公开(公告)号：US08417971B2

公开(公告)日：2013-04-09

申请号：US12655384

申请日：2009-12-30

申请人： Zhen Huang ,  Zhongqing Li

发明人： Zhen Huang ,  Zhongqing Li

IPC分类号： G06F1/26 ,  G06F3/023

CPC分类号： G06F3/0227 ,  G06F1/26 ,  G06F1/3203 ,  G06F1/3287 ,  G06F1/3293 ,  G06F3/023 ,  Y02D10/122 ,  Y02D10/171 ,  Y02D50/20

摘要： Disclosed is a data processing device, which comprises: an input device for generating first input information; a central processor; an embedded controller, connected to the power supply, the input device and the central processor. When the data processing device is powered on, the embedded controller is adapted to control the power supply to supply power to the input device and the central processor; process the first input information as second information, which can be identified by the central processor; and send the second information to the central processor. When the data processing device is powered off or sleeping, the embedded controller is adapted to control the power supply to supply power to the input device; detect whether a terminal device comprising an operating system is connected and generate a detection result; electrically connect to the terminal device when the detection result indicates that the terminal device comprising the operating system is connected; process the first input information to obtain third input information, which can be processed by at least one program running based on the operating system in the terminal device; and send the third input information to the terminal device. The present invention provides a data processing device and data processing method for solving the inconvenient operations of the traditional handsets and the like terminal devices.

摘要翻译： 公开了一种数据处理装置，包括：用于产生第一输入信息的输入装置; 中央处理器 一个嵌入式控制器，连接到电源，输入设备和中央处理器。 当数据处理装置通电时，嵌入式控制器适于控制电源向输入装置和中央处理器供电; 将第一输入信息作为第二信息处理，其可由中央处理器识别; 并将第二信息发送到中央处理器。 当数据处理装置断电或休眠时，嵌入式控制器适于控制电源以向输入装置供电; 检测包括操作系统的终端设备是否连接并产生检测结果; 当检测结果指示包括操作系统的终端设备被连接时，电连接到终端设备; 处理第一输入信息以获得第三输入信息，其可以由基于终端设备中的操作系统运行的至少一个程序来处理; 并将第三输入信息发送到终端设备。 本发明提供一种用于解决传统手机等终端装置的不方便的数据处理装置和数据处理方法。

公开(公告)号：US20120282702A1

公开(公告)日：2012-11-08

申请号：US13553901

申请日：2012-07-20

申请人： Zhen Huang

发明人： Zhen Huang

IPC分类号： C07H21/04 ,  G01N31/00 ,  C07H21/02 ,  C07H19/048 ,  C07H19/10

CPC分类号： C07H19/073 ,  C07H5/08 ,  C07H21/04

摘要： Disclosed are compounds of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Also disclosed are methods of preparing compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Further disclosed are methods of conducting drug discovery and research comprises applying the compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer in an investigation.

摘要翻译： 公开了式（I）的化合物，其衍生物或互变异构体，或所述化合物或所述互变异构体的药学上可接受的盐。 还公开了制备式（I）化合物，其衍生物或其互变异构体或所述化合物或所述互变异构体的药学上可接受的盐的方法。 进一步披露的是进行药物发现和研究的方法包括在调查中应用式（I）化合物，其衍生物或互变异构体，或所述化合物或所述互变异构体的药学上可接受的盐。

公开(公告)号：US07982030B2

公开(公告)日：2011-07-19

申请号：US12562960

申请日：2009-09-18

申请人： Zhen Huang

发明人： Zhen Huang

IPC分类号： C07H19/173 ,  C07H21/04 ,  C07H19/00 ,  C07D239/46 ,  C07D421/04 ,  A61K31/506 ,  A61P48/00

CPC分类号： C07H19/06 ,  C07H5/08 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00

摘要： The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonucleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.

