-
61.Large capacity viral amplicon using a minimal orilyt from human cytomegalovirus 失效
标题翻译: 大容量的病毒扩增子,使用人巨细胞病毒的最小量公开(公告)号:US07589071B1
公开(公告)日:2009-09-15
申请号:US10178049
申请日:2002-06-19
申请人: Richard R. Spaete , George Kemble
发明人: Richard R. Spaete , George Kemble
CPC分类号: C07K14/805 , C12N7/00 , C12N15/111 , C12N15/86 , C12N2330/51 , C12N2710/16143 , C12N2799/06 , C12N2820/60
摘要: A novel Human Cytomegalovirus vector system is provided. The vector system is characterized by an amplicon vector, having an HCMV derived origin and cleavage packaging signal, and a helper virus function. The vector system is capable of infecting a wide range of host cells, including human CD34+ hematopoietic progenitor cells. Methods, including therapeutic and prophylactic methods, for introducing heterologous polynucleotide sequences into cells using the vector system are also provided.
摘要翻译: 提供了一种新的人巨细胞病毒载体系统。 载体系统的特征在于具有HCMV衍生来源和切割包装信号的扩增子载体和辅助病毒功能。 载体系统能够感染多种宿主细胞,包括人类CD34 +造血祖细胞。 还提供了使用载体系统将异源多核苷酸序列引入细胞的方法,包括治疗和预防方法。
-
公开(公告)号:US07566458B2
公开(公告)日:2009-07-28
申请号:US10870690
申请日:2004-06-16
申请人: Chin-Fen Yang , George Kemble , Chongguang Liu
发明人: Chin-Fen Yang , George Kemble , Chongguang Liu
IPC分类号: A61K39/00 , A61K39/38 , A61K39/295 , A61K39/12 , A61K39/145 , C12P21/04 , A61K31/70 , A61K39/23
CPC分类号: C07K14/005 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5254 , A61K2039/53 , C07H21/04 , C12N7/00 , C12N9/2402 , C12N15/86 , C12N2740/16122 , C12N2740/16222 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16161 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16261
摘要: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
摘要翻译: 提供了包含流感血凝素和神经氨酸酶变体的多肽,多核苷酸,方法,组合物和疫苗。
-
公开(公告)号:US20090175909A1
公开(公告)日:2009-07-09
申请号:US12399312
申请日:2009-03-06
申请人: Chin-Fen Yang , George Kemble
发明人: Chin-Fen Yang , George Kemble
IPC分类号: A61K39/145 , C12N7/00 , A61K35/76 , A61P37/04 , A61P31/12
CPC分类号: C12N7/00 , A61K39/12 , A61K2039/5254 , A61K2039/543 , A61K2039/58 , C07K14/005 , C12N2501/70 , C12N2760/16121 , C12N2760/16122 , C12N2760/16134 , C12N2760/16161 , C12N2760/16162 , C12N2760/16171 , C12Q1/701
摘要: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
摘要翻译: 提供了包含(禽流感)流感血凝素和神经氨酸酶变体的多肽,多核苷酸,方法,组合物和疫苗。
-
公开(公告)号:US20090175898A1
公开(公告)日:2009-07-09
申请号:US12262215
申请日:2008-10-31
申请人: Chin-Fen Yang , George Kemble , Chongguang Liu
发明人: Chin-Fen Yang , George Kemble , Chongguang Liu
IPC分类号: A61K39/145 , C12N7/01 , C12N7/02 , A61P31/16
CPC分类号: C07K14/11 , A61K39/12 , A61K39/145 , A61K2039/525 , A61K2039/5254 , C07K14/005 , C12N7/045 , C12N9/2402 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , C12Y302/01018
摘要: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
摘要翻译: 提供了包含流感血凝素和神经氨酸酶变体的多肽,多核苷酸,方法,组合物和疫苗。
-
公开(公告)号:US07550149B2
公开(公告)日:2009-06-23
申请号:US11614141
申请日:2006-12-21
