公开(公告)号：US08754047B2

公开(公告)日：2014-06-17

申请号：US13015456

申请日：2011-01-27

申请人： Basil Rigas ,  Yu Sun

发明人： Basil Rigas ,  Yu Sun

IPC分类号： A61K38/00 ,  A61K38/16 ,  A61K38/10 ,  A61K9/127

CPC分类号： C07K14/8121 ,  C07K7/06

摘要： The present invention provides isolated peptides with at least two cysteine residues capable of forming one or more disulfide bonds. Pharmaceutical compositions comprising the isolated peptides of the present invention are also provided. The invention also provides methods for inhibiting, preventing or improving the pathological or clinical manifestations of cancer or an inflammatory disease or disorder in a subject, comprising administering a peptide of the invention.

摘要翻译： 本发明提供具有至少两个能够形成一个或多个二硫键的半胱氨酸残基的分离的肽。 还提供了包含本发明的分离的肽的药物组合物。 本发明还提供了抑制，预防或改善受试者中癌症或炎性疾病或病症的病理或临床表现的方法，包括施用本发明的肽。

公开(公告)号：US08623222B2

公开(公告)日：2014-01-07

申请号：US13652851

申请日：2012-10-16

申请人： Yu Sun ,  Keekyoung Kim

发明人： Yu Sun ,  Keekyoung Kim

IPC分类号： C23F1/00

CPC分类号： B81C99/002 ,  B25J9/104 ,  B81B2201/0292 ,  B81B2201/031 ,  B81B2201/033

摘要： The present invention relates to a design and microfabrication method for microgrippers that are capable of grasping micro and nano objects of a large range of sizes and two-axis force sensing capabilities. Gripping motion is produced by one or more electrothermal actuators. Integrated force sensors along x and y directions enable the measurement of gripping forces as well as the forces applied at the end of microgripper arms along the normal direction, both with a resolution down to nanoNewton. The microfabrication method enables monolithic integration of the actuators and the force sensors.

摘要翻译： 本发明涉及一种微抓爪的设计和微细加工方法，其能够抓住大范围尺寸和双轴力感测能力的微型和纳米物体。 夹持运动由一个或多个电热致动器产生。 沿x和y方向的集成力传感器可以测量夹紧力以及沿着法向方向施加在微夹臂末端的力，并且分辨率低至纳摩顿。 微加工方法可实现致动器和力传感器的整体集成。

公开(公告)号：US08564042B2

公开(公告)日：2013-10-22

申请号：US11702845

申请日：2007-02-05

申请人： Fred Cheung ,  Hiroyuki Kinoshita ,  Chungho Lee ,  Yu Sun ,  Chi Chang

发明人： Fred Cheung ,  Hiroyuki Kinoshita ,  Chungho Lee ,  Yu Sun ,  Chi Chang

IPC分类号： H01L29/94

CPC分类号： H01L29/66833 ,  G11C16/0475 ,  G11C16/3418 ,  G11C16/3427 ,  H01L27/115 ,  H01L27/11521

摘要： An embodiment of the present invention is directed to a memory cell. The memory cell includes a first charge storage element and a second charge storage element, wherein the first and second charge storage elements include nitrides. The memory cell further includes an insulating layer formed between the first and second charge storage elements. The insulating layer provides insulation between the first and second charge storage elements.

摘要翻译： 本发明的实施例涉及存储单元。 存储单元包括第一电荷存储元件和第二电荷存储元件，其中第一和第二电荷存储元件包括氮化物。 存储单元还包括形成在第一和第二电荷存储元件之间的绝缘层。 绝缘层提供第一和第二电荷存储元件之间的绝缘。

公开(公告)号：US08557582B2

公开(公告)日：2013-10-15

申请号：US12240310

申请日：2008-09-29

申请人： Christopher Moraes ,  Craig Simmons ,  Yu Sun

发明人： Christopher Moraes ,  Craig Simmons ,  Yu Sun

IPC分类号： C12M3/00 ,  C12M1/22 ,  C12N5/00

CPC分类号： C12M23/16 ,  C12M25/04 ,  C12M35/04

摘要： The present invention details the design and operation of a miniaturized device array in which a range of simultaneous mechanical forces are produced by a single external pressure source. The invention is primarily embodied in a microfabricated device arrays designed to rapidly probe biological cell response to various combinations of mechanical, chemical and extra-cellular matrix parameters in a high-throughput fashion.

