公开(公告)号：US07239384B2

公开(公告)日：2007-07-03

申请号：US11209693

申请日：2005-08-24

申请人： Yoshihiro Kawano

发明人： Yoshihiro Kawano

IPC分类号： G01J3/30

CPC分类号： G01N21/6456 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/1256 ,  G01J3/4406 ,  G01J2003/1221 ,  G01J2003/1286 ,  G01N21/6486 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6463

摘要： A laser-scanning fluoroscopy apparatus includes a laser light source of a plurality of wavelengths; a spectroscopic device for splitting laser beams according to wavelength; a focusing lens for focusing the split laser beams; a wavelength-selecting reflection device which includes a plurality of reflection sections disposed near the focal positions, spaced out at predetermined intervals in a split direction to reflect the laser beams with different wavelengths and a transmission section arranged adjacent to the reflection sections; a diffraction grating for combining the reflected laser beams; a scanning section for two-dimensionally scanning the combined laser beams; an objective optical system for focusing the scanned laser beams onto a tissue; and a photodetector for detecting fluorescence emitted from the tissue.

摘要翻译： 激光扫描透视设备包括多个波长的激光光源; 用于根据波长分割激光束的分光装置; 用于聚焦分束激光束的聚焦透镜; 波长选择反射装置，其包括设置在聚焦位置附近的多个反射部分，以分割方向以预定间隔隔开以反射具有不同波长的激光束;以及透射部分，布置成与反射部分相邻; 用于组合反射的激光束的衍射光栅; 用于二维扫描组合的激光束的扫描部分; 用于将扫描的激光束聚焦到组织上的物镜光学系统; 以及用于检测从组织发出的荧光的光电检测器。

公开(公告)号：US20060009682A1

公开(公告)日：2006-01-12

申请号：US11159204

申请日：2005-06-23

申请人： Nobuyuki Nagasawa ,  Yoshihisa Tanikawa ,  Yoshihiro Kawano ,  Yasunori Makara

发明人： Nobuyuki Nagasawa ,  Yoshihisa Tanikawa ,  Yoshihiro Kawano ,  Yasunori Makara

IPC分类号： A61B1/06

CPC分类号： A61B1/07 ,  A61B1/00172 ,  A61B1/0057

摘要： The invention provides an in-vivo examination apparatus that can examine a minute examination site in a living organism with a simple configuration. The invention provides an in-vivo examination apparatus comprising a light source; a flexible light-conveying member that transmits light from the light source to irradiate the light from an end face thereof onto an examination site and that receives return light returning from the examination site at the end face thereof to transmit the return light; a long thin insertion part in which the light-conveying member is disposed along the longitudinal direction thereof; and an optical detector that detects the return light from biological tissue, which is transmitted through the insertion part via the light-conveying member. The end face of the insertion part, where the end face of the light-conveying member is exposed, is configured so as to be cut at an angle with respect to the longitudinal direction to provide a pointed portion that can incise the biological tissue at the tip thereof.

摘要翻译： 本发明提供一种体内检查装置，其能够以简单的结构检查活体中的分检体位。 本发明提供了一种体内检查装置，其包括光源; 柔性光输送构件，其从所述光源透射光，以将光从其端面照射到检查部位，并且接收从其端面处的所述检查部位返回的返回光，以传送所述返回光; 长条状的薄插入部，沿着其长度方向配置有所述光输送部; 以及光检测器，其检测来自生物组织的返回光，所述返回光经由所述光输送构件透过所述插入部。 导光部的端面露出的插入部的端面被配置为相对于长度方向成一角度地切断，以提供能够将生物体组织切开的尖端部 其尖端。

公开(公告)号：US20050207005A1

公开(公告)日：2005-09-22

申请号：US11130182

申请日：2005-05-17

申请人： Yoshihiro Kawano

发明人： Yoshihiro Kawano

IPC分类号： G02B26/00 ,  G02B21/00 ,  G02B21/02 ,  G02B21/06 ,  G02B21/08 ,  G02B21/10 ,  G02B21/18 ,  G02B21/36 ,  G02B27/00

