中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

1257 records (took 0.027 seconds)

    Polyacetylenic compounds for protecting against pancreatic islet atrophy
    633.
    发明授权
    Polyacetylenic compounds for protecting against pancreatic islet atrophy 有权
    用于防止胰岛萎缩的聚乙炔化合物

    公开(公告)号：US08575116B1

    公开(公告)日：2013-11-05

    申请号：US13964583

    申请日：2013-08-12

    Applicant: Academia Sinica

    Inventor： Wen-Chin Yang

    IPC: A61K31/7028

    CPC classification number: A61K31/7004 ,  A61K39/395 ,  A61K2300/00

    Abstract: Pharmaceutical compositions and methods for protecting against atrophy of pancreatic islets in a human with metabolic syndromes are disclosed. The method comprises administering to the mammal a pharmaceutical composition comprising a compound having a chemical structure of formula (I) in an effective amount and a pharmaceutically acceptable carrier: wherein R is H or COCH2COOH; m=3 or 4; n=0 or 1; o=2; and p=1 or 2.

    Abstract translation: 公开了用于保护具有代谢综合征的人胰岛胰岛的萎缩的药物组合物和方法。 该方法包括向哺乳动物施用包含具有式（I）化学结构的化合物和药学上可接受的载体的药物组合物：其中R是H或COCH 2 COOH; m = 3或4; n = 0或1; o = 2; 和p = 1或2。

    Polyacetylenic compounds for protecting against pancreatic islet atrophy
    634.
    发明授权
    Polyacetylenic compounds for protecting against pancreatic islet atrophy 有权
    用于防止胰岛萎缩的聚乙炔化合物

    公开(公告)号：US08536141B2

    公开(公告)日：2013-09-17

    申请号：US13096106

    申请日：2011-04-28

    Applicant: Wen-Chin Yang

    Inventor： Wen-Chin Yang

    IPC: A61K31/7028

    CPC classification number: A61K31/7004 ,  A61K39/395 ,  A61K2300/00

    Abstract: Pharmaceutical compositions and methods for protecting against atrophy of pancreatic islets in a mammal with metabolic syndrome, prediabetes or diabetes are disclosed. The method comprises administering to the mammal a pharmaceutical composition comprising a compound having a chemical structure of formula (I) in an effective amount and a pharmaceutically acceptable carrier: wherein R is H or COCH2COOH; m=3 or 4; n=0 or 1; o=2; and p=1 or 2.

    Abstract translation: 公开了具有代谢综合征，糖尿病前期或糖尿病的哺乳动物中用于防止胰岛萎缩的药物组合物和方法。 该方法包括向哺乳动物施用包含具有式（I）化学结构的化合物和药学上可接受的载体的药物组合物：其中R是H或COCH 2 COOH; m = 3或4; n = 0或1; o = 2; 和p = 1或2。

    ZANAMIVIR PHOSPHONATE CONGENERS WITH ANTI-INFLUENZA ACTIVITY AND DETERMINING OSELTAMIVIR SUSCEPTIBILITY OF INFLUENZA VIRUSES
    637.
    发明申请
    ZANAMIVIR PHOSPHONATE CONGENERS WITH ANTI-INFLUENZA ACTIVITY AND DETERMINING OSELTAMIVIR SUSCEPTIBILITY OF INFLUENZA VIRUSES 有权
    具有抗流感病毒活性的ZAMAMIVIR磷酸盐浓缩物，并确定了OSELTAMIVIR流感病毒的易感性

    公开(公告)号：US20130225532A1

    公开(公告)日：2013-08-29

    申请号：US13697794

    申请日：2011-05-10

    Applicant: Chi-Huey Wong ,  Jim-Min Fang ,  Yih-Shyun Edmund Cheng ,  Jiun-Jie Shie

    Inventor： Chi-Huey Wong ,  Jim-Min Fang ,  Yih-Shyun Edmund Cheng ,  Jiun-Jie Shie

    IPC: C07F9/655

    CPC classification number: G01N33/56983 ,  A61K31/665 ,  A61K31/683 ,  C07F9/6552 ,  G01N2333/11

    Abstract: Methods and compositions for detection of drug resistant pathogens and treatment against infections thereof are provided. Methods for detection of oseltamivir-resistant influenza viruses by competitive binding assays utilizing non-oseltamivir influenza virus neuraminidase inhibitors and oseltamivir carboxylate are provided. Influenza virus neuraminidase inhibitors coupled to sensors and useful for employment in the methods of the invention are disclosed. Novel phosphonate compounds active as neuraminidase inhibitors against wild-type and oseltamivir-resistant influenza strains of H1N1, H5N1 and H3N2 viruses are disclosed. An enantioselective synthetic route to preparation of these phosphonate compounds via sialic acid is provided.

