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61.发明申请公开(公告)号：US20130084569A1
公开(公告)日：2013-04-04
申请号：US13637645
申请日：2011-03-28
Applicant: Joseph Wang , Jie Wu , Shankar Balasubramanian , Daniel Kagan , Kalayil Manian Manesh
Inventor： Joseph Wang , Jie Wu , Shankar Balasubramanian , Daniel Kagan , Kalayil Manian Manesh
IPC: C12Q1/68 , C12N15/115 , C07K17/14 , G01N33/558 , G01N33/58
CPC classification number: C12Q1/6886 , B82Y15/00 , C07K17/14 , C12N15/115 , C12Q1/6816 , G01N33/557 , G01N33/558 , G01N33/587 , Y10S977/726 , Y10S977/773 , Y10S977/92 , C12Q2563/113 , C12Q2563/155
Abstract: Techniques and systems are disclosed for detecting biomolecular interactions based on the motion of nanomotors. In one aspect, a method of detecting biomolecular interactions based on a motion of a nanomachine includes functionalizing a nanomachine with a capture probe adapted to interact with biological targets; and detecting a presence of the biological targets in an environment based on a motion of the nanomachine.
Abstract translation: 公开了用于基于纳米电动机的运动来检测生物分子相互作用的技术和系统。 在一个方面，基于纳米机械的运动来检测生物分子相互作用的方法包括用适于与生物靶相互作用的捕获探针对纳米机械进行功能化; 以及基于所述纳米机械的运动在环境中检测所述生物学目标的存在。
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公开(公告)号：US20100317531A1
公开(公告)日：2010-12-16
申请号：US12804025
申请日：2010-07-13
Applicant: Shankar Balasubramanian , Colin Barnes , Xiaohai Liu
Inventor： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu
IPC: C40B20/04
CPC classification number: C12Q1/6869 , C07H19/10 , C07H19/20 , C07H21/00 , C12P19/34 , C12Q1/6806 , C12Q1/6818 , C12Q1/6823 , C12Q1/6834 , C12Q1/6874 , C12Q1/6876 , C12Q2525/186
Abstract: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
Abstract translation: 公开了通过可切割连接基团与可检测标记物连接的核苷和核苷酸。
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公开(公告)号：US20100130368A1
公开(公告)日：2010-05-27
申请号：US12583658
申请日：2009-08-24
Applicant: Shankar Balasubramanian , Colin Barnes , David Klenerman , Mark Allen Osborne
Inventor： Shankar Balasubramanian , Colin Barnes , David Klenerman , Mark Allen Osborne
CPC classification number: C12Q1/6874 , B01J2219/00317 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/0054 , B01J2219/00572 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/00707 , B01J2219/00722 , C12Q1/6837 , C12Q2525/301 , C40B40/06 , C40B60/14 , C12Q2565/601 , C12Q2565/537 , C12Q2565/507 , C12Q2563/107 , C12Q2525/204
Abstract: Provided herein is a method of determining a sequence of a target polynucleotide. The method can include the steps of a) providing a device including an array of relatively short polynucleotides and relatively long polynucleotides immobilised on a surface of a solid support, wherein the relatively long polynucleotides are fragments of the target polynucleotide and wherein the relatively long polynucleotides are separated by a distance of at least 10 nm, whereby parts of the relatively long polynucleotides that extend beyond the relatively short polynucleotides can be individually optically resolved; and b) determining the sequence of the target polynucleotide by detecting incorporation of nucleotides into strands complementary to the relatively long polynucleotide fragments using fluorescent labels associated with the incorporated nucleotides. Also provided is system for determining a sequence of a target polynucleotide. The system can include means for carrying out steps a) and b) of the above method.