CPC分类号： G02B21/365 ,  G02B21/002 ,  G02B21/02 ,  G02B21/082 ,  G02B21/16 ,  G02B21/18 ,  G02B21/361 ,  G02B27/0018 ,  G02B2207/113

摘要： A high-performance microscope allows total internal reflection fluorescence microscopy, fluorescence microscopy and interference reflection microscopy (or reflection contrast microscopy) to be selectively performed by using the same objective. The microscope has an objective optical system and an image-forming optical system for imaging light from a sample passing through the objective optical system onto an image pickup device. An optical member is provided in a viewing optical path extending from the objective optical system to the image-forming optical system. The optical member reflects illuminating light from an illuminating optical system so that the illuminating light enters the objective optical system, and allows the light from the sample passing through the objective optical system to pass through the image-forming optical system. The illuminating optical system is provided therein with a mechanism for adjusting an illuminating light collecting position on a pupil plane of the objective optical system in a direction perpendicular to an optical axis. The viewing optical path is provided therein with a wavelength selecting device for selecting an observation wavelength according to the illuminating light collecting position on the pupil plane of the objective optical system.

摘要翻译： 高性能显微镜允许通过使用相同的目标选择性地进行全内反射荧光显微镜，荧光显微镜和干涉反射显微镜（或反射对比显微镜）。 显微镜具有物镜光学系统和成像光学系统，用于将来自通过物镜光学系统的样品的光成像到图像拾取装置上。 光学构件设置在从物镜光学系统延伸到成像光学系统的观察光路中。 光学构件反射来自照明光学系统的照明光，使得照明光进入物镜光学系统，并且允许来自通过物镜光学系统的样品的光通过成像光学系统。 照明光学系统在其中设置有用于在垂直于光轴的方向上调整物镜光学系统的光瞳平面上的照明光收集位置的机构。 观察光路设置有用于根据物镜光学系统的光瞳面上的照明光收集位置选择观察波长的波长选择装置。

公开(公告)号：US06898004B2

公开(公告)日：2005-05-24

申请号：US10252434

申请日：2002-09-23

申请人： Keiji Shimizu ,  Shuzo Mishima ,  Yoshihiro Kawano

发明人： Keiji Shimizu ,  Shuzo Mishima ,  Yoshihiro Kawano

IPC分类号： G02B21/06 ,  G02B21/00 ,  G02B21/16

CPC分类号： G02B21/16

摘要： In a microscope system, illumination light rays are emitted from a light source. The illumination light rays are collimated and reflected from a mirror to the optical element array. The optical element array is located at a conjugate position of a specimen, and includes a plurality of micro mirrors arranged in a matrix form. The micro mirrors are individually controlled to selectively reflect the illumination light rays for illuminating the specimen. Thus, a predetermined pattern of the light rays is reflected from the optical element array to an objective lens. The illumination light rays are projected on the specimen from the objective lens and the specimen is illuminated by the predetermined illumination pattern.

摘要翻译： 在显微镜系统中，照明光线从光源发射。 照明光线被准直并从反射镜反射到光学元件阵列。 光学元件阵列位于样本的共轭位置，并且包括以矩阵形式布置的多个微反射镜。 微镜被单独控制以选择性地反射用于照射样本的照明光线。 因此，光线的预定图案从光学元件阵列反射到物镜。 照明光线从物镜投影在样本上，并且样本被预定的照明图案照射。

公开(公告)号：US06323998B1

公开(公告)日：2001-11-27

申请号：US09144274

申请日：1998-08-31

申请人： Yoshihiro Kawano ,  Kazuo Kajitani ,  Hiroshi Ishiwata

发明人： Yoshihiro Kawano ,  Kazuo Kajitani ,  Hiroshi Ishiwata

IPC分类号： G03B1306

CPC分类号： G02B21/0088 ,  G02B21/14

摘要： A microscope apparatus includes an objective lens, an imaging lens, a pupil relay lens, and an image relay lens. The primary image of a specimen is formed between the imaging lens and the pupil relay lens, and the image of the pupil of the objective lens is projected between the pupil relay lens and the image relay lens so that a pupil modulator is disposed at the position of the projected pupil image. This arrangement makes it possible to produce pupil modulation, observe various specimens, and set the optimum position of an eyepoint.

