公开(公告)号：US09695239B2

公开(公告)日：2017-07-04

申请号：US14436568

申请日：2013-10-24

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung E.V.

发明人： Stefan Barth ,  Theopilus Thepen ,  Dmitrij Hristodorov ,  Radoslav Mladenov

IPC分类号： C12P21/06 ,  C12N15/00 ,  C07H21/04 ,  C12P21/08 ,  C07K16/00 ,  C07K16/28 ,  C07K14/52 ,  C07K14/54 ,  C07K14/47

CPC分类号： C07K16/283 ,  C07K14/47 ,  C07K14/521 ,  C07K14/54 ,  C07K16/2878 ,  C07K16/2896 ,  C07K2317/622 ,  C07K2319/21 ,  C07K2319/33

摘要： A compound formed from at least one component A comprising a binding domain for extra-cellular surface structures of a diseased proliferating cell that internalized upon binding of component A of said compound, and at least one component B, characterized in that component B is a polypeptide which amino acid sequence comprises a microtubule-associated protein (MAP) or comprises at least a partial sequence of the MAP, the partial sequence having maintained the binding function of the MAP to a microtubule.

公开(公告)号：US09693539B2

公开(公告)日：2017-07-04

申请号：US12672883

申请日：2008-08-08

申请人： Daniel K. Rohrer ,  Nancy Amelia Black ,  Nils Lonberg

发明人： Daniel K. Rohrer ,  Nancy Amelia Black ,  Nils Lonberg

IPC分类号： C12N15/13 ,  C12N15/79 ,  C12P21/08 ,  A01K67/027 ,  C07K16/00 ,  C12N15/85

CPC分类号： A01K67/0275 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/01 ,  C07K16/00 ,  C07K2317/21 ,  C12N15/8509 ,  C12N2015/8518 ,  C12N2800/204

摘要： The instant invention relates to transgenic non-human animals capable of producing heterologous antibodies, transgenes used to produce such transgenic animals, transgenes capable of functionally rearranging a heterologous D gene in V-D-J recombination, immortalized B-cells capable of producing heterologous antibodies, methods and transgenes for producing heterologous antibodies of multiple isotypes, methods and transgenes for producing heterologous antibodies wherein a variable region sequence comprises somatic mutation as compared to germline rearranged variable region sequences, transgenic nonhuman animals which produce antibodies having a human primary sequence and which bind to human antigens, hybridomas made from B cells of such transgenic animals, and monoclonal antibodies expressed by such hybridomas.

公开(公告)号：US09688775B2

公开(公告)日：2017-06-27

申请号：US14019399

申请日：2013-09-05

申请人： Genentech, Inc.

发明人： Laura Simmons ,  Dana Andersen

IPC分类号： C12P21/02 ,  C12P21/08 ,  C07K16/36 ,  C07K16/00 ,  C07K16/28 ,  C12N15/13 ,  C12N15/63 ,  C12N15/67 ,  C12N15/70

CPC分类号： C07K16/36 ,  C07K16/00 ,  C07K16/2845 ,  C07K16/2896 ,  C07K2317/54

摘要： The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can be used in various aspects of biological research, diagnosis and medical treatment.

公开(公告)号：US09676846B2

公开(公告)日：2017-06-13

申请号：US14832803

申请日：2015-08-21

申请人： THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

发明人： Dimiter S. Dimitrov ,  Zhongyu Zhu ,  Qi Zhao

IPC分类号： A61K39/395 ,  C12N5/00 ,  C12N15/00 ,  C12P21/08 ,  C07K16/22 ,  G01N33/74 ,  G01N33/574 ,  A61K39/00

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57484 ,  G01N33/74 ,  G01N2333/475 ,  G01N2800/7028

摘要： Disclosed herein are human monoclonal antibodies that specifically bind both IGF-I and IGF-II with picomolar affinity and potently inhibit the IGF-IR signal transduction function. These antibodies are active in both an IgG and a scFv format. Bispecific forms of these antibodies are also disclosed. Nucleic acids encoding these antibodies, vectors including these nucleic acids, and host cells transformed with these vectors are also disclosed herein. Also disclosed are pharmaceutical compositions including these antibodies. Methods are provided for treating a subject with cancer and for inhibiting phosphorylation of the insulin-like growth factor-I receptor. Methods are also provided for diagnosing cancer.

公开(公告)号：US09657060B2

公开(公告)日：2017-05-23

申请号：US13859054

申请日：2013-04-09

申请人： Children's Medical Center Corporation ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： Michael C. Carroll ,  Francis D. Moore ,  Herbert B. Hechtman

IPC分类号： C07K16/00 ,  C12P21/08 ,  G01N33/53 ,  A61K39/395 ,  A61K39/40 ,  C07K7/08 ,  C07K16/18 ,  C07K16/28 ,  A61K39/00 ,  A61K38/00

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/57 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/52

摘要： The invention provides natural IgM antibody inhibitors that may be used to treat various inflammatory diseases or disorders.

公开(公告)号：US09574010B2

公开(公告)日：2017-02-21

申请号：US13668098

申请日：2012-11-02

申请人： Zymeworks Inc.

