公开(公告)号：USD979401S1

公开(公告)日：2023-02-28

申请号：US29762026

申请日：2020-12-14

Applicant: Gilead Sciences, Inc.

Designer： Trevor Zimmermann ,  Robert Bridges ,  Joseph Cordova ,  Gaurav Dabholkar ,  Alexandra Fideler ,  Monica Vazirani ,  Caricia Catalani ,  Kangil Cheon ,  Hortense Caroline Agnes Desodt ,  Jesse Arnold Fourt ,  Brittany Jeannette Margot

公开(公告)号：US20230039553A1

公开(公告)日：2023-02-09

申请号：US17243911

申请日：2021-04-29

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Hon C. Hui ,  Richard L. Mackman ,  Michael R. Mish ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Dustin S. Siegel ,  Doris T. Tang ,  Hai Yang

IPC: C07D487/04 ,  C07D519/00 ,  A61K45/06 ,  C07K16/28

Abstract: The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.

公开(公告)号：US20230038823A1

公开(公告)日：2023-02-09

申请号：US17357376

申请日：2021-06-24

Applicant: Gilead Sciences, Inc.

Inventor： Chienhung Chou ,  Darryl Kato ,  Scott E. Lazerwith ,  Scott D. Schroeder ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D471/04 ,  C07D498/04 ,  C07D519/00 ,  C07D513/04 ,  C07D403/12 ,  A61K45/06

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of a Retroviridae viral infection, including an infection caused by the HIV virus.

公开(公告)号：US20230027019A1

公开(公告)日：2023-01-26

申请号：US17361758

申请日：2021-06-29

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Hongyan Guo ,  Xiaochun Han ,  Lan Jiang ,  Jiayao Li ,  Michael L. Mitchell ,  Hyung-Jung Pyun ,  Scott D. Schroeder ,  Gregg M. Schwarzwalder ,  Nathan D. Shapiro ,  Devleena M. Shivakumar ,  Qiaoyin Wu ,  Hong Yang ,  Jennifer R. Zhang

IPC: C07D498/18 ,  C07D471/18 ,  A61P31/18

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20230014026A1

公开(公告)日：2023-01-19

申请号：US17354442

申请日：2021-06-22

Applicant: MorphoSys AG ,  Gilead Sciences, Inc.

Inventor： Jan ENDELL ,  Günter FINGERLE-ROWSON ,  Mark Ping CHAO

IPC: C07K16/28 ,  A61P35/00

Abstract: The present disclosure is directed to a combination therapy comprising an antibody or antibody fragment specific for CD19 and a polypeptide that blocks the SIRPα-CD47 innate immune checkpoint for use in the treatment of cancer, in particular hematological cancer such as leukemia or lymphoma.

公开(公告)号：US11548902B1

公开(公告)日：2023-01-10

申请号：US17361758

申请日：2021-06-29

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Hongyan Guo ,  Xiaochun Han ,  Lan Jiang ,  Jiayao Li ,  Michael L. Mitchell ,  Hyung-Jung Pyun ,  Scott D. Schroeder ,  Gregg M. Schwarzwälder ,  Nathan D. Shapiro ,  Devleena M. Shivakumar ,  Qiaoyin Wu ,  Hong Yang ,  Jennifer R. Zhang

IPC: C07D498/18 ,  C07D471/18 ,  A61P31/18

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20220274985A1

公开(公告)日：2022-09-01

申请号：US17673141

申请日：2022-02-16

Applicant: Gilead Sciences, Inc.

Inventor： Andrea Ambrosi ,  Florence J. Bachrach ,  Pavel R. Badalov ,  Stephen P. Lathrop ,  Jeffrey E. Merit ,  Beau P. Pritchett ,  Christopher S. Regens ,  Tiago Vieira ,  Adam B. Weinstein ,  Todd A. Wenderski ,  Zehua Zheng

IPC: C07D471/04 ,  C07D213/81 ,  C07D413/04

Abstract: The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.

公开(公告)号：US11420972B2

公开(公告)日：2022-08-23

申请号：US16879491

申请日：2020-05-20

Applicant: Gilead Sciences, Inc.

Inventor： Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dorothy Agnes Theodore

IPC: C07D487/04 ,  C07H19/04 ,  A61K9/00 ,  A61K31/706 ,  A61K45/06 ,  C07H7/06 ,  C07F9/6561

Abstract: Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.

公开(公告)号：US20220227787A1

公开(公告)日：2022-07-21

申请号：US17558130

申请日：2021-12-21

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Eda Y. Canales ,  Laurent P. Debien ,  Petr Jansa ,  Rick A. Lee ,  Jennifer A. Loyer-Drew ,  Stephane Perreault ,  Hyung-Jung Pyun ,  Roland D. Saito ,  Michael S. Sangi ,  Adam J. Schrier ,  Marina E. Shatskikh ,  James G. Taylor ,  Jennifer A. Treiberg ,  Joshua J. Van Veldhuizen ,  Lianhong Xu

IPC: C07D519/00

Abstract: The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

公开(公告)号：US20220226337A1

公开(公告)日：2022-07-21

申请号：US17550591

申请日：2021-12-14

Applicant: Gilead Sciences, Inc.

Inventor： Peter A. Blomgren ,  Taryn Campbell ,  Jayaraman Chandrasekhar ,  Christopher T. Clark ,  Julian A. Codelli ,  Kevin S. Currie ,  Jeffrey E. Kropf ,  Yasamin Moazami ,  Nicole Nava ,  Leena Patel ,  Stephane Perreault ,  Jason K. Perry ,  Kassandra F. Sedillo ,  Natalie Seeger ,  Kirk L. Stevens ,  Jennifer Anne Treiberg ,  Suet C. Yeung ,  Zhongdong Zhao

IPC: A61K31/5377 ,  A61K31/343 ,  A61K31/353 ,  A61K31/357 ,  A61K31/416 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/513 ,  A61K31/519 ,  A61K31/538 ,  A61K31/541 ,  A61K45/06 ,  C07D295/00 ,  C07D307/87 ,  C07D319/18 ,  C07D405/10 ,  C07D407/10 ,  C07D413/14 ,  C07D471/04

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.