公开(公告)号：US08838240B2

公开(公告)日：2014-09-16

申请号：US12283234

申请日：2008-09-10

申请人： Dan Li ,  Krzysztof Siejko ,  Abhilash Patangay

发明人： Dan Li ,  Krzysztof Siejko ,  Abhilash Patangay

IPC分类号： A61N1/36 ,  A61N1/368 ,  A61B5/0464 ,  A61N1/365

CPC分类号： A61N1/36585 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578

摘要： Systems and methods provide for sensing, during an event of tachycardia, hemodynamic signals concurrently from at least two spatially separated locations within a patient, and quantifying a spatial relationship between the hemodynamic signals. Hemodynamic stability or state of the patient during the tachycardia event is determined based at least in part on the quantified spatial relationship. One or more anti-tachycardia therapies to treat the tachycardia may be selected based at least in part on the determined stability or state of patient hemodynamics, and the selected one or more anti-tachycardia therapies may be delivered to treat the tachycardia. The hemodynamic signals may comprise at least two, or a mixed combination, of cardiac impedance signals, cardiac chamber pressure signals, arterial pressure signals, heart sounds; and acceleration signals.

摘要翻译： 系统和方法提供在心动过速事件期间从患者内的至少两个空间上分离的位置同时感测血液动力学信号，并且量化血液动力学信号之间的空间关系。 至少部分地基于定量的空间关系确定在心动过速事件期间患者的血流动力学稳定性或状态。 可以至少部分地基于所确定的患者血液动力学的稳定性或状态来选择治疗心动过速的一种或多种抗心动过速疗法，并且可以递送所选择的一种或多种抗心动过速疗法以治疗心动过速。 血液动力学信号可以包括心脏阻抗信号，心室压力信号，动脉压信号，心音的至少两个或混合组合; 和加速度信号。

公开(公告)号：US08712525B2

公开(公告)日：2014-04-29

申请号：US12877583

申请日：2010-09-08

申请人： Dan Li ,  Cheng Zhang

发明人： Dan Li ,  Cheng Zhang

IPC分类号： A61N1/362

CPC分类号： A61N1/3622 ,  A61N1/3712

摘要： A cardiac rhythm management (CRM) system includes an implantable medical device that delivers anti-tachyarrhythmia therapies including anti-tachyarrhythmia pacing (ATP) and a hemodynamic sensor that senses a hemodynamic signal. The implantable medical device includes a hemodynamic sensor-controlled closed-loop ATP system that uses the hemodynamic signal for ATP capture verification. When ATP pulses are delivered according to a selected ATP protocol to terminate a tachyarrhythmia episode, the implantable medical device performs the ATP capture verification by detecting an effective cardiac contraction from the hemodynamic signal. The ATP protocol is adjusted using an outcome of the ATP capture verification.

摘要翻译： 心律管理（CRM）系统包括可植入的医疗装置，其传递抗心律失常疗法，包括抗心动过速起搏（ATP）和感测血液动力学信号的血液动力学传感器。 可植入医疗装置包括血液动力学传感器控制的闭环ATP系统，其使用血流动力学信号进行ATP捕获验证。 当根据选定的ATP方案递送ATP脉冲以终止快速性心律失常发作时，可植入医疗装置通过从血液动力学信号检测有效的心脏收缩来执行ATP捕获验证。 使用ATP捕获验证的结果调整ATP方案。

公开(公告)号：US20140088312A1

公开(公告)日：2014-03-27

申请号：US14118158

申请日：2011-09-14

申请人： Dan Li ,  Xiaoping Zhou ,  Jie Liu

发明人： Dan Li ,  Xiaoping Zhou ,  Jie Liu

IPC分类号： C07F15/04 ,  C07F1/08 ,  C07F13/00 ,  C07F3/06

CPC分类号： C07F15/045 ,  B01D2253/204 ,  B01D2257/504 ,  B01J20/22 ,  B01J20/226 ,  C07F1/005 ,  C07F1/08 ,  C07F3/00 ,  C07F3/06 ,  C07F13/005

摘要： The present invention discloses zeolite metal bis(imidazole) coordination polymers and preparation method thereof. The new class of zeolite coordination polymers of the present invention is a chemical compound with the following general chemical formula {[M(Blm)]×xDMF×yC2H6O×zH2O}∞, in which when M=Zn, x=0.9, y=0, z=0; when M=Cu, x=1.2, y=0, z=0; when M=Mn, x=2.0, y=0, z=0; when M=Ni, x=0.4, y=1.2, z=1.0, Blm is 1,2-bis((5H-imidazol-4-yl)methylene)hydrazine, DMF is N,N-dimethyl formamide, H2O is water. A solvothermal method or slow diffusion is used on the compounds to obtain crystals of high purity. The coordination polymers of the present invention have good thermal stability, and have strong adsorption performance for CO2 under conditions of 0° C. and normal pressure as adsorbent materials.

