公开(公告)号：US20230242611A1

公开(公告)日：2023-08-03

申请号：US18107573

申请日：2023-02-09

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rachel Lea EISENBACH ,  David BASSAN ,  Yosi GOZLAN ,  Esther TZEHOVAL ,  Nir FRIEDMAN ,  Erez GREENSTEIN

IPC: C07K14/725 ,  C12N9/78 ,  A61K39/00 ,  A61P35/00

CPC classification number: C07K14/7051 ,  C12Y305/04005 ,  C12N9/78 ,  A61K39/4632 ,  A61K39/4611 ,  A61K39/464486 ,  A61P35/00 ,  A61K39/4637 ,  A61K2239/25

Abstract: MAGE-A1 specific T cell receptors (TCRs) are provided. Accordingly, there is provided a TCR comprising a TCR α chain as set forth in SEQ ID NO: 1 having at least one mutation at an amino acid position selected from the group consisting of S189, G125, W55 and Y56; and/or a TCR β chain as set forth in SEQ ID NO: 2 having at least one mutation at an amino acid position selected from the group consisting of S32, S109 and T63, the TCR binds a MAGE-A1 peptide as set forth in SEQ ID NO: 25. Also provided are polynucleotides encoding the TCR and T cells expressing same and methods of use thereof.

公开(公告)号：US20230206065A1

公开(公告)日：2023-06-29

申请号：US18060584

申请日：2022-12-01

Applicant: New York University ,  Yeda Research And Development Co., Ltd.

Inventor： Itay KEZURER ,  Yoram Eshel ,  Achiau Ludomirsky ,  Yaron Lipman

IPC: G06N3/08 ,  G06T3/20 ,  G06T7/00 ,  G06T11/00 ,  G16H30/40 ,  A61B8/00 ,  A61B5/00 ,  A61B8/13 ,  G09B23/28 ,  G06T3/60

CPC classification number: G06N3/08 ,  G06T3/20 ,  G06T7/0012 ,  G06T11/003 ,  G16H30/40 ,  A61B8/463 ,  A61B8/4427 ,  A61B8/4254 ,  A61B5/7267 ,  A61B8/13 ,  G09B23/286 ,  G06T3/60 ,  G06T2207/30048 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/20084

Abstract: A device for a mobile ultrasound unit having an ultrasound probe includes a trained orientation neural network and a result converter. The trained orientation neural network receives a non-canonical image of a body part from the mobile ultrasound unit and generates a transformation transforming between a position and rotation associated with a canonical image and a position and rotation associated with the non-canonical image. The result converter converts the transformation into position and/or rotation instructions of the probe and displays the position and/or rotation instructions to a user to change the position and/or rotation of the probe.

公开(公告)号：US20230201257A1

公开(公告)日：2023-06-29

申请号：US17986080

申请日：2022-11-14

Applicant: Yeda Research and Development Co. Ltd. ,  The Walter and Eliza Hall Institute of Medical Research

Inventor： Sarel FLEISHMAN ,  Assaf ELAZAR ,  Jonathan Y. WEINSTEIN ,  Melissa J. CALL ,  Matthew E. CALL ,  Nicholas J. CHANDLER

IPC: A61K35/17 ,  C07K14/725 ,  C07K14/705 ,  C07K16/32 ,  A61P35/00

CPC classification number: A61K35/17 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K16/32 ,  C07K2317/622 ,  C07K2319/03 ,  C07K2319/41

Abstract: Provided herein is a family of programmable de novo designed transmembranal protein domain polypeptides, and uses thereof in the production of engineered chimeric antigen receptor T (CAR T) cells, which are used, for example, to fight cancer.

