公开(公告)号：US20230257741A1

公开(公告)日：2023-08-17

申请号：US17759402

申请日：2021-01-29

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Gabrijela Dumbovic ,  John Rinn ,  Marvin Caruthers ,  Katarzyna Jastrzebska ,  Heera K. Langner

IPC: C12N15/113 ,  A61K31/7115 ,  A61P35/00

CPC classification number: C12N15/113 ,  A61K31/7115 ,  A61P35/00

Abstract: The inventive technology relates to systems and methods for the use of chemically modified antisense oligonucleotides (ASOs) to sterically prevent intron excision thus causing nuclear retention of the RNA and inhibiting nuclear export. In preferred therapeutic embodiments, ASOs may be engineered to quarantine clinically relevant RNAs in the nucleus of the cell.

公开(公告)号：US20230250025A1

公开(公告)日：2023-08-10

申请号：US18127498

申请日：2023-03-28

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Christopher Bartel ,  Alan W. Weimer ,  Rebecca Jean O'Toole ,  Maila Kodas

IPC: C04B35/488 ,  C04B35/624 ,  C04B35/628 ,  H01M8/1253

CPC classification number: C04B35/4885 ,  C04B35/624 ,  C04B35/62813 ,  H01M8/1253 ,  C04B2235/3217 ,  C04B2235/3246 ,  C04B2235/6026 ,  H01M2008/1293

Abstract: Disclosed herein is a ceramic particle comprising a core substrate chosen from yttria-stabilized zirconia, partially stabilized zirconia, zirconium oxide, aluminum nitride, silicon nitride, silicon carbide, and cerium oxide, and a conformal coating of a sintering aid film having a thickness of less than three nanometers and covering the core substrate, and methods for producing the ceramic particle.

公开(公告)号：US11717140B2

公开(公告)日：2023-08-08

申请号：US16573567

申请日：2019-09-17

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Joel Friedlander ,  Jeremy Prager ,  Emily Deboer ,  Robin Deterding

IPC: A61B1/00 ,  A61B1/233 ,  A61M21/00 ,  A61B5/0205 ,  A61B90/00 ,  A61B5/06 ,  A61B5/01 ,  A61B3/16 ,  A61B3/11 ,  A61B5/12 ,  A61B5/03 ,  A61B7/00 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/145 ,  G06F3/14 ,  A61B5/08 ,  A61B5/021 ,  A61B5/024

CPC classification number: A61B1/00097 ,  A61B1/233 ,  A61B3/111 ,  A61B3/112 ,  A61B3/16 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/03 ,  A61B5/062 ,  A61B5/064 ,  A61B5/126 ,  A61B5/14517 ,  A61B5/14552 ,  A61B5/442 ,  A61B5/6803 ,  A61B7/003 ,  A61B90/39 ,  G06F3/14 ,  A61B5/021 ,  A61B5/024 ,  A61B5/082 ,  A61B5/0816 ,  A61B2090/3945 ,  A61B2090/3954 ,  A61M2021/005 ,  A61M2021/0027

Abstract: A system having a scope with a longitudinal length extending between a proximal end and a distal end includes a plurality of markers spaced along the longitudinal length. The system also includes a disassociation and positioning device that is configured to enhance unsedated transnasal endoscopic procedures by at least partially occluding the vision of a patient while enabling body cavity access, and optionally record and sense body functions such as temperature, heart rate and oxygenation of the blood stream. The system further includes a sensor integrated into the distraction device, wherein the sensor is configured to detect the markers on the longitudinal length of the scope.

公开(公告)号：US20230233517A1

公开(公告)日：2023-07-27

申请号：US17852475

申请日：2022-06-29

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Ding Xue ,  Yu Peng ,  Man Zhang ,  Lingjun Zheng ,  Qian Liang ,  Hanzeng Li ,  Jau-Song Yu ,  Jeng-Ting Chen

IPC: A61K31/353 ,  A61K31/336 ,  A61K31/4025 ,  A61K31/7048

CPC classification number: A61K31/353 ,  A61K31/336 ,  A61K31/4025 ,  A61K31/7048

Abstract: The invention provides novel compositions and methods for the treatment of Radiation-Induced Bystander Effects (RIBE), resulting from radiation exposure. In one preferred embodiment the inventions includes novel therapeutic agents, including but not limited to quercetin and quercetin analogs, as well as E64, CA074, CA074Me, that interfere with the activity of Cathepsin B.

