公开(公告)号：US20070144919A1

公开(公告)日：2007-06-28

申请号：US11318175

申请日：2005-12-23

Applicant: Kuang Cheng

Inventor： Kuang Cheng

IPC: G01F1/64 ,  G01N27/26

CPC classification number: G01N27/333

Abstract: An ion selective electrode (ISE) includes an electrode body or housing having an ion selective membrane located at one end thereof and an indicator electrode formed at or adjacent to the ion selective membrane. A sealed vessel is disposed inside the electrode body, the sealed vessel holding an electrically conductive solution and a reference electrode conductor, wherein a portion of the reference electrode conductor is submerged in the electrically conductive solution. The ISE includes a conductive member having a proximal end and a distal end, wherein the proximal end of the conductive member terminates inside the sealed vessel and the distal end terminates outside the housing. The construction of the ISE keeps the reference electrode separate from the indicator electrode. Electrons are passed to the reference electrode via the conductive member obviating the need for a salt bridge. Importantly, no reference electrode is needed that connects to the inner membrane surface. The ISE operates on the double capacitor mechanism which is fundamentally different from the conventional Nernst redox reactions described in the prior art.

Abstract translation: 离子选择电极（ISE）包括具有位于其一端的离子选择性膜的电极体或壳体，以及形成在离子选择膜上或邻近离子选择性膜的指示电极。 密封容器设置在电极体的内部，密封容器保持导电溶液和参比电极导体，其中参考电极导体的一部分浸没在导电溶液中。 ISE包括具有近端和远端的导电构件，其中导电构件的近端终止在密封容器内，并且远端终止于外壳外部。 ISE的结构使参考电极与指示电极分离。 电子通过导电部件传递到参考电极，从而避免了对盐桥的需要。 重要的是，不需要连接到内膜表面的参考电极。 ISE工作在双电容器机构上，这与现有技术中描述的常规能斯恩氧化还原反应基本不同。

公开(公告)号：US20070138027A1

公开(公告)日：2007-06-21

申请号：US11304065

申请日：2005-12-15

Applicant: David Dinsmoor ,  Michael Mattes ,  Rogier Receveur ,  Arun Gupta

Inventor： David Dinsmoor ,  Michael Mattes ,  Rogier Receveur ,  Arun Gupta

IPC: G01F1/64 ,  G01N27/26

CPC classification number: G01N27/4035

Abstract: The disclosure provides monolithic electrodes including a substrate defining a walled cavity having a floor, an electrically conductive cathode layer overlaying the cavity floor, an electrically conductive contact pad overlaying the substrate, an electrically conductive via in electrical communication with the cathode layer and the contact pad, and a porous membrane layer overlaying the cavity and defining a chamber formed by the porous membrane layer, the walled cavity, and the cavity floor. The disclosure also provides pH transducers including monolithic indicator and reference electrodes, and methods of making and using monolithic pH electrodes and transducers.

Abstract translation: 本公开提供了单片电极，其包括限定具有底板的壁腔的衬底，覆盖空腔底板的导电阴极层，覆盖衬底的导电接触垫，与阴极层和接触垫电连通的导电通孔 以及覆盖所述空腔并且限定由所述多孔膜层，所述壁腔和所述空腔底板形成的室的多孔膜层。 本公开还提供了包括单片指示剂和参比电极的pH换能器，以及制造和使用单片pH电极和换能器的方法。

公开(公告)号：US20070125665A1

公开(公告)日：2007-06-07

申请号：US11297153

申请日：2005-12-07

Applicant: David Kubinski ,  Richard Soltis ,  Jacobus Visser ,  Yi Ding ,  Michael Parsons

Inventor： David Kubinski ,  Richard Soltis ,  Jacobus Visser ,  Yi Ding ,  Michael Parsons

IPC: G01N27/26 ,  G01F1/64

CPC classification number: G01N27/417

Abstract: A method of operating a gas sensor is disclosed, wherein the sensor includes a pumping electrode configuration and a measuring electrode configuration, and wherein the method includes operating the sensor in a first mode in which a first, lower pumping potential sufficient to electrochemically remove an interfering compound from the sensor without electrochemically removing the analyte from the sensor is applied across the pumping electrode configuration and a measuring potential sufficient to electrochemically remove the analyte from the sensor is applied across the measuring electrode configuration; and operating the sensor in a second mode in which a second, higher pumping potential sufficient to electrochemically remove the analyte from the sensor is applied to the pumping electrode configuration.

