公开(公告)号：US20050185105A1

公开(公告)日：2005-08-25

申请号：US11037546

申请日：2005-01-19

申请人： Koichi Miyachi ,  Seiji Shibahara ,  Iichiro Inoue ,  Shoichi Ishihara ,  Akihito Jinda ,  Kiyoshi Ogishima

发明人： Koichi Miyachi ,  Seiji Shibahara ,  Iichiro Inoue ,  Shoichi Ishihara ,  Akihito Jinda ,  Kiyoshi Ogishima

IPC分类号： C09K19/02 ,  G02F1/07 ,  G02F1/133 ,  G02F1/1335 ,  G02F1/1343 ,  G02F1/135 ,  G09F9/00 ,  G09F9/30 ,  G09F9/35

CPC分类号： G02F1/134363 ,  C09K19/02 ,  C09K2019/0418 ,  G02F1/07

摘要： A display element according to the present invention is provided with a pair of substrates, at least one of which is transparent; a medium between the substrates, wherein optical anisotropy magnitude of the medium is changeable by and according to an electric field applied thereon; at least one pair of electrodes for applying, on the medium, the electric field substantially parallel to the substrates; and a shielding electrode overlapping at least a display portion of at least one of the substrates, and used for shielding the display element from static electricity.

摘要翻译： 根据本发明的显示元件设置有一对基板，其中至少一个是透明的; 基板之间的介质，其中介质的光学各向异性幅度可以根据施加在其上的电场改变; 至少一对电极，用于在介质上施加基本平行于基板的电场; 以及与至少一个基板的至少一个显示部分重叠的屏蔽电极，用于屏蔽显示元件免受静电影响。

公开(公告)号：US20050179847A1

公开(公告)日：2005-08-18

申请号：US11035425

申请日：2005-01-14

申请人： Koichi Miyachi ,  Seiji Shibahara ,  Iichiro Inoue ,  Akihito Jinda ,  Takako Koide ,  Kiyoshi Ogishima

发明人： Koichi Miyachi ,  Seiji Shibahara ,  Iichiro Inoue ,  Akihito Jinda ,  Takako Koide ,  Kiyoshi Ogishima

IPC分类号： C09K19/02 ,  G02F1/133 ,  G02F1/1343

CPC分类号： C09K19/02 ,  C09K2019/0418 ,  G02F1/134363

摘要： A display element of the present invention includes: a pair of substrates at least one of which is transparent; a medium layer, made of a medium sandwiched between the substrates 1 and 2, whose magnitude of an optical anisotropy is changed by applying an electric field; and at least a pair of electrodes applying to the medium layer an electric field which is substantially parallel to the substrates. The electrodes are provided above the substrate via insulating layers each of which is formed in a convex shape. Therefore, a maximal electric field region generated by the electrodes is separated from interfaces of the substrates.

摘要翻译： 本发明的显示元件包括：至少一个透明的一对基板; 由夹在基板1和2之间的介质制成的中等层，其光学各向异性的大小通过施加电场而改变; 以及至少一对电极，其向介质层施加基本上平行于基板的电场。 电极通过各自形成为凸形的绝缘层设置在基板的上方。 因此，由电极产生的最大电场区域与基板的界面分离。

公开(公告)号：US06930750B2

公开(公告)日：2005-08-16

申请号：US10688948

申请日：2003-10-21

申请人： Koichi Miyachi ,  Seiji Shibahara

发明人： Koichi Miyachi ,  Seiji Shibahara

IPC分类号： C09K19/02 ,  C09K19/20 ,  G02F1/13 ,  G02F1/141 ,  G02F1/1335

CPC分类号： C09K19/0266 ,  C09K19/02 ,  G02F1/141

摘要： A liquid crystal optical element includes two substrates, a liquid crystal layer, and at least two electrodes. The liquid crystal layer is provided between the substrates and includes liquid crystal molecules and dichroic dye molecules. The at least two electrodes are provided on the substrates so as to face each other with the liquid crystal layer interposed between them, and define one of multiple unit regions. In each unit region, the liquid crystal layer includes first and second liquid crystal regions within a range, which is approximately half or less as long as the wavelength of visible radiation as measured in a direction parallel to the surfaces of the substrates. The orientation directions of each pair of liquid crystal molecules in the first and second liquid crystal regions have azimuthal directions defining an angle of approximately 90 degrees while no voltage is being applied between the electrodes.