摘要翻译： 本发明公开了沸石金属双（咪唑）配位聚合物及其制备方法。 本发明的新型沸石配位聚合物是具有以下一般化学式{[M（Blm）]×xDMF×yC2H6O×zH2O}∞的化合物，其中当M = Zn时，x = 0.9，y = 0，z = 0; 当M = Cu时，x = 1.2，y = 0，z = 0; 当M = Mn时，x = 2.0，y = 0，z = 0; 当M = Ni时，x = 0.4，y = 1.2，z = 1.0，Blm是1,2-双（（5H-咪唑-4-基）亚甲基）肼，DMF是N，N-二甲基甲酰胺，H 2 O是水 。 在化合物上使用溶剂热法或缓慢扩散以获得高纯度的晶体。 本发明的配位聚合物具有良好的热稳定性，在0℃和常压作为吸附材料的条件下对CO 2具有很强的吸附性能。

公开(公告)号：US08649860B2

公开(公告)日：2014-02-11

申请号：US12781459

申请日：2010-05-17

申请人： Yanting Dong ,  David L. Perschbacher ,  Jeffrey E. Stahmann ,  Dan Li ,  Deepa Mahajan

发明人： Yanting Dong ,  David L. Perschbacher ,  Jeffrey E. Stahmann ,  Dan Li ,  Deepa Mahajan

IPC分类号： A61N1/39

CPC分类号： A61N1/37252 ,  A61B5/02 ,  A61B5/04 ,  A61B5/0452 ,  A61B5/6846 ,  A61N1/025 ,  A61N1/3621 ,  A61N1/3702 ,  A61N1/372 ,  A61N1/3925

摘要： Monitoring physiological parameter using an implantable physiological monitor in order to detect a condition predictive of a possible future pathological episode and collecting additional physiological data associated with the condition predictive of a possible future pathological episode. Monitoring another physiological parameter in order to detect a condition indicative of the beginning of a present pathological episode and collecting additional pathological data in response to the condition. Determining that the condition predictive of a future episode and the condition indicative of a present episode are associated and, in response thereto, storing all the collected physiological data.

摘要翻译： 使用植入式生理监测器监测生理参数，以便检测预测可能的未来病理发作的状况并收集与预测可能的未来病理发作相关的条件相关的附加生理数据。 监测另一个生理参数，以便检测指示本病理发作开始的病症，并根据病情收集额外的病理资料。 确定预测未来事件的状况和指示当前情节的状况是相关联的，并且响应于此，存储所有收集的生理数据。

公开(公告)号：US08620429B2

公开(公告)日：2013-12-31

申请号：US13457630

申请日：2012-04-27

申请人： Dan Li ,  Jaeho Kim ,  Joseph M. Bocek

发明人： Dan Li ,  Jaeho Kim ,  Joseph M. Bocek

IPC分类号： A61N1/39

CPC分类号： A61N1/3621 ,  A61N1/368 ,  A61N1/3688

摘要： An implantable medical device delivers anti-tachyarrhythmia therapies including anti-tachycardia pacing (ATP). If a detected tachyarrhythmia is classified as a type suitable for treatment using ATP, the implantable medical device selects one of an atrial ATP (A-ATP) mode, a ventricular ATP (V-ATP) mode, and a concurrent atrio-ventricular ATP (concurrent AV-ATP) mode according to the characteristics of the detected tachyarrhythmia. The concurrent ATP mode is an ATP mode during which the atrial pacing pulses and the ventricular pacing pulses are delivered concurrently. In one embodiment, the concurrent AV-ATP mode includes a synchronized atrio-ventricular ATP (synchronized AV-ATP) mode during which atrial and ventricular pacing pulses are delivered synchronously and an independent atrio-ventricular ATP (independent AV-ATP) mode during which atrial and ventricular pacing pulses are delivered concurrently but timed independently.