公开(公告)号：US20230173023A1

公开(公告)日：2023-06-08

申请号：US18106903

申请日：2023-02-07

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eldad Tzahor ,  Kfir Baruch Umansky ,  Rabea Hinkel ,  Christian Kupatt

IPC: A61K38/17 ,  A61P9/10

CPC classification number: A61K38/1709 ,  A61P9/10

Abstract: A method of treating an ischemic heart disease in a subject in need thereof is provided. The method comprises administering to the subject a therapeutically effective amount of Agrin in an anterograde intracoronary manner, thereby treating the ischemic heart disease in the subject.

公开(公告)号：US20230151129A1

公开(公告)日：2023-05-18

申请号：US17872050

申请日：2022-07-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob KLEIN ,  Weifeng LIN ,  Ronit GOLDBERG

IPC: C08F130/02 ,  A61K9/127 ,  C07F9/10 ,  A61K9/08 ,  A61P19/02 ,  A61K9/00

CPC classification number: C08F130/02 ,  A61K9/08 ,  A61K9/0051 ,  A61K9/1273 ,  A61P19/02 ,  C07F9/106 ,  A61K9/0019 ,  A61K47/6909 ,  C08F2438/01

Abstract: A polymeric compound is disclosed herein, having the general formula I:





wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.

公开(公告)号：US20230127559A1

公开(公告)日：2023-04-27

申请号：US17911277

申请日：2021-03-15

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Varda ROTTER ,  Moshe OREN ,  Perry TAL ,  Fernando ALBERICIO

IPC: A61K38/10 ,  A61K9/00 ,  A61P35/00

Abstract: Peptide analogs which are endowed with the property of at least partially reactivating a mutant p53 protein are provided. Also provided are uses thereof in the treatment of diseases associated with mutant p53.

公开(公告)号：US11610681B2

公开(公告)日：2023-03-21

申请号：US17151232

申请日：2021-01-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran Segal ,  Eran Elinav

IPC: G16H50/20 ,  G16H50/70 ,  G06N20/00 ,  G16H10/60 ,  G16H70/00 ,  G16H20/60

Abstract: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.

公开(公告)号：US20230050605A1

公开(公告)日：2023-02-16

申请号：US17758839

申请日：2021-01-13

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Noam SOBEL ,  Eva MISHOR ,  Yaara ENDEVELT-SHAPIRA ,  Shiri KARAGACH ,  Yaniv MAMA ,  Yigal SHARON

IPC: A61K31/11 ,  A61P25/20 ,  A61K9/00

Abstract: The present invention discloses uses of hexadecanal in managing stress.

公开(公告)号：US20230024587A1

公开(公告)日：2023-01-26

申请号：US17735146

申请日：2022-05-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Yaki EIDELSTEIN ,  Eran OPHIR ,  Assaf LASK ,  Ran AFIK ,  Noga OR-GEVA ,  Esther BACHAR-LUSTIG

IPC: A61K35/17 ,  A61K39/00 ,  C12N5/0783 ,  A61K35/22 ,  A61K35/26 ,  A61K35/28 ,  A61K35/34 ,  A61K35/36 ,  A61K35/38 ,  A61K35/39 ,  A61K35/407 ,  A61K35/42

Abstract: A method of generating an isolated population of cells comprising anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) contacting peripheral blood mononuclear cells (PBMC) with a third party antigen or antigens in the presence of IL-21 so as to allow enrichment of antigen reactive cells; and (b) culturing the cells resulting from step (a) in the presence of IL-21, IL-15 and IL-7 in an antigen free environment so as to allow proliferation of cells comprising the central memory T-lymphocyte (Tcm) phenotype.

公开(公告)号：US20230020006A1

公开(公告)日：2023-01-19

申请号：US17783431

申请日：2020-12-10

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Yuval GILAD ,  Yoav POLITI ,  Idan ALYAGOR

IPC: A01N1/02

Abstract: The present invention provides methods for cryopreservation of insect embryos comprising chorion layers and waxy layer, particularly fly embryos including embryos of Black Soldier Fly (Hermetia illucens, BSF) useful in mass rearing of beneficial fly adults. The present invention further provides cryopreserved embryos having an industrially suitable adult recovery and survival rate.