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179 条记录 (耗时 0.042 秒)

    FLUIDIC PROCESSING WORKSTATION
    62.
    发明申请
    FLUIDIC PROCESSING WORKSTATION 有权

    公开(公告)号：US20220379310A1

    公开(公告)日：2022-12-01

    申请号：US17804211

    申请日：2022-05-26

    申请人： FloDesign Sonics, Inc.

    发明人： Brian Dutra ,  Christopher Jurkiewicz ,  Brian McCarthy ,  Richard Grant ,  Jeffrey King ,  Bart Lipkens ,  Yasser Ali ,  Stefano Berti Perez

    IPC分类号： B01L3/00 ,  C12N5/078

    摘要： A workstation for processing particles entrained in a fluid includes a consumable portion and a reusable portion. The consumable portion is mounted to the reusable portion to form a fluid chamber in which an acoustic wave can be generated. The consumable portion implements a closed, isolated fluid environment that is managed using components of the reusable portion, such as valves, sensors and pumps. The workstation can be operated to retain particles from the fluid via the acoustic wave and provide a new fluid media to the retained particles. Following processing, the consumable portion can be removed and discarded.

    Acoustic transducer driver and controller
    64.
    发明授权
    Acoustic transducer driver and controller 有权

    公开(公告)号：US11381922B2

    公开(公告)日：2022-07-05

    申请号：US16943303

    申请日：2020-07-30

    申请人： FloDesign Sonics, Inc.

    发明人： Bart Lipkens ,  Ronald Musiak ,  John Artis

    IPC分类号： H04R9/06 ,  H04R1/28 ,  B01D17/04 ,  B06B1/02 ,  B01D21/28

    摘要： An acoustophoretic system is controlled and driven to attain a desired level of performance. An RF controller and a driver provide a frequency and power to an acoustic transducer, which can be implemented as a piezoelectric element, which presents a reactive load or a complex load. A controller implements a control technique for efficient transducer operation. The control technique can locate a frequency for operation that is at a reactance minimum or maximum for the system to produce a modal pattern and to provide efficient operation of the transducer. A method of detecting a minimum or maximum reactance in a acoustophoretic system used to trap, separate, deflect, cluster, fractionate or otherwise process particles or secondary fluids or tertiary fluids in a primary fluid and utilizing the frequency of the detected reactance to operate the acoustophoretic system.

    ACOUSTIC TRANSDUCER DRIVER AND CONTROLLER
    68.
    发明申请
    ACOUSTIC TRANSDUCER DRIVER AND CONTROLLER 审中-公开

    公开(公告)号：US20190191252A1

    公开(公告)日：2019-06-20

    申请号：US16221283

    申请日：2018-12-14

    申请人： FloDesign Sonics, Inc.

    发明人： Bart Lipkens ,  Ronald Musiak ,  John Artis

    IPC分类号： H04R9/06 ,  H04R1/28

    摘要： An acoustophoretic system is controlled and driven to attain a desired level of performance. An RF controller and a driver provide a frequency and power to an acoustic transducer, which can be implemented as a piezoelectric element, which presents a reactive load or a complex load. A controller implements a control technique for efficient transducer operation. The control technique can locate a frequency for operation that is at a reactance minimum or maximum for the system to produce a modal pattern and to provide efficient operation of the transducer. A method of detecting a minimum or maximum reactance in a acoustophoretic system used to trap, separate, deflect, cluster, fractionate or otherwise process particles or secondary fluids or tertiary fluids in a primary fluid and utilizing the frequency of the detected reactance to operate the acoustophoretic system.

    System for generating high concentration factors for low cell density suspensions
    69.
    发明授权
    System for generating high concentration factors for low cell density suspensions 有权

    公开(公告)号：US10308928B2

    公开(公告)日：2019-06-04

    申请号：US15690190

    申请日：2017-08-29

    申请人： FloDesign Sonics, Inc.

    发明人： Bart Lipkens ,  Jason Dionne ,  Goutam Ghoshal

    IPC分类号： B01D17/04 ,  C12N13/00 ,  C12M1/00 ,  G10K15/04 ,  B01D21/28 ,  B06B1/06 ,  H01L41/09 ,  H01L41/187 ,  G10K15/00

    摘要： Acoustophoretic devices and methods for concentrating targeted biological cells in a reduced volume using multi-dimensional acoustic standing waves are disclosed. The methods include flowing a mixture of a host fluid and the biological cells through an acoustophoretic device. The acoustophoretic devices include an inlet, an outlet, and a flow chamber having an ultrasonic transducer-reflector pair. Biological cells, such as T cells, are separated from a host fluid for utilization in allergenic or autologous cell therapies. The disclosed devices and methods are capable of concentrating biological cells to at least 100 times their original cell concentration. The disclosed methods and devices are further capable of decreasing an original feed volume to a final concentrated volume that is less than one percent of the original feed volume.

    Methods and apparatus for particle aggregation using acoustic standing waves
    70.
    发明授权
    Methods and apparatus for particle aggregation using acoustic standing waves 有权

    公开(公告)号：US10106770B2

    公开(公告)日：2018-10-23

    申请号：US15397326

    申请日：2017-01-03

    申请人： FloDesign Sonics, Inc.

    发明人： Walter M. Presz, Jr. ,  Kedar Chitale ,  Bart Lipkens

    IPC分类号： C02F1/36 ,  C12M1/00 ,  C02F1/00 ,  B01D21/28 ,  B01D21/34 ,  B01D15/08 ,  C12N13/00 ,  B06B1/06 ,  C12M1/42 ,  C02F101/32

    摘要： Methods for generating particulate clusters and nodal trapping lines having desired widths are disclosed. The devices include an acoustic chamber having an inlet and an outlet. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave that generates particulate clusters separated by a channel of fluid running therebetween and creates nodal trapping lines. The frequency of the multi-dimensional acoustic standing wave can be selectively tuned so as to selectively control at least one of (a) a width of each particulate cluster, or (b) a width of each channel of fluid. The frequency of the multi-dimensional acoustic standing wave can also be selectively tuned so as to selectively control the width of each nodal trapping line. Also disclosed are particulate clusters separated by a channel of fluid, wherein a ratio of the widths of the particulate clusters and the channel of fluid can be varied as desired.