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196 条记录 (耗时 0.057 秒)

    14-3-3 zeta over-expression as a poor prognosis factor, and a therapeutic target in multiple cancer types
    61.
    发明授权
    14-3-3 zeta over-expression as a poor prognosis factor, and a therapeutic target in multiple cancer types 有权
    14-3-3ζ过表达作为一种不良预后因子，是多种癌症类型的治疗靶点

    公开(公告)号：US07316907B2

    公开(公告)日：2008-01-08

    申请号：US10938387

    申请日：2004-09-10

    申请人： Dihua Yu ,  Jun Yao ,  Christopher L. Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael E. Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina T. Nguyen

    发明人： Dihua Yu ,  Jun Yao ,  Christopher L. Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael E. Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina T. Nguyen

    IPC分类号： G01N33/53 ,  G01N33/574

    CPC分类号： G01N33/574 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/178

    摘要： Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, including the steps of obtaining one or more candidate, testing the one or more candidate substances to determine their ability to modulate the expression and/or function of 14-3-3 zeta, selecting a candidate substance determined to modulate the expression and/or function of 14-3-3 zeta, and making a pharmaceutical composition that includes the selected candidate substance. In addition, methods of treating a subject with a hyperproliferative disease, including making a pharmaceutical agent by the methods set forth herein, and administering the pharmaceutical agent to a subject, are disclosed. The hyperproliferative disease can be cancer, such as breast cancer.

    摘要翻译： 公开了确定患有过度增生性疾病的受试者的预后的方法，包括确定受试者中14-3-3ζ的表达和/或功能。 还公开了制备调节凋亡的药剂的方法，包括获得一种或多种候选物的步骤，测试一种或多种候选物质以确定其调节14-3-3ζ的表达和/或功能的能力， 选择确定调节14-3-3ζ的表达和/或功能的候选物质，并制备包含所选候选物质的药物组合物。 此外，公开了通过本发明所述的方法制备药剂并且将药剂施用于受试者的治疗患有过度​​增殖性疾病的受试者的方法。 过度增生性疾病可以是癌症，例如乳腺癌。

    Oxidant/catalyst nanoparticles to reduce tobacco smoke constituents such as carbon monoxide
    63.
    发明申请
    Oxidant/catalyst nanoparticles to reduce tobacco smoke constituents such as carbon monoxide 审中-公开
    氧化剂/催化剂纳米颗粒以减少烟草成分如一氧化碳

    公开(公告)号：US20070113862A1

    公开(公告)日：2007-05-24

    申请号：US11471721

    申请日：2006-06-21

    申请人： Ping Li ,  Mohammad Hajaligol ,  Eun-Jae Shin ,  Firooz Rasouli

    发明人： Ping Li ,  Mohammad Hajaligol ,  Eun-Jae Shin ,  Firooz Rasouli

    IPC分类号： A24D3/06

    CPC分类号： A24B15/288 ,  A24B15/28 ,  A24B15/286 ,  A24B15/287

    摘要： Cut filler compositions, cigarettes, methods for making cigarettes and methods for smoking cigarettes are provided, which involve the use of nanoparticle additives capable of reducing amounts of at least one constituent from mainstream and/or sidestream tobacco smoke, the at least one constituent being selected from the group consisting of aldehyde, carbon monoxide, 1,3-butadiene, isoprene, acrolein, acrylonitrile, hydrogen cyanide, o-toluidine, 2-naphtylamine, nitrogen oxide, benzene, N-nitrosonornicotine, phenol, catechol, benz(a)anthracene, benzo(a)pyrene, and mixtures thereof. Preferably, the nanoparticle additives are effective as an oxidant for the conversion of carbon monoxide to carbon dioxide and/or as a catalyst for the conversion of carbon monoxide to carbon dioxide and/or catalyst for conversion of aldehydes such as acetaldehyde and acrolein, hydrocarbons such as isoprene and/or phenolic compounds such as catechol to carbon dioxide and water vapor.

    摘要翻译： 提供了切割填充剂组合物，香烟，制造香烟的方法和吸烟香烟的方法，其涉及使用能够从主流和/或侧流烟草烟中减少至少一种成分的量的纳米颗粒添加剂，所选择的至少一种成分 来自由醛，一氧化碳，1,3-丁二烯，异戊二烯，丙烯醛，丙烯腈，氰化氢，邻甲苯胺，2-萘胺，氮氧化物，苯，N-亚硝基降烟碱，苯酚，邻苯二酚，苯并（a） 蒽，苯并（a）芘及其混合物。 优选地，纳米颗粒添加剂作为用于将一氧化碳转化为二氧化碳和/或作为用于将一氧化碳转化为二氧化碳和/或用于转化醛（例如乙醛和丙烯醛）的催化剂的催化剂的氧化剂是有效的，烃类如 作为异戊二烯和/或酚类化合物如儿茶酚与二氧化碳和水蒸汽。