摘要翻译： 本发明提供了核苷，核苷亚磷酰胺，核苷酸，核苷酸三磷酸，寡核苷酸，多核苷酸和较大的核酸的硒衍生物及其合成方法。 公开了核糖核酸和脱氧核糖核酸的硒衍生物，以及它们的合成，结晶和用于结构测定的方法，特别是通过X射线晶体学技术。 本发明的硒衍生物也可用作食品添加剂。

公开(公告)号：US20110105743A1

公开(公告)日：2011-05-05

申请号：US12933619

申请日：2009-03-20

申请人： Zhen Huang ,  Jia Sheng

发明人： Zhen Huang ,  Jia Sheng

IPC分类号： C07H1/00 ,  C07D307/02

CPC分类号： C07H19/06 ,  C07H19/16

摘要： A method is disclosed for synthesizing 2′,3′-didehydro-2′,3′-dideoxynucleosides (d4Ns) from a nucleophile-mediated elimination, such as a telluride-mediated elimination reaction. After substitution of 2,2′-anhydronucleosides with a nucleophile, such as a telluride monoanion, a telluride intermediate is formed, and its elimination leads to formation of the olefin products (d4Ns). This disclosure describes this telluride-assisted (or nucleophile-assisted) reaction and how to facilitate the substitution and elimination in order to form d4Ns.

摘要翻译： 公开了从亲核试剂介导的消除如碲化物介导的消除反应合成2'，3'-二脱氢-2'，3'-二脱氧核苷（d4Ns）的方法。 用亲核试剂（如碲化物单阴离子）代替2,2'-脱水核苷后，形成碲化物中间体，其消除导致烯烃产物（d4Ns）的形成。 本公开描述了这种碲化物辅助（或亲核试剂辅助）反应以及如何促进取代和消除以形成d4N。

公开(公告)号：US20100137573A1

公开(公告)日：2010-06-03

申请号：US12562960

申请日：2009-09-18

申请人： Zhen Huang

发明人： Zhen Huang

IPC分类号： C07H1/00 ,  C07H19/06 ,  C07H19/16

CPC分类号： C07H19/06 ,  C07H5/08 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00

摘要： The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonucleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.

摘要翻译： 本发明提供了核苷，核苷亚磷酰胺，核苷酸，核苷酸三磷酸，寡核苷酸，多核苷酸和较大的核酸的硒衍生物及其合成方法。 公开了核糖核酸和脱氧核糖核酸的硒衍生物，以及它们的合成，结晶和用于结构测定的方法，特别是通过X射线晶体学技术。 本发明的硒衍生物也可用作食品添加剂。

公开(公告)号：US07601823B2

公开(公告)日：2009-10-13

申请号：US11256726

申请日：2005-10-24

申请人： Li Niu ,  Zhen Huang ,  Hua Shi ,  John T. Lis

发明人： Li Niu ,  Zhen Huang ,  Hua Shi ,  John T. Lis

IPC分类号： C07H21/02

CPC分类号： C12N15/115 ,  C12N2310/16

摘要： The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.

摘要翻译： 本发明涉及结合并抑制离子型谷氨酸受体的α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）亚型的活化的新型核酸配体或适体。 还公开了技术的新型组合，即SELEX和激光脉冲光解用于选择和筛选抑制受体功能的适体，因此可用于治疗与离子型谷氨酸受体的过度活化相关的疾病。

公开(公告)号：US07592446B2

公开(公告)日：2009-09-22

申请号：US10104995

申请日：2002-03-22

申请人： Zhen Huang

发明人： Zhen Huang

IPC分类号： C07D421/04 ,  C07D239/46 ,  C07H21/04 ,  C07H19/073 ,  A61K31/506 ,  A61K48/00

CPC分类号： C07H19/06 ,  C07H5/08 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00

摘要： The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonulcleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.

摘要翻译： 本发明提供了核苷，核苷亚磷酰胺，核苷酸，核苷酸三磷酸，寡核苷酸，多核苷酸和较大的核酸的硒衍生物及其合成方法。 公开了核糖核酸和脱氧核糖核酸的硒衍生物，以及它们的合成，结晶和用于结构测定的方法，特别是通过X射线晶体学技术。 本发明的硒衍生物也可用作食品添加剂。

公开(公告)号：US20060148746A1

公开(公告)日：2006-07-06

申请号：US11256726

申请日：2005-10-24

申请人： Li Niu ,  Zhen Huang ,  Hua Shi ,  John Lis

发明人： Li Niu ,  Zhen Huang ,  Hua Shi ,  John Lis

IPC分类号： A61K48/00 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C12N15/115 ,  C12N2310/16

摘要： The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.

