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公开(公告)号：US20220112282A1
公开(公告)日：2022-04-14
申请号：US17496057
申请日：2021-10-07
摘要： Methods and compositions for clinical proven safe and effective treatment of Crohn's disease, particularly moderately to severely active Crohn's disease in patients, comprise intravenous initial dosing and subcutaneous maintenance dosing of an anti-IL12/IL23p40 antibody with maintenance dose intervals determined by evaluating clinical indicators.
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公开(公告)号：US20220090140A1
公开(公告)日：2022-03-24
申请号：US17595160
申请日：2020-04-21
发明人： Hsu-Feng Ko , Ravinder Bhatia , Soumya Mohanan Krishnathu , Vaishali Yannone , Jeffrey Edward Landau , Bas Diepenbroek , Guus Bjorn Erkens , Elisabeth Meulenbroek , Feras Nachmi Alazi
IPC分类号： C12N15/86
摘要： A method for purifying a viral vector from a solution including the viral vector and host cell proteins (HCP) is provided. The method includes circulating the solution across an ultrafiltration/diafiltration membrane using tangential flow filtration (TFF) mode with continuous addition of diafiltration buffer. The method further includes filtering the solution across the ultrafiltration/diafiltration membrane to provide a permeate and a retentate. The retentate is collected such that a purified viral vector solution is obtained and retained in the retentate. A volume of the retentate is kept constant by the continuous addition of diafiltration buffer and the HCP is filtered out via the permeate.
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公开(公告)号：US20220089737A1
公开(公告)日：2022-03-24
申请号：US17472237
申请日：2021-09-10
摘要： Provided herein are trispecific antibodies or antigen binding fragments thereof that bind to Vβ17, CD28 and another target (e.g., a cancer antigen, such as BCMA or PSMA) are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
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公开(公告)号：US20220064306A1
公开(公告)日：2022-03-03
申请号：US17411158
申请日：2021-08-25
发明人： Roland Knoblauch , Sheri Moores
摘要： The present invention relates to treatment of subjects having EGFR exon 20 insertion and other uncommon EGFR mutations.
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公开(公告)号：US20220064284A1
公开(公告)日：2022-03-03
申请号：US17376874
申请日：2021-07-15
发明人： Ellen CHI , Wilson EDWARDS , Matt HUSOVSKY , Ann LACOMBE , Christian MARTINEZ , H. Mimi ZHOU , John T. LEE
摘要： In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a GP5B83 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include GP5B83.
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公开(公告)号：US20220062415A1
公开(公告)日：2022-03-03
申请号：US17524516
申请日：2021-11-11
发明人： Hong Xie , Andrew Cakana
IPC分类号： A61K39/395 , A61K31/198 , A61K31/573 , C07K16/28 , A61K9/00 , A61K47/12 , A61K47/02 , A61K47/26 , A61K47/42 , A61K47/22 , A61K47/20 , A61P35/00 , A61K31/69 , G06Q30/00 , G06Q30/06 , G06Q30/02
摘要： Described herein are methods of treating multiple myeloma with clinically proven safe and effective amounts of an antibody that specifically recognizes CD38 with bortezomib, melphalan, and prednisone. Also described are methods of selling or offering for sale an antibody that specifically recognizes CD38 or pharmaceutical compositions thereof with bortezomib, melphalan, and prednisone.
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公开(公告)号：US20220056109A1
公开(公告)日：2022-02-24
申请号：US17508026
申请日：2021-10-22
IPC分类号： C07K16/00 , C12P21/00 , C07K1/107 , C07K14/435
摘要： Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
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公开(公告)号：US20220054634A1
公开(公告)日：2022-02-24
申请号：US17522423
申请日：2021-11-09
发明人： Jacquelne Benson , Mark Cunningham , Cynthia Duchala , Jill Giles-Komar , Jinquan Luo , Michael Rycyzyn , Raymond Sweet
IPC分类号： A61K39/395 , G01N33/68 , C07K16/24 , A61K45/06
摘要： An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
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公开(公告)号：US20220033522A1
公开(公告)日：2022-02-03
申请号：US17391744
申请日：2021-08-02
发明人： Rajkumar GANESAN , Adam ZWOLAK , Ian WHITE , Ninkka TAMOT , Paul B. HARVILLA , Rajitha DODDAREDDY , Sanjaya SINGH , Martin Jack BORROK III
摘要： Provided herein are multispecific molecules comprising a first binding domain that specifically binds to polymeric immunoglobulin receptor (pIgR) and a second binding domain that specifically binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and related methods for the treatment of patients infected with SARS-CoV-2.
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公开(公告)号：US11230609B2
公开(公告)日：2022-01-25
申请号：US16117522
申请日：2018-08-30
发明人： Par Oskar Vilhelmsson Timmermand , Amanda Thuy Tran , Sven-Erik Strand , Urpo Juhani Lamminmaki , Kjell Sjostrom
摘要： The present invention provides antibody polypeptides with binding specificity for human kallikrein-2 (hK2), wherein the antibody polypeptide comprises (a) a heavy chain variable region comprising the amino acid sequences of SEQ ID NO:1 and SEQ ID NO:2 and SEQ ID NO:3 and/or (b) a light chain variable region comprising the amino acid sequences of SEQ ID NO:4 and SEQ ID NO:5 and SEQ ID NO:6, and wherein the heavy chain variable region and light chain variable region comprise framework amino acid sequences from one or more human antibodies. The invention further provides use of said antibody polypeptides in the diagnosis and treatment of prostate cancer.
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