摘要翻译： 本发明详细说明了通过单个外部压力源产生同时机械力的范围的小型化装置阵列的设计和操作。 本发明主要体现在设计成以高通量方式快速探测生物细胞对机械，化学和细胞外基质参数的各种组合的响应的微制造装置阵列中。

公开(公告)号：US20130099134A1

公开(公告)日：2013-04-25

申请号：US13639737

申请日：2010-04-07

申请人： Yu Sun ,  Changai Ru ,  Yong Zhang

发明人： Yu Sun ,  Changai Ru ,  Yong Zhang

IPC分类号： H01J37/20

CPC分类号： H01J37/20 ,  H01J37/185 ,  H01J37/28 ,  H01J2237/2007 ,  H01J2237/2008 ,  H01J2237/204 ,  H01J2237/206 ,  H01J2237/208

摘要： The present invention relates to a carrier device for transporting one or more manipulators into a vacuum specimen chamber of an electron microscope, characterized in that the carrier device comprises: (i) a platform having securing means for detachably securing the one or more manipulators to the platform, and (ii) electrical connectors secured to the platform for the electrical connection of the one or more manipulators. The present invention also relates to a method for transporting the carrier device into the vacuum specimen chamber of the electron microscope without altering the vacuum of the vacuum specimen chamber comprising transporting the carrier device of the invention through the specimen exchange chamber of the electron microscope and into the vacuum specimen chamber.

摘要翻译： 本发明涉及一种用于将一个或多个操纵器输送到电子显微镜的真空样品室中的载体装置，其特征在于，载体装置包括：（i）具有用于将一个或多个操纵器可拆卸地固定到 平台，以及（ii）固定到平台的用于一个或多个操纵器的电连接的电连接器。 本发明还涉及一种用于将载体装置输送到电子显微镜的真空样品室中而不改变真空试样室的真空的方法，包括将本发明的载体装置通过电子显微镜的试样更换室输送到 真空试样室。

公开(公告)号：US08134809B2

公开(公告)日：2012-03-13

申请号：US12081699

申请日：2008-04-18

申请人： MingGao Yao ,  Lin Guo ,  Yu Sun

发明人： MingGao Yao ,  Lin Guo ,  Yu Sun

IPC分类号： G11B5/56 ,  G11B21/24

CPC分类号： G11B5/4826 ,  G11B5/483 ,  G11B5/4873 ,  G11B5/5552

摘要： A PZT micro-actuator for a head gimbal assembly includes a pair of separate PZT elements and each PZT element has a body and a plurality of electrical pads. The body has at least two electrode-piezoelectric combination layers laminated together. The at least two electrode-piezoelectric combination layers are physically connected with but electrically isolated from each other. Each electrode-piezoelectric combination layer has at least two of the electrical pads thereon. The electrical pads extend out from the body of the corresponding PZT element. All the electrical pads of each PZT element are offset a predetermined distance therebetween to be electrically isolated. The present invention also discloses a head gimbal assembly (HGA) with the PZT micro-actuator, an assembling method for the head gimbal assembly and a disk drive unit having such HGA.

摘要翻译： 用于头万向节组件的PZT微致动器包括一对单独的PZT元件，并且每个PZT元件具有主体和多个电垫。 主体具有层叠在一起的至少两个电极 - 压电组合层。 所述至少两个电极 - 压电组合层在物理上彼此连接但是电隔离。 每个电极 - 压电组合层在其上具有至少两个电焊垫。 电焊盘从相应的PZT元件的主体延伸出来。 每个PZT元件的所有电焊垫偏移预定距离以进行电隔离。 本发明还公开了一种具有PZT微型致动器的头部万向节组件（HGA），用于头部万向节组件的组装方法和具有这种HGA的盘驱动单元。

公开(公告)号：US07910744B2

公开(公告)日：2011-03-22

申请号：US11666317

申请日：2005-10-17

申请人： Werner Thiel ,  Yu Sun ,  Antje Hienzsch

发明人： Werner Thiel ,  Yu Sun ,  Antje Hienzsch

IPC分类号： C07F9/06

CPC分类号： C07F9/6512 ,  C07F9/65031

摘要： The invention relates to a method for the manufacture of substituted phosphanes and substituted phosphanes manufactured according to the method. Phosphanes, phosphane oxides, sulfides or selenides are used as ligands in coordination compounds. They play a central role in controlling the activity and selectivity of catalysts. The object is achieved by the invention by synthesizing heterocyclic substituents on aromatic groups by introducing acetyl groups. In this manner, previously unknown representatives of the families of phosphanes, phosphane oxides, sulfides and selenides are made accessible.