Abstract translation: 公开了一种操作气体传感器的方法，其中所述传感器包括泵送电极配置和测量电极配置，并且其中所述方法包括以第一模式操作所述传感器，其中第一较低的泵送电势足以电化学地去除干扰 来自传感器的化合物不经电化学去除传感器中的分析物跨越泵送电极配置，并且在测量电极配置上施加足以电化学去除传感器分析物的测量电位; 并且在第二模式下操作所述传感器，其中将第二较高泵送电势充分地电化学地从所述传感器中去除所述分析物到所述泵送电极配置。

公开(公告)号：US20070125664A1

公开(公告)日：2007-06-07

申请号：US11295030

申请日：2005-12-05

Applicant: William LaBarge ,  Joachim Kupe ,  Walter Symons

Inventor： William LaBarge ,  Joachim Kupe ,  Walter Symons

IPC: G01F1/64 ,  G01N27/26

CPC classification number: G01N27/4071

Abstract: In one embodiment, a gas sensor element comprises: an electrolyte disposed between and in ionic communication with a first electrode and a second electrode; and a protective layer disposed adjacent to the first electrode. The protective layer comprises a catalytic coating comprising a reducible support material, a catalyst, and a water activator material. The catalyst coating is capable of converting an oxygen consuming species in a gas to an oxygen donating species.

Abstract translation: 在一个实施例中，气体传感器元件包括：设置在第一电极和第二电极之间并与其离子连通的电解质; 以及与第一电极相邻设置的保护层。 保护层包括包含可还原的载体材料，催化剂和水活化剂材料的催化涂层。 催化剂涂层能够将气体中的耗氧物质转化为供氧物质。

公开(公告)号：US20070119708A1

公开(公告)日：2007-05-31

申请号：US11602983

申请日：2006-11-22

Applicant: Seiji Oya ,  Tomohiro Wakazono ,  Koji Shiotani ,  Tomonori Kondo ,  Mineji Nasu ,  Hiroshi Kubota ,  Kazuo Yanada ,  Koichi Awano

Inventor： Seiji Oya ,  Tomohiro Wakazono ,  Koji Shiotani ,  Tomonori Kondo ,  Mineji Nasu ,  Hiroshi Kubota ,  Kazuo Yanada ,  Koichi Awano

IPC: G01N27/26 ,  G01F1/64

CPC classification number: G01N33/0037 ,  G01N27/4175 ,  Y02A50/245

Abstract: In a sensor diagnosis process, a controller for controlling an NOx gas sensor performs processing of changing the oxygen partial pressure in a second measurement chamber by changing the oxygen partial pressure in a first measurement chamber (S190), processing of detecting a current flowing through a second pump cell before the change of the oxygen partial pressure (S180), and processing of detecting a current flowing through the second pump cell after the change of the oxygen partial pressure (S230). Furthermore, the controller performs processing of judging whether or not the ratio between the current values detected by the respective current detecting unit falls within an allowable range, judging that the second pump cell 113 is in a normal state if the ratio between the current values falls within the allowable range, and judging that the second pump cell 113 is in a deteriorated state if the ratio between the current values is out of the allowable range (S240 and S250).

Abstract translation: 在传感器诊断过程中，用于控制NOx气体传感器的控制器通过改变第一测量室中的氧分压来执行改变第二测量室中的氧分压的处理（S 190），检测流过的电流的处理 在氧分压变化之前的第二泵电池（S1080），以及在氧分压变化之后检测流过第二泵电池的电流的处理（S 230）。 此外，控制器执行判断由各个电流检测单元检测的电流值之间的比率是否落在容许范围内的判断处理，如果当前值之间的比率下降，则判定第二泵浦单元113处于正常状态 在容许范围内，如果电流值之间的比例在允许范围之外，则判定第二泵电池113处于劣化状态（S 240和S 250）。

公开(公告)号：US20070074977A1

公开(公告)日：2007-04-05

申请号：US11240797

申请日：2005-09-30

Applicant: Sherry Guo ,  Alastair Hodges ,  Ronald Chatelier ,  Bin Zhang

Inventor： Sherry Guo ,  Alastair Hodges ,  Ronald Chatelier ,  Bin Zhang

IPC: G01F1/64

CPC classification number: A61B5/14532 ,  A61B5/1486 ,  A61B2562/0295 ,  G01N27/3273

Abstract: Methods and apparatus for electrochemically determining an analyte concentration value in a physiological sample are disclosed. The methods include using a test strip in which two time-current transients are measured by a meter electrically connected to an electrochemical test strip. Integrative current values are derived from the time-current transients and used in the calculation of analyte concentration.

Abstract translation: 公开了用于电化学测定生理样品中分析物浓度值的方法和装置。 这些方法包括使用测试条，其中通过电连接到电化学测试条的仪表测量两个时间电流瞬变。 积分电流值来自时间 - 电流瞬变，并用于计算分析物浓度。

公开(公告)号：US07182853B2

公开(公告)日：2007-02-27

申请号：US09957729

申请日：2001-09-21

Applicant: Jay Johnson

Inventor： Jay Johnson

IPC: G01F1/64 ,  G01N27/26 ,  G01N33/553

CPC classification number: C12Q1/001

Abstract: The invention is a redox control and monitoring platform that is to be used in conduction with another detection scheme. The platform includes a portion of an electrochemical control. The electrochemical control can be operated to control and measure the redox environment of a sample. The electrochemical control can be provided in a multiplicity of test regions to allow high throughput analysis of a multiplicity of samples. The present method and system allows the determination of the effect of the change in redox environment on the binding or other activity of the species in the sample that is directly affected by the redox environment.