公开(公告)号：US6139021A

公开(公告)日：2000-10-31

申请号：US175510

申请日：1998-10-20

申请人： Zhen Huang

发明人： Zhen Huang

IPC分类号： F16J15/3208 ,  B60T11/236

CPC分类号： F16J15/3208 ,  Y10S277/91

摘要： A seal for hydraulically sealing a piston rod (1) that travels axially into and out of a holder, preferably a hydraulic shock absorber. A sealing component (11) of elastic plastic has one edge (12) resting against the piston rod, tensioned over an elastomeric component, and accommodated along with that component in a sealing chamber (10). The object is to simplify the seal, reduce friction, and ensure that it will work even at very low temperatures. The tension is accordingly generated by two rings (13 & 14) of packing cord positioned diagonally opposite each other in the cross-section of the chamber. The rings, as long as they are not tensioned against each other, against the inner surface of the chamber, and against the back (15) of the sealing component, occupy most of the space inside the chamber.

摘要翻译： 用于液压密封活塞杆（1）的密封件，该活塞杆（1）轴向地进入和离开保持器，优选地是液压减震器。 弹性塑料的密封部件（11）具有一个靠在活塞杆上的边缘（12），张紧在弹性体部件上，并与该部件一起容纳在密封室（10）中。 目的是简化密封，减少摩擦，并确保即使在非常低的温度下也能工作。 因此，张力由腔室的横截面上彼此对角相对定位的包装绳的两个环（13和14）产生。 只要它们彼此不被张紧在腔室的内表面上并且抵靠密封部件的背部（15）的环就占据了腔室内的大部分空间。

公开(公告)号：US5540309A

公开(公告)日：1996-07-30

申请号：US355642

申请日：1994-12-14

申请人： Zhen Huang ,  Klaus Schmidt ,  Hans Scheerer ,  Andreas Opara

发明人： Zhen Huang ,  Klaus Schmidt ,  Hans Scheerer ,  Andreas Opara

IPC分类号： F16F9/32 ,  F16F9/36 ,  B60G17/08 ,  B60G13/08 ,  F16F9/46

CPC分类号： F16F9/3235 ,  F16F9/369

摘要： A regulable hydraulic dashpot for motor vehicles with a shock-absorption piston equipped with pressure-sensitive throttle valves traveling back and forth on the end of a piston rod inside a shock-absorption cylinder full of shock-absorbing fluid and dividing the cylinder into two displacement chambers. A gas-filled pressure-compensation chamber operates in conjunction with one displacement chamber. A shock-absorption performance-curve selection valve is positioned outside the cylinder and opens and closes a bypass. To create a hydraulic-fluid channel, the cylinder comprises two parts of different width between the two displacement chambers. One of the parts overlaps the other to the length of the stroke traveled by the piston and its open end is sealed tight to the outer part. The outer part is provided with two hydraulic-fluid conveying connections into the shock-absorption performance-curve selection valve. The parts of the cylinder between the connections are sealed off from each other by a sealing component.

摘要翻译： 用于机动车辆的可调节液压缓冲器，其具有减震活塞，其配备有压力节流阀，在活塞杆的端部前后移动，该活塞杆内装有缓冲液体并且将气缸分成两个位移 房间。 气体充填压力补偿室与一个位移室联合操作。 减震性能曲线选择阀位于气缸外部并打开和关闭旁路。 为了产生液压流体通道，气缸在两个位移室之间包括两个不同宽度的部分。 其中一个部分与活塞的行程长度重叠，其开口端与外部部分密封。 外部设有两个液压流体输送连接到减震性能曲线选择阀中。 连接件之间的气缸部分通过密封部件彼此密封。