公开(公告)号：US20150338376A1

公开(公告)日：2015-11-26

申请号：US14646816

申请日：2013-11-19

Applicant: UNIVERSITEIT TWENTE

Inventor： Sebastiaan WAANDERS ,  Martijn VISSCHER ,  Tasio Olmo Borendissi ODERKERK ,  Hendrikus Johannes Gradus KROOSHOOP ,  Bernard HAKEN

IPC: G01N27/72 ,  G01R33/16

CPC classification number: G01N27/72 ,  G01N27/76 ,  G01R33/0017 ,  G01R33/16

Abstract: Method and apparatus for measuring an amount of superparamagnetic material in an object, the method including a) applying a magnetic field having a first component alternating with a first period to the object and a magnetic field strength lower than a magnetic field strength at which the superparamagnetic material is driven in saturation; b) measuring a first magnetic susceptibility of the object with a detection coil; c) applying a static second component to the magnetic field for a second period being equal or larger than the first period, the strength of the magnetic field during the second period is such that the superparamagnetic material is driven towards saturation; d) measuring a second magnetic susceptibility of the object with the detection coil during the application of the static second component; and e) determining the amount of superparamagnetic material from a difference between the measured first and second susceptibility of the object.

Abstract translation: 用于测量物体中的超顺磁性材料的量的方法和装置，该方法包括：a）将具有与第一周期交替的第一分量的磁场施加到物体，并且磁场强度低于磁场强度，其中超顺磁性 材料驱动饱和; b）用检测线圈测量物体的第一磁化率; c）在等于或大于第一周期的第二周期中将静态第二分量施加到磁场，第二周期期间的磁场强度使得超顺磁材料被驱动朝向饱和; d）在施加静态第二部件期间用检测线圈测量物体的第二磁化率; 以及e）根据测量的第一和第二敏感性之间的差异确定超顺磁性材料的量。

公开(公告)号：US20150306560A1

公开(公告)日：2015-10-29

申请号：US14431524

申请日：2013-09-24

Applicant: TECHNISCHE UNIVERSITEIT TWENTE ,  STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK

Inventor： Erhan BAT ,  Pascal JONKHEIJM ,  Jurriaan HÜSKENS

IPC: B01J19/00 ,  B05D1/18

CPC classification number: B01J19/0046 ,  B01J2219/00382 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00619 ,  B01J2219/00659 ,  B05D1/18 ,  C40B60/14

Abstract: A stamp for making a microarray of biomolecules, wherein the stamp has a stamp body having a stamping surface for stamping the biomolecules onto a substrate, a plurality of reservoirs for liquids having the biomolecules, wherein each of the reservoirs has a bottom wall and a plurality of channels extending between each of the bottom wall and the stamping surface, wherein each of the reservoirs and the channels has a macroporous hydrogel and wherein the stamping surface is provided with a hydrophobic coating.

Abstract translation: 一种用于制造生物分子微阵列的印模，其中所述印模具有印模体，所述印模体具有用于将所述生物分子冲压到基底上的冲压表面，用于具有所述生物分子的液体的多个储存器，其中每个所述储存器具有底壁和多个 在每个底壁和冲压表面之间延伸的通道，其中每个储存器和通道具有大孔水凝胶，并且其中冲压表面设置有疏水涂层。

公开(公告)号：US20150158724A1

公开(公告)日：2015-06-11

申请号：US14570652

申请日：2014-12-15

Applicant: Universiteit Twente

Inventor： Johan Willem Berenschot ,  Niels Roelof Tas

IPC: B81C1/00 ,  G01Q70/16

CPC classification number: B81C1/00111 ,  B33Y10/00 ,  B33Y80/00 ,  B81C2201/034 ,  B82Y35/00 ,  G01Q70/10 ,  G01Q70/16 ,  Y10T428/2913 ,  Y10T428/2982

Abstract: The invention relates to a method for making a 3D nanostructure having a nanosubstructure, comprising the steps of: i) providing a mold comprising at least one sharp concave corner; ii) conformational depositing at least one structural material in the sharp concave corner; iii) isotropically removing structural material; iv) depositing at least one other structural material; v) removing earlier deposited structural material; vi) forming a nanosubstructure; and vii) removing the mold thereby providing the 3D nanostructure having the nanosubstructure.

