公开(公告)号：US09660523B2

公开(公告)日：2017-05-23

申请号：US15117201

申请日：2015-02-06

申请人： The Trustees of Dartmouth College

发明人： Jason T. Stauth ,  Kapil Kesarwani ,  Christopher Schaef

IPC分类号： H02M3/07 ,  H02J7/00 ,  H02M1/00

CPC分类号： H02M3/07 ,  H02J7/0014 ,  H02M2001/0058 ,  Y02B70/1491

摘要： A system and method allows for controlling a resonant switched-mode converter to provide a variable conversion ratio. The system and method operates to control the switching devices such that the impedance of the switched-mode converter is set to a plurality of configurations for a plurality of time intervals. The system and method may further include off-time modulation techniques for varying or maintaining the overall switching period of the switched-mode converter.

公开(公告)号：US20170119330A1

公开(公告)日：2017-05-04

申请号：US15402077

申请日：2017-01-09

申请人： The Trustees of Dartmouth College

发明人： Kenneth M. TICHAUER ,  Scott C. DAVIS ,  Brian William POGUE

IPC分类号： A61B6/00 ,  G06T7/00 ,  G06T5/50 ,  G06T3/40 ,  A61B5/055 ,  A61B6/03

CPC分类号： A61B6/481 ,  A61B5/055 ,  A61B6/032 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5235 ,  A61B6/5247 ,  G06T5/50 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/20224 ,  G06T2207/30024

摘要： An apparatus and method for medical imaging uses a first and second contrast agent, the second agent targeted to a particular tissue type. First images are obtained using the first agent, and second images using the second agent using medical imaging systems. An image processing system is adapted to process the first and second medical images by fitting parameters of a pharmacokinetic model to the first medical images, identifying a nontargeted tissue type, scaling the fitted parameters to best match the nontargeted tissue in the second medical images, executing the pharmacokinetic model to prepare a correction image, and generating corrected medical images by subtracting the correction image from the second medical images.

公开(公告)号：US20170067972A1

公开(公告)日：2017-03-09

申请号：US15309201

申请日：2015-05-06

申请人： The Trustees of Dartmouth College

发明人： Solomon G. Diamond ,  Bradley W. Ficko

IPC分类号： G01R33/12 ,  A61N1/40 ,  A61B5/05

CPC分类号： G01R33/1276 ,  A61B5/0515 ,  A61N1/403

摘要： A magnetic nanoparticle imaging system has driving coils driven at multiple frequencies, the driving coils positioned to provide magnetic fields and field gradients to an imaging zone, and a static bias field magnet positioned to provide a static magnetic field and/or field gradient to the imaging zone. Magnetic sensors are positioned to sense magnetic fields from the imaging zone, and a signal processor processes signals from the sensors to find at least signal magnitude and phase at harmonics and/or intermodulation products of the multiple frequencies. In embodiments, the signal processing apparatus also determines signal magnitudes and phase of at least second and third harmonics of the first frequency, and maps location of nanoparticles in the imaging zone based upon the magnitudes of harmonics and magnitudes of the intermodulation products.

摘要翻译： 磁性纳米颗粒成像系统具有以多个频率驱动的驱动线圈，驱动线圈定位成向成像区域提供磁场和场梯度，以及静态偏置磁场磁体，其定位成为成像提供静态磁场和/或场梯度 区。 磁传感器被定位成感测来自成像区域的磁场，并且信号处理器处理来自传感器的信号，以在多个频率的谐波和/或互调产物处至少找到信号幅度和相位。 在实施例中，信号处理设备还确定第一频率的至少第二和第三谐波的信号幅度和相位，并且基于互调产物的谐波和幅度的大小来映射纳米颗粒在成像区域中的位置。

公开(公告)号：US20170024983A1

公开(公告)日：2017-01-26

申请号：US15215083

申请日：2016-07-20

申请人： THE TRUSTEES OF DARTMOUTH COLLEGE

发明人： Jason Reeves ,  Sean Smith

IPC分类号： G08B13/02

CPC分类号： G08B13/02 ,  G08B21/182

摘要： A system and method are disclosed that use information from a distributed, sensor-based network to decide if unwanted tampering is occurring within a utility infrastructure and how to respond. The system and method receive data from sensors located in embedded devices on the edge of the network (i.e., edge devices) and process the data to identify the presence or absence of indicators. A factor graph is generated and. updated with the indicators, along with historical incident and user-defined data, and relationships between the sensors. Based upon the factor graph, the system and method determine what events are occurring at edge devices and decide whether the events are tamper events caused by unwanted tampering. Enforcement programs are used to appropriately mitigate the tamper events.