公开(公告)号：US11709132B2

公开(公告)日：2023-07-25

申请号：US16302911

申请日：2017-05-18

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Michael Tanksalvala ,  Daniel E. Adams ,  Dennis Gardner ,  Christina L. Porter ,  Giulia F. Mancini ,  Margaret M. Murnane ,  Henry C. Kapteyn

IPC: G01N21/47 ,  G01N21/956 ,  G01N21/45 ,  G01N21/33 ,  G01N21/17

CPC classification number: G01N21/4788 ,  G01N21/33 ,  G01N21/45 ,  G01N21/4795 ,  G01N21/956 ,  G01N2021/1782 ,  G01N2021/335 ,  G01N2021/4711 ,  G01N2201/061

Abstract: Apparatus and methods for forming an image of an object which involves focusing partially to fully spatially-coherent radiation onto a sample and collecting the resulting scattered radiation (the “standard data set”) on an array detector. In addition to the standard dataset, an additional measurement or plurality of measurements is made of a relatively-unscattered beam, using the array detector, which comprises the “modulus enforced probe (MEP) dataset”. This MEP dataset serves as an extra constraint, called the MEP constraint, in the phase retrieval algorithm used to reconstruct the image of the object.

公开(公告)号：US20230174614A1

公开(公告)日：2023-06-08

申请号：US17997575

申请日：2021-04-30

Applicant: Terry J FRY ,  The Regents of the University of Colorado, A Body Corporate

Inventor： Terry J. FRY

IPC: C07K14/705 ,  A61P35/02 ,  C12N15/63 ,  A61K35/17

CPC classification number: C07K14/70503 ,  A61P35/02 ,  C12N15/63 ,  A61K35/17

Abstract: The present disclosure provides multispecific chimeric antigen receptors (CARs) having antigenic specificity for FLT3 and CD19, FLT3 and CD22, FLT3 and CD123 or FLT3 and CD33. Nucleic acids, expression constructs, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the multispecific CARs are disclosed. Methods of treating or preventing ALL, AML and/or other forms of cancer in a mammal are also disclosed.

公开(公告)号：US20230132035A1

公开(公告)日：2023-04-27

申请号：US17962656

申请日：2022-10-10

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Hang Hubert Yin ,  Shuting Zhang ,  Zhenyi Hu

IPC: C07D401/04 ,  C07D215/20 ,  A61P19/02 ,  A61P37/06

Abstract: Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.

公开(公告)号：US20230129562A1

公开(公告)日：2023-04-27

申请号：US17959901

申请日：2022-10-04

Applicant: University of Maryland, College Park ,  The Regents of the University of Colorado, a body corporate ,  Government of the United States of America as Represented by the Secretary of Commerce

Inventor： Minh C. TRAN ,  Abhinav DESHPANDE ,  Andrew Y. GUO ,  Andrew LUCAS ,  Alexey GORSHKOV

IPC: G06N10/20

Abstract: A system for quantum state transfer and entanglement generation includes a quantum system including a plurality of qubits, a processor, and a memory. The memory includes instructions stored thereon, which, when executed by the processor, cause the quantum system to: access a signal of the quantum system; encode unknown coefficients in one qubit of the plurality of qubits; initialize each of the remaining qubits of the plurality of qubits in state |0; group the plurality of qubits into a plurality of subsystems; in each of the plurality of subsystems: encode quantum information into Greenberger-Horne-Zeilinger-like (GHZ-like) states using nearest-neighbor interactions; and apply a generalized controlled-phase gate between the plurality of subsystems to merge the GHZ-like states into an entangled state between of the plurality of subsystems.

公开(公告)号：US20230099219A1

公开(公告)日：2023-03-30

申请号：US18076195

申请日：2022-12-06

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Malik Y. Kahook

IPC: A61F9/007 ,  A61B17/3211 ,  A61B17/32

Abstract: A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade device can be used for cutting the trabecular meshwork (“TM”) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.2-0.3 mm width) and configuration where a ramp elevates the TM away from the outer wall of the Schlemm's canal and guides the TM to first and second lateral elements for creating first and second incisions through the TM. The dimensions and configuration of the blade is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.

公开(公告)号：US11602556B2

公开(公告)日：2023-03-14

申请号：US16451188

申请日：2019-06-25

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Aaron Michels ,  Peter A. Gottlieb

IPC: A61K38/28 ,  G01N33/50 ,  C07K14/62

Abstract: Methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that induces conversion of naive T cells into Foxp3+ regulatory T cells to induce immunosuppression in the subject. Methods for detecting in a subject an autoimmune disease or a predisposition to a autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease, particularly type 1 diabetes.