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    EXTERNAL CARDIAC STIMULATION PATCH
    61.
    发明申请
    EXTERNAL CARDIAC STIMULATION PATCH 审中-公开
    外部心脏刺激贴

    公开(公告)号：US20100249860A1

    公开(公告)日：2010-09-30

    申请号：US12720246

    申请日：2010-03-09

    申请人： Allan C. Shuros ,  Eric A. Mokelke ,  James A. Esler

    发明人： Allan C. Shuros ,  Eric A. Mokelke ,  James A. Esler

    IPC分类号： A61N1/365 ,  A61N1/39

    CPC分类号： A61N1/3625 ,  A61N1/3627 ,  A61N1/37247 ,  A61N1/3925 ,  A61N1/3968 ,  A61N1/3993

    摘要： An external cardiac stimulation patch integrates a transcutaneous cardiac stimulation device and body-surface electrodes with a skin patch. The skin patch is to be attached onto a patient to provide for electrical contacts between the body-surface electrodes and a patient. The transcutaneous cardiac stimulation device delivers pacing pulses to the heart of the patient through pacing electrodes selected from the body-surface electrodes.

    摘要翻译： 外部心脏刺激贴片将经皮心脏刺激装置和体表电极与皮肤贴片集成。 将皮肤贴片贴在患者身上，以提供身体表面电极与患者之间的电接触。 经皮心脏刺激装置通过选自身体表面电极的起搏电极将起搏脉冲提供给患者的心脏。

    HEMODYNAMIC MORPHOLOGICAL ANALYSIS FOR RHYTHM IDENTIFICATION
    63.
    发明申请
    HEMODYNAMIC MORPHOLOGICAL ANALYSIS FOR RHYTHM IDENTIFICATION 审中-公开
    用于RHYTHM识别的HEMODYMM MORPHOLOGICAL ANALYSIS

    公开(公告)号：US20090264716A1

    公开(公告)日：2009-10-22

    申请号：US12425193

    申请日：2009-04-16

    申请人： Allan C. Shuros ,  Dan Li

    发明人： Allan C. Shuros ,  Dan Li

    IPC分类号： A61N1/365 ,  A61B5/0205 ,  A61B5/00 ,  A61N1/39

    CPC分类号： A61N1/36585 ,  A61B5/02028 ,  A61B5/04525 ,  A61B5/0464 ,  A61N1/3962

    摘要： This document discusses, among other things, an apparatus comprising an implantable hemodynamic sensor circuit that provides a hemodynamic signal representative of mechanical function of a cardiovascular system of a subject and a controller circuit communicatively coupled to the hemodynamic sensor circuit. The controller circuit includes a detection module configured to detect an onset of tachyarrhythmia, a signal analyzer module configured to determine a measure of morphological variability of the hemodynamic signal during the episode of tachyarrhythmia, and a rhythm discrimination module configured to deem whether the tachyarrhythmia episode is indicative of ventricular tachycardia (VT) according to the measure of morphological variability.

    摘要翻译： 本文件尤其涉及一种包括可植入血液动力学传感器电路的装置，其提供表示受试者的心血管系统的机械功能的血液动力学信号和通信地耦合到血液动力学传感器电路的控制器电路。 所述控制器电路包括检测模块，所述检测模块被配置为检测快速性心律失常的发作，信号分析器模块被配置为确定在快速性心律失常发作期间的血液动力学信号的形态变异性的度量;以及节律辨别模块，其被配置为认为是否发生快速性心律失常发作 根据形态变异性的测量指示室性心动过速（VT）。

    AUTONOMIC BALANCE MONITORING TO CONTROL INTERMITTENT THERAPY
    64.
    发明申请
    AUTONOMIC BALANCE MONITORING TO CONTROL INTERMITTENT THERAPY 有权
    自动平衡监测来控制间接治疗

    公开(公告)号：US20090234409A1

    公开(公告)日：2009-09-17

    申请号：US12396132

    申请日：2009-03-02

    申请人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy

    发明人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61B5/02405 ,  A61B5/0452 ,  A61B5/4035 ,  A61B5/4047 ,  A61N1/36114 ,  A61N1/36514 ,  A61N1/36592

    摘要： Various system embodiments comprise a myocardial stimulator, at least one sensor adapted for use in detecting heart rate to determine heart rate turbulence (HRT), and a controller connected to the myocardial stimulator and the at least one sensor. The myocardial stimulator is adapted to deliver pacing pulses through at least one electrode to provide cardiac pacing. The controller is adapted to intermittently deliver a sequence of stress-inducing pacing pulses adapted to increase sympathetic tone during the stress-inducing pacing. The controller is further adapted to determine HRT from the detected heart rate to assess cardiac stress to the stress-inducing pacing pulses, and adjust at least one parameter of the stress-inducing pacing pulses to adjust cardiac stress if the cardiac stress to the stress-inducing pacing pulses is undesirable.