Abstract translation: 本发明涉及一种制备具有纳米级结构的3D纳米结构的方法，包括以下步骤：i）提供包括至少一个锐角凹入角的模具; ii）在锋利的凹角中构造沉积至少一种结构材料; iii）各向同性地除去结构材料; iv）沉积至少一种其他结构材料; v）清除较早沉积的结构材料; vi）形成纳米结构; 和vii）去除模具，从而提供具有纳米结构的3D纳米结构。

公开(公告)号：US12196827B2

公开(公告)日：2025-01-14

申请号：US18000514

申请日：2021-06-02

Applicant: Universiteit Twente

Inventor： Melissa Mathilde van de Loosdrecht ,  Hendrikus Johannes Gradus Krooshoop ,  Bernard ten Haken ,  Lejla Alic

IPC: G01R33/12 ,  A61B5/06

Abstract: The invention relates to a method and apparatus for detecting superparamagnetic material. The method comprises applying, by an excitation coil, a magnetic field during a first period to an object to modulate a magnetization of the superparamagnetic material, the magnetic field comprising a first component with a first frequency; positioning a sensing device at a first position from the excitation coil receiving a first signal by a first detection sub-coil in the sensing device and a second signal by a second detection-sub-coil in the sensing device; determining a sensor signal from the first signal and the second signal; determining a detection signal based on the sensor signal; determining a parameter indicating an amount of superparamagnetic material by dividing the detection signal by the first signal, and repeating steps to at at least one different position in order to determine a location where the parameter has a maximal value.

公开(公告)号：US20240425997A1

公开(公告)日：2024-12-26

申请号：US18749040

申请日：2024-06-20

Applicant: KETEK GmbH Halbleiter- und Reinraumtechnik ,  Universiteit Twente

Inventor： Michael Bachmann ,  Simon Edler ,  Dirk Jonker ,  J.G.E. Gardeniers

IPC: C25B9/15 ,  C25B3/26 ,  C25B11/043 ,  C25B15/021 ,  C25B15/025 ,  C25B15/08

Abstract: In an embodiment a reactor includes an electron source having a first gate-insulator-substrate electron-emission structure (GIS-EE) and configured to inject electrons into a fluid and a transportation system for the fluid configured to adjust a velocity of the fluid when passing the electron source, wherein the electron source is configured to provide the electrons to be injected into the fluid in an interior of the electron source and distant from the fluid, wherein the injected electrons are to initiate at least one chemical reaction in the fluid, wherein, when reaching the fluid, at least part of the injected electrons has a kinetic energy of at most 50 eV, wherein the electrons are propagatable only in solid matter from the interior until emission into the fluid, and wherein the GIS-EE includes an electrically conductive substrate, a transfer layer of a material with a band gap of at least 4 eV on the substrate, a gate electrode of a further electrically conductive material directly on the transfer layer, a first electrical connection structure on the substrate, and a second electrical connection structure on the gate electrode.

公开(公告)号：US12156938B2

公开(公告)日：2024-12-03

申请号：US16982990

申请日：2019-03-20

Applicant: Universiteit Twente

Inventor： Jai Prakash ,  Peter Van Hoogevest ,  Gerrit Storm

IPC: A61K9/127 ,  A61K38/05 ,  A61K38/21 ,  A61K47/40

Abstract: A composition comprising a liposome comprising a first phospholipid comprising a C14-C19:0 fatty acid and a C3-C15:0 fatty acid with a c-terminal carboxyl or a carboxaldehyde group; a second phospholipid comprising a C14-C19:0 fatty acid and a C14-C19:0 fatty acid and a sterol. The first phospholipid is preferably a phosphatidylcholine. The second phospholipid is preferably HSPC and the sterol is preferably cholesterol. In some embodiments, the molar ratio of the respective ingredients is 2-3:5-6:2-3; preferably 2:6:2; or 3:5:2, respectively. The invention also relates to the use of this composition in the targeting of M2 macrophages.

