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    COMPOSITIONS AND METHODS FOR THE PRODUCTION AND DELIVERY OF DOUBLE STRANDED RNA
    62.
    发明申请
    COMPOSITIONS AND METHODS FOR THE PRODUCTION AND DELIVERY OF DOUBLE STRANDED RNA 审中-公开
    用于生产和递送双链RNA的组合物和方法

    公开(公告)号：US20170035056A1

    公开(公告)日：2017-02-09

    申请号：US15237214

    申请日：2016-08-15

    Applicant: Monsanto Technology LLC

    Inventor： James A. Baum ,  Allen T. Christian ,  Artem Evdokimov ,  Farhad Moshiri ,  Lisa Marie Weaver ,  Haitao Zhang

    IPC: A01N63/02 ,  C12N15/72 ,  A01N63/00 ,  C12N9/22

    CPC classification number: A01N63/02 ,  A01H3/00 ,  A01N63/00 ,  C12N9/22 ,  C12N15/67 ,  C12N15/72

    Abstract: Compositions and methods for efficiently producing and delivering double stranded RNA (dsRNA) are provided. Vector constructs useful for in vitro and in vivo expression of dsRNA are described. Also described are cell expression systems for efficient and cost-effective production of dsRNA in living cells and methods and compositions for providing the expressed dsRNA to target organisms. The described compositions and methods can be used to produce RNA molecules for screening or other uses, and to amplify RNA sequences for analysis.

    Abstract translation: 提供了有效生产和递送双链RNA（dsRNA）的组合物和方法。 描述了可用于dsRNA的体外和体内表达的载体构建体。 还描述了用于在活细胞中有效和成本有效地生产dsRNA的细胞表达系统，以及用于将表达的dsRNA提供给靶生物的方法和组合物。 所述的组合物和方法可用于产生用于筛选或其它用途的RNA分子，并扩增用于分析的RNA序列。

    METHODS AND COMPOSITIONS FOR MAKING AND USING COMPATIBLE INSECTICIDAL PROTEINS
    69.
    发明申请
    METHODS AND COMPOSITIONS FOR MAKING AND USING COMPATIBLE INSECTICIDAL PROTEINS 有权

    公开(公告)号：US20220243221A1

    公开(公告)日：2022-08-04

    申请号：US17677648

    申请日：2022-02-22

    Applicant: Monsanto Technology LLC

    Inventor： James A. Baum ,  Artem G. Evdokimov ,  Agoston Jerga ,  Farhad Moshiri

    IPC: C12N15/82 ,  G01N33/50

    Abstract: Pesticidal proteins (FFPP's) are used to produce derivatives (DP's) that are ineffective and disabled relative to conferring toxic properties upon a target pest, yet the ability of the DP to bind to the receptor to which said FFPP binds is unaffected. Such DP's are useful in inhibiting the FFPP from which it was derived when both are fed to a target pest and for comparing receptor binding capability and efficiency relative to different FFPP's from which the DP has been derived, providing for an assessment of different FFPP's relative to each other, and providing uniformity and certainty in combinations of such FFPP's for compositions, including transgenic plants, that can be used to control pest populations susceptible to both FFPP's, creating more durable transgenic plant products, inhibiting the development of resistance to such FFPP's when used in plants commercially, and in providing a durable and viable resistance management strategy for crops using such FFPP combinations. Polynucleotide sequences intended for use in expression of the DP's and FFPP's are also provided. Particular embodiments provide methods of designing and preparing DP's, as well as compositions and methods of using DP's and the FFPP's from which the DP's have been derived in more effective pesticidal compositions and products.

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