公开(公告)号：US20140365161A1

公开(公告)日：2014-12-11

申请号：US14362031

申请日：2012-11-30

Applicant: CSIR

Inventor： Thegaran Naidoo ,  Johan Hendrik Swart ,  Suzanne Hugo ,  Pieter Van Rooyen

IPC: G01N21/84 ,  G03H1/00 ,  G01N33/49

CPC classification number: G01N21/84 ,  G01B9/04 ,  G01N15/0227 ,  G01N15/1434 ,  G01N15/1463 ,  G01N33/49 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1445 ,  G01N2015/1486 ,  G03H1/0005 ,  G03H1/0443 ,  G03H1/08 ,  G03H1/0866 ,  G03H2001/0033 ,  G03H2001/0038 ,  G03H2001/005 ,  G03H2001/0447 ,  G03H2001/0452 ,  G03H2001/0825 ,  G03H2001/0833 ,  G03H2226/04 ,  G03H2227/02 ,  G06F17/40 ,  G06F19/00

Abstract: The invention relates to a system and method of analysing material as well as to an apparatus for analysing material, particularly, though not necessarily exclusively, biomaterial. The invention entails receiving holographic intensity data comprising at least a holographic intensity pattern associated with a sample of the material of interest and processing, by applying image processing algorithms and techniques, the received holographic intensity data at least to perform one or both steps of detecting and identifying at least one object of interest in the sample thereby at least to generate a suitable output.

Abstract translation: 本发明涉及一种分析材料的系统和方法以及用于分析材料的装置，特别是但不一定仅仅是生物材料。 本发明需要接收包括至少全息强度图案的全息强度数据，所述全息强度图案至少包括与感兴趣的材料的样品相关联并且通过应用图像处理算法和技术，所接收的全息强度数据至少执行一个或两个步骤的检测和 识别样品中的至少一个感兴趣对象，从而至少产生合适的输出。

公开(公告)号：US20140147888A1

公开(公告)日：2014-05-29

申请号：US13688310

申请日：2012-11-29

Applicant: CSIR

Inventor： Petrus Jakobus Van Zyl

IPC: C12P21/00 ,  C12R1/645

CPC classification number: C12R1/645 ,  C12N1/16 ,  C12P21/02

Abstract: This invention relates to a method for the production of proteins, preferably, heterologous proteins, under the regulation of the hp4d promoter, in Yarrowia lipolytica. In particular, this invention describes a method for manipulating the growth rate of Y. lipolytica by regulating the carbon and/or nitrogen supply. A growth rate of less than 0.045 h″1 was found to be optimal for increasing Y. lipolytica biomass and increasing the amount of heterologous proteins of interest produced.

Abstract translation: 本发明涉及在解脂耶氏酵母中在hp4d启动子的调控下生产蛋白质，优选异源蛋白质的方法。 特别地，本发明描述了一种通过调节碳和/或氮供应来操纵解脂耶氏酵母的生长速率的方法。 发现小于0.045h -1的生长速率对于增加解脂耶氏酵母生物量和增加产生的感兴趣的异源蛋白质的量是最佳的。

公开(公告)号：US20020168427A1

公开(公告)日：2002-11-14

申请号：US10073357

申请日：2002-02-13

Applicant: CSIR

Inventor： Fanie Retief Van Heerden ,  Robert Vleggaar ,  Roelof Marthinus Horak ,  Robin Alec Learmonth ,  Vinesh Maharaj ,  Rory Desmond Whittal

IPC: A61K035/78

CPC classification number: A61K31/57 ,  A23L33/105 ,  A61K31/58 ,  A61K31/704 ,  A61K31/78 ,  A61K36/27 ,  C07H3/04 ,  C07H3/06 ,  C07H5/10 ,  C07H13/08 ,  C07J7/002 ,  C07J7/0025 ,  C07J7/0035 ,  C07J7/007 ,  C07J15/00 ,  C07J17/00 ,  C07J17/005 ,  C07J41/00 ,  Y02P20/582 ,  A61K2300/00

Abstract: A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for synthesizing compound (1) and its analogues and derivatives is also provided. The invention also extends to the use of such extracts and compound (1) and its analogues for the manufacture of medicaments having appetite suppressant activity. The invention further provides novel intermediates for the synthesis of compound (1).