Abstract translation: 本文提供了确定靶多核苷酸序列的方法。 该方法可以包括以下步骤：a）提供包含相对短的多核苷酸阵列和固定在固体支持物表面上的相对长的多核苷酸的装置的装置，其中相对长的多核苷酸是靶多核苷酸的片段，其中相对长的多核苷酸是 分离至少10nm的距离，由此延伸超过相对短的多核苷酸的相对长的多核苷酸的部分可以单独地光学拆分; 和b）使用与所掺入的核苷酸相关联的荧光标记，通过检测核苷酸与相对长的多核苷酸片段互补的链中的核苷酸来确定靶多核苷酸的序列。 还提供了用于确定靶多核苷酸序列的系统。 该系统可以包括用于执行上述方法的步骤a）和b）的装置。
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Patent Agency Ranking
公开(公告)号：US07566537B2
公开(公告)日：2009-07-28
申请号：US11301578
申请日：2005-12-13
Applicant: Shankar Balasubramanian , Colin Barnes , Xiaohai Liu , John Milton , Harold Swerdlow , Xiaolin Wu
Inventor： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu , John Milton , Harold Swerdlow , Xiaolin Wu
CPC classification number: C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q1/6869 , C12Q2525/186 , C12Q2535/113 , C12Q2525/197
Abstract: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
Abstract translation: 公开了通过可切割连接基团与可检测标记物连接的核苷和核苷酸。
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公开(公告)号：US07232656B2
公开(公告)日：2007-06-19
申请号：US10610305
申请日：2003-06-30
Applicant: Shankar Balasubramanian , David Klenerman , Colin Barnes , Mark Allen Osborne
Inventor： Shankar Balasubramanian , David Klenerman , Colin Barnes , Mark Allen Osborne
CPC classification number: C12Q1/6837 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/0054 , B01J2219/00572 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/00707 , B01J2219/00722 , C12Q2525/301 , C40B40/06 , C40B60/14 , C12Q2521/501 , C12Q2565/507
Abstract: The invention is directed to a method for analysing genome wide variation in an individual. The method comprises randomly fragmenting the individual's genome and generating sequence reads of multiple bases on all fragments of the individual's genome, aligning the sequence reads generated with a known genomic reference sequence, and analysing variations between the sequence reads derived from the individual's genome and the known genomic reference sequence.
Abstract translation: 本发明涉及用于分析个体中全基因组变异的方法。 该方法包括随机碎片个体的基因组，并在个体基因组的所有片段上生成多个碱基的序列读数，使用已知基因组参考序列生成的序列读数进行比对，并分析源自个体基因组的序列读数与已知 基因组参考序列。
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公开(公告)号：US20060281109A1
公开(公告)日：2006-12-14
申请号：US11431939
申请日：2006-05-10
Applicant: Tobias Barr Ost , Geoffrey Smith , Shankar Balasubramanian , Roberto Rigatti , Raquel Sanches
Inventor： Tobias Barr Ost , Geoffrey Smith , Shankar Balasubramanian , Roberto Rigatti , Raquel Sanches
CPC classification number: C12N9/1252 , C12Q1/686 , C12Y207/07007
Abstract: Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate DNA templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-DNA complexes in each reaction cycle. The modified polymerases may be used in a number of DNA sequencing applications, especially in the context of clustered arrays.
Abstract translation: 修饰的DNA聚合酶对DNA具有亲和力，使得聚合酶具有在每个反应循环中将一个或多个核苷酸并入到多个单独的DNA模板中的能力。 聚合酶能够在每个反应循环中形成增加数量的生产性聚合酶-DNA复合物。 修饰的聚合酶可用于许多DNA测序应用，特别是在簇阵列的上下文中。
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公开(公告)号：US07139845B2
公开(公告)日：2006-11-21
申请号：US10425559
申请日：2003-04-29
Applicant: Balakumar N. Kaushik , Shankar Balasubramanian , Richard L. Hammons
Inventor： Balakumar N. Kaushik , Shankar Balasubramanian , Richard L. Hammons
CPC classification number: G06F11/1464 , G06F11/1466 , G06F2201/84 , H04L49/357 , H04L67/1097 , Y10S707/99953 , Y10S707/99955
Abstract: The snapshot capability moving into the SAN fabric and being provided as a snapshot service. A well-known address is utilized to receive snapshot commands. Each switch in the fabric connected to a host contains a front end or service interface to receive the snapshot command. Each switch of the fabric connected to a storage device used in the snapshot process contains a write interceptor module which cooperates with hardware in the switch to capture any write operations which would occur to the snapshot data area. The write interceptor then holds these particular write operations until the original blocks are transferred to a snapshot or separate area so that the original read data is maintained. Should a read operation occur to the snapshot device and the original data from requested location has been relocated, a snapshot server captures these commands and redirects the read operation to occur from the snapshot area. If, however, the read operation is directed to the original drive, the read is provided from the original data areas, even if the data had been replaced. The snapshot server determines the existence of particular snapshot devices, allocates their storage locations, provides this information to both the service interfaces and the write interceptors and handles read and write operations to the snapshot device.
