公开(公告)号：US11974586B1

公开(公告)日：2024-05-07

申请号：US18480335

申请日：2023-10-03

申请人： Sonomaceuticals, LLC

发明人： Torey Arvik ,  Ralph Jerome

IPC分类号： A23G1/48

CPC分类号： A23G1/48 ,  A23G2200/14

摘要： The present invention relates to agricultural marc, and food compositions incorporating such agricultural marc to improve the texture, flavor, aroma, mouthfeel, nutritional content, or shelf life of the food composition. In one example, the agricultural marc may be obtained from Chardonnay grapes, which when incorporated into chocolate can give the resulting composition an altered flavor and/or aromatic profile.

公开(公告)号：US11965023B2

公开(公告)日：2024-04-23

申请号：US17740100

申请日：2022-05-09

申请人： Alector LLC

发明人： Kate Monroe ,  Helen Lam ,  Patricia Culp ,  Arnon Rosenthal

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07K16/2803 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/00 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-5 protein, e.g., human Siglec-5 or a mammalian Siglec-5, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11964967B2

公开(公告)日：2024-04-23

申请号：US17255336

申请日：2019-06-25

申请人： Cytokinetics, Inc.

发明人： Bradley P. Morgan ,  Chihyuan Chuang

IPC分类号： C07D413/12 ,  A61P9/04 ,  C07D413/04 ,  C07D498/10

CPC分类号： C07D413/12 ,  A61P9/04 ,  C07D413/04 ,  C07D498/10

摘要： Provided are compounds of Formula (I):




or a pharmaceutically acceptable salt thereof, wherein X, R1, R2, and R3 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11958809B2

公开(公告)日：2024-04-16

申请号：US17448833

申请日：2021-09-24

申请人： Cytokinetics, Inc.

发明人： Sheng Cui ,  Henry Morrison ,  Karthik Nagapudi ,  Shawn D. Walker ,  Charles Bernard ,  Karl Bennett Hansen ,  Neil Fred Langille ,  Alan Martin Allgeier ,  Steven M. Mennen ,  Jacqueline C. S. Woo ,  Bradley Paul Morgan ,  Alex Muci

IPC分类号： C07D213/75 ,  A61K9/20 ,  A61K31/444 ,  A61K31/496 ,  A61K47/38 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06

CPC分类号： C07D213/75 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K31/496 ,  A61K47/38

摘要： Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

公开(公告)号：US11956620B2

公开(公告)日：2024-04-09

申请号：US18340744

申请日：2023-06-23

申请人： Magic Leap, Inc.

发明人： Anastasia Andreyevna Tajik

IPC分类号： H04S7/00 ,  G02B27/01 ,  G06T19/00 ,  H04R1/40 ,  H04R3/12

CPC分类号： H04S7/303 ,  G02B27/0101 ,  G02B27/0172 ,  G06T19/006 ,  H04R1/403 ,  H04R3/12 ,  G02B2027/0138 ,  H04R2430/20 ,  H04R2499/15 ,  H04S2400/11 ,  H04S2420/01

摘要： A method of presenting audio comprises: identifying a first ear listener position and a second ear listener position in a mixed reality environment; identifying a first virtual sound source in the mixed reality environment; identifying a first object in the mixed reality environment; determining a first audio signal in the mixed reality environment, wherein the first audio signal originates at the first virtual sound source and intersects the first ear listener position; determining a second audio signal in the mixed reality environment, wherein the second audio signal originates at the first virtual sound source, intersects the first object, and intersects the second ear listener position; determining a third audio signal based on the second audio signal and the first object; presenting, to a first ear of a user, the first audio signal; and presenting, to a second ear of the user, the third audio signal.

公开(公告)号：US11952408B2

公开(公告)日：2024-04-09

申请号：US16652379

申请日：2018-09-28

申请人： Juno Therapeutics, Inc. ,  Editas Medicine, Inc.