Abstract translation: 本发明是用于与另一种检测方案一起使用的氧化还原控制和监测平台。 平台包括一部分电化学控制。 可以操作电化学控制来控制和测量样品的氧化还原环境。 可以在多个测试区域中提供电化学控制，以允许多个样品的高通量分析。 本方法和系统允许确定氧化还原环境变化对直接受氧化还原环境影响的样品中物种的结合或其他活性的影响。

公开(公告)号：US20060246443A1

公开(公告)日：2006-11-02

申请号：US10538062

申请日：2003-07-04

Applicant: Ulrich Bockelmann ,  Francois Pouthas ,  Cedric Gentil

Inventor： Ulrich Bockelmann ,  Francois Pouthas ,  Cedric Gentil

IPC: C12Q1/68 ,  G01F1/64

CPC classification number: C12Q1/6825 ,  C12Q1/6837 ,  G01N27/4145 ,  C12Q2527/137 ,  C12Q2565/501

Abstract: The invention concerns a method for detecting at least one specific interaction between probe molecules and target biomiolecules fixed to at least one active zone of a sensor. Said sensor consists of an array of field-effect transistors (T1, T2,), each of which has a gate region constituting an active zone (3) whereon said specific interaction is to be detected.

Abstract translation: 本发明涉及一种用于检测探针分子与固定在传感器的至少一个活性区域上的目标生物分子之间的至少一种特异性相互作用的方法。 所述传感器由场效应晶体管阵列（T 1，T 2，）构成，每个场效应晶体管具有构成所述特定相互作用被检测的有源区（3）的栅极区。

公开(公告)号：US20060231422A1

公开(公告)日：2006-10-19

申请号：US10907750

申请日：2005-04-14

Applicant: Michael Rhodes ,  Peter Kroot

Inventor： Michael Rhodes ,  Peter Kroot

IPC: G01F1/64 ,  G01N27/26

CPC classification number: G01N27/419

Abstract: Apparatus and methods for measuring gas component concentrations are disclosed. The method includes measuring a total gas concentration, including a first gaseous component and a second gaseous component, in an atmosphere with a gas sensor. The gas sensor includes a first cell and a second cell. The first cell is electrically coupled to a pump controller and the second cell is electrically coupled to a sense controller. The pump controller and sense controller are then switched such that the pump controller is electrically coupled to the second cell and the sense controller is electrically coupled to the first cell. Then a first gaseous component concentration is measured.

Abstract translation: 公开了用于测量气体组分浓度的装置和方法。 该方法包括在具有气体传感器的气氛中测量包括第一气体组分和第二气体组分的总气体浓度。 气体传感器包括第一电池和第二电池。 第一单元电耦合到泵控制器，并且第二单元电耦合到感测控制器。 然后切换泵控制器和感测控制器，使得泵控制器电耦合到第二单元，并且感测控制器电耦合到第一单元。 然后测量第一气体组分浓度。

公开(公告)号：US20060207891A1

公开(公告)日：2006-09-21

申请号：US10553584

申请日：2004-04-16

Applicant: John Althaus ,  Lee Kyonghoon ,  Vijay Namasivayam ,  Sundaresh Brahmasandra ,  Kalyan Handique

Inventor： John Althaus ,  Lee Kyonghoon ,  Vijay Namasivayam ,  Sundaresh Brahmasandra ,  Kalyan Handique

IPC: G01N27/26 ,  G01F1/64

CPC classification number: G01N33/54373 ,  C12Q1/6825 ,  G01N33/5438 ,  Y10T436/143333 ,  C12Q2565/607 ,  C12Q2563/173

Abstract: The present invention relates to an electrochemical method for detecting a target polynucleotide. An electrode comprising an electrode surface is provided. The electrode surface includes at least one probe molecule reverisbly immobilized with respect to the electrode surface. A first electrochemical signal indicative of an amount of probe molecule immobilized with respect to the electrode surface is obtained. The electrode surface is contacted with a liquid comprising the target polynucleotide. Upon the contacting step, at least some of the probe molecule immobilized with respect to the electrode surface dissociates therefrom. A second electrochemical signal indicative of an amount of probe molecule immobilized with respect to the electrode surface is obtained. The presence of the target polynucleotide is determined at least partially on the basis of the first and second electrochemical signals.

Abstract translation: 本发明涉及一种用于检测靶多核苷酸的电化学方法。 提供了包括电极表面的电极。 电极表面包括相对于电极表面反复固定的至少一个探针分子。 获得指示相对于电极表面固定的探针分子的量的第一电化学信号。 电极表面与包含靶多核苷酸的液体接触。 在接触步骤中，相对于电极表面固定的至少一些探针分子与其分离。 获得指示相对于电极表面固定的探针分子的量的第二电化学信号。 至少部分地基于第一和第二电化学信号确定靶多核苷酸的存在。