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51.发明授权O- or S-substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity 失效O-或S-取代的四氢萘衍生物，其具有类视黄醇和/或维生素A拮抗剂样生物活性公开(公告)号：US06465663B2
公开(公告)日：2002-10-15
申请号：US09900593
申请日：2001-07-06
申请人： Vidyasagar Vuligonda , Min Teng , Richard L. Beard , Alan T. Johnson , Yuan Lin , Roshantha A. Chandraratna
发明人： Vidyasagar Vuligonda , Min Teng , Richard L. Beard , Alan T. Johnson , Yuan Lin , Roshantha A. Chandraratna
IPC分类号： C07D40900
CPC分类号： C07D339/08 , C07C69/587 , C07C69/734 , C07C69/76 , C07C233/81 , C07C235/66 , C07C245/10 , C07C251/44 , C07C309/65 , C07C317/44 , C07C323/55 , C07C2602/10 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/24 , C07D317/26 , C07D333/24 , C07D409/10
摘要： Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
摘要翻译： 符号具有本申请中描述的含义的化合物具有类视黄醇样或类视黄醇拮抗剂样的生物活性。
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52.发明授权ACETYLENES DISUBSTITUTED WITH A 5 ALKYL, ARYL OR HETEROARYL SUBSTITUTED DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUP HAVING RETINOID-LIKE WITH AN ARYL OR HETEROARYL GROUP HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY 失效用5种亚烷基，芳基或杂芳基取代的二氢噻吩基团和与具有类似生物活性的芳族或异构体具有类似性的ARYL或HETEROARYL类发生的乙酰胺公开(公告)号：US06355806B1
公开(公告)日：2002-03-12
申请号：US09398613
申请日：1999-09-16
申请人： Alan T. Johnson , Min Teng , Vidyasagar Vuligonda , Richard L. Beard , Samuel J. Gillett , Tien T. Duong , Roshantha A. Chandraratna
发明人： Alan T. Johnson , Min Teng , Vidyasagar Vuligonda , Richard L. Beard , Samuel J. Gillett , Tien T. Duong , Roshantha A. Chandraratna
IPC分类号： C07D21170
CPC分类号： C07D213/80 , C07C17/10 , C07C17/263 , C07C17/35 , C07C45/28 , C07C45/673 , C07C63/66 , C07C69/76 , C07C229/46 , C07C233/58 , C07C251/48 , C07C255/41 , C07C255/47 , C07C309/65 , C07C323/61 , C07C327/32 , C07C2602/10 , C07D213/55 , C07D277/30 , C07D307/54 , C07D309/06 , C07D309/12 , C07D333/24 , C07D339/08 , C07F7/081 , C07F7/1804 , C07C25/22 , C07C25/24 , C07C49/697 , C07C49/683
摘要： Compounds of the formula wherein the symbols have the meaning described in the specification, have retinoid-like biological activity.
摘要翻译： 符号表示的化合物具有说明书中描述的含义，具有类视黄醇样生物活性。
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53.发明授权O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity 失效O-或S-取代的四氢萘衍生物，其具有类视黄醇和/或维生素A拮抗剂样生物活性公开(公告)号：US06344561B2
公开(公告)日：2002-02-05
申请号：US09735172
申请日：2000-12-11
申请人： Vidyasagar Vuligonda , Min Teng , Richard L. Beard , Alan T. Johnson , Yuan Lin , Roshantha A. Chandraratna
发明人： Vidyasagar Vuligonda , Min Teng , Richard L. Beard , Alan T. Johnson , Yuan Lin , Roshantha A. Chandraratna
IPC分类号： C07D21170
CPC分类号： C07D339/08 , C07C69/587 , C07C69/734 , C07C69/76 , C07C233/81 , C07C235/66 , C07C245/10 , C07C251/44 , C07C309/65 , C07C317/44 , C07C323/55 , C07C2602/10 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/24 , C07D317/26 , C07D333/24 , C07D409/10
摘要： Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
摘要翻译： 符号具有本申请中描述的含义的化合物具有类视黄醇样或类视黄醇拮抗剂样的生物活性。
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![Process for preparing substituted benzo[1,2-G]-chrome-3-ene, benzo[1,2-G]-thiochrom-3-ene and benzo[1,2-G]-1,2-dihydroquinoline derivatives](/abs-image/US/2001/04/03/US06211385B1/abs.jpg.150x150.jpg)
54.发明授权Process for preparing substituted benzo[1,2-G]-chrome-3-ene, benzo[1,2-G]-thiochrom-3-ene and benzo[1,2-G]-1,2-dihydroquinoline derivatives 失效取代苯并[1,2-G] - 色烯-3-烯，苯并[1,2-G] - 硫代色烯-3-烯和苯并[1,2-G] -1,2-二氢喹啉衍生物的制备方法公开(公告)号：US06211385B1
公开(公告)日：2001-04-03
申请号：US09492492
申请日：2000-01-27
IPC分类号： C07D33504
CPC分类号： C07D307/92
摘要： Compounds of Formula 1 where the symbols have the meaning disclosed in the specification are prepared by reaction of a compound of Formula 2 with an organometal reagent R—M to provide a compound of Formula 3 that is reacted with the reagent X3—Y(R2)—A—B in the presence of a catalyst to provide the compounds of Formula 1.