Abstract translation: 药物组合物含有可从含有具有式（1）的食欲抑制剂的Trichocaulon或Hoodia属的植物获得的提取物。 还提供了获得提取物的方法和化合物（1）及其类似物和衍生物的合成方法。 本发明还涉及这种提取物和化合物（1）及其类似物用于制造具有食欲抑制活性的药物的用途。 本发明还提供了用于合成化合物（1）的新型中间体。

公开(公告)号：US12109616B2

公开(公告)日：2024-10-08

申请号：US16617335

申请日：2018-05-28

Applicant: University of the Witwatersrand, Johannesburg ,  CSIR

Inventor： Claudia Polese ,  Daniel Glaser ,  Lesley A. Cornish ,  Rodney M. Genga

IPC: B22F3/105 ,  B22F3/24 ,  B22F5/00 ,  C21D10/00 ,  C22C29/06 ,  C22C29/08 ,  C22F3/00

CPC classification number: B22F3/105 ,  B22F3/24 ,  B22F5/00 ,  C21D10/005 ,  C22C29/067 ,  C22C29/08 ,  C22F3/00 ,  B22F2005/001 ,  B22F2301/15 ,  B22F2302/10

Abstract: Methods of improving the wear resistance of a cemented carbide are provided. The methods include using fracture toughness as a selection criterion and selecting a cemented carbide which has a fracture toughness between about 6 and about 15 MPa·m1/2. Cutting tools and/or cutting tool inserts prepared using methods of the disclosure are also disclosed.

公开(公告)号：US12061385B2

公开(公告)日：2024-08-13

申请号：US17255278

申请日：2019-06-26

Applicant: CSIR ,  AEROSUD INNOVATION CENTRE (PTY) LTD

Inventor： Hencharl Strauss ,  Darryl Naidoo

IPC: G02F1/01 ,  H01S5/00

CPC classification number: G02F1/0147 ,  H01S5/005

Abstract: A laser beam shaping system includes at least one doped medium which is doped with a dopant and which is optically transparent at the first wavelength range and a beam input or coupling configured to generate or receive a shaped beam that is required to be shaped, the shaped beam being at a first wavelength range and directed towards the doped medium. The system includes an absorbed beam input or coupling configured to generate or receive at least one absorbed beam at a second wavelength range which is different from the first wavelength range and which is directed towards the doped medium. The doped medium has a higher beam absorption characteristic at the second wavelength range than at the first wavelength range, causing the absorbed beam to have a higher absorption than the shaped beam in the doped medium. The doped medium has a coating which allows high transmission of both the first and the second wavelength ranges.

公开(公告)号：US11485083B2

公开(公告)日：2022-11-01

申请号：US16470398

申请日：2017-12-15

Applicant: CSIR ,  Aerosud Innovation Centre (Pty) Ltd

Inventor： Marius Vermeulen ,  Dieter Rainer Preussler

IPC: B29C64/264 ,  B29C64/153 ,  B29C64/232 ,  B29C64/245 ,  B29C64/295 ,  B29C64/236 ,  B33Y30/00 ,  B33Y40/10 ,  B29C64/314 ,  B29C64/209 ,  B33Y10/00

Abstract: An additive manufacturing apparatus is disclosed. The apparatus includes a build platform, a scanning unit and a preheating arrangement. Material is operatively deposited on the build platform to form a material bed, with a surface of the material bed defining a material area. The scanning unit is configured to consolidate deposited material in a scan area on the surface of the material bed, wherein the scan area forms part of and is substantially smaller than the material area. The preheating arrangement is configured to focus energy onto the surface of the material bed substantially in the scan area and not in the remainder of the material area. A method of preheating material in an additive manufacturing apparatus, a method of forming an object by additive manufacturing and a preheating arrangement for an additive manufacturing apparatus are also disclosed.