摘要翻译： 显微镜装置包括物镜，成像透镜，光瞳中继透镜和图像中继透镜。 在成像透镜和光瞳中继透镜之间形成样本的主要图像，并且物镜的光瞳的图像被投影在瞳孔中继透镜和图像中继透镜之间，使得光瞳调制器设置在位置 的投影瞳孔图像。 这种布置使得可以产生瞳孔调制，观察各种样本，并设置眼点的最佳位置。

公开(公告)号：US5227914A

公开(公告)日：1993-07-13

申请号：US729346

申请日：1991-07-12

申请人： Toyoharu Hanzawa ,  Tomonori Ishikawa ,  Shinichi Nakamura ,  Hiroshi Fujiwara ,  Masahiko Kinukawa ,  Kimihiko Nishioka ,  Masami Hamada ,  Takashi Fukaya ,  Shigeo Tokunaga ,  Yoshihiro Kawano ,  Masaaki Yamagishi

发明人： Toyoharu Hanzawa ,  Tomonori Ishikawa ,  Shinichi Nakamura ,  Hiroshi Fujiwara ,  Masahiko Kinukawa ,  Kimihiko Nishioka ,  Masami Hamada ,  Takashi Fukaya ,  Shigeo Tokunaga ,  Yoshihiro Kawano ,  Masaaki Yamagishi

IPC分类号： G02B21/02 ,  G02B21/22

CPC分类号： G02B21/025 ,  G02B21/22

摘要： A stereomicroscope is equipped with an objective lens, a variable magnification optical system having an optical axis common with that of the objective lens, a splitting optical system splitting emergent light from the variable magnification optical system into a plurality of optical paths, and an eyepiece disposed in at least one of the optical paths, having a diameter larger than the interpupil distance of an observer. Thus, the stereomicroscope has advantages that, with a simple structure and easy adjustment, many people can make observations, the mountings of photographic and TV devices are possible, the directions in which plural observers see through the microscope can be changed, and eyestrain is difficult to occur which may be caused by the difference in magnification between the images of a bilateral observation optical system.

摘要翻译： 立体显微镜配备有物镜，具有与物镜共有的光轴的可变倍率光学系统，将可变倍率光学系统的出射光分离成多个光路的分光光学系统，以及配置 在至少一个光路中，其直径大于观察者的间距距离。 因此，立体显微镜的优点在于，结构简单，调整方便，许多人可以观察，摄影和电视设备的安装是可能的，多个观察者通过显微镜观察的方向可以改变，眼睛疲劳很困难 可能由双侧观察光学系统的图像之间的放大率的差异引起。

公开(公告)号：US5059005A

公开(公告)日：1991-10-22

申请号：US571407

申请日：1990-08-23

申请人： Yoshihiro Kawano

发明人： Yoshihiro Kawano

IPC分类号： G02B9/00 ,  G02B21/02

CPC分类号： G02B21/02

摘要： An objective lens system for microscopes comprising a plurality of lens units including a first lens unit arranged at the foremost location and having a positive refractive power, and using a GRIN lens or GRIN lenses designed taking into consideration the characteristic of the glass materials currently available. The objective lens system for microscopes consists of a small number of lens elements and has favorably corrected aberrations.

摘要翻译： 一种用于显微镜的物镜系统，包括多个透镜单元，所述多个透镜单元包括布置在最前部位置并且具有正折光力的第一透镜单元，并且使用考虑到当前可用的玻璃材料的特性设计的GRIN透镜或GRIN透镜。 用于显微镜的物镜系统由少量的透镜元件组成，并具有良好的校正像差。