摘要翻译： 符号具有本说明书中公开的含义的式1化合物通过式2的化合物与有机金属试剂RM的反应制备，得到式3的化合物，其在存在下与试剂X3-Y（R2）-AB反应 的催化剂以提供式1的化合物。
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55.发明授权O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity 失效O-或S-取代的四氢萘衍生物，其具有类视黄醇和/或维生素A拮抗剂样生物活性公开(公告)号：US06187933B1
公开(公告)日：2001-02-13
申请号：US09492495
申请日：2000-01-27
申请人： Vidyasagar Vuligonda , Min Teng , Richard L. Beard , Alan T. Johnson , Yuan Lin , Roshantha A. Chandraratna
发明人： Vidyasagar Vuligonda , Min Teng , Richard L. Beard , Alan T. Johnson , Yuan Lin , Roshantha A. Chandraratna
IPC分类号： C07D30912
CPC分类号： C07D339/08 , C07C69/587 , C07C69/734 , C07C69/76 , C07C233/81 , C07C235/66 , C07C245/10 , C07C251/44 , C07C309/65 , C07C317/44 , C07C323/55 , C07C2602/10 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/24 , C07D317/26 , C07D333/24 , C07D409/10
摘要： Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
摘要翻译： 符号具有本申请中描述的含义的化合物具有类视黄醇样或类视黄醇拮抗剂样的生物活性。
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56.发明授权Alkylidene substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity 失效具有类视黄醇和/或维生素A拮抗剂的生物活性的亚烷基取代的四氢萘衍生物
公开(公告)号：US5998655A
公开(公告)日：1999-12-07
申请号：US30353
申请日：1998-02-25
申请人： Vidyasagar Vuligonda , Min Teng , Richard L. Beard , Alan T. Johnson , Tien T. Duong , Yuan Lin , Roshantha A. Chandraratna
发明人： Vidyasagar Vuligonda , Min Teng , Richard L. Beard , Alan T. Johnson , Tien T. Duong , Yuan Lin , Roshantha A. Chandraratna
IPC分类号： C07C69/587 , C07C69/76 , C07C233/81 , C07C245/10 , C07C251/44 , C07C309/65 , C07C317/44 , C07C323/55 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/24 , C07D317/26 , C07D333/24 , C07D339/08 , C07D409/10
CPC分类号： C07D409/10 , C07C233/81 , C07C245/10 , C07C251/44 , C07C309/65 , C07C317/44 , C07C323/55 , C07C69/587 , C07C69/76 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/24 , C07D317/26 , C07D333/24 , C07D339/08 , C07C2102/10
摘要： Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
摘要翻译： 符号具有本申请中描述的含义的式的化合物具有类视黄醇样或维生素A拮抗剂样生物活性。
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57.发明授权Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity 失效具有类视黄醇和/或维生素A拮抗剂的生物活性的烷基或芳基取代的二氢萘衍生物
公开(公告)号：US5773594A
公开(公告)日：1998-06-30
申请号：US667663
申请日：1996-06-21
申请人： Alan T. Johnson , Min Teng , Vidyasagar Vuligonda , Richard L. Beard , Samuel J. Gillett , Tien T. Duong , Roshantha A. Chandraratna
发明人： Alan T. Johnson , Min Teng , Vidyasagar Vuligonda , Richard L. Beard , Samuel J. Gillett , Tien T. Duong , Roshantha A. Chandraratna
IPC分类号： C07C69/587 , C07C69/76 , C07C233/81 , C07C245/10 , C07C251/44 , C07C309/65 , C07C317/44 , C07C323/55 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/24 , C07D317/26 , C07D333/24 , C07D339/08 , C07D409/10
CPC分类号： C07D409/10 , C07C233/81 , C07C245/10 , C07C251/44 , C07C309/65 , C07C317/44 , C07C323/55 , C07C69/587 , C07C69/76 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/24 , C07D317/26 , C07D333/24 , C07D339/08 , C07C2102/10
摘要： Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
摘要翻译： 符号具有本申请中描述的含义的式“IMAGE”的化合物具有类视黄醇样或维生素A拮抗剂样的生物活性。
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58.发明授权Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity 失效具有类视黄醇激动剂，拮抗剂或反向激动剂型生物活性的芳基和杂芳基环己烯基取代的烯烃
公开(公告)号：US5760276A
公开(公告)日：1998-06-02
申请号：US810826
申请日：1997-03-06
申请人： Richard L. Beard , Alan T. Johnson , Min Teng , Vidyasagar Vuligonda , Roshantha A. Chandraratna
发明人： Richard L. Beard , Alan T. Johnson , Min Teng , Vidyasagar Vuligonda , Roshantha A. Chandraratna
IPC分类号： A61P3/02 , A61K31/192 , A61K31/215 , A61K31/216 , A61P9/00 , A61P17/02 , A61P17/06 , A61P17/10 , A61P25/00 , A61P37/00 , C07C63/33 , C07C63/66 , C07C69/76 , C07C309/65 , C07C66/76
CPC分类号： C07C403/02 , C07C309/65 , C07C69/76 , C07C2101/16
摘要： Compounds of the formula ##STR1## wherein the symbols have the meaning defined in the specification, have retinoid-like, retinoid antagonist or retinoid inverse agonist-like biological activity.