摘要翻译： 液晶光学元件包括两个基板，液晶层和至少两个电极。 液晶层设置在基板之间，并且包括液晶分子和二色性染料分子。 所述至少两个电极设置在所述基板上，以便彼此面对，并且液晶层插入在它们之间，并且限定多个单元区域中的一个。 在每个单位区域中，液晶层包括在与基板表面平行的方向上测量的可见光辐射的大约一半或更小的范围内的第一和第二液晶区域。 第一和第二液晶区域中的每对液晶分子的取向方向具有限定大约90度的角度的方位角方向，而在电极之间没有施加电压。

公开(公告)号：US5488038A

公开(公告)日：1996-01-30

申请号：US154002

申请日：1993-11-18

申请人： Shinichi Kondo ,  Seiji Shibahara ,  Takayuki Usui ,  Toshiaki Kudo ,  Shuichi Gomi ,  Atsushi Tamura ,  Yoko Ikeda ,  Daishiro Ikeda ,  Tomio Takeuchi

发明人： Shinichi Kondo ,  Seiji Shibahara ,  Takayuki Usui ,  Toshiaki Kudo ,  Shuichi Gomi ,  Atsushi Tamura ,  Yoko Ikeda ,  Daishiro Ikeda ,  Tomio Takeuchi

IPC分类号： C07H15/236 ,  A61K31/70 ,  C07H15/22

CPC分类号： C07H15/234

摘要： As new dibekacin derivatives and new arbekacin derivatives are now provided 2"-amino-2"-deoxydibekacin, 2"-amino-5,2"-dideoxydibekacin, 2"-amino-2"-deoxyarbekacin, 2"-amino-5,2"-dideoxyarbekacin, 2"-amino-5,2"-dideoxy-5-epi-fluoroarbekacin and 2"-amino-5,2"-dideoxy-5-epi-aminoarbekacin which all exhibit high antibacterial activity against a wide variety of gram-positive and gram-negative bacteria, including resistant bacteria such as methicillin-resistant Staphylococcus aureus and which are of low toxicity to mammals and are useful as antibacterial agent for treatment of bacterial infections.

摘要翻译： 现在提供新的二卡辛衍生物和新的阿贝卡星衍生物2' - 氨基-2' - 脱氧胆碱，2“ - 氨基-5,2” - 脱氧胆酸，2“ - 氨基-2'-脱氧阿糖胞苷，2 “ - 氨基-5,2” - 双脱氧肉豆蔻素，2“ - 氨基-5,2” - 双脱氧-5-表 - 氟代贝卡星和2“ - 氨基-5,2” - 双脱氧-5-表 所有这些都表现出对各种革兰氏阳性和革兰氏阴性细菌的高抗菌活性，包括耐甲氧西林金黄色葡萄球菌等抗性细菌，对哺乳动物毒性低，可用作细菌治疗的抗菌剂 感染。

公开(公告)号：US5407918A

公开(公告)日：1995-04-18

申请号：US143125

申请日：1993-10-29

申请人： Keiichi Ajito ,  Ken-ichi Kurihara ,  Akira Shimizu ,  Shuichi Gomi ,  Nobue Kikuchi ,  Minako Araake ,  Tsuneo Ishizuka ,  Aiko Miyata ,  Osamu Hara ,  Seiji Shibahara

发明人： Keiichi Ajito ,  Ken-ichi Kurihara ,  Akira Shimizu ,  Shuichi Gomi ,  Nobue Kikuchi ,  Minako Araake ,  Tsuneo Ishizuka ,  Aiko Miyata ,  Osamu Hara ,  Seiji Shibahara

IPC分类号： C07H17/08 ,  C12P19/62 ,  A61K31/70 ,  C12P19/60

CPC分类号： C07H17/08

摘要： 16-membered macrolide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 represents a straight-chain alkyl group having 1 to 3 carbon atoms; R.sup.2 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.3 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.4 represents a straight-chain alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted allyl group; and R.sup.5 represents a substituted or unsubstituted, straight-chain or branched alkyl, alkenyl or aralkyl group having 1 to 10 carbon atoms; and pharmaceutically acceptable salts thereof are disclosed. These compounds show excellent and long-acting antimicrobial activities. A novel process for producing these 16-membered macrolide derivatives is further disclosed.