    Abstract translation: 提供了用于检测耐药性病原体的方法和组合物以及对其感染的治疗。 提供了通过使用非奥司他韦流感病毒神经氨酸酶抑制剂和奥司他韦羧酸酯的竞争性结合测定法检测奥司他韦抗性流感病毒的方法。 公开了耦合到传感器并且可用于本发明方法中的流感病毒神经氨酸酶抑制剂。 公开了作为抗H1N1，H5N1和H3N2病毒的野生型和奥司他韦抗性流感病毒株的神经氨酸酶抑制剂活性的新型膦酸酯化合物。 提供了通过唾液酸制备这些膦酸酯化合物的对映选择性合成途径。

    Method for fabricating foam scaffolds to culture cells
    638.
    发明授权
    Method for fabricating foam scaffolds to culture cells 有权
    制造泡沫支架培养细胞的方法

    公开(公告)号：US08513014B2

    公开(公告)日：2013-08-20

    申请号：US12582575

    申请日：2009-10-20

    Applicant: Keng-Hui Lin ,  Narayan Mishra ,  Yen-Liang Liu ,  Chen-Chie Wang

    Inventor： Keng-Hui Lin ,  Narayan Mishra ,  Yen-Liang Liu ,  Chen-Chie Wang

    IPC: C12N5/00 ,  C12N5/07 ,  C12M1/00

    CPC classification number: C12N5/0655 ,  B29C44/00 ,  C12M25/14 ,  C12N5/0068 ,  C12N2533/74

    Abstract: Methods and apparatuses for using microfluidics to generate bubbles and using the generated bubbles to construct scaffolds and cell-holding structures for culturing biological samples or analytes. In one implementation, a scaffold for growing cells is provided to include a matrix of interconnected cavities formed from mixing a gas and a liquid containing a cross linkable material to produce a matrix of gas bubbles of substantially the same size and cross linking the cross linkable material to form a structure in which cells are grown. In another implementation, a scaffold apparatus for growing cells includes a ball of a cross linked material forming an exterior shell that encloses to form a hollow interior inside the ball and biological samples embedded in the external shell.

    Abstract translation: 使用微流体产生气泡并使用生成的气泡构建用于培养生物样品或分析物的支架和细胞保持结构的方法和装置。 在一个实施方案中，提供了用于生长细胞的支架，以包括通过混合气体和含有可交联材料的液体形成的互连腔的基质，以产生基本上相同尺寸的气泡基质并交联可交联材料 以形成细胞生长的结构。 在另一实施方案中，用于生长细胞的支架装置包括形成外壳的交联材料球，所述外壳包围以形成球内的中空内部并嵌入外壳中的生物样品。

    Anti-C-Met Antibody and Methods of Use Thereof
    639.
    发明申请
    Anti-C-Met Antibody and Methods of Use Thereof 有权
    抗C-Met抗体及其使用方法

    公开(公告)号：US20130209365A1

    公开(公告)日：2013-08-15

    申请号：US13818283

    申请日：2011-08-30

    Applicant: Han-Chung Wu ,  Ruei-Min Lu

    Inventor： Han-Chung Wu ,  Ruei-Min Lu

    IPC: C07K16/28

    CPC classification number: C07K16/2869 ,  A61K9/0019 ,  A61K9/1271 ,  A61K47/24 ,  A61K47/6913 ,  A61K49/0058 ,  A61K49/0067 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/622 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/30

    Abstract: Antibodies that bind to c-Met are provided herein, as well as related compositions and methods of use. Methods of use encompass cancer therapies and diagnostics. In certain embodiments, antibodies bind mammalian cell surface antigen (e.g., cancer cell surface antigen). The antibodies can also be endocytosed upon binding to cells. Cells that can be targeted by the antibodies include carcinomas, such as those in lung, kidney, liver, stomach, breast, and brain, etc.

    Abstract translation: 本文提供了与c-Met结合的抗体，以及相关组合物和使用方法。 使用方法包括癌症治疗和诊断。 在某些实施方案中，抗体结合哺乳动物细胞表面抗原（例如癌细胞表面抗原）。 抗体还可以在与细胞结合时被内吞。 可以由抗体靶向的细胞包括癌，如肺，肾，肝，胃，乳腺和脑等。

    MOLECULAR ION ACCELERATOR
    640.
    发明申请
    MOLECULAR ION ACCELERATOR 有权
    分子加速器

    公开(公告)号：US20130206975A1

    公开(公告)日：2013-08-15

    申请号：US13691785

    申请日：2012-12-01

    Applicant: Academia Sinica

    Inventor： Chung-Hsuan CHEN ,  Jung-Lee LIN ,  Nien-Yeen HSU ,  Yi-Sheng WANG

    IPC: H05H5/04 ,  H01J49/40

    CPC classification number: H05H5/047 ,  H01J49/06 ,  H01J49/40 ,  H01J49/403

    Abstract: A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrometry, performing collision-induced dissociation molecular structure analysis, and probing surfaces and samples using accelerated analyte.

    Abstract translation: 提供了一种用于加速分析物的新系统和方法，包括但不限于分子离子，生物分子，聚合物，纳米和微粒。 本发明可用于在诸如质谱法，进行碰撞诱导的解离分子结构分析和使用加速分析物的探测表面和样品等应用中提高检测灵敏度。

Patent Agency Ranking