摘要翻译： 植入式医疗装置提供抗心律失常疗法，包括抗心动过速起搏（ATP）。 如果检测到的快速性心律失常被分类为适合于使用ATP治疗的类型，则可植入医疗装置选择心房ATP（A-ATP）模式，心室ATP（V-ATP）模式和并发心室ATP 并发AV-ATP）模式根据检测到的快速性心律失常的特点。 并发ATP模式是ATP模式，其中心房起搏脉冲和心室起搏脉冲同时传递。 在一个实施方案中，并发的AV-ATP模式包括同步的心房ATP（同步的AV-ATP）模式，其中同步递送心房和心室起搏脉冲以及独立的心房ATP（独立的AV-ATP）模式，在此期间 心房和心室起搏脉冲同时传递，但可以独立计时。

公开(公告)号：US20130342023A1

公开(公告)日：2013-12-26

申请号：US13821267

申请日：2011-03-11

申请人： Dan Li ,  Yangtao Dang ,  Hui Sun ,  Depeng Diao ,  Xuetao Huang ,  Bao Liu

发明人： Dan Li ,  Yangtao Dang ,  Hui Sun ,  Depeng Diao ,  Xuetao Huang ,  Bao Liu

IPC分类号： H04B5/00

CPC分类号： H04B5/0037 ,  H02J5/005 ,  H02J7/025 ,  H02J50/10 ,  H02J50/40 ,  H02J50/80 ,  H04B5/0081

摘要： There is provided a wireless power supplying device and method. The device includes a control part and at least one transmitting part connected with the control part. The control part includes a control circuit and a power supply module. The control circuit is used to determine the power requirement of the transmitting part connected with the control part and control the power supply module to transmit an electrical signal satisfying the power requirement to the transmitting part. The transmitting part generates a magnetic field based on the electrical signal and supplies power to a load of a receiver. The wireless power supply device and method enable each coil to generate electromagnetic induction with desired power, to supply power for the receiver reasonably, and reduce the number and the complexity of the transmitting part.

摘要翻译： 提供了一种无线供电装置和方法。 该装置包括控制部分和与控制部分连接的至少一个传送部分。 控制部分包括控制电路和电源模块。 控制电路用于确定与控制部分连接的发送部分的电力需求，并控制电源模块向发送部分发送满足电力要求的电气信号。 发射部分基于电信号产生磁场，并向接收机的负载供电。 无线供电装置和方法使得每个线圈能够产生具有期望功率的电磁感应，以便合理地为接收器供电，并且减少发射部分的数量和复杂性。

公开(公告)号：US08572514B2

公开(公告)日：2013-10-29

申请号：US12642142

申请日：2009-12-18

申请人： Dan Li ,  Zhiming Li ,  Fly Wang ,  Bin Ni

发明人： Dan Li ,  Zhiming Li ,  Fly Wang ,  Bin Ni

IPC分类号： G06F3/033 ,  G09G5/00

CPC分类号： G06F3/043 ,  G06F3/03545

摘要： Methods and apparatus to provide a handheld pointer-based user interface are described herein. An example apparatus includes a wireless pointer component and one or more base components. The wireless pointer component is configured to transmit one or more human-computer interaction (HCI) signals associated with an HCI event via a first communication link. One or more base components are operatively coupled to a screen of a display to receive the one or more HCI signals from the wireless pointer component via the first communication link. Further, the one or more base components are configured to generate at least one of operating information and position information of the wireless pointer component based on the one or more HCI signals, and to transmit the at least one of operating information and position information to a processor configured to generate screen information on the screen of the display via a second communication link.

摘要翻译： 在此描述了提供基于手持式指针的用户界面的方法和装置。 示例性设备包括无线指针组件和一个或多个基本组件。 无线指针部件被配置为经由第一通信链路发送与HCI事件相关联的一个或多个人机交互（HCI）信号。 一个或多个基本组件可操作地耦合到显示器的屏幕，以经由第一通信链路从无线指针组件接收一个或多个HCI信号。 此外，一个或多个基本组件被配置为基于一个或多个HCI信号来生成无线指针组件的操作信息和位置信息中的至少一个，并且将操作信息和位置信息中的至少一个发送到 处理器，被配置为经由第二通信链路在所述显示器的屏幕上生成屏幕信息。

公开(公告)号：US08532762B2

公开(公告)日：2013-09-10

申请号：US11312279

申请日：2005-12-20

申请人： Shelley Cazares ,  Carlos Ricci ,  Dan Li ,  Yayun Lin ,  Yi Zhang ,  Jaeho Kim ,  Joseph Bocek

发明人： Shelley Cazares ,  Carlos Ricci ,  Dan Li ,  Yayun Lin ,  Yi Zhang ,  Jaeho Kim ,  Joseph Bocek

