Abstract:
The present disclosure provides methods of treating a disease or delivering a therapeutic agent to a mammal comprising administering to the mammal's cisterna magna and/or ventricle an rAAV particle containing a vector comprising a nucleic acid encoding a therapeutic protein inserted between a pair of AAV inverted terminal repeats in a manner such that cells with access to the cerebrospinal fluid (CSF) express the therapeutic agent and in certain embodiments secretes the therapeutic agent into the CSF for distribution to the brain.
Abstract:
An electronic apparatus includes a body and a display panel installed at a front side of the body to display an image. The body includes a first member to form a portion of the body and allowing the display panel to be installed thereon, and a second member to form a remaining portion of the body and rotatably installed at the first member. As the second member serves as a support, the electronic apparatus may be disposed in a second mode for a user to conveniently use the electronic apparatus.
Abstract:
A red, green, and blue (RGB) primary generation system and method for a wide color gamut, and a color encoding system using the RGB primaries. The RGB primary generation system may achieve a wide color gamut by generating a color gamut having a gamut coverage which meets a gamut coverage threshold, meeting a unique hue, having a maximum gamut efficiency, and a minimum quantization error.
Abstract:
An inverter executing a PWM routine is configured to synchronize the switching periods of the PWM routine to an external signal. The external signal is generated, for example, by another inverter, a converter, or a high level controller. The external signal is preferably generated periodically, and the switching period is resynchronized to the external signal each time the external signal is received. Optionally, either the start time or the midpoint of the switching period may be aligned with external signal. Further, the external signal may be sent to multiple inverters. Preferably, a first portion of the inverters align the start time of their respective switching period to the external signal and a second portion of the inverters align the midpoint of their respective switching period to the external signal.
Abstract:
A thin film transistor array panel includes a gate line, a gate insulating layer that covers the gate line, a semiconductor layer that is disposed on the gate insulating layer, a data line and drain electrode that are disposed on the semiconductor layer, a passivation layer that covers the data line and drain electrode and has a contact hole that exposes a portion of the drain electrode, and a pixel electrode that is electrically connected to the drain electrode through the contact hole. The data line and drain electrode each have a double layer that includes a lower layer of titanium and an upper layer of copper, and the lower layer is wider than the upper layer, and the lower layer has a region that is exposed. The gate insulating layer may have a step shape.
Abstract:
The washing machine includes a rotating tub arranged to be rotatable about a shaft. A first mass member is mounted to the rotating tub so as not to be moved relative to the rotating tub in a circumferential direction of the rotating tub. The first mass member serves to apply load imbalance to the rotating tub upon rotation of the rotating tub. Also, a second mass member is arranged to be movable in the circumferential direction of the rotating tub. The second mass member serves to compensate for load imbalance of the rotating tub upon rotation of the rotating tub.
Abstract:
An electro-hydro valve lift system may include a drive cam, a pump piston, a first and a second EHV apparatus, a first oil control valve, a first oil control hydraulic line fluid-communicating the main chamber with the first oil control valve, a second oil control hydraulic line fluid-communicating the first oil control valve with the first EHV apparatus, a third oil control hydraulic line fluid-communicating the main chamber with the second EHV apparatus, a fourth oil control hydraulic line selectively fluid-communicated with the second oil control hydraulic line according to the first oil control valve, an accumulator fluid-communicated with the fourth oil control hydraulic line, and a second oil control valve disposed on the fourth oil control hydraulic line, wherein the fourth oil control hydraulic line is fluid-communicated with the third oil control hydraulic line according to the second oil control valve.
Abstract:
Provided is an interface apparatus. The interface apparatus comprises a signal synthesizer, a connector, and a signal separator. The signal synthesizer outputs at least one of display signals, display control signals, and chip control signals. The connector includes a transmission line connected with the signal synthesizer and through which the display signals and the chip control signals are transmitted in common, and a transmission line through which the display control signals are transmitted. The signal separator separates the display signals and chip control signals from the signals transmitted through the transmission line through which the display signals and the chip control signals are transmitted in common.
Abstract:
A die attach apparatus includes a stage, a collet member that is movable to apply load to the stage, a load measuring member that is arranged between the collet member and the stage and that measures load between the collet member and the stage, the load measuring member is divided into a plurality of loading measuring regions and the plurality of load measuring regions measure loads within the plurality of load measuring regions, respectively, and a controller member that determines whether the collet member is in a tilted state or a non-tilted state based on the loads measured within the plurality of load measuring regions by the load measuring member.
Abstract:
The invention provides a nitride semiconductor light emitting device. In the invention, a first conductivity-type nitride semiconductor layer is formed on a conductive substrate having light transmissibility. An active layer is formed on the first conductivity-type nitride semiconductor layer. Also, a second conductivity-type nitride semiconductor layer is formed on the active layer. Further, a conductive light scattering layer made of a conductive material is formed on an underside of the substrate. The conductive light scattering layer has light transmissibility of 70% or more and has a rough pattern formed on an outer surface to scatter light.