Abstract translation: 快照功能进入SAN架构，并作为快照服务提供。 利用着名的地址接收快照命令。 连接到主机的每个交换机都包含一个前端或服务接口来接收快照命令。 连接到快照过程中使用的存储设备的结构的每个交换机都包含一个写入拦截器模块，该模块与交换机中的硬件配合，以捕获快照数据区域将发生的任何写入操作。 写拦截器然后保存这些特定的写入操作，直到原始块被传送到快照或分离区域，以便保持原始读取数据。 如果快照设备发生读取操作，并且重新定位了来自请求位置的原始数据，则快照服务器捕获这些命令并重定向从快照区域发生的读取操作。 但是，如果读取操作指向原始驱动器，则即使已更换数据，也会从原始数据区域提供读取。 快照服务器确定特定快照设备的存在，分配其存储位置，将此信息提供给服务接口和写截取器，并处理对快照设备的读写操作。
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公开(公告)号：US20060248300A1
公开(公告)日：2006-11-02
申请号：US11457768
申请日：2006-07-14
Applicant: BALAKUMAR KAUSHIK , SHANKAR BALASUBRAMANIAN , RICHARD HAMMONS
Inventor： BALAKUMAR KAUSHIK , SHANKAR BALASUBRAMANIAN , RICHARD HAMMONS
CPC classification number: G06F11/1464 , G06F11/1466 , G06F2201/84 , H04L49/357 , H04L67/1097 , Y10S707/99953 , Y10S707/99955
Abstract: The snapshot capability moving into the SAN fabric and being provided as a snapshot service. A well-known address is utilized to receive snapshot commands. Each switch in the fabric connected to a host contains a front end or service interface to receive the snapshot command. Each switch of the fabric connected to a storage device used in the snapshot process contains a write interceptor module which cooperates with hardware in the switch to capture any write operations which would occur to the snapshot data area. The write interceptor then holds these particular write operations until the original blocks are transferred to a snapshot or separate area so that the original read data is maintained. Should a read operation occur to the snapshot device and the original data from requested location has been relocated, a snapshot server captures these commands and redirects the read operation to occur from the snapshot area. If, however, the read operation is directed to the original drive, the read is provided from the original data areas, even if the data had been replaced. The snapshot server determines the existence of particular snapshot devices, allocates their storage locations, provides this information to both the service interfaces and the write interceptors and handles read and write operations to the snapshot device.
Abstract translation: 快照功能进入SAN架构，并作为快照服务提供。 利用着名的地址接收快照命令。 连接到主机的每个交换机都包含一个前端或服务接口来接收快照命令。 连接到快照过程中使用的存储设备的结构的每个交换机都包含一个写入拦截器模块，该模块与交换机中的硬件配合，以捕获快照数据区域将发生的任何写入操作。 写拦截器然后保存这些特定的写入操作，直到原始块被传送到快照或分离区域，以便保持原始读取数据。 如果快照设备发生读取操作，并且重新定位了来自请求位置的原始数据，则快照服务器捕获这些命令并重定向从快照区域发生的读取操作。 但是，如果读取操作指向原始驱动器，则即使已更换数据，也会从原始数据区域提供读取。 快照服务器确定特定快照设备的存在，分配其存储位置，将此信息提供给服务接口和写截取器，并处理对快照设备的读写操作。
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