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    Anti-infectious carbohydrates
    62.
    发明授权
    Anti-infectious carbohydrates 失效
    抗感染性碳水化合物

    公开(公告)号：US07858595B2

    公开(公告)日：2010-12-28

    申请号：US10490102

    申请日：2002-09-25

    申请人： Bernd Stahl ,  Berndt Finke ,  Joachim Schmitt ,  Werner Goebel ,  Jörg Slaghuis

    发明人： Bernd Stahl ,  Berndt Finke ,  Joachim Schmitt ,  Werner Goebel ,  Jörg Slaghuis

    IPC分类号： A61K31/715 ,  A61K31/70 ,  C07H5/06 ,  C07H1/00 ,  A23G3/00

    CPC分类号： A61K31/702 ,  A61K31/715

    摘要： Neutral straight-chain or branched oligosaccharides for preventing the invasion and infection of mammal cells by pathogens and for fighting diseases caused by such pathogens are disclosed. Food, dietetic products and pharmaceutical agents containing oligosaccharides consist of a base unit of formula (I), and between 0 and 19 other units of formula (II), which are linked directly or indirectly to the base unit. Gal represents a galactose monosaccharide unit; Glc represents a glucose monosaccharide unit; HexNAc rpresents an N-acetylated galactosamine or glucosamine monosaccharide unit (GalNAc or GlcNAc); R independently represent a β 1-3 or β 1-6 glycosidic link to HexNAc monosaccharide of the next [Gal-HexNAc] unit (II), and on a terminal [Gal-HexNAc] unit, or R are not present; and a terminal [Gal-HexNAc] unit, wherein R represent a deoxyhexose radical, can have another deoxyhexose radical on the HexNAc monosaccharide unit.

    摘要翻译： 公开了用于防止病原体侵染和感染哺乳动物细胞并用于与这种病原体引起的疾病的中性直链或支链寡糖。 含有寡糖的食品，饮食产品和药剂由式（I）的基本单元和0至19个式（II）的其它单元直接或间接连接到基础单元组成。 Gal代表半乳糖单糖单位; Glc表示葡萄糖单糖单元; HexNAc表示N-乙酰化的半乳糖胺或葡糖胺单糖单元（GalNAc或GlcNAc）; R独立地代表一个 1-3或＆bgr; 1-6糖苷键连接到下一个[Gal-HexNAc]单元（II）的HexNAc单糖和末端[Gal-HexNAc]单元或R不存在; 和末端[Gal-HexNAc]单元，其中R表示脱氧己糖基团，可以在HexNAc单糖单元上具有另一脱氧己糖基团。

    Carbohydrates mixture
    64.
    发明申请
    Carbohydrates mixture 有权
    碳水化合物混合物

    公开(公告)号：US20070248649A1

    公开(公告)日：2007-10-25

    申请号：US11649879

    申请日：2007-01-05

    申请人： Gunther Sawatzki ,  Bernd Stahl

    发明人： Gunther Sawatzki ,  Bernd Stahl

    IPC分类号： A61K47/36 ,  A61K31/7004 ,  A61K31/7016 ,  A61K31/702 ,  A61P1/14 ,  A61P1/00 ,  A61K31/715 ,  A61K31/733

    CPC分类号： A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A23L33/21 ,  A23L33/40 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/715 ,  A61K31/733 ,  A61K31/7004 ,  A61K2300/00

    摘要： A carbohydrate mixture for dietetic foods and pharmaceuticals containing several carbohydrates is provided according to the present invention. Said carbohydrate mixture is characterized in that they contain or consist of two different, substantially soluble carbohydrate components A and B, which remain undigested in the gastrointestinal tract and enter the large intestine without being resorbed, that said carbohydrate component A is composed of at least one monosaccharide or of at least one oligosaccharide (disaccharide to hexasaccharide) or of a mixture of two or more of these saccharides, that the carbohydrate component B is composed of a polysaccharide (from heptasaccharide onwards) or of a mixture of two or more polysaccharides, that the carbohydrate component A=5 to 95 wt-% and the carbohydrate component B=5 to 95 wt-% of the sum of the carbohydrate components A+B (=100 wt-%), and that at least 80 wt-% of the carbohydrates/saccharides of the carbohydrate components A and B have a prebiotic effect. The inventive carbohydrate mixture have not only a nutritive effect but they also stimulate health-promoting microorganisms present in the natural flora of the large intestine.

