公开(公告)号：US20150025346A1

公开(公告)日：2015-01-22

申请号：US14508990

申请日：2014-10-07

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Matthew D. Wightlin

IPC: A61B5/1473 ,  A61B5/145

CPC classification number: A61B5/1473 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/6848 ,  A61B2562/028

Abstract: Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

Abstract translation: 提供涉及具有含颗粒结构域的传感器的系统和使用方法用于在主机中连续分析物测量。 在一些实施例中，连续分析物测量系统被配置为完全，经皮，血管内或体外植入。

公开(公告)号：US20130131478A1

公开(公告)日：2013-05-23

申请号：US13732848

申请日：2013-01-02

Applicant: DEXCOM, INC.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  James R. Petisce ,  Mark C. Brister ,  Monica A. Rixman ,  Kum Ming Woo ,  Lisa Nguyen ,  Seth R. Brunner ,  Arthur Chee ,  Melissa A. Nicholas ,  Matthew D. Wightlin ,  Jack Pryor ,  Dubravka Markovic

IPC: A61B5/1486 ,  A61B5/145 ,  A61B5/00 ,  A61B5/1473

CPC classification number: A61B5/14735 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6848 ,  A61B5/7203

Abstract: Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

Abstract translation: 提供涉及具有基本上不受非恒定噪声影响的信噪比的传感器的系统和方法用于主机中的连续分析物测量。 在一些实施例中，连续分析物测量系统被配置为完全，经皮，血管内或体外植入。

公开(公告)号：US20240245332A1

公开(公告)日：2024-07-25

申请号：US18586306

申请日：2024-02-23

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Sebastian Bohm ,  James H. Brauker ,  Paul V. Neale

IPC: A61B5/1486 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1468 ,  A61B5/1473

CPC classification number: A61B5/14865 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/6843 ,  A61B5/6848 ,  A61B5/6849 ,  A61B2560/0443 ,  A61B2562/04

Abstract: A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.

公开(公告)号：US11918354B2

公开(公告)日：2024-03-05

申请号：US16732121

申请日：2019-12-31

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Matthew Wightlin ,  Mark C. Shults

IPC: A61B5/1473 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/1473 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/6848 ,  A61B2562/028

Abstract: Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

公开(公告)号：US20240041356A1

公开(公告)日：2024-02-08

申请号：US18219453

申请日：2023-07-07

Applicant: DexCom, Inc.

Inventor： Jonathan Hughes ,  Robert J. Boock ,  Chris W. Dring

IPC: A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/14532 ,  A61B5/14865 ,  A61B5/14503 ,  G01N27/333

Abstract: Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the devices include a membrane that has an interference domain designed to reduce the permeation of one or more interferents.

公开(公告)号：US20220384007A1

公开(公告)日：2022-12-01

申请号：US17884884

申请日：2022-08-10

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  David DeRenzy ,  Laura J. Dunn ,  Matthew Lawrence Johnson ,  Katherine Yerre Koehler ,  Apurv Ullas Kamath ,  Andrew Attila Pal ,  David Price ,  Eli Reihman ,  Mark Wu

IPC: G16H20/10 ,  A61B5/145 ,  G09B19/00 ,  A61B5/11 ,  A61B5/1495 ,  A61B5/00

Abstract: A method of monitoring compliance with an insulin regimen prescribed for a diabetic patient includes receiving continuous glucose monitoring (CGM) data for the patient over a period of time; determining a degree of variability in the CGM data obtained over the period of time; evaluating compliance with the prescribed insulin regimen based at least in part on the degree of variability in the CGM data that is determined; and responsive to the evaluating, causing at least one action to be performed to facilitate a change in patient behavior that increases compliance with the prescribed insulin regimen when compliance is determined to be less than required to optimize therapeutic treatment of diabetes in the diabetic patient.

公开(公告)号：US11262326B2

公开(公告)日：2022-03-01

申请号：US15395892

申请日：2016-12-30

Applicant: DexCom, Inc.

Inventor： Shanger Wang ,  Robert J. Boock ,  Andrew Trinin Dennis ,  Ted Tang Lee ,  Jeff T. Suri ,  David Sze ,  Mark A Tapsak ,  Huashi Zhang ,  Jiong Zou

IPC: A61B5/145 ,  G01N27/327 ,  C08G18/08 ,  C08G18/48 ,  C08G18/40 ,  C08G18/38 ,  C08G18/12 ,  C08G18/44 ,  C08G18/75 ,  C12N11/089 ,  C12N11/093 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12Q1/00 ,  A61B5/00 ,  A61B5/1486 ,  G01N33/66 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  A61B5/1473

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than −50 C.

公开(公告)号：US20210361205A1

公开(公告)日：2021-11-25

申请号：US17394690

申请日：2021-08-05

Applicant: DexCom, Inc.

Inventor： Robert J. Boock ,  Chris W. Dring

IPC: A61B5/1486 ,  A61B5/145

Abstract: Devices are provided for measurement of an analyte concentration, e.g., glucose in a host. The device can include a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises a diffusion resistance domain configured to control a flux of the analyte therethrough. The diffusion resistance domain comprises one or more zwitterionic compounds and a base polymer comprising both hydrophilic and hydrophobic regions.

公开(公告)号：US10908114B2

公开(公告)日：2021-02-02

申请号：US14567293

申请日：2014-12-11

Applicant: DexCom, Inc.

Inventor： Michael J. Estes ,  Jennifer Blackwell ,  Sebastian Bohm ,  Robert J. Boock ,  Jack Pryor ,  Peter C. Simpson ,  Matthew D. Wightlin

IPC: A61B5/145 ,  G01N27/403 ,  A61B5/1486 ,  A61B5/1495

Abstract: Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration.

公开(公告)号：US10667733B2

公开(公告)日：2020-06-02

申请号：US14968643

申请日：2015-12-14

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Sebastian Böhm ,  James H. Brauker ,  Paul V. Neale

IPC: A61B5/1486 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/00

Abstract: A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.