    Catalyst to reduce carbon monoxide and nitric oxide from the mainstream smoke of a cigarette
    64.
    发明授权
    Catalyst to reduce carbon monoxide and nitric oxide from the mainstream smoke of a cigarette 有权
    从主流烟雾中减少一氧化碳和一氧化氮的催化剂

    公开(公告)号：US07152609B2

    公开(公告)日：2006-12-26

    申请号：US10460303

    申请日：2003-06-13

    申请人： Ping Li ,  Firooz Rasouli ,  Mohammad Hajaligol

    发明人： Ping Li ,  Firooz Rasouli ,  Mohammad Hajaligol

    IPC分类号： A24B15/18

    CPC分类号： A24B15/286 ,  A24B15/28 ,  A24B15/282 ,  A24B15/287 ,  A24D3/16

    摘要： Cut filler compositions, cigarettes, methods for making cigarettes and methods for smoking cigarettes are provided, which involve the use of a catalyst capable converting carbon monoxide to carbon dioxide and/or nitric oxide to nitrogen. Cut filler compositions comprise tobacco and at least one catalyst. Cigarettes are provided, which comprise a cut filler having at least one catalyst. The catalyst comprises nanoscale metal and/or metal oxide particles supported on a fibrous support. The catalyst can be prepared by combining a dispersion of nanoscale particles with a fibrous support, or by combining a metal precursor solution with a fibrous support and then heat treating the fibrous support.

    摘要翻译： 提供了切割填料组合物，香烟，制造香烟的方法和吸烟香烟的方法，其涉及使用能够将一氧化碳转化成二氧化碳和/或一氧化氮至氮气的催化剂。 切割填料组合物包含烟草和至少一种催化剂。 提供了香烟，其包括具有至少一种催化剂的切割填料。 催化剂包括负载在纤维载体上的纳米金属和/或金属氧化物颗粒。 催化剂可以通过将纳米尺寸颗粒的分散体与纤维载体组合，或通过将金属前体溶液与纤维载体组合，然后热处理纤维载体来制备。

    Inline power for multiple devices in a wired data telecommunications network
    65.
    发明申请
    Inline power for multiple devices in a wired data telecommunications network 有权
    有线数据电信网络中多个设备的在线电源

    公开(公告)号：US20060273661A1

    公开(公告)日：2006-12-07

    申请号：US11144094

    申请日：2005-06-02

    申请人： John Toebes ,  Ping Li ,  Jack Cham

    发明人： John Toebes ,  Ping Li ,  Jack Cham

    IPC分类号： H03K3/00

    CPC分类号： G06F1/266 ,  H04L12/10 ,  H04L25/0278

    摘要： A power sourcing equipment-powered device (PSE-PD) combination unit requests inline power from a connected PSE or other PSE-PD combination unit by having the PD portion of the PD-PSE combination unit adapt its electrical characteristics, if necessary, to obtain the maximum power available. The PD-PSE combination device keeps track of available power less power consumed locally with a summation unit. A PSE manager unit grants PD power requests from downstream devices based upon the available power left (e.g., original PSE power less losses less local consumption).

    摘要翻译： 电源设备供电设备（PSE-PD）组合单元通过使PD-PSE组合单元的PD部分适应其电气特性（如果需要）来请求来自连接的PSE或其他PSE-PD组合单元的内联电力以获得 最大功率可用。 PD-PSE组合设备通过求和单元跟踪可用功率消耗在本地消耗的功率。 PSE管理器单元基于剩余的可用功率（例如，原始PSE功率损耗减少本地消耗）向下游设备授予PD功率请求。

    Oxidant/catalyst nanoparticles to reduce carbon monoxide in the mainstream smoke of a cigarette
    66.
    发明授权
    Oxidant/catalyst nanoparticles to reduce carbon monoxide in the mainstream smoke of a cigarette 有权