摘要翻译： 由式（I）表示的16元大环内酯衍生物：其中R 1表示氢原子或COR 6基团，其中R 6表示具有1至3个碳原子的直链烷基; R2表示氢原子或COR6基团，其中R6如上所定义; R3表示氢原子或COR6基团，其中R6如上所定义; R4表示碳原子数1〜4的直链烷基或取代或未取代的烯丙基; R 5表示具有1〜10个碳原子的取代或未取代的直链或支链烷基，烯基或芳烷基; 及其药学上可接受的盐。 这些化合物显示出优异的长效抗菌活性。 进一步公开了一种制备这些16元大环内酯衍生物的新方法。

公开(公告)号：US5334723A

公开(公告)日：1994-08-02

申请号：US937112

申请日：1992-08-31

申请人： Tsuneo Okonogi ,  Osamu Makabe ,  Yuichi Yamamoto ,  Osamu Itoh ,  Tsutomu Tsuruoka ,  Takayuki Usui ,  Seiji Shibahara ,  Kozo Nagaoka ,  Shigeharu Inouye ,  Nobuko Okada ,  Susumu Nishimura

发明人： Tsuneo Okonogi ,  Osamu Makabe ,  Yuichi Yamamoto ,  Osamu Itoh ,  Tsutomu Tsuruoka ,  Takayuki Usui ,  Seiji Shibahara ,  Kozo Nagaoka ,  Shigeharu Inouye ,  Nobuko Okada ,  Susumu Nishimura

IPC分类号： C07D211/90 ,  C07D211/76 ,  C07D211/86 ,  C07D211/88

CPC分类号： C07D211/90

摘要： A novel 2-piperidinecarboxylic acid derivative represented by the formula: ##STR1## wherein X represents an oxygen atom, a sulfur atom or a nitrogen atom to which a hydrogen atom is bound; and * represents that the configuration of the carbon atom binding to the carboxyl group is (S), (R) or a mixture of (S) and (R); and a pharmaceutically acceptable salt thereof which exerts an antitumor effect over a wide range of tumor cells.

摘要翻译： 由下式表示的新颖的2-哌啶羧酸衍生物：其中X表示与氢原子结合的氧原子，硫原子或氮原子; 和*表示与羧基结合的碳原子的构型是（S），（R）或（S）和（R）的混合物。 和其药学上可接受的盐在广泛的肿瘤细胞上发挥抗肿瘤作用。

公开(公告)号：US5332731A

公开(公告)日：1994-07-26

申请号：US623215

申请日：1990-12-06

申请人： Yuichi Yamamoto ,  Tsuneo Okonogi ,  Seiji Shibahara ,  Shigeharu Inoue

发明人： Yuichi Yamamoto ,  Tsuneo Okonogi ,  Seiji Shibahara ,  Shigeharu Inoue

IPC分类号： C07D501/00 ,  C07D501/59 ,  C07D501/36

CPC分类号： C07D501/00

摘要： A new class of cephalosporin derivatives is provided, which is useful as antibacterial agent to be particularly suitable for oral administrations in mammals including man, and which is represented by general formula (I) ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkyl group; R.sup.2 is a hydrogen atom or an ester-forming group capable of being cleaved easily with an esterase existing in the digestive tracts; n is an integer of zero or 1; Z is a saturated heterocyclic group containing one or two oxygen atoms as the hetero-atoms with or without one or more lower alkyl substituents, or a pharmaceutically acceptable salt thereof.

摘要翻译： 提供了一类新的头孢菌素衍生物，其可用作特别适合于包括人在内的哺乳动物的口服给药的抗菌剂，其由通式（I）表示，其中R 1是氢原子或 低级烷基; R2是能够容易地与存在于消化道中的酯酶裂解的氢原子或成酯基团; n是0或1的整数; Z是含有一个或两个氧原子作为具有或不具有一个或多个低级烷基取代基的杂原子的饱和杂环基，或其药学上可接受的盐。

公开(公告)号：US5206384A

公开(公告)日：1993-04-27

申请号：US754543

申请日：1991-09-04

申请人： Seiji Shibahara ,  Yoshiyuki Koyama ,  Shigeharu Inoue ,  Mitsugu Hachisu ,  Shinichi Kondo ,  Takaaki Aoyagi ,  Tomio Takeuchi

发明人： Seiji Shibahara ,  Yoshiyuki Koyama ,  Shigeharu Inoue ,  Mitsugu Hachisu ,  Shinichi Kondo ,  Takaaki Aoyagi ,  Tomio Takeuchi