发明人： Cameron Brandt ,  Brian Belmont ,  Christopher Borges ,  Stephen Michael Burleigh ,  Alexandra Croft ,  Stephen Jacob Goldfless ,  David Jeffrey Huss ,  Yue Jiang ,  Timothy G. Johnstone ,  David Koppstein ,  Hieu Nguyen ,  Christopher Heath Nye ,  Haley Peper ,  Blythe D. Sather ,  Sonia Timberlake ,  Dean Y. Toy ,  Queenie Vong ,  Gordon Grant Welstead ,  James Sissons

IPC分类号： C07K14/705 ,  A61K35/17 ,  A61P31/20 ,  A61P35/00 ,  C07K14/725 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90

CPC分类号： C07K14/7051 ,  A61K35/17 ,  A61P31/20 ,  A61P35/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/907 ,  C12N2310/20 ,  C12N2800/80

摘要： Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.

公开(公告)号：US11949562B2

公开(公告)日：2024-04-02

申请号：US16399855

申请日：2019-04-30

申请人： Nomadix, Inc.

发明人： Vadim Olshansky

IPC分类号： H04L41/0896 ,  G06F3/04847 ,  H04L41/0893 ,  H04L47/20 ,  H04L47/70 ,  H04W8/04

CPC分类号： H04L41/0896 ,  G06F3/04847 ,  H04L41/0893 ,  H04L47/20 ,  H04L47/828 ,  H04W8/04

摘要： An embodiment is a method of managing bandwidth, performed by a computing system. The system receives user-selected connection parameters associated with a subscriber device. The system associates a network identifier of the subscriber device with a group bandwidth policy, based on the user-selected connection parameters. The system stores, in computer-readable storage media, parameters associated with the group bandwidth policy, in association with the network identifier of the subscriber device. The system receives, at a gateway device, network communication data from the subscriber device. The system limits, at the gateway device, bandwidth available to the network communication data, based on the stored parameters associated with the group bandwidth policy.

公开(公告)号：US11940629B2

公开(公告)日：2024-03-26

申请号：US17843459

申请日：2022-06-17

申请人： Mentor Acquisition One, LLC

发明人： John N. Border ,  Joseph Bietry ,  John D. Haddick

IPC分类号： G02B27/01 ,  G02B5/30 ,  G02B27/28

CPC分类号： G02B27/0172 ,  G02B5/30 ,  G02B27/0176 ,  G02B27/28 ,  G02B27/283 ,  G02B2027/0118 ,  G02B2027/0152 ,  G02B2027/0178

摘要： An optical system for a head-worn computer includes an upper optical module adapted to convert illumination into image light by illuminating a reflective display through a field lens, wherein the image light is transmitted back through the field lens, then through a partially reflective partially transmissive surface and into a lower optic module adapted to present the image light to an eye of a user wearing the head-worn computer and the upper optical module being positioned within a housing for the head-worn computer and having a height of less than 24 mm, as measured from the reflective display to the bottom edge of the rotationally curved partial mirror.

公开(公告)号：US11939393B2

公开(公告)日：2024-03-26

申请号：US17677873

申请日：2022-02-22

申请人： ALX Oncology Inc.

发明人： Jaume Pons ,  Bang Janet Sim ,  Hong Wan ,  Tracy Chia-Chien Kuo

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K45/06

CPC分类号： C07K16/2896 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  A61K45/06

摘要： Provided herein, inter alia, are isolated, humanized antibodies that bind an extracellular domain of a human SIRP-α polypeptide. Also provided are polynucleotides, vectors, host cells, and methods of production and use related thereto.

公开(公告)号：US11937738B2

公开(公告)日：2024-03-26

申请号：US16993938

申请日：2020-08-14

申请人： The Cashmere Caveman Co, Wild Kitchens Limited

发明人： Nigel Bruce True ,  Guy Stuart Ritchie

IPC分类号： A47J37/07 ,  A47B31/02 ,  A47J37/06 ,  F24B1/00 ,  F24B5/06 ,  F24C1/02 ,  A47B33/00 ,  F24B1/02

CPC分类号： A47J37/0781 ,  A47B31/02 ,  A47J37/0647 ,  A47J37/0704 ,  A47J37/0786 ,  F24B1/006 ,  F24B5/06 ,  F24C1/02 ,  A47B33/00 ,  A47J2037/0795 ,  F24B1/028

摘要： A mechanism for raising and lowering a cooking surface within a recessed combustion chamber is provided.