摘要翻译： 本发明涉及根据该方法制造取代的膦和取代的磷烷的方法。 膦配位化合物中使用膦，氧化膦，硫化物或硒化物作为配位体。 它们在控制催化剂的活性和选择性方面起核心作用。 本发明的目的是通过引入乙酰基合成芳族基团上的杂环取代基。 以这种方式，可以使得先前未知的膦烷，磷烷氧化物，硫化物和硒化物族的代表。

公开(公告)号：US20110009983A1

公开(公告)日：2011-01-13

申请号：US12922211

申请日：2009-03-13

申请人： Yu Sun ,  Xinyu Liu

发明人： Yu Sun ,  Xinyu Liu

IPC分类号： G02B21/26 ,  G05D3/12

CPC分类号： G05B19/232 ,  G02B21/26 ,  G05B19/291 ,  G05B19/351 ,  G05B2219/41346 ,  G05B2219/49368

摘要： The present invention relates to a compact motorized rotational stage for microscopy applications and control methods for automated sample orientation/rotation. The rotational stage includes a motor, a rotational motion transmission mechanism, and a rotating sample holder for accommodating a holding device such as glass slides/Petri dishes of different sizes. Mouse embryos are used as an example to explain the control methods. A pattern recognition utility was developed for identifying mouse embryo structures. The transformation between the holding device rotational coordinate frame and the translational positioning stage coordinate frame is calibrated during image-based visual servo control. The polar body of an embryo is oriented through purely image-based visual servo control or through coordinate transformation and closed-loop position control.

摘要翻译： 本发明涉及用于显微镜应用的紧凑型电动旋转台和用于自动取样/旋转的控制方法。 旋转台包括电动机，旋转运动传递机构和用于容纳诸如不同尺寸的玻璃板/培养皿的保持装置的旋转样品保持器。 以小鼠胚胎为例来说明对照方法。 开发了识别小鼠胚胎结构的模式识别实用程序。 在基于图像的视觉伺服控制期间校准保持装置旋转坐标系和平移定位台坐标系之间的变换。 胚胎的极体通过纯粹的基于图像的视觉伺服控制或通过坐标变换和闭环位置控制来定向。

公开(公告)号：US07538971B2

公开(公告)日：2009-05-26

申请号：US11789500

申请日：2007-04-25

申请人： Yu Sun ,  Xiaoping Hu

发明人： Yu Sun ,  Xiaoping Hu

IPC分类号： G11B5/596

CPC分类号： G11B5/5552

摘要： Embodiments of the present invention allow for controlling a microactuator based at least in part on an output of a temperature sensor. Also, embodiments of the present invention allow for adjusting a control of a microactuator so as to compensate for changes in a gain of the microactuator due to changes in temperature.

摘要翻译： 本发明的实施例允许至少部分地基于温度传感器的输出来控制微致动器。 此外，本发明的实施例允许调节微致动器的控制，以便补偿由于温度变化引起的微致动器的增益的变化。

公开(公告)号：US07474496B1

公开(公告)日：2009-01-06

申请号：US11429427

申请日：2006-05-05

申请人： Yu Sun ,  Xiaoping Hu

发明人： Yu Sun ,  Xiaoping Hu

IPC分类号： G11B5/596 ,  G11B15/18

CPC分类号： G11B5/5556 ,  G11B5/5534 ,  G11B5/59655

摘要： A servo system for a hard disk drive comprising a first actuator, a second actuator, a head, and a disk on which is formed a plurality of tracks containing servo data. The servo system comprises a first stimulus, a second stimulus, and a calibration system. The first stimulus causes the first actuator to move the head to at least two calibration tracks on the disk. The second stimulus causes the second actuator to move the head relative to the at least two calibration tracks. The calibration system generates a calibration factor based on the second calibration signal and the movement of the second actuator relative to each of the at least two calibration tracks.

摘要翻译： 一种用于硬盘驱动器的伺服系统，包括第一致动器，第二致动器，头部和盘，其上形成有包含伺服数据的多个轨道。 伺服系统包括第一刺激，第二刺激和校准系统。 第一个刺激使第一个致动器将磁头移动到磁盘上的至少两个校准磁道。 第二刺激使得第二致动器相对于至少两个校准轨道移动头部。 所述校准系统基于所述第二校准信号和所述第二致动器相对于所述至少两个校准轨道中的每一个产生校准因子。