摘要翻译： 其中符号具有本说明书中定义的含义的式“IMAGE”的化合物具有类视黄醇样维生素A拮抗剂或类视色素反向激动剂样生物活性。
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59.发明授权Oxo-substituted tetrahydronaphthalene derivatives having retinold and/or retinoid antagonist-like biological activity 失效具有视黄醇和/或维生素A拮抗剂的生物活性的氧代取代的四氢萘衍生物
公开(公告)号：US5747542A
公开(公告)日：1998-05-05
申请号：US667666
申请日：1996-06-21
申请人： Vidyasagar Vuligonda , Alan T. Johnson , Richard L. Beard , Min Teng , Tae K. Song , Harold N. Wong , Roshantha A. Chandraratna
发明人： Vidyasagar Vuligonda , Alan T. Johnson , Richard L. Beard , Min Teng , Tae K. Song , Harold N. Wong , Roshantha A. Chandraratna
IPC分类号： C07C69/587 , C07C69/76 , C07C233/81 , C07C245/10 , C07C251/44 , C07C309/65 , C07C317/44 , C07C323/55 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/24 , C07D317/26 , C07D333/24 , C07D339/08 , C07D409/10 , A61K31/135 , A61K31/15 , A61K31/235 , A61K31/56 , C07C241/00 , C07D333/22
CPC分类号： C07D317/26 , C07C233/81 , C07C245/10 , C07C251/44 , C07C309/65 , C07C317/44 , C07C323/55 , C07C69/587 , C07C69/76 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/24 , C07D333/24 , C07D339/08 , C07D409/10 , C07C2102/10
摘要： Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
摘要翻译： 符号具有本申请中描述的含义的式“IMAGE”的化合物具有类视黄醇样或维生素A拮抗剂样生物活性。
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60.发明授权Benzo�1,2-g!-chrom-3-ene and benzo�1,2-g!-thiochrom-3-ene derivatives 失效苯并[1,2-g] - 色烯-3-烯和苯并[1,2-g] - 硫代色烯-3-烯衍生物
公开(公告)号：US5728846A
公开(公告)日：1998-03-17
申请号：US764466
申请日：1996-12-12
IPC分类号： A61K31/192 , A61K31/235 , A61K31/352 , A61K31/381 , A61K31/382 , A61K31/44 , A61P1/00 , A61P3/06 , A61P9/00 , A61P17/00 , A61P25/28 , A61P27/00 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07C45/00 , C07C47/548 , C07C61/08 , C07C61/29 , C07C69/00 , C07C69/74 , C07C69/78 , C07C233/00 , C07D213/55 , C07D311/92 , C07D333/24 , C07D335/08 , C07D409/06 , C07D417/02 , C07F7/02 , C07F7/08 , C07D495/00 , A61K31/38 , C07D277/04 , C07D401/04
CPC分类号： C07C69/76 , C07C45/00 , C07C47/548 , C07D213/55 , C07D311/92 , C07D333/24 , C07D335/08 , C07D409/06 , C07C2103/24
摘要： Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist and/or retinoid inverse-agonist-like biological activity.
摘要翻译： 符号具有本说明书中定义的含义的式“IMAGE”的化合物具有类视黄醇，维生素A拮抗剂和/或维甲酸反相激动剂样生物活性。
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