansen , Paul O. Sheppard
IPC分类号： C12N15/09 , A61K38/00 , A61P9/10 , A61P19/08 , A61P21/00 , C07K14/50 , C07K16/22 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/077 , C12N5/10 , C12N15/18 , C12P21/02 , C12P21/08 , C12N5/00 , C12N15/63
CPC分类号： A61K47/48238 , A61K47/48507 , C07K14/50 , C07K16/22 , C12N5/0657 , A61K38/00 , C07K2319/00 , C12N2501/119
摘要： The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.
摘要翻译： 本发明涉及用于zFGF-5的FGF家族的新成员的多核苷酸和多肽分子。 多肽和编码它们的多核苷酸对于肌肉细胞是增殖性的，并且可以用于重塑心脏组织和改善心脏功能。 本发明还包括对zFGF-5多肽的抗体。
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公开(公告)号：US5952011A
公开(公告)日：1999-09-14
申请号：US452800
申请日：1995-05-30
CPC分类号： C12N9/1044 , C12Y203/02013 , A61K38/00
摘要： Human prostatic and placental transglutaminases are identified and cloned. The human transglutaminases herein are useful for, inter alia, therapeutic wound repair, closure of skin grafts, stabilizing food preparations, and markers for identifying agents which act as agonists or antagonists of cellular apoptosis.
摘要翻译： 人前列腺和胎盘转谷氨酰胺酶被鉴定和克隆。 本文中的人转谷氨酰胺酶尤其可用于治疗性伤口修复，皮肤移植物闭合，稳定食物制剂和用于鉴定作为细胞凋亡的激动剂或拮抗剂的药剂的标记物。
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公开(公告)号：US08124065B2
公开(公告)日：2012-02-28
申请号：US13028101
申请日：2011-02-15
CPC分类号： C07K14/56 , C12Q2600/158
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
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57.发明申请USE OF TRUNCATED CYSTEINE IL28 AND IL29 MUTANTS TO TREAT CANCERS AND AUTOIMMUNE DISORDERS 有权使用截短的CYSTEINE IL28和IL29突变体治疗癌症和自身免疫性疾病公开(公告)号：US20110177024A1
公开(公告)日：2011-07-21
申请号：US13042210
申请日：2011-03-07
申请人： Paul O. Sheppard
发明人： Paul O. Sheppard
CPC分类号： C07K14/54 , A61K38/20 , A61K38/21 , A61K47/60 , A61K2300/00
摘要： Methods for treating patients with cancer and autoimmune disorders using IL-28 and IL-29 molecules. The IL-28 and IL-29 molecules include polypeptides that have homology to the human IL-28 or IL-29 polypeptide sequence and proteins fused to a polypeptide with IL-28 and IL-29 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer and/or autoimmune therapeutics.
摘要翻译： 使用IL-28和IL-29分子治疗患有癌症和自身免疫疾病的患者的方法。 IL-28和IL-29分子包括与人IL-28或IL-29多肽序列具有同源性的多肽，以及与具有IL-28和IL-29功能活性的多肽融合的蛋白质。 分子可以用作单一疗法或与其它已知的癌症和/或自身免疫治疗剂组合使用。
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58.发明申请USE OF TRUNCATED CYSTEINE IL28 AND IL29 MUTANTS TO TREAT CANCERS AND AUTOIMMUNE DISORDERS 审中-公开使用截短的CYSTEINE IL28和IL29突变体治疗癌症和自身免疫性疾病公开(公告)号：US20100298230A1
公开(公告)日：2010-11-25
申请号：US12611067
申请日：2009-11-02
申请人： Paul O. Sheppard
发明人： Paul O. Sheppard
IPC分类号： A61K38/16 , A61K31/711 , A61P25/28
CPC分类号： C07K14/54 , A61K38/20 , A61K38/21 , A61K47/60 , A61K2300/00
摘要： Methods for treating patients with cancer and autoimmune disorders using IL-28 and IL-29 molecules. The IL-28 and IL-29 molecules include polypeptides that have homology to the human IL-28 or IL-29 polypeptide sequence and proteins fused to a polypeptide with IL-28 and IL-29 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer and/or autoimmune therapeutics.
摘要翻译： 使用IL-28和IL-29分子治疗患有癌症和自身免疫疾病的患者的方法。 IL-28和IL-29分子包括与人IL-28或IL-29多肽序列具有同源性的多肽，以及与具有IL-28和IL-29功能活性的多肽融合的蛋白质。 分子可以用作单一疗法或与其它已知的癌症和/或自身免疫治疗剂组合使用。
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公开(公告)号：US07662927B2
公开(公告)日：2010-02-16
申请号：US12201399
申请日：2008-08-29
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
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公开(公告)号：US07655447B2
公开(公告)日：2010-02-02
申请号：US12239535
申请日：2008-09-26
CPC分类号： C07K14/63 , A61K38/00 , C07K14/575
摘要： The present invention relates to polynucleotide related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译： 本发明涉及与zsig33肽相关的多核苷酸，包括激动剂，拮抗剂和抗体。 还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。
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