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公开(公告)号：US10107997B2
公开(公告)日：2018-10-23
申请号：US15943595
申请日：2018-04-02
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
IPC: G01N15/10 , G01N15/14 , G01N33/80 , G02B21/00 , G02B21/36 , C12M1/34 , G01T1/02 , G06T7/00 , G06K9/00 , G01N11/00 , G01B9/02 , G03H1/00 , G03H1/04 , G01N15/00
Abstract: Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject. The method also comprises automatically differentiating cells of different types in the image, generating a count of one or more cell types based on the automatic differentiation, and deriving a radiation dose the subject has absorbed based on the count.
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公开(公告)号：US09910254B2
公开(公告)日：2018-03-06
申请号：US14572164
申请日：2014-12-16
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
IPC: G02B21/00 , G01N15/14 , G01N15/00 , G02B21/36 , G06K9/00 , G01N33/80 , G01T1/02 , G01N15/10 , G06T7/00 , G01B9/02 , G03H1/04 , G01N11/00 , G03H1/00 , C12M1/34
CPC classification number: G02B21/0008 , C12M41/36 , G01B9/02041 , G01N15/1429 , G01N15/1434 , G01N15/1463 , G01N15/1475 , G01N33/80 , G01N2011/008 , G01N2015/0069 , G01N2015/1006 , G01N2015/1486 , G01N2015/149 , G01T1/02 , G02B21/00 , G02B21/0004 , G02B21/361 , G02B21/365 , G03H2001/005 , G03H2001/045 , G06K9/00127 , G06K9/00147 , G06T7/0012 , G06T2207/10056 , G06T2207/30242 , Y10S435/808
Abstract: Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject. The method also comprises automatically differentiating cells of different types in the image, generating a count of one or more cell types based on the automatic differentiation, and deriving a radiation dose the subject has absorbed based on the count.
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公开(公告)号：US20170285059A1
公开(公告)日：2017-10-05
申请号：US15627866
申请日：2017-06-20
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
CPC classification number: G02B21/0008 , C12M41/36 , G01B9/02041 , G01N15/1429 , G01N15/1434 , G01N15/1463 , G01N15/1475 , G01N33/80 , G01N2011/008 , G01N2015/0069 , G01N2015/1006 , G01N2015/1486 , G01N2015/149 , G01T1/02 , G02B21/00 , G02B21/0004 , G02B21/361 , G02B21/365 , G03H2001/005 , G03H2001/045 , G06K9/00127 , G06K9/00147 , G06T7/0012 , G06T2207/10056 , G06T2207/30242 , Y10S435/808
Abstract: Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject. The method also comprises automatically differentiating cells of different types in the image, generating a count of one or more cell types based on the automatic differentiation, and deriving a radiation dose the subject has absorbed based on the count.
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公开(公告)号：US20160356999A1
公开(公告)日：2016-12-08
申请号：US14572164
申请日：2014-12-16
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
CPC classification number: G02B21/0008 , C12M41/36 , G01B9/02041 , G01N15/1429 , G01N15/1434 , G01N15/1463 , G01N15/1475 , G01N33/80 , G01N2011/008 , G01N2015/0069 , G01N2015/1006 , G01N2015/1486 , G01N2015/149 , G01T1/02 , G02B21/00 , G02B21/0004 , G02B21/361 , G02B21/365 , G03H2001/005 , G03H2001/045 , G06K9/00127 , G06K9/00147 , G06T7/0012 , G06T2207/10056 , G06T2207/30242 , Y10S435/808
Abstract: Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject. The method also comprises automatically differentiating cells of different types in the image, generating a count of one or more cell types based on the automatic differentiation, and deriving a radiation dose the subject has absorbed based on the count.
Abstract translation: 除其他之外，一种方法包括成像在传感器表面和显微镜样品室的表面之间移动的样品，以产生至少一部分样品的图像。 该图像使用无镜片光学显微镜制作，并且该样品至少含有来自受试者的血液。 该方法还包括在图像中自动区分不同类型的细胞，基于自动分化产生一个或多个细胞类型的计数，并且基于计数导出受试者吸收的辐射剂量。
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公开(公告)号：US12241893B2
公开(公告)日：2025-03-04
申请号：US18674179
申请日：2024-05-24
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
IPC: G01N33/543 , G01N21/41 , G01N21/55 , G01N21/59 , G01N33/569 , G01N21/17
Abstract: A method includes attaching two or more beads to each unit of one or more units of a chemical component in a sample, to form, for each unit of the chemical component, a multi-bead complex including two or more beads and the unit of the chemical component; placing the sample on a surface of an image sensor; at the image sensor, receiving light originating at a light source, the received light including light reflected by, refracted by, or transmitted through the beads of the multi-bead complexes; at the image sensor, capturing one or more images of the sample from the received light; and identifying, in at least one of the images of the sample, separate multi-bead complexes, the identifying of the separate multi-bead complexes including associating the two or more beads of each of the multi-bead complexes based on proximity to one another.