摘要翻译： 公开了一种系统和方法，其使用来自分布式基于传感器的网络的信息来确定在公用事业基础设施内是否发生不需要的篡改以及如何响应。 系统和方法从位于网络边缘的嵌入式设备（即边缘设备）的传感器接收数据，并处理数据以识别是否存在指示器。 生成因子图。 更新了指标，以及历史事件和用户定义的数据以及传感器之间的关系。 基于因子图，系统和方法确定边缘设备发生的事件，并确定事件是否是由不需要的篡改引起的篡改事件。 执行程序用于适当地减轻篡改事件。

公开(公告)号：US20160370446A1

公开(公告)日：2016-12-22

申请号：US15187389

申请日：2016-06-20

申请人： THE TRUSTEES OF DARTMOUTH COLLEGE

发明人： Sergey V. Petryakov ,  Wilson A. Schreiber ,  Harold M. Swartz ,  Benjamin B. Williams

IPC分类号： G01R33/60 ,  A61B5/00 ,  A61B5/055 ,  G01R33/36

CPC分类号： G01R33/60 ,  A61B5/055 ,  A61B5/4547 ,  G01R33/34007 ,  G01R33/341 ,  G01R33/3628 ,  G01R33/3642 ,  G01R33/3685 ,  G01R33/3802

摘要： An apparatus and method for triaging patients according to radiation exposure operates by measuring electron paramagnetic resonance spectra of teeth. When operating in vivo, radiation induced spectra are obtained from intact teeth placed within a magnetic field and with a resonator having a loop and two capacitors formed in metal layers on a printed circuit substrate and located near teeth. The resonator is magnetically coupled to an RF measuring system. The spectra are used to determine radiation dose of a subject. The characteristics of the method and the apparatus make it feasible to utilize the system to measure radiation dose using previously untrained operators working in the field under emergency conditions.

摘要翻译： 根据辐射暴露对患者进行分类的装置和方法通过测量牙齿的电子顺磁共振光谱进行操作。 当在体内操作时，辐射诱导的光谱从放置在磁场内的完整的牙齿获得，并且具有环路的谐振器和形成在印刷电路基板上并位于牙齿附近的金属层中的两个电容器。 谐振器磁耦合到RF测量系统。 光谱用于确定受试者的辐射剂量。 该方法和设备的特点使得利用该系统可以在紧急情况下使用在现场工作的先前未经训练的操作者来测量辐射剂量。

公开(公告)号：US09482736B1

公开(公告)日：2016-11-01

申请号：US14703989

申请日：2015-05-05

申请人： The Trustees of Dartmouth College

发明人： Laura Ray ,  Teresa Ou ,  Carsten Schafer ,  Alaa Abdeen ,  Harrison Hall

IPC分类号： G01S3/80 ,  G01S3/808

CPC分类号： G01S3/808

摘要： A system and device phase-aligns and sums signals from a very large array of sensors, such as microphones or ultrasonic transducers, without prior knowledge of time delays of signals reaching each sensor, so as to accommodate effects of reverberant fields or acoustic or ultrasonic media containing multiple reflectors or scatterers and/or having heterogeneous, unknown acoustic properties.

摘要翻译： 系统和设备将来自诸如麦克风或超声换能器之类的非常大的传感器阵列的信号相互对准和加和，而无需事先知道到达每个传感器的信号的时间延迟，以便适应混响场或声或超声波介质的影响 包含多个反射器或散射体和/或具有异质，未知的声学特性。

公开(公告)号：US20160278678A1

公开(公告)日：2016-09-29

申请号：US15044097

申请日：2016-02-15

申请人： The Trustees of Dartmouth College

发明人： Pablo Valdes ,  Frederic Leblone ,  Keith D. Paulsen ,  Brian Campbell Wilson ,  David W. Roberts ,  Michael Jermyn

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B1/04 ,  A61B5/055 ,  A61B5/1495 ,  A61B1/06 ,  A61B1/00 ,  A61B5/1459 ,  A61B5/145

CPC分类号： A61B5/14556 ,  A61B1/00009 ,  A61B1/00165 ,  A61B1/00193 ,  A61B1/042 ,  A61B1/043 ,  A61B1/05 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/0684 ,  A61B1/07 ,  A61B1/3132 ,  A61B5/0071 ,  A61B5/0077 ,  A61B5/055 ,  A61B5/14546 ,  A61B5/14553 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/4836 ,  A61B5/7264 ,  G01J3/0229 ,  G01J3/1256 ,  G01J3/2823 ,  G01J2003/1269 ,  G01J2003/2826

摘要： An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared. The images are displayed to a surgeon for use in surgery.

