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116 条记录 (耗时 0.041 秒)

    Selective organ cooling apparatus and method employing turbulence-inducing element with curved terminations
    62.
    发明授权
    Selective organ cooling apparatus and method employing turbulence-inducing element with curved terminations 有权
    选择性器官冷却装置和采用具有弯曲终端的湍流诱发元件的方法

    公开(公告)号：US06238428B1

    公开(公告)日：2001-05-29

    申请号：US09246514

    申请日：1999-02-09

    申请人： Randell L. Werneth ,  John D. Dobak, III ,  Juan C. Lasheras

    发明人： Randell L. Werneth ,  John D. Dobak, III ,  Juan C. Lasheras

    IPC分类号： A61F700

    CPC分类号： A61B18/02 ,  A61B2017/00292 ,  A61B2018/0212 ,  A61B2018/0281 ,  A61F7/12 ,  A61F2007/0056 ,  A61F2007/126

    摘要： A selective organ heat transfer device with deep irregularities in a turbulence-inducing exterior surface. The device can have a plurality of elongated, articulated segments, each having a turbulence-inducing exterior surface. A flexible joint connects adjacent elongated, articulated segments. An inner lumen is disposed within the heat transfer segments. The inner lumen is capable of transporting a pressurized working fluid to a distal end of the heat transfer element. The irregularities may be grooves, and the grooves have a curved termination point which directs blood along a direction having a component perpendicular to the axis of the segments, thereby enhancing turbulence and heat transfer.

    摘要翻译： 湍流诱导外表面具有深度不规则的选择性器官传热装置。 该装置可以具有多个细长的关节节段，每个节段具有引起湍流的外表面。 柔性接头连接相邻的细长铰接段。 内腔设置在传热段内。 内腔能够将加压工作流体输送到传热元件的远端。 凹凸可以是凹槽，并且凹槽具有弯曲的终止点，其将血液沿着具有垂直于段的轴线的分量的方向引导，从而增强湍流和热传递。

    Circulating fluid hypothermia method and apparatus
    63.
    发明授权
    Circulating fluid hypothermia method and apparatus 失效

    公开(公告)号：US06231595B1

    公开(公告)日：2001-05-15

    申请号：US09052545

    申请日：1998-03-31

    申请人： John D. Dobak, III

    发明人： John D. Dobak, III

    IPC分类号： A61F700

    CPC分类号： A61F7/12 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61F2007/0056 ,  A61F2007/126

    摘要： A method and apparatus for performing hypothermia of a selected organ without significant effect on surrounding organs or other tissues. A flexible coaxial catheter is inserted through the vascular system of a patient to place the distal tip of the catheter in an artery feeding the selected organ. A chilled perfluorocarbon fluid is pumped through an insulated inner supply conduit of the catheter to cool a flexible bellows shaped heat transfer element in the distal tip of the catheter. The heat transfer bellows cools the blood flowing through the artery, to cool the selected organ, distal to the tip of the catheter.

    Selective organ cooling apparatus and method
    64.
    发明授权
    Selective organ cooling apparatus and method 有权
    选择性器官冷却装置及方法

    公开(公告)号：US06224624B1

    公开(公告)日：2001-05-01

    申请号：US09291824

    申请日：1999-04-14

    申请人： Juan C. Lasheras ,  Randell L. Werneth ,  John D. Dobak, III

    发明人： Juan C. Lasheras ,  Randell L. Werneth ,  John D. Dobak, III

    IPC分类号： A61F700

    CPC分类号： A61F7/12 ,  A61F2007/0056 ,  A61F2007/126

    摘要： The present invention involves a selective organ heat transfer device having a flexible coaxial catheter capable of insertion into a selected feeding artery in the vascular system of a patient. A heat transfer element is attached to a distal portion of the catheter as well as a turbulence-enhancing element which is adapted to enhance turbulent blood flow along the heat transfer element. The heat transfer element may include the turbulence-enhancing element and/or a turbulence-enhancing element may be located proximal of the heat transfer element.

    摘要翻译： 本发明涉及一种选择性器官传热装置，其具有能够插入患者血管系统中的选定进食动脉的柔性同轴导管。 传热元件附接到导管的远端部分以及湍流增强元件，其适于增强沿着传热元件的湍流血流。 传热元件可以包括湍流增强元件和/或湍流增强元件可以位于传热元件的近侧。

    Electric modulation of sympathetic nervous system
    67.
    发明授权
    Electric modulation of sympathetic nervous system 有权
    交感神经系统的电调制

    公开(公告)号：US08340760B2

    公开(公告)日：2012-12-25

    申请号：US13230525

    申请日：2011-09-12

    申请人： John D Dobak, III

    发明人： John D Dobak, III

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36085 ,  A61N1/36007 ,  A61N1/36017 ,  A61N1/36071

    摘要： A method is described for the treatment of obesity or other disorders, by electrical activation or inhibition of the sympathetic nervous system. This activation or inhibition can be accomplished by electrically stimulating the greater splanchnic nerve or other portion of the sympathetic nervous system using an implantable pulse generator. This nerve activation can result in reduced food intake and increased energy expenditure. Reduced food intake may occur through a variety of mechanisms that reduce appetite and cause satiety. Increased adrenal gland hormone levels will result in increased energy expenditure. Fat and carbohydrate metabolism, which are also increased by sympathetic nerve activation, will accompany the increased energy expenditure.