IPC分类号： A61N1/365

CPC分类号： A61N1/3622 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0472 ,  A61B5/7264 ,  A61N1/3702 ,  A61N1/3962

摘要： Cardiac arrhythmias are classified based on the morphology of the arrhythmia episode beats. Templates are formed using morphological features of the cardiac beats of the episode. The arrhythmia episode is classified as a monomorphic tachyarrhythmia or polymorphic tachyarrhythmia based on the one or more templates. The arrhythmia episode may be classified based on a number templates formed from the arrhythmia episode. The templates are formed by determining a measure of similarity between morphological features of a cardiac beat to a template. The similarities can be determined based on a pairing rule that determines which beat morphologies are compared. Selection of therapy for treating the arrhythmia episode may depend on the historical success of a therapy at mitigating previous arrhythmias of the same type as the arrhythmia episode.

摘要翻译： 心律失常根据心律失常发作的形态进行分类。 使用情节心脏搏动的形态学特征形成模板。 基于一个或多个模板，心律失常发作被分类为单形性快速性心律失常或多态性快速性心律失常。 心律失常发作可以基于由心律失常发作形成的数字模板进行分类。 模板通过确定心跳的形态特征与模板之间的相似性的度量来形成。 可以基于确定哪些拍子形态进行比较的配对规则来确定相似度。 选择治疗心律失常发作的治疗可能取决于治疗在缓解与心律失常事件相同类型的以前心律失常方面的历史成功。

公开(公告)号：US08470203B2

公开(公告)日：2013-06-25

申请号：US12724252

申请日：2010-03-15

申请人： Richard B. Kaner ,  Dan Li ,  Jiaxing Huang

发明人： Richard B. Kaner ,  Dan Li ,  Jiaxing Huang

IPC分类号： H01B1/00 ,  C08G73/00 ,  B05D5/12

CPC分类号： C08G73/0266 ,  D01D5/38 ,  D01D5/40 ,  D01F6/76

摘要： A new method for forming stable polyaniline nanofiber colloids uses electrostatic repulsion to maintain dispersion of the nanofibers and prevent aggregation during synthesis of the nanofibers. The colloidal suspensions are formed directly from the reactants in solution maintained at a pH of about 1.0 to about 4.0 and a temperature of about 10° C. to about 100° C. with minimal or no stirring. Also set forth are new methods for forming ultrathin films of polyaniline nanofibers via self-assembly.

摘要翻译： 用于形成稳定的聚苯胺纳米纤维胶体的新方法使用静电排斥来保持纳米纤维的分散并防止在纳米纤维合成期间的聚集。 胶体悬浮液直接由溶液中的反应物形成，保持在约1.0至约4.0的pH和约10℃至约100℃的温度，同时最小或不搅拌。 还阐述了通过自组装形成聚苯胺纳米纤维超薄膜的新方法。

公开(公告)号：US20130138004A1

公开(公告)日：2013-05-30

申请号：US13483387

申请日：2012-05-30

申请人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

发明人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

IPC分类号： A61B5/04 ,  A61N1/39

CPC分类号： A61B5/04012 ,  A61B5/0245 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/7217 ,  A61N1/3704 ,  A61N1/3937

摘要： A system and method for performing independent, off-line evaluation of event sensing for collected electrograms, comprising: sensing an electrogram using an implantable medical device (IMD); determining locations of heart beats on at least one channel of the electrogram using a multi-pass process, resulting in a group of multi-pass beat locations; storing the electrogram and device-identified beat locations in a memory location; and retrieving the electrogram and device-identified beat locations from the memory location. The multi-pass process determines locations of heart beats on at least a first channel of the electrogram. The device-identified group of beat locations are then compared to the multi-pass group of beat locations identified using the multi-pass method. Based on the comparing step, oversensing of beats, undersensing of beats, or noise from the device can be detected.

摘要翻译： 一种用于对收集的电描记图执行事件感测的独立离线评估的系统和方法，包括：使用可植入医疗装置（IMD）感测电描记图; 使用多遍处理确定心电图的至少一个通道上的心跳位置，从而产生一组多通拍位置; 将电描记图和设备识别的节拍位置存储在存储器位置中; 以及从存储器位置检索电描记图和设备标识的拍摄位置。 多遍处理确定心电图的至少第一个通道的位置。 然后将设备识别的拍摄位置组与使用多遍方法识别的拍摄位置的多通道组进行比较。 基于比较步骤，可以检测节拍过度，节拍不足或来自装置的噪音。