摘要翻译： 诸如手术显微镜，腹腔镜或内窥镜或与这些装置集成的成像系统包括提供图案化的白光和/或荧光激发光的照明器。 在使用高光谱成像阵列的实施例中，系统接收并高光图像光，并且/或使用窄带可调滤波器将滤波的接收光传递到成像器。 实施例可以从立体图像构造3-D表面模型，并且将使用在图案化光线中拍摄的图像或使用从白光曝光获得的其它近似来估计目标的光学性质。 在激发光下拍摄的高光谱图像显示为荧光图像，并对组织的光学性质进行校正，以提供荧光团浓度的定量图谱。 处理来自高光谱图像的光谱信息，以提供组织表面下方的荧光团的深度。 还准备了深度荧光的定量图像。 图像显示给外科医生用于手术。

公开(公告)号：US20160263402A1

公开(公告)日：2016-09-15

申请号：US15160576

申请日：2016-05-20

申请人： THE TRUSTEES OF DARTMOUTH COLLEGE

发明人： Rongxiao Zhang ,  Brian William Pogue ,  Adam K. Glaser ,  David J. Gladstone ,  Lesley A. Jarvis ,  Jacqueline M. Andreozzi ,  Shudong Jiang ,  Scott Christian Davis ,  Johan Jakob Axelsson

IPC分类号： A61N5/10

CPC分类号： A61N5/1071 ,  A61N5/1049 ,  A61N5/1065 ,  A61N5/1077 ,  A61N2005/1054 ,  A61N2005/1059

摘要： A monitor for pulsed high energy radiation therapy using a radiation beam passing through a treatment zone, the radiation of 0.2 MEV or greater; has a camera for imaging Cherenkov light from the treatment zone; apparatus for preventing interference by room lighting, the camera synchronized to pulses of the radiation beam; and an image processor adapted to determine extent of the beam area on the patient skin from the images. Additionally an image processor determines cumulative skin dose in the treatment zone from the images. In embodiments, the processor uses a three-dimensional model of a subject to determine mapping of image intensity in images of Cherenkov light to radiation intensity in skin, applies the mapping to images of Cherenkov light to verify skin dose delivered, and accumulates skin dose by summing the maps of skin dose.

摘要翻译： 使用穿过治疗区域的辐射束进行脉冲高能量放射治疗的监测仪，0.2MEV或更大的辐射; 有一个摄像头，用于对来自治疗区的切伦科夫灯进行成像; 用于防止室内照明干扰的装置，照相机与辐射束的脉冲同步; 以及图像处理器，适于从图像确定患者皮肤上的束区域的范围。 此外，图像处理器从图像确定处理区域中的累积皮肤剂量。 在实施例中，处理器使用对象的三维模型来确定切伦科夫光图像中的图像强度与皮肤中的辐射强度的映射，将切布伦科夫光图像应用于图像以验证皮肤剂量递送，并且通过 总结皮肤剂量图。

公开(公告)号：US20160251379A1

公开(公告)日：2016-09-01

申请号：US15056580

申请日：2016-02-29

申请人： The Trustees of Dartmouth College

发明人： Ivan Abrahamian ,  Russel P. Hughes ,  Yin Yang

IPC分类号： C07F5/02 ,  A61N5/06

CPC分类号： C07F5/022 ,  A61N5/062 ,  A61N2005/066 ,  A61N2005/0662 ,  C07F5/02

摘要： Provided herein are photochromic organic compounds of Formula I or Formula II, which are useful as molecular switches capable of being triggered via a cis/trans isomerization process. Methods of using the molecular switch compounds to form photopharmaceutical compounds that may be used to provide selective spatiotemporal activation of pharmaceutical agents are also disclosed.

摘要翻译： 本文提供了式I或式II的光致变色有机化合物，其可用作能够通过顺式/反式异构化方法触发的分子开关。 还公开了使用分子开关化合物形成可用于提供药物的选择性时空激活的光药物化合物的方法。

公开(公告)号：US20160168248A1

公开(公告)日：2016-06-16

申请号：US14940940

申请日：2015-11-13

申请人： The Trustees of Dartmouth College

发明人： Randolph J. NOELLE ,  Li Wang

IPC分类号： C07K16/28

CPC分类号： C07K16/2827 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/70596 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/505 ,  Y02A50/412 ,  Y02A50/423

摘要： The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon αCD3/αGITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis is disclosed

摘要翻译： 本发明涉及新型调节性T细胞蛋白。 称为PD-L3的一种蛋白质类似于PD-L1家族的成员，并且在体外共同刺激T细胞的αCD3增殖。 第二种TNF样蛋白也被鉴定为在αCD3/αGITR刺激下上调。 该蛋白质已被命名为Treg-sTNF。 公开了蛋白质，抗体，活化的T细胞和使用它们的方法。 特别是使用这些蛋白质和化合物（优选抗体）的方法，其结合或调节（激动或拮抗）这些蛋白质的活性，作为免疫调节剂和用于治疗癌症，自身免疫疾病，变态反应，感染和炎性病症，例如， 公开了多发性硬化