    公开(公告)号：US07011096B2

    公开(公告)日：2006-03-14

    申请号：US09942881

    申请日：2001-08-31

    申请人： Ping Li ,  Mohammad Hajaligol

    发明人： Ping Li ,  Mohammad Hajaligol

    IPC分类号： A24B15/18

    CPC分类号： A24B15/288 ,  A24B15/28 ,  A24B15/286 ,  A24B15/287

    摘要： Cut filler compositions, cigarettes, methods for making cigarettes and methods for smoking cigarettes are provided, which involve the use of nanoparticle additives capable of acting as an oxidant for the conversion of carbon monoxide to carbon dioxide and/or as a catalyst for the conversion of carbon monoxide to carbon dioxide. Cut filler compositions are described which comprise tobacco and at least one nanoparticle additive. Cigarettes are provided, which comprise a tobacco rod, containing a cut filler having at least one nanoparticle additive. Methods for making a cigarette are provided, which involve (i) adding a nanoparticle additive to a cut filler; (ii) providing the cut filler comprising the additive to a cigarette making machine to form a tobacco rod; and (iii) placing a paper wrapper around the tobacco rod to form the cigarette. Further, methods of smoking the cigarette described above are described, which involve lighting the cigarette to form smoke and inhaling the smoke, wherein during the smoking of the cigarette, the additive acts as an oxidant for the conversion of carbon monoxide to carbon dioxide and/or as a catalyst for the conversion of carbon monoxide to carbon dioxide.

    Use of oxyhydroxide compounds for reducing carbon monoxide in the mainstream smoke of a cigarette
    67.
    发明授权
    Use of oxyhydroxide compounds for reducing carbon monoxide in the mainstream smoke of a cigarette 有权

    公开(公告)号：US06769437B2

    公开(公告)日：2004-08-03

    申请号：US10117220

    申请日：2002-04-08

    申请人： Mohammad Hajaligol ,  Ping Li

    发明人： Mohammad Hajaligol ,  Ping Li

    IPC分类号： A24B1500

    CPC分类号： A24B15/288 ,  A24B15/18 ,  A24B15/286 ,  A24B15/287

    摘要： Cut filler compositions, cigarettes, methods for making cigarettes and methods for smoking cigarettes are provided, which involve the use of an oxyhydroxide compound that is capable of decomposing to form at least one product capable of acting as an oxidant for the conversion of carbon monoxide to carbon dioxide and/or as a catalyst for the conversion of carbon monoxide to carbon dioxide. The oxyhydroxide compound and/or the product formed from the decomposition of the oxyhydroxide can be in the form of nanoparticles. Cut filler compositions are described which comprise tobacco and at least one such oxyhydroxide compound. Cigarettes are provided, which comprise a tobacco rod, containing a cut filler having at least one such oxyhydroxide compound. Methods for making a cigarette are provided, which involve (i) adding at least one such oxyhydroxide compound to a cut filler; (ii) providing the cut filler comprising the oxyhydroxide compound to a cigarette making machine to form a tobacco rod; and (iii) placing a paper wrapper around the tobacco rod to form the cigarette. Methods of smoking the cigarette, as described above, are also provided, which involve lighting the cigarette to form smoke and inhaling the smoke, wherein during the smoking of the cigarette, the oxyhydroxide compound decomposes during smoking to form a compound that acts as an oxidant for the conversion of carbon monoxide to carbon dioxide and/or as a catalyst for the conversion of carbon monoxide to carbon dioxide.

    Linearization using parallel cancellation in linear power amplifier
    68.
    发明授权
    Linearization using parallel cancellation in linear power amplifier 有权
    在线性功率放大器中使用并联消除的线性化

    公开(公告)号：US06242979B1

    公开(公告)日：2001-06-05

    申请号：US09510872

    申请日：2000-02-23

    申请人： Ping Li

    发明人： Ping Li

    IPC分类号： H03F126

    CPC分类号： H03F1/3252 ,  H03F1/3276

    摘要： A predistortion linear power amplifier and method employs parallel predistortion cancellation. In one embodiment the predistortion linear power amplifier (200) utilizes a signal splitter (202) to split an input carrier signal. A first amplifier, such as a main power amplifier (206) in a first path (214), receives the first split carrier signal (216). A signal predistortor (210) in a second path (218) is operatively coupled to receive a second split carrier signal (220) and to output a predistorted carrier signal (226). A second amplifier, such as a linear power amplifier (212) serially coupled with the signal predistortor (210) in the second path, amplifies the predistorted carrier signal (226). A signal combiner (208) operatively combines the output from the first amplifier and the output from the second amplifier to provide an amplified carrier output signal (230) from which nonlinear distortion has been substantially cancelled.

    摘要翻译： 预失真线性功率放大器和方法采用并行预失真消除。 在一个实施例中，预失真线性功率放大器（200）利用信号分离器（202）来分离输入载波信号。 诸如第一路径（214）中的主功率放大器（206）的第一放大器接收第一分路载波信号（216）。 在第二路径（218）中的信号预失真器（210）可操作地耦合以接收第二分裂载波信号（220）并输出预失真载波信号（226）。 诸如与第二路径中的信号预失真器（210）串联耦合的线性功率放大器（212）的第二放大器放大预失真的载波信号（226）。 信号组合器（208）可操作地组合来自第一放大器的输出和来自第二放大器的输出，以提供已经基本上消除了非线性失真的放大的载波输出信号（230）。