    摘要翻译： 各种系统实施例包括心肌刺激器，适于用于检测心率以确定心率湍流（HRT）的至少一个传感器，以及连接到心肌刺激器和至少一个传感器的控制器。 心肌刺激器适于通过至少一个电极输送起搏脉冲以提供心脏起搏。 控制器适于间歇地递送一系列应力诱导起搏脉冲，其适于在应力引发起搏期间增加交感神经张力。 所述控制器进一步适于根据检测到的心率来确定HRT以评估心脏应激对应激引起的起搏脉冲，并且如果对于应力诱发起搏脉冲的心脏应力，则调整应力诱发起搏脉冲的至少一个参数以调节心脏应激， 引起起搏脉冲是不期望的。

    DEACTIVATION OF INTERMITTENT PACING THERAPY
    65.
    发明申请
    DEACTIVATION OF INTERMITTENT PACING THERAPY 失效
    间歇性治疗的绝食

    公开(公告)号：US20090234401A1

    公开(公告)日：2009-09-17

    申请号：US12405990

    申请日：2009-03-17

    申请人： John R. Zielinski ,  Shantha Arcot-Krishnamurthy ,  Joseph M. Pastore ,  Jeffrey E. Stahmann ,  Allan C. Shuros

    发明人： John R. Zielinski ,  Shantha Arcot-Krishnamurthy ,  Joseph M. Pastore ,  Jeffrey E. Stahmann ,  Allan C. Shuros

    IPC分类号： A61N1/39 ,  A61N1/365 ,  A61N1/37

    CPC分类号： A61N1/3627 ,  A61N1/368 ,  A61N1/3688 ,  A61N1/3962

    摘要： This document discusses, among other things, an apparatus comprising an implantable cardiac depolarization sensing circuit, an electrical stimulation circuit, and a pacing mode controller. The pacing mode controller is configured to deliver pacing therapy according to a first pacing mode that is a normal operating mode, and to deliver pacing therapy according to second and third pacing modes. The second and third pacing modes increase mechanical stress on at least a particular portion of the ventricle as compared to the pacing therapy delivered during the first pacing mode. The pacing mode controller alternates between the second and third pacing modes when pacing is changed from the normal operating mode to a stress augmentation mode. The pacing mode controller suspends the change from the normal operating mode to the stress augmentation mode when a condition to prevent the change is detected.

    摘要翻译： 本文件尤其涉及包括可植入心脏去极化感测电路，电刺激电路和起搏模式控制器的装置。 起搏模式控制器被配置为根据作为正常操作模式的第一起搏模式提供起搏治疗，并且根据第二和第三起搏模式输送起搏治疗。 与在第一起搏模式期间递送的起搏治疗相比，第二和第三起搏模式增加至少在心室的特定部分上的机械应力。 当起搏从正常操作模式改变为应力增强模式时，起搏模式控制器在第二和第三起搏模式之间交替。 当检测到防止变化的条件时，起搏模式控制器将更改从正常操作模式暂停到应力增强模式。

    Method and device for lymphatic system monitoring
    66.
    发明授权
    Method and device for lymphatic system monitoring 有权
    淋巴系统监测方法及装置

    公开(公告)号：US07526337B2

    公开(公告)日：2009-04-28

    申请号：US11422417

    申请日：2006-06-06

    申请人： Allan C. Shuros ,  Michael J. Kane

    发明人： Allan C. Shuros ,  Michael J. Kane

    IPC分类号： A61N1/365

    CPC分类号： A61B5/03 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/14546 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4839 ,  A61N1/3627 ,  A61N1/36514

    摘要： A device and method are disclosed for physiological monitoring of the lymphatic system. An implantable device is configured with a lymphatic sensor disposed in a lymphatic vessel for sensing pressure, flow, and/or the concentration of particular markers within the vessel. The device may be further configured to deliver appropriate therapy in accordance with the lymphatic monitoring.

    摘要翻译： 公开了用于淋巴系统的生理监测的装置和方法。 可植入装置配置有设置在淋巴管中的淋巴传感器，用于感测容器内的特定标记物的压力，流量和/或浓度。 该装置还可以被配置成根据淋巴监测进行适当的治疗。

    Autonomic balance monitoring to control intermittent therapy
    70.
    发明授权
    Autonomic balance monitoring to control intermittent therapy 有权
    自动平衡监测来控制间歇性治疗

    公开(公告)号：US08812108B2

    公开(公告)日：2014-08-19

    申请号：US12396132

    申请日：2009-03-02

    申请人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy

    发明人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy

    IPC分类号： A61N1/08 ,  A61N1/365

    CPC分类号： A61N1/3627 ,  A61B5/02405 ,  A61B5/0452 ,  A61B5/4035 ,  A61B5/4047 ,  A61N1/36114 ,  A61N1/36514 ,  A61N1/36592

    摘要： Various system embodiments comprise a myocardial stimulator, at least one sensor adapted for use in detecting heart rate to determine heart rate turbulence (HRT), and a controller connected to the myocardial stimulator and the at least one sensor. The myocardial stimulator is adapted to deliver pacing pulses through at least one electrode to provide cardiac pacing. The controller is adapted to intermittently deliver a sequence of stress-inducing pacing pulses adapted to increase sympathetic tone during the stress-inducing pacing. The controller is further adapted to determine HRT from the detected heart rate to assess cardiac stress to the stress-inducing pacing pulses, and adjust at least one parameter of the stress-inducing pacing pulses to adjust cardiac stress if the cardiac stress to the stress-inducing pacing pulses is undesirable.

    摘要翻译： 各种系统实施例包括心肌刺激器，适于用于检测心率以确定心率湍流（HRT）的至少一个传感器，以及连接到心肌刺激器和至少一个传感器的控制器。 心肌刺激器适于通过至少一个电极输送起搏脉冲以提供心脏起搏。 控制器适于间歇地递送一系列应力诱导起搏脉冲，其适于在应力引发起搏期间增加交感神经张力。 所述控制器进一步适于根据检测到的心率来确定HRT以评估心脏应激对应激引起的起搏脉冲，并且如果对于应力诱发起搏脉冲的心脏应力，则调整应力诱发起搏脉冲的至少一个参数以调节心脏应激， 引起起搏脉冲是不期望的。