公开(公告)号：US11851446B2

公开(公告)日：2023-12-26

申请号：US17353627

申请日：2021-06-21

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Alex Kiselyov ,  Christopher John Brown ,  Michael Edward Prime ,  Peter David Johnson ,  Daniel Clark-Frew

IPC: C07D519/00 ,  C07D471/04 ,  A61K51/04

CPC classification number: C07D519/00 ,  A61K51/0455 ,  A61K51/0459 ,  C07D471/04

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20220409615A1

公开(公告)日：2022-12-29

申请号：US17318693

申请日：2021-05-12

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Elizabeth M. Doherty ,  Longbin Liu ,  Matthew Lee ,  Mark Stuart Chambers ,  Karine Fabienne Malagu ,  Perla Breccia ,  Alan F. Haughan ,  Huw D. Vater ,  Andrew J. Stott ,  William R. K. Esmieu ,  Stephen John Webster ,  Amanda J. Van De Poël

IPC: A61K31/497 ,  C07D471/04 ,  C07D519/00 ,  A61K31/4985 ,  C07D487/04 ,  C07D403/14 ,  A61K31/506 ,  A61K31/501 ,  C07D413/14 ,  A61P25/28

Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.

公开(公告)号：US20220372045A1

公开(公告)日：2022-11-24

申请号：US17729881

申请日：2022-04-26

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Celia Dominguez ,  Jonathan Bard ,  Vinod Khetarpal ,  Ashley Jarvis ,  Sarah Hayes ,  John E. Mangette

IPC: C07D498/04 ,  A61K51/04

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：US20210380608A1

公开(公告)日：2021-12-09

申请号：US17353627

申请日：2021-06-21

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Alex Kiselyov ,  Christopher John Brown ,  Michael Edward Prime ,  Peter David Johnson ,  Daniel Clark-Frew

IPC: C07D519/00 ,  C07D471/04 ,  A61K51/04

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20210379211A1

公开(公告)日：2021-12-09

申请号：US17353611

申请日：2021-06-21

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Thomas Martin Krulle ,  Daniel Clark-Frew ,  Sarah Hayes

IPC: A61K51/04 ,  C07D401/14 ,  C07D403/04 ,  C07D401/04 ,  C07D487/04 ,  C07D513/04 ,  C07D513/14

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US11173156B2

公开(公告)日：2021-11-16

申请号：US16898239

申请日：2020-06-10

Applicant: CHDI Foundation, Inc.

Inventor： Leticia M. Toledo-Sherman ,  Celia Dominguez ,  Vinod Khetarpal ,  Travis Lee Houston ,  Stephan D. Parent ,  Jian-xie Chen ,  Charles H. Montgomery ,  Geetha Banda

IPC: A61K31/505 ,  C07D239/28

Abstract: Forms of 6-(3-chloro-4-cyclopropoxyphenyl)pyrimidine-4-carboxylic acid (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the forms of Compound I and salts or co-crystals thereof.

公开(公告)号：US20190185463A1

公开(公告)日：2019-06-20

申请号：US16046268

申请日：2018-07-26

Applicant: CHDI Foundation, Inc.

Inventor： Michel C. Maillard ,  Perla Breccia ,  Celia Dominguez ,  Alan F. Haughan ,  Rebecca E. Jarvis ,  Christopher A. Luckhurst ,  Elizabeth A. Saville-Stones ,  Andrew J. Stott ,  Amanda Van de Poël ,  Michael Wall ,  Grant Wishart

IPC: C07D413/12 ,  C07D491/107

CPC classification number: C07D413/12 ,  C07D491/107

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US10258621B2

公开(公告)日：2019-04-16

申请号：US15326317

申请日：2015-07-17

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Ignacio Muñoz-Sanjuán ,  Leticia Toledo-Sherman

IPC: C07D239/42 ,  A61K31/52 ,  A61K31/70 ,  A61K31/505 ,  A61K31/675 ,  A61K31/506 ,  A61K31/34 ,  C07D239/28 ,  A61K45/06

Abstract: Certain adjunctive therapies comprising a kynurenine-3-monooxygenase inhibitor and an antiviral agent for treating HIV-related disorders are provided herein. These disorders include AIDS dementia complex, AIDS-induced encephalopathy, HIV-associated neurocognitive disorder, asymptomatic neurocognitive impairment, minor neurocognitive disorder, minor cognitive motor disorder, vacuolar myelopathy, peripheral neuropathies, and polymyositis. Also provided are pharmaceutical compositions comprising a kynurenine-3-monooxygenase inhibitor and an antiviral agent.

公开(公告)号：US10105363B2

公开(公告)日：2018-10-23

申请号：US15411535

申请日：2017-01-20

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Vahri Beaumont ,  Ignacio Muñoz-Sanjuán ,  Roland W. Bürli ,  Alan F. Haughan ,  Christopher A. Luckhurst ,  Michael Wall ,  Gilles Raphy ,  Beth Thomas

IPC: A61K31/505 ,  C07D239/26

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US10053434B2

公开(公告)日：2018-08-21

申请号：US15148907

申请日：2016-05-06

Applicant: CHDI Foundation, Inc.

Inventor： Michel C. Maillard ,  Perla Breccia ,  Celia Dominguez ,  Alan F. Haughan ,  Amanda Van de Poël ,  Andrew J. Stott ,  Christopher A. Luckhurst ,  Elizabeth A. Saville-Stones ,  Grant Wishart ,  Michael Wall ,  Rebecca E. Jarvis

IPC: C07D413/12 ,  C07D271/06 ,  C07D471/04

CPC classification number: C07D271/06 ,  C07D413/12 ,  C07D471/04

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.