发明人： Thomas Spreter Von Kreudenstein ,  Surjit Bhimarao Dixit ,  Eric Escobar-Cabrera ,  Paula Irene Lario ,  David Kai Yuen Poon

IPC分类号： C07K16/00 ,  C12P21/08 ,  A61K39/395 ,  A61K39/40 ,  C07K16/32 ,  C07K16/46 ,  C07K16/28 ,  G06F19/12 ,  C07K1/00

CPC分类号： C07K16/32 ,  C07K16/2887 ,  C07K16/46 ,  C07K16/468 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/94 ,  G06F19/12

摘要： The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. CH2 and CH3) to accomplish selectivity between the various Fc receptors involved in modulating effector function, beyond those achievable with a natural homodimeric (symmetric) Fc molecule, and increased stability and purity of the resulting variant Fc heterodimers. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics.

公开(公告)号：US09562109B2

公开(公告)日：2017-02-07

申请号：US13289934

申请日：2011-11-04

申请人： Thomas Spreter Von Kreudenstein ,  Eric Escobar Cabrera ,  Surjit Bhimarao Dixit ,  Paula Irene Lario ,  David Kai Yuen Poon

发明人： Thomas Spreter Von Kreudenstein ,  Eric Escobar Cabrera ,  Surjit Bhimarao Dixit ,  Paula Irene Lario ,  David Kai Yuen Poon

IPC分类号： C07K16/00 ,  C12P21/08 ,  C07K16/46 ,  C07K16/32 ,  C07K1/00

CPC分类号： C07K16/468 ,  C07K16/00 ,  C07K16/32 ,  C07K2317/30 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/64

摘要： The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. CH2 and CH3) to accomplish selectivity between the various Fc receptors involved in modulating effector function, beyond those achievable with a natural homodimeric (symmetric) Fc molecule, and increased stability and purity of the resulting variant Fc heterodimers. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics.

摘要翻译： 所提供的支架具有在各种结构域（例如CH2和CH3）中不对称的重链，以实现参与调节效应子功能的各种Fc受体之间的选择性，超过天然同二聚体（对称）Fc分子可达到的那些，以及增加的稳定性和 所得变体Fc异源二聚体的纯度。 这些新型分子包含异构组分的复合物，其设计用于改变抗体行为的自然方式并且可用于治疗。

公开(公告)号：US09556281B2

公开(公告)日：2017-01-31

申请号：US14238811

申请日：2012-08-15

申请人： Olaf Schneewind ,  Dominique M. Missiakas ,  Hwan Keun Kim ,  Carla Emolo ,  Andrea DeDent

发明人： Olaf Schneewind ,  Dominique M. Missiakas ,  Hwan Keun Kim ,  Carla Emolo ,  Andrea DeDent

IPC分类号： A61K39/395 ,  A61K39/085 ,  A61K39/40 ,  C12P21/08 ,  C07K16/00 ,  C07K16/42 ,  A61K45/06 ,  C07K16/12 ,  A61K38/00 ,  A61K39/00

CPC分类号： C07K16/1271 ,  A61J1/00 ,  A61K38/00 ,  A61K39/085 ,  A61K39/40 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K16/4233 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6854 ,  G01N2333/31 ,  G01N2500/04 ,  A61K39/395 ,  A61K2300/00

摘要： Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Staphylococcal protein A (SpA).

摘要翻译： 实施方案涉及用于治疗或预防细菌感染，特别是葡萄球菌细菌感染的方法和组合物。 方面包括提供针对细菌的被动免疫应答的方法和组合物。 在某些实施方案中，所述方法和组合物涉及结合葡萄球菌蛋白A（SpA）的抗体。

公开(公告)号：US09499610B2

公开(公告)日：2016-11-22

申请号：US14009492

申请日：2012-03-29

申请人： Søren Christensen ,  Lone Helboe

发明人： Søren Christensen ,  Lone Helboe

IPC分类号： C07K16/00 ,  C12P21/08 ,  C07K16/18 ,  C07K1/00

CPC分类号： C07K16/18 ,  A61K39/0007 ,  A61K2039/575 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/70 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

摘要： The present disclosure relates to antibodies specific for pyroglutamated Aβ, as well as their use in the treatment of Alzheimer's disease and as use in diagnostic methods or as diagnostic imaging ligands Further, is provided pyroglutamated N-terminal fragments of murine or human Aβ to generate antibodies and for use m therapeutic purposes.

摘要翻译： 本公开内容涉及对焦谷氨酸化的Aβ特异性的抗体，以及它们在治疗阿尔茨海默氏病中的用途，以及用于诊断方法或诊断成像配体。此外，还提供了鼠或人Aβ的焦谷氨酰胺化的N-末端片段以产生抗体 并用于治疗目的。

公开(公告)号：US09453080B2

公开(公告)日：2016-09-27

申请号：US14407421

申请日：2013-06-11

申请人： Amgen Inc.

发明人： Huiquan Han ,  Xiaolan Zhou ,  Qing Chen ,  Mei-Mei Tsai

IPC分类号： C07K16/28 ,  C12N15/13 ,  C12P21/08 ,  A61K39/395 ,  C07K16/46 ,  A61K39/00

CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K16/42 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

摘要： This disclosure relates to antagonistic dual receptor antigen-binding proteins, e.g. antibodies and methods of using the dual receptor antibodies for treatment of pathological diseases. The dual receptor antibodies may comprise an antibody to ActRII receptors and may be used to treat pathological condition. The pathological conditions can comprise muscle wasting diseases or any disease that requires stimulation of muscle growth.

摘要翻译： 本公开涉及拮抗性双重受体抗原结合蛋白，例如 抗体和使用双重受体抗体治疗病理性疾病的方法。 双重受体抗体可以包含ActRII受体的抗体，并可用于治疗病理状态。 病理状况可能包括肌肉消瘦疾病或任何需要刺激肌肉生长的疾病。