    摘要翻译： 根据本发明提供了含有几种碳水化合物的饮食食品和药物的碳水化合物混合物。 所述碳水化合物混合物的特征在于它们含有两种不同的，基本上可溶的碳水化合物组分A和B，其中所述碳水化合物组分A和B在胃肠道中未消化并进入大肠而不被再吸收，所述碳水化合物组分A由至少一种 单糖或至少一种寡糖（二糖与六糖）或两种或多种这些糖的混合物，碳水化合物组分B由多糖（来自七糖以上）或两种或多种多糖的混合物组成，该 碳水化合物组分A = 5至95重量％，碳水化合物组分B = 5至95重量％的碳水化合物组分A + B（= 100重量％）和至少80重量％的碳水化合物组分 碳水化合物组分A和B的碳水化合物/糖具有益生元效应。 本发明的碳水化合物混合物不仅具有营养效果，而且还刺激存在于大肠的天然菌群中的健康促进微生物。

    Trans-sialidases obtained from trypanosoma congolense
    65.
    发明申请
    Trans-sialidases obtained from trypanosoma congolense 失效
    从锥虫congolense获得的反唾液酸酶

    公开(公告)号：US20070004656A1

    公开(公告)日：2007-01-04

    申请号：US10538840

    申请日：2003-12-11

    申请人： Joachim Schmitt ,  Gunter Boehm ,  Bernd Stahl ,  Roland Schauer ,  Evelin Tiralongo ,  Silke Schrader

    发明人： Joachim Schmitt ,  Gunter Boehm ,  Bernd Stahl ,  Roland Schauer ,  Evelin Tiralongo ,  Silke Schrader

    IPC分类号： A61K48/00 ,  A61K39/00 ,  C12Q1/68 ,  G01N33/569 ,  C07H21/04 ,  C12N9/24 ,  C12N1/10 ,  A61K39/002

    CPC分类号： C12N9/1081

    摘要： The invention relates to novel enzymes, which transfer sialic acid from a donor molecule onto an acceptor molecule (trans-sialidases). The enzymes are isolated from the protozoan Trypanosoma congolense. The invention also relates to functional equivalents of said enzymes, to the nucleic acid sequences and amino acid sequences that code for the enzymes and their functional equivalents, to expression constructs and vectors that contain said sequences, to recombinant microorganisms that carry the inventive coding nucleic-acid sequences, to a method for the recombinant production of the inventive enzymes, to a method for isolating said enzyme from Trypanosoma congolense, to a method for the enzymatic sialization of acceptor molecules using the inventive enzymes, to effectors of the inventive trans-sialidases, to the use of the nucleic acid sequences, amino acid sequences, enzymes, effectors or sialization products for producing vaccines, medicaments, foodstuffs or food additives, in addition to the latter products obtained by the inventive method.

    摘要翻译： 本发明涉及将唾液酸从供体分子转移到受体分子（反唾液酸酶）上的新型酶。 这些酶是从原生动物锥虫中分离的。 本发明还涉及所述酶的功能等同物，编码酶及其功能等同物的核酸序列和氨基酸序列，含有所述序列的表达构建体和载体，携带本发明编码核酸的重组微生物， 酸序列，重组生产本发明酶的方法，用于将所述酶与锥虫属分离的方法，使用本发明酶将受体分子酶促唾液酸化的方法用于本发明的反唾液酸酶的实施者， 使用除了通过本发明方法获得的后一种产品之外的核酸序列，氨基酸序列，酶，效应物或用于生产疫苗，药物，食品或食品添加剂的唾液化产品。