公开(公告)号：US20110133101A1

公开(公告)日：2011-06-09

申请号：US12987736

申请日：2011-01-10

Applicant: Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

Inventor： Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

IPC: G01J1/58 ,  G02B6/06

CPC classification number: G01N21/6458 ,  A61B1/00117 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086 ,  G02B6/29362 ,  G02B21/16

Abstract: An imaging device including an illumination module including at least one emitter for emitting at least one excitation beam, a scanning and injection module including an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers, and a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide, and a detection module including at least one detector for detecting at least one luminous flux collected at the distal end of the image guide. At least one of the illumination module and the detection module is optically conjugated with the scanning and injection module by a conjugating optical fiber.

Abstract translation: 一种成像装置，包括包括至少一个用于发射至少一个激发光束的发射器的照明模块，包括图像引导件的扫描和注射模块，其近端和远端由多根光纤连接， 扫描和注射光学系统，被配置为将至少一个激发光束从图像引导件的近端交替地注入到图像引导件的光纤中，以及检测模块，包括至少一个检测器，用于检测在 图像引导件的远端。 照明模块和检测模块中的至少一个通过共轭光纤与扫描和注入模块光学共轭。

公开(公告)号：US07903848B2

公开(公告)日：2011-03-08

申请号：US10520917

申请日：2003-07-11

Applicant: Aymeric Perchant ,  Georges Le Goualher ,  Frederic Berier

Inventor： Aymeric Perchant ,  Georges Le Goualher ,  Frederic Berier

IPC: G02B6/06 ,  G06K9/00 ,  G06K9/36 ,  H04N13/02 ,  H04N5/00

CPC classification number: G06T5/008 ,  G06T2207/10056

Abstract: A method for processing an image acquired through a guide consisting of a plurality of optical fibers includes, for each optical fiber, isolating on the acquired image a zone corresponding to the optical fiber, locally processing each zone individually to correct the photon flux detected in each optical fiber, then reconstructing the acquired image by eliminating the pattern caused by the optical fiber. The method also includes a sampling process for obtaining, for each optical fiber and from a sampling image, a sample injection rate which can be used for reconstructing the acquired images. The method also includes a prior step which consists in detecting the fibers from a target.

Abstract translation: 用于处理通过由多根光纤组成的导向器获取的图像的方法包括：对于每个光纤，在所获取的图像上隔离与光纤对应的区域，分别对每个区域进行局部处理，以校正每个光纤中检测到的光子通量 光纤，然后通过消除由光纤引起的图案来重构获取的图像。 该方法还包括用于从每个光纤和采样图像获得可用于重建获取的图像的样本注入速率的采样处理。 该方法还包括一个前期步骤，其中包括从目标物中检测纤维。

公开(公告)号：US20110015529A1

公开(公告)日：2011-01-20

申请号：US12294672

申请日：2007-03-23

Applicant: Benjamin Abrat ,  Charlotte Cave ,  Alexandre Loiseau ,  Jerome Lopez ,  Anne Osdoit ,  Bertrand viellerobe

Inventor： Benjamin Abrat ,  Charlotte Cave ,  Alexandre Loiseau ,  Jerome Lopez ,  Anne Osdoit ,  Bertrand viellerobe

IPC: A61B6/00

CPC classification number: A61B5/0071 ,  A61B1/043 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0084 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6484

Abstract: The invention relates to a method for the fabric using an acquisition system that includes at acquisition of in-vivo fluorescence imaging from a least one optical fibre exciting the fabric by scanning light beam. According to the invention, the system is used to detect fluorescence signals emitted by the Methylene Blue present in the fabric.

Abstract translation: 本发明涉及一种使用采集系统的织物的方法，所述采集系统包括从通过扫描光束激发织物的至少一个光纤获取体内荧光成像。 根据本发明，该系统用于检测由织物中存在的亚甲基蓝发射的荧光信号。

公开(公告)号：US07658495B2

公开(公告)日：2010-02-09

申请号：US12210058

申请日：2008-09-12

Applicant: François Lacombe ,  David Lafaille ,  Marie Glanc ,  Eric Gendron ,  Douchane Stefanovitch

Inventor： François Lacombe ,  David Lafaille ,  Marie Glanc ,  Eric Gendron ,  Douchane Stefanovitch

IPC: A61B3/10 ,  A61B3/14 ,  A61B3/00

CPC classification number: A61B3/0091

Abstract: A sighting device for an examination by in vivo tomography of an eye of a subject including a viewer controlled by a control system for displaying at least one moving target where the at least one moving target has at least one of a programmable shape and a programmable trajectory, and is visible by the eye of the subject during the examination period to allow the subject to fixate and follow the target with their eye.

Abstract translation: 一种用于通过体内层析成像进行检查的瞄准装置，包括由控制系统控制的观察者，用于显示至少一个移动目标的至少一个移动目标，其中所述至少一个移动目标具有可编程形状和可编程轨迹中的至少一个 并且在检查期间由受试者的眼睛可见，以允许受试者用眼睛固定和跟踪目标。

公开(公告)号：US20090097806A1

公开(公告)日：2009-04-16

申请号：US12249665

申请日：2008-10-10

Applicant: Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

Inventor： Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

IPC: G02B6/06

CPC classification number: G01N21/6458 ,  A61B1/00165 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086

Abstract: An imaging device includes an illumination module comprising at least one emitter for emitting at least one excitation beam; a scanning and injection module comprising an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers; a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide; a detection module comprising a detector for detecting a luminous flux collected at the distal end of the image guide, wherein at least one of the illumination module and the detection module is optically conjugated with the scanning and injection module using a conjugating optical fiber.