申请人: George Kemble , Gregory M. Duke , Richard Spaete
发明人: George Kemble , Gregory M. Duke , Richard Spaete
IPC分类号: A61K39/12 , A61K39/245 , C12Q1/70
CPC分类号: C12N7/00 , C12N2710/16162
摘要: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
摘要翻译: 提供了一种减毒巨细胞病毒的方法,其包括功能性地破坏托莱多基因组区域的开放阅读框或其同源物并制备嵌合CMV病毒基因组。
-
公开(公告)号:US20090136530A1
公开(公告)日:2009-05-28
申请号:US12354085
申请日:2009-01-15
申请人: Chin-Fen Yang , George Kemble , Kanta Subbarao , Brian Murphy
发明人: Chin-Fen Yang , George Kemble , Kanta Subbarao , Brian Murphy
IPC分类号: A61K39/145 , C07K14/00 , A61K39/00 , C07H21/00 , C12N15/63 , C12P21/06 , C12N5/00 , C07K16/00 , C12N7/01
CPC分类号: C12N7/00 , A61K39/12 , A61K2039/5254 , A61K2039/543 , A61K2039/58 , C07K14/005 , C12N2501/70 , C12N2760/16121 , C12N2760/16122 , C12N2760/16134 , C12N2760/16161 , C12N2760/16162 , C12N2760/16171 , C12Q1/701
摘要: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
摘要翻译: 提供了包含(禽流感)流感血凝素和神经氨酸酶变体的多肽,多核苷酸,方法,组合物和疫苗。
-
公开(公告)号:US07537770B2
公开(公告)日:2009-05-26
申请号:US11613501
申请日:2006-12-20
申请人: George Kemble , Gregory M. Duke , Richard Spaete
发明人: George Kemble , Gregory M. Duke , Richard Spaete
IPC分类号: A61K39/12 , A61K39/245 , C12Q1/70
CPC分类号: C12N7/00 , C12N2710/16162
摘要: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
-
公开(公告)号:US07459162B2
公开(公告)日:2008-12-02
申请号:US11368246
申请日:2006-03-06
申请人: Chin-Fen Yang , George Kemble , Chongguang Liu
发明人: Chin-Fen Yang , George Kemble , Chongguang Liu
IPC分类号: A61K39/145 , A61K39/12 , C12N7/02
CPC分类号: C07K14/005 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5254 , A61K2039/53 , C07H21/04 , C12N7/00 , C12N9/2402 , C12N15/86 , C12N2740/16122 , C12N2740/16222 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16161 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16261
摘要: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
摘要翻译: 提供了包含流感血凝素和神经氨酸酶变体的多肽,多核苷酸,方法,组合物和疫苗。
-
公开(公告)号:US20080019945A1
公开(公告)日:2008-01-24
申请号:US11613501
申请日:2006-12-20
申请人: George Kemble , Gregory M. Duke , Richard Spaete
发明人: George Kemble , Gregory M. Duke , Richard Spaete
CPC分类号: C12N7/00 , C12N2710/16162
摘要: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
摘要翻译: 提供了一种减毒巨细胞病毒的方法,其包括功能性地破坏托莱多基因组区域的开放阅读框或其同源物并制备嵌合CMV病毒基因组。
-
公开(公告)号:US20050042229A1
公开(公告)日:2005-02-24
申请号:US10870690
申请日:2004-06-16
申请人: Chin-Fen Yang , George Kemble , Chongguang Liu
发明人: Chin-Fen Yang , George Kemble , Chongguang Liu
CPC分类号: C07K14/005 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5254 , A61K2039/53 , C07H21/04 , C12N7/00 , C12N9/2402 , C12N15/86 , C12N2740/16122 , C12N2740/16222 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16161 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16261
摘要: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
摘要翻译: 提供了包含流感血凝素和神经氨酸酶变体的多肽,多核苷酸,方法,组合物和疫苗。
-
-
-
-
-
-
-
-
-