IPC分类号： A61K31/40 ,  A61K38/55 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07D207/08 ,  C07D207/16 ,  C07K5/06 ,  C07K14/81 ,  C12N9/99

CPC分类号： C07D207/08 ,  C07D207/16

摘要： A novel actinonin derivative and a salt thereof are provided, which are useful as enzyme inhibitors and particularly have strong inhibitory activities against enkephalinase and angiotensin-converting enzymes. This actinonin derivative is represented by general formula (I): ##STR1## wherein R.sup.1 is sulfoxymethyl or carboxyl or a substituted carboxyl group selected from carboxamide, hydroxyaminocarbonyl and alkoxycarbonyl groups; and R.sup.2 is hydroxyl, alkoxy, hydroxyamino or sulfoxyamino group.

公开(公告)号：US5171746A

公开(公告)日：1992-12-15

申请号：US683176

申请日：1991-04-09

申请人： Tomoya Machinami ,  Kazue Yasufuku ,  Seiji Shibahara ,  Yasukatsu Yuda ,  Fumiya Hirano

发明人： Tomoya Machinami ,  Kazue Yasufuku ,  Seiji Shibahara ,  Yasukatsu Yuda ,  Fumiya Hirano

IPC分类号： A61K31/415 ,  A61K31/4184 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/443 ,  A61K31/445 ,  A61K31/454 ,  A61K31/535 ,  A61K31/5355 ,  A61P1/04 ,  C07D233/84 ,  C07D235/28 ,  C07D277/20 ,  C07D277/36 ,  C07D277/56 ,  C07D277/74 ,  C07D277/76 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D417/04 ,  C07D417/12

CPC分类号： C07D417/04 ,  C07D235/28 ,  C07D277/36 ,  C07D277/56 ,  C07D277/74 ,  C07D277/76 ,  C07D417/12

摘要： A thiazole or imidazole derivative having the general formula (I): ##STR1## wherein: R.sup.1 and R.sup.2, which may be the same or different, each independently represent a hydrogen atom, or a phenyl or heteroaryl group, or R.sup.1 and R.sup.2 may together form a benzene ring which may be optionally substituted by a halogen atom or a lower alkyl optionally substituted by a halogen atom, lower alkoxy or nitro group;A represents a sulfur atom or --NH--;B represents a lower alkoxy group optionally substituted by a halogen atom; a five- or six-membered saturated heterocyclic ring containing one nitrogen or oxygen atom which ring may be optionally substituted; a six-membered saturated heterocyclic ring containing one oxygen atom plus one nitrogen atom; a group --XR.sup.3 where X represents a group --NR.sup.4 wherein R.sup.3 and R.sup.4, which may be the same or different, each independently represent a lower alkyl group; or a group --NHC(.dbd.Y)R.sup.5 where Y represents an oxygen or sulfur atom or a group .dbd.NCN or .dbd.CHNO.sub.2, and R.sup.5 represents a group --NHR.sup.6 or --SR.sup.6 wherein R.sup.6 represents a lower alkyl group optionally substituted by a halogen atom;m is an integer from 1 to 4; andn is an integer from 0 to 2;and their pharmacologically acceptable salts. The compounds have an antiulcerative activity.

公开(公告)号：US5066677A

公开(公告)日：1991-11-19

申请号：US489358

申请日：1990-07-06

申请人： Yasuo Sato ,  Shinsuke Kato ,  Takako Taniguchi ,  Kunio Atsumi ,  Mitsugu Hachisu ,  Seiji Shibahara

发明人： Yasuo Sato ,  Shinsuke Kato ,  Takako Taniguchi ,  Kunio Atsumi ,  Mitsugu Hachisu ,  Seiji Shibahara

IPC分类号： A61K31/19 ,  A61P9/00 ,  A61P25/28 ,  C07C231/12 ,  C07C233/36 ,  C07C233/56

CPC分类号： C07C233/56

摘要： Novel N-(dialkylaminoalkyl)-substituted derivatives or N-(dialkylaminoalkyl)-N-alkyl-substituted derivatives of oxamic acid are now synthetized and found to exhibit the cerebral protective effect against cerebral anoxia in brain of a mammalian animal, including human, and to be useful as an agent for improving or ameliorating the damaged or disturbed functions of the brain.