    摘要翻译： 描述了通过电活化或抑制交感神经系统来治疗肥胖症或其它疾病的方法。 这种激活或抑制可以通过使用可植入脉冲发生器电刺激更大的内脏神经或交感神经系统的其他部分来实现。 这种神经激活可导致食物摄入减少并增加能量消耗。 通过减少食欲和引起饱腹感的各种机制可能减少食物摄取。 增加的肾上腺激素水平将导致能量消耗的增加。 脂肪和碳水化合物的代谢，也因交感神经激活而增加，将伴随着增加的能量消耗。

    Method and device for performing cooling-or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
    68.
    发明授权
    Method and device for performing cooling-or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation 有权
    用于进行冷冻或低温治疗的方法和装置，例如血管成形术，减少再狭窄或肺静脉细胞坏死以抑制心房颤动

    公开(公告)号：US08157794B2

    公开(公告)日：2012-04-17

    申请号：US11978888

    申请日：2007-10-30

    申请人： John D. Dobak, III ,  Hans W. Kramer ,  Steven A. Yon

    发明人： John D. Dobak, III ,  Hans W. Kramer ,  Steven A. Yon

    IPC分类号： A61B18/02

    CPC分类号： A61F7/12 ,  A61B18/02 ,  A61B2017/22002 ,  A61B2017/22054 ,  A61B2018/00023 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61F2007/126

    摘要： The present invention provides an enhanced method and device to inhibit or reduce the rate of restenosis following angioplasty or stent placement. The invention involves placing a balloon tipped catheter in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place from a balloon angioplasty. A fluid such as a perfluorocarbon may be flowed into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. The catheter may also be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon is in contact with at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium.

    摘要翻译： 本发明提供了抑制或降低血管成形术或支架放置后再狭窄发生率的增强方法和装置。 本发明涉及将气囊顶端的导管放置在血管成形术后立即通过球囊血管成形术处理或打开的区域中。 可以具有双气囊结构的气囊可以通过引导导管并且已经从球囊血管成形术已经就位的导线传送。 诸如全氟化碳的流体可以流入气囊中以冷冻邻近球囊的组织，这种冷却与再狭窄的减少有关。 导管还可用于通过插入和充气气囊来减少心房颤动，使得球囊的外表面与邻近左心房的肺静脉部分的至少部分圆周接触。

    NEURAL STIMULATION FOR TREATMENT OF METABOLIC SYNDROME AND TYPE 2 DIABETES
    69.
    发明申请
    NEURAL STIMULATION FOR TREATMENT OF METABOLIC SYNDROME AND TYPE 2 DIABETES 有权
    治疗代谢综合征和2型糖尿病的神经刺激

    公开(公告)号：US20110238128A1

    公开(公告)日：2011-09-29

    申请号：US13152777

    申请日：2011-06-03

    申请人： John D. Dobak, III

    发明人： John D. Dobak, III

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3615 ,  A61N1/36007 ,  A61N1/36085 ,  A61N1/36135 ,  A61N1/36167

    摘要： Systems and methods are described for treating metabolic syndrome and/or Type 2 diabetes, and/or one or more of their attendant conditions, by neural stimulation. In one embodiment, an implantable pulse generator is electrically coupled to a peripheral nerve, such as the splanchnic nerve. Neural stimulation configured to either block transmission or stimulate transmission of the peripheral nerve may be used to treat metabolic syndrome and Type 2 diabetes.

    摘要翻译： 描述了通过神经刺激来治疗代谢综合征和/或2型糖尿病和/或其伴随状况中的一种或多种的系统和方法。 在一个实施例中，可植入脉冲发生器电耦合到外周神经，例如内脏神经。 配置为阻止传播或刺激周围神经传播的神经刺激可用于治疗代谢综合征和2型糖尿病。

    Electric modulation of sympathetic nervous system
    70.
    发明授权
    Electric modulation of sympathetic nervous system 有权
    交感神经系统的电调制

    公开(公告)号：US08024035B2

    公开(公告)日：2011-09-20

    申请号：US11804449

    申请日：2007-05-17

    申请人： John D. Dobak, III

    发明人： John D. Dobak, III

    IPC分类号： A61N1/372

    CPC分类号： A61N1/36085 ,  A61N1/36007 ,  A61N1/36017 ,  A61N1/36071

    摘要： A method is described for the treatment of obesity or other disorders, by electrical activation or inhibition of the sympathetic nervous system. This activation or inhibition can be accomplished by electrically stimulating the greater splanchnic nerve or other portion of the sympathetic nervous system using an implantable pulse generator. This nerve activation can result in reduced food intake and increased energy expenditure. Reduced food intake may occur through a variety of mechanisms that reduce appetite and cause satiety. Increased adrenal gland hormone levels will result in increased energy expenditure. Fat and carbohydrate metabolism, which are also increased by sympathetic nerve activation, will accompany the increased energy expenditure.

    摘要翻译： 描述了通过电活化或抑制交感神经系统来治疗肥胖症或其它疾病的方法。 这种激活或抑制可以通过使用可植入脉冲发生器电刺激更大的内脏神经或交感神经系统的其他部分来实现。 这种神经激活可导致食物摄入减少并增加能量消耗。 通过减少食欲和引起饱腹感的各种机制可能减少食物摄取。 增加的肾上腺激素水平将导致能量消耗的增加。 脂肪和碳水化合物的代谢，也因交感神经激活而增加，将伴随着增加的能量消耗。