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    REAGENT TUBE
    5.
    发明申请
    REAGENT TUBE 有权
    试剂管

    公开(公告)号：US20110027151A1

    公开(公告)日：2011-02-03

    申请号：US12904901

    申请日：2010-10-14

    申请人： Kalyan Handique ,  Theodore Springer

    发明人： Kalyan Handique ,  Theodore Springer

    IPC分类号： B01L3/14

    CPC分类号： F16K99/0001 ,  B01L3/5082 ,  B01L2200/026 ,  B01L2200/16 ,  B01L2300/0851 ,  F16K99/003 ,  F16K99/0032 ,  F16K99/0044 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N2035/00881

    摘要： A reagent tube configured with a stellated shaped pattern, on its bottom interior surface, configured to facilitate complete or near-complete withdrawal of fluid from the tube, via a pipette tip. The reagent tube may be used for transporting reagents and for carrying out processing operations on biological samples with the reagents, such as preparing polynucleotides extracted from the sample for amplification.

    摘要翻译： 配置有在其底部内表面上具有星形图案的试剂管被配置为便于通过移液管尖端从管中完全或接近完全地排出流体。 试剂管可以用于运送试剂和用试剂进行生物样品的处理操作，例如制备从样品中提取的多核苷酸用于扩增。

    HEAT-REDUCTION METHODS AND SYSTEMS RELATED TO MICROFLUIDIC DEVICES
    7.
    发明申请
    HEAT-REDUCTION METHODS AND SYSTEMS RELATED TO MICROFLUIDIC DEVICES 审中-公开
    与微流体装置相关的减热方法和系统

    公开(公告)号：US20080138250A1

    公开(公告)日：2008-06-12

    申请号：US12032631

    申请日：2008-02-15

    申请人： Kalyan Handique

    发明人： Kalyan Handique

    IPC分类号： B01L7/00 ,  B01L3/00

    CPC分类号： C12Q1/6806 ,  B01L3/5027 ,  B01L7/00 ,  B01L2300/0816 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1883 ,  B01L2300/1894 ,  B01L2400/0442 ,  H05B3/22 ,  H05K3/10 ,  Y10T29/49155

    摘要： A system and method for preventing or reducing unwanted heat in a microfluidic of the device while generating heat in selected regions of the device.In one example, current is supplied to a heating element through electric leads, wherein the leads are designed so that the current density in the leads is substantially lower than the current density in the heating element. This may be accomplished using conductive leads which have a cross-sectional area which is substantially greater than the cross-sectional area of the heating element.In another example, unwanted heat in the microfluidic complex is reduced by thermally isolating the electric leads from the microfluidic complex. This may be accomplished by running each lead directly away from the microfluidic complex, through a thermally isolating substrate. After the leads pass through the thermally isolating substrate, they are then routed to the current source. Thus, the thermally isolating substrate substantially blocks the transfer of heat from the leads to the microfluidic complex.In another example, unwanted heat is removed from selected regions of the microfluidic complex using one or more cooling devices. One or more Peltier cooling devices may be attached to a substrate to remove heat generated by heating elements and/or other electronic circuitry.

    摘要翻译： 一种用于在装置的选定区域中产生热量的同时防止或减少装置的微流体中不需要的热量的系统和方法。 在一个示例中，通过电引线将电流供应到加热元件，其中引线被设计成使得引线中的电流密度显着低于加热元件中的电流密度。 这可以使用具有基本上大于加热元件的横截面面积的横截面积的导电引线来实现。 在另一个实例中，通过将电引线与微流体络合物热隔离来减少微流体络合物中的不需要的热量。 这可以通过将每个引线直接远离微流体复合物，通过热隔离衬底来实现。 在引线通过隔热衬底之后，它们被引导到电流源。 因此，隔热衬底基本上阻止了从引线到微流体络合物的热传递。 在另一个实例中，使用一个或多个冷却装置从微流体复合物的选定区域去除不需要的热量。 一个或多个珀耳帖冷却装置可以附接到基板以去除由加热元件和/或其它电子电路产生的热量。

    System and method for electrochemical detection of biological compounds
    10.
    发明申请
    System and method for electrochemical detection of biological compounds 有权
    生物化学物质电化学检测系统及方法

    公开(公告)号：US20060207891A1

    公开(公告)日：2006-09-21

    申请号：US10553584

    申请日：2004-04-16

    申请人： John Althaus ,  Lee Kyonghoon ,  Vijay Namasivayam ,  Sundaresh Brahmasandra ,  Kalyan Handique

    发明人： John Althaus ,  Lee Kyonghoon ,  Vijay Namasivayam ,  Sundaresh Brahmasandra ,  Kalyan Handique

    IPC分类号： G01N27/26 ,  G01F1/64

    CPC分类号： G01N33/54373 ,  C12Q1/6825 ,  G01N33/5438 ,  Y10T436/143333 ,  C12Q2565/607 ,  C12Q2563/173

    摘要： The present invention relates to an electrochemical method for detecting a target polynucleotide. An electrode comprising an electrode surface is provided. The electrode surface includes at least one probe molecule reverisbly immobilized with respect to the electrode surface. A first electrochemical signal indicative of an amount of probe molecule immobilized with respect to the electrode surface is obtained. The electrode surface is contacted with a liquid comprising the target polynucleotide. Upon the contacting step, at least some of the probe molecule immobilized with respect to the electrode surface dissociates therefrom. A second electrochemical signal indicative of an amount of probe molecule immobilized with respect to the electrode surface is obtained. The presence of the target polynucleotide is determined at least partially on the basis of the first and second electrochemical signals.

    摘要翻译： 本发明涉及一种用于检测靶多核苷酸的电化学方法。 提供了包括电极表面的电极。 电极表面包括相对于电极表面反复固定的至少一个探针分子。 获得指示相对于电极表面固定的探针分子的量的第一电化学信号。 电极表面与包含靶多核苷酸的液体接触。 在接触步骤中，相对于电极表面固定的至少一些探针分子与其分离。 获得指示相对于电极表面固定的探针分子的量的第二电化学信号。 至少部分地基于第一和第二电化学信号确定靶多核苷酸的存在。