公开(公告)号：US11420388B2

公开(公告)日：2022-08-23

申请号：US16756641

申请日：2018-10-17

Applicant: CSIR ,  Aerosud Innovation Centre (Pty) Ltd.

Inventor： Marius Vermuelen ,  Johannes Paulus Bothma

IPC: B29C64/245 ,  B33Y30/00 ,  B29C64/153

Abstract: The invention relates to an additive manufacturing apparatus which includes a platform guiding arrangement 10 having a build platform 12 and a mounting arrangement 14 comprising guiding elements 16, 18 mounted to the build platform 12. The mounting arrangement 14 is configured to permit displacement of the build platform 12 in a vertical or Z direction whilst permitting unconstrained thermal expansion and contraction of the build platform in the horizontal or X-Y plane. The guide elements 16, 18 abut against adjacent sides of the build platform 12 to inhibit angular displacement about a vertical axis and permit unconstrained thermal expansion and contraction in the X-Y plane.

公开(公告)号：US11268842B2

公开(公告)日：2022-03-08

申请号：US16877208

申请日：2020-05-18

Applicant: CSIR

Inventor： Hartmut Johannes Ilgner

IPC: G01F1/74 ,  G01F1/708 ,  G01F1/684 ,  G01F1/7084

Abstract: A method of electronically deriving a conclusion of a condition of slurry flow in a non-vertical conduit having a conduit wall and which contains a slurry to flow or flowing along the conduit is provided.

公开(公告)号：US20210388366A1

公开(公告)日：2021-12-16

申请号：US17335404

申请日：2021-06-01

Applicant: CSIR ,  UNIVERSITY OF CAPE TOWN ,  ONDERSTEPOORT BIOLOGICAL PRODUCTS SOC LTD

Inventor： Albertha René VAN ZYL ,  Ann Elizabeth MEYERS ,  Daria Anna RUTKOWSKA ,  Edward Peter RYBICKI ,  Hester Catharina STARK ,  Martha Magaretha O'KENNEDY ,  Nobalanda Betty MOKOENA

IPC: C12N15/82 ,  A61K39/12 ,  A61P31/14 ,  A61K35/76

Abstract: This invention relates to a second generation, plant-produced synthetic Orbivirus candidate vaccine. The vaccine comprises a plant produced chimaeric Orbivirus virus like particle (VLP) comprising at least one structural protein from one Orbivirus serotype and at least one structural protein selected from another serotype of the Orbivirus, wherein both structural capsid proteins are from the same Orbivirus species. In particular the invention relates to a vaccine against an Orbivirus, a method of producing chimaeric Orbivirus virus-like particles (VLPs) for use in a method of prevention and/or treatment of an Orbivirus infection, the use of the chimaeric Orbivirus VLPs in the manufacture of a vaccine for an Orbivirus, and a method of preventing and/or treating an Orbivirus infection.

公开(公告)号：US11183692B2

公开(公告)日：2021-11-23

申请号：US16510527

申请日：2019-07-12

Applicant: CSIR

Inventor： Kenneth Ikechukwu Ozoemena ,  Charl Jeremy Jafta

IPC: H01M4/525 ,  H01M4/505 ,  H01M10/0525 ,  C01G53/00 ,  H01M4/02

Abstract: A process for producing a layered lithium-manganese-nickel-cobalt oxide material, includes producing a raw layered lithium-manganese-nickel-cobalt oxide (“LMNC”) material. Optionally, a dopant capable of enhancing the performance of the layered LMNC material when used as a cathode material in an electrochemical cell, is introduced during the production of the raw LMNC material. Before any annealing of the raw LMNC material is effected, it is subjected to microwave treatment. The resultant treated material is annealed to obtain the layered LMNC material.