Abstract translation: 一种成像装置包括：照明模块，包括至少一个用于发射至少一个激发光束的发射器; 扫描和注射模块，包括图像引导件，其近端和远端由多根光纤连接; 扫描和注射光学系统，被配置为从所述图像引导件的近端交替地将所述至少一个激发光束注入到所述图像引导件的光纤中; 检测模块，包括用于检测在图像引导件的远端处收集的光通量的检测器，其中照明模块和检测模块中的至少一个使用共轭光纤与扫描和注射模块光学共轭。

公开(公告)号：US07447539B2

公开(公告)日：2008-11-04

申请号：US10521607

申请日：2003-07-11

Applicant: Magalie Genet ,  Bertrand Viellerobe ,  Frederic Berier ,  Sophie Clade

Inventor： Magalie Genet ,  Bertrand Viellerobe ,  Frederic Berier ,  Sophie Clade

IPC: A61B1/06

CPC classification number: H04N1/0281 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0084 ,  G02B21/0028 ,  G02B21/0032 ,  G02B21/0048 ,  G02B21/0072 ,  G02B21/0076 ,  G02B21/0084 ,  G02B23/26 ,  G02B26/101

Abstract: A method using an image guide having several thousands of optical fibers, an excitation signal emitted by a source, deflected and injected by turns into the optical fibers, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method focuses the beam in the fiber output to excite a subsurface plane to produce a confocal image. The production of a divergent beam in the fiber output can excite a micro-volume of the tissue from the surface. The method deflects the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one-by-one.

Abstract translation: 使用具有数千光纤的图像引导器的方法，由源发射的激发信号，被偏转并被轮流注入光纤中，光纤输出中的组织的每个激发点发射，以返回由 光纤，然后检测并数字化以形成图像元素。 该方法将光束聚焦在光纤输出中以激发地下平面以产生共焦图像。 纤维输出中的发散光束的产生可以从表面激发组织的微量。 该方法使得激励信号以对应于每秒钟拍摄的图像的速度相应的速度偏转，足以实时使用，并且检测在对应于最小频率的检测频率处的荧光信号，以对纤维进行逐一采样。

公开(公告)号：US20080029711A1

公开(公告)日：2008-02-07

申请号：US11629213

申请日：2005-06-09

Applicant: Bertrand Viellerobe ,  Florence Jean ,  Genevieve Bourg-Heckly ,  Alexandre Loiseau

Inventor： Bertrand Viellerobe ,  Florence Jean ,  Genevieve Bourg-Heckly ,  Alexandre Loiseau

IPC: G01N21/64

CPC classification number: G01N21/6458 ,  G01N21/6428 ,  G01N2021/6417 ,  G01N2021/6423

Abstract: The invention relates to a method for producing a fluorescent fiber image of a sample, wherein a sample is scanned with the aid of an excitation signal; the fluorescent signal emanating from the sample is detected, wherein the excitation signal and fluorescent signal use the same optical path; the optical path is used to excite at least two fluorophors contained in the sample; a final image is produced, including areas that are colored according to the at least two fluorophors. The multimarking according to the invention makes it possible to simultaneously acquire two images in two different wavelength bands. The system according to the invention can comprise a spectrometer for spectral quantification of the fluorescent signal.

Abstract translation: 本发明涉及一种用于制备样品的荧光纤维图像的方法，其中借助于激发信号扫描样品; 检测从样品发出的荧光信号，其中激发信号和荧光信号使用相同的光路; 光路用于激发样品中包含的至少两种荧光体; 产生最终图像，包括根据至少两个荧光体着色的区域。 根据本发明的多标记使得可以同时获取两个不同波长带中的两个图像。 根据本发明的系统可以包括用于荧光信号的光谱定量的光谱仪。

公开(公告)号：US20050157981A1

公开(公告)日：2005-07-21

申请号：US10499987

申请日：2002-12-20

Applicant: Frederic Berier ,  Stephane Bourriaux ,  Magalie Genet ,  Bertrand Viellerobe ,  Alexandre Loiseau ,  Benjamin Abrat

Inventor： Frederic Berier ,  Stephane Bourriaux ,  Magalie Genet ,  Bertrand Viellerobe ,  Alexandre Loiseau ,  Benjamin Abrat

IPC: G02B23/26 ,  A61B1/00 ,  G02B21/02 ,  G02B6/32

CPC classification number: A61B1/00188 ,  A61B2562/0242 ,  A61B2562/146

Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.

Abstract translation: 一种用于装备柔性光纤束的远端的光学头，设计成被推动与分析表面接触并且包括用于将激发信号聚焦到位于分析器下方特定深度处的所谓的激发焦点的光学元件 表面，并对由纤维束承载的激发焦点反向散射的信号采样。 头部包括光纤保持器管，其中插入在纤维束的远端部分的一侧和另一个光学元件上，其中光学元件包括与纤维束的端部接触的板，其中指数接近 光纤芯和聚焦光学块的输出窗口进一步提供适于提供指标适应以消除在分析表面上发生的寄生反射。