公开(公告)号：US11937909B2

公开(公告)日：2024-03-26

申请号：US15521918

申请日：2015-10-27

Applicant: Stichting Het Nederlands Kanker Instituut-Antoni Van Leeuwenhoek Ziekenhuis ,  Universiteit Twente

Inventor： Theodoor Jacques Marie Ruers ,  Bram Schermers ,  Bennie Ten Haken

IPC: A61B5/06 ,  A61B5/05 ,  A61B10/02 ,  A61B90/00 ,  A61M37/00 ,  G01N27/72 ,  G01R33/02

CPC classification number: A61B5/062 ,  A61B5/05 ,  A61B10/02 ,  A61B90/39 ,  A61M37/0069 ,  G01N27/72 ,  G01R33/02 ,  A61B2090/3908 ,  A61B2090/3954 ,  A61B2090/3987

Abstract: A magnetic marker for use in locating tissue for surgery includes a casing and two to five magnetic elements arranged in a row. The two or more magnetic elements are separated from each other by an isolating material. The magnetic marker may be non-bio-absorbable. This means that the magnetic marker is invariable as it does not decay over time. This invariability ensures that on the basis of the signal measured by a magnetometer device a distance between a probe of the magnetometer device and the magnetic marker can be determined.

公开(公告)号：US20240033998A1

公开(公告)日：2024-02-01

申请号：US18022779

申请日：2021-08-27

Applicant: Patrick Neuvel ,  Universiteit Twente

Inventor： Stefano Stramigioli ,  Alexander Dijkshoorn ,  Gijsbertus Jacobus Maria Krijnen ,  Patrick Neuvel

IPC: B29C64/393 ,  B22F10/85 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/02

CPC classification number: B29C64/393 ,  B22F10/85 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/02 ,  B29K2995/0005

Abstract: A system for additive manufacturing of a product from an electrically conductive depositable material. The system comprises a support element, a material addition system, and two electrodes. The support element supports the product, wherein the two electrodes comprise electrodes configured at a surface of the support element. The material addition system deposits the material at one or more of (i) the support element and (ii) deposited material, thereby forming the product. Any one of the electrodes is configured for (i) electrically contacting the material being deposited or (ii) electrically contacting the deposited material, during depositing of the material. (i) the material is deposited with a portion of the deposited material and arranged between the electrode and another one of the electrodes to define an electrically conductive path. Alternatively, (ii) a portion of the deposited material is arranged between the electrode and another one of the electrodes to define the electrically conductive path.

公开(公告)号：US20240025965A1

公开(公告)日：2024-01-25

申请号：US18295068

申请日：2023-04-03

Applicant: Jai Prakash ,  Universiteit Twente

Inventor： Jai Prakash

IPC: C07K14/705 ,  A61K49/00 ,  C07K14/78 ,  C07K7/08 ,  C07K7/06 ,  A61K47/62 ,  A61K47/60 ,  A61P1/16

CPC classification number: C07K14/70546 ,  A61K49/0045 ,  C07K14/78 ,  C07K7/08 ,  C07K7/06 ,  A61K47/62 ,  A61K47/60 ,  A61P1/16 ,  A61K49/0056 ,  A61K38/00

Abstract: The disclosure relates to integrin binding peptides, pharmaceutical compositions comprising the peptides and to uses thereof as therapeutic, diagnostic, imaging and targeting agents.

公开(公告)号：US20230363666A1

公开(公告)日：2023-11-16

申请号：US18028998

申请日：2021-09-27

Applicant: UNIVERSITEIT TWENTE

Inventor： Rob HAGMEIJER ,  Rutger Hendrik Johan HEBBINK

IPC: A61B5/087 ,  A61B5/091

CPC classification number: A61B5/087 ,  A61B5/091 ,  A61B2562/0247 ,  A61B5/742

Abstract: A method for determining a scaled respiratory flow rate and volume during respiration of a patient includes a) successively determining a plurality of values for a difference between a pressure in at least a first location in an upper respiratory tract of the patient and a reference pressure, b) deriving the scaled respiratory flow rate from the plurality of values for the pressure difference by using a first relationship, c) deriving the scaled respiratory volume from the plurality of values for the pressure difference by using a second relationship, and d) displaying the scaled respiratory flow rate derived in step b) and the scaled respiratory volume derived in step c) or a further variable derived from the scaled respiratory flow rate and volume in a graphical representation. Step a) is performed during tidal breathing of the patient. A system for performing the aforementioned method.