摘要:
The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu- A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
摘要翻译:本发明提供衍生自GIP(1-29,SEQ ID NO:1)的GIP类似物具有GLP-1激动剂活性和GIPR刺激活性,并且包含由下式I表示的氨基酸序列: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp- Leu- A27-A28-A29-Y。 本发明还提供了包含GIP类似物及其用途的药物组合物。
摘要:
Provided are methods for overcoming resistance to an ErbB pathway inhibitor, such as an EGFR inhibitor or a HER2 inhibitor. The resistance may be acquired resistance to an EGFR inhibitor, such as acquired resistance to gefitinib. In the methods provided, a subject exhibiting resistance to an ErbB pathway inhibitor is selected and both an ErbB 3 inhibitor and a second ErbB pathway inhibitor are administered to the subject, such as an EGFR inhibitor or a HER2 inhibitor. Also provided are methods for inhibiting the growth of a tumor comprising a T790M EGFR mutation by contacting the tumor with an ErbB3 inhibitor and an EGFR inhibitor. Compositions for overcoming resistance to an ErbB pathway inhibitor, comprising both an ErbB 3 inhibitor and a second ErbB pathway inhibitor, such as an EGFR inhibitor or a HER2 inhibitor, are also provided.
摘要:
A processing device provides a method for protecting a program from unauthorized copying. The processing device may include an encrypted version of the program. According to one example method, the processing device creates a secure enclave, and in response to a request to execute the encrypted program, the processing device automatically generates a decrypted version of the program in the secure enclave by decrypting the encrypted program in the secure enclave. After automatically generating the decrypted version of the program in the secure enclave, the processing device may automatically execute the decrypted version of the program in the secure enclave. Other embodiments are described and claimed.
摘要:
An electronic device includes a voice processing unit, a wireless communication unit, and a combining unit. The voice processing unit receives speech signals. The wireless communication unit sends the speech signals to a server. The server converts the speech signals into a text message. The wireless communication unit receives the text message from the server. The combining unit combines the text message and the speech signals into a combined message. The wireless communication unit further sends the combined message to a recipient. A related server is also provided.
摘要:
This invention involves with a low power IC (Integrated Circuit) with high energy efficiency. This invention describes a Buck converter that can track the minimum energy point of the load. It works by estimating input energy of every sensing period, taking advantage of energy consumption curve of IC in sub-threshold. Energy estimation is implemented with counting conducted pulses, while maintaining constant input energy of each pulse by regulating output voltage and ON time with digital control circuit. With digital control circuit, minimum energy point can be tracked with a lookup table stored inside. Most of this invention's control circuit is digital, with benefits of low power consumption and small chip area.
摘要:
The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu-A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
摘要翻译:本发明提供衍生自GIP(1-29,SEQ ID NO:1)的GIP类似物具有GLP-1激动剂活性和GIPR刺激活性,并且包含由下式I表示的氨基酸序列: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp- Leu-A27-A28-A29-Y。 本发明还提供了包含GIP类似物及其用途的药物组合物。
摘要:
A user behavior model provides personalized recommendations based in part on time and location, particularly to users of mobile devices. Entity types are ranked according to relevance to the user. Example entity types are restaurant, hotel, etc. The relevance may be based on reference to a large-scale database containing queries from other users. Additionally, entities within each entity type may be ranked based on relevance to the user and the time and location context. A user interface may display a ranked list of entity types, such as restaurant, hotel, etc., wherein each entity type is represented by a highest-ranked entity with the entity type. Thus, the user interface may display a highest-ranked restaurant, a highest-ranked hotel, etc. Upon user selection of one such entity type the user interface is replaced with a second user interface, for example showing a ranked hierarchy of restaurants, headed by the highest-ranked restaurant.
摘要:
The present invention discloses a multi-phase switch-mode power supply (SMPS). The multi-phase SMPS may comprise a plurality of comparing circuits and a controller. Wherein each comparing circuit comprises a first input coupled to a threshold voltage, a second input coupled to a feedback signal of the output voltage, and an output configured to provide a load indication signal. The controller may have a plurality of inputs coupled to the outputs of the comparing circuit, and a plurality of outputs configured to provide control signals for driving a plurality of switches of the multi-phase SMPS. And the controller is configured to selectively turn on a plurality of the switches according to the load indication signals.
摘要:
This invention involves with a low power IC (Integrated Circuit) with high energy efficiency. This invention describes a Buck converter that can track the minimum energy point of the load. It works by estimating input energy of every sensing period, taking advantage of energy consumption curve of IC in sub-threshold. Energy estimation is implemented with counting conducted pulses, while maintaining constant input energy of each pulse by regulating output voltage and ON time with digital control circuit. With digital control circuit, minimum energy point can be tracked with a lookup table stored inside. Most of this invention's control circuit is digital, with benefits of low power consumption and small chip area.
摘要:
A method and apparatus for realizing service protection are provided. The method includes the following steps: determining paths corresponding to automatic protection switching (APS)/protection communication channel (PCC) overhead bytes that are available to all nodes in a service protection trail; selecting a path for service protection from the determined paths corresponding to the APS/PCC; and using the selected path for implementing the service protection. Therefore, it is ensured that several service protections using APS/PCC may coexist in an optical transport network (OTN) and different kinds of service protection can be easily distinguished from one another.