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Patent Agency Ranking
公开(公告)号：US20250016288A1
公开(公告)日：2025-01-09
申请号：US18662064
申请日：2024-05-13
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Hershel Macaulay , Laurent Kreplak
Abstract: An imaging device includes light sensitive locations that are separately sensitive to light received at a surface with respect to a portion of a sample associated with the surface, the light sensitive locations having a resolution of 5 microns or smaller. There is a device to associate the portion of the sample with the surface. The imaging device and a distance of the portion of the sample to the light sensitive locations are such that usable useful image of the portion of the sample can be acquired directly by operation of the imaging device.
An imaging device includes light sensitive sources that are separately able to deliver light with respect to a portion of a sample associated with the surface. The light source locations having a resolution of 5 microns or smaller. There is a device to associate the portion of the sample with the surface. The imaging device and a distance of the portion of the sample to the light source locations are such that a useful image of the portion of the sample can be acquired directly by operation of the imaging device.
An imaging device can include both the light source locations and the light source locations and the light sensitive locations.-
公开(公告)号：US20240385212A1
公开(公告)日：2024-11-21
申请号：US18666013
申请日：2024-05-16
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.
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公开(公告)号：US12123868B2
公开(公告)日：2024-10-22
申请号：US18167557
申请日：2023-02-10
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
IPC: G01N33/53 , G01N21/77 , G01N33/50 , G01N33/536 , G01N33/543 , G01N33/58
CPC classification number: G01N33/5302 , G01N21/77 , G01N33/5094 , G01N33/536 , G01N33/543 , G01N33/54313 , G01N33/582 , G01N33/585
Abstract: An indicator of a first type and an indicator of a second type are attached to a unit of a chemical component in a sample to form a first multi-indicator complex. The first multi-indicator complex includes the unit of the chemical component, the indicator of the first type, and the indicator of the second type. The indicator of the first type and the indicator of the second type have different discernible characteristics. An image of the sample, including the first multi-indicator complex corresponding to the unit of the chemical component, is captured by an image sensor. Based on a first image of the sample, a count is generated of multi-indicator complexes that include an indicator of the first type and an indicator of the second type, including the first multi-indicator complex. Based on the count, a presence or a level of the chemical component in the sample is identified.
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公开(公告)号：US12022236B2
公开(公告)日：2024-06-25
申请号：US17981228
申请日：2022-11-04
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Hershel Macaulay , Laurent Kreplak
CPC classification number: H04N7/18 , G02B21/0008 , B01L3/502761 , B01L2200/027
Abstract: An imaging device includes light sensitive locations that are separately sensitive to light received at a surface with respect to a portion of a sample associated with the surface, the light sensitive locations having a resolution of 5 microns or smaller. There is a device to associate the portion of the sample with the surface. The imaging device and a distance of the portion of the sample to the light sensitive locations are such that usable useful image of the portion of the sample can be acquired directly by operation of the imaging device.
An imaging device includes light sensitive sources that are separately able to deliver light with respect to a portion of a sample associated with the surface. The light source locations having a resolution of 5 microns or smaller. There is a device to associate the portion of the sample with the surface. The imaging device and a distance of the portion of the sample to the light source locations are such that a useful image of the portion of the sample can be acquired directly by operation of the imaging device.
An imaging device can include both the light source locations and the light source locations and the light sensitive locations.-
公开(公告)号：US20230184778A1
公开(公告)日：2023-06-15
申请号：US18167557
申请日：2023-02-10
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
IPC: G01N33/58 , G01N33/543 , G01N33/50 , G01N21/77 , G01N33/53 , G01N33/536
CPC classification number: G01N33/582 , G01N33/54313 , G01N33/5094 , G01N21/77 , G01N33/5302 , G01N33/543 , G01N33/585 , G01N33/536
Abstract: An indicator of a first type and an indicator of a second type are attached to a unit of a chemical component in a sample to form a first multi-indicator complex. The first multi-indicator complex includes the unit of the chemical component, the indicator of the first type, and the indicator of the second type. The indicator of the first type and the indicator of the second type have different discernible characteristics. An image of the sample, including the first multi-indicator complex corresponding to the unit of the chemical component, is captured by an image sensor. Based on a first image of the sample, a count is generated of multi-indicator complexes that include an indicator of the first type and an indicator of the second type, including the first multi-indicator complex. Based on the count, a presence or a level of the chemical component in the sample is identified.
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