公开(公告)号：US07575718B2

公开(公告)日：2009-08-18

申请号：US11436670

申请日：2006-05-19

申请人： Hitoshi Shimizu

发明人： Hitoshi Shimizu

IPC分类号： G01N33/00

CPC分类号： B01L3/0293 ,  B01L3/0275 ,  B01L3/502 ,  B01L3/565 ,  B01L2200/027 ,  B01L2200/0642 ,  B01L2300/0636 ,  B01L2300/0877 ,  B01L2300/123 ,  B01L2300/14 ,  G01N21/05 ,  G01N21/11 ,  G01N21/553 ,  G01N2021/0346

摘要： A fluid feeding system consists of a flow channel member and a fluid feeding apparatus. The flow channel member has at least a flow channel for feeding a fluid to a sensor surface. Pipette catchers are formed at inlet and outlet openings of the flow channel. The fluid feeding apparatus comprises a movable pipette head having a couple of pipettes, a head moving mechanism and pumps for sucking and ejecting the fluid through the pipettes. To inject the fluid into the flow channel, ends of the pipettes are pressed onto the pipette catchers. The pipette catchers are formed from a soft material, so that they are deformed resiliently when the ends of the pipettes are pressed onto the pipette catchers, thereby ensuring water-tightness between the pipettes and the flow channel, without the need for fitting the pipettes in the inlet and outlet openings.

摘要翻译： 流体供给系统由流动通道构件和流体供给装置组成。 流动通道构件至少具有用于将流体供给到传感器表面的流动通道。 移液管捕集器形成在流动通道的入口和出口处。 流体供给装置包括具有一对移液管的移动移液管头，头部移动机构和用于通过移液管抽吸和排出流体的泵。 为了将流体注入流动通道中，移液管的端部被压到移液管捕集器上。 移液管捕集器由柔软的材料形成，使得当移液管的端部被压到移液管捕集器上时弹性变形，从而确保移液管和流动通道之间的水密性，而不需要将移液管安装在 入口和出口开口。

公开(公告)号：US07322702B2

公开(公告)日：2008-01-29

申请号：US11145929

申请日：2005-06-07

申请人： Hitoshi Shimizu

发明人： Hitoshi Shimizu

IPC分类号： G03B21/14

CPC分类号： G03B21/005

摘要： A projector engine is provided with an illuminating optical system having an optical axis in parallel with a horizontal direction of a screen and a projecting optical system having an optical axis perpendicular to the optical axis. A first mirror, a total reflection prism and DMD are provided between the illuminating optical system and the projecting optical system. The total reflection prism guides illuminating light incident from the illuminating optical system to DMD and totally reflects image light emitted from DMD to emit to the projecting optical system. DMD is inclined by 45 degrees to the horizontal direction of the screen along with a circuit board and is rotated by 45 degrees centering on a direction of a normal line of DMD.

摘要翻译： 投影仪引擎设置有具有与屏幕的水平方向平行的光轴的照明光学系统和具有垂直于光轴的光轴的投影光学系统。 在照明光学系统和投影光学系统之间设置第一反射镜，全反射棱镜和DMD。 全反射棱镜将从照明光学系统入射的光引导到DMD，并且将从DMD发射的图像光全反射到投影光学系统。 DMD与电路板一起相对于屏幕的水平方向倾斜45度，并且以DMD的法线方向为中心旋转45度。

公开(公告)号：US07187444B2

公开(公告)日：2007-03-06

申请号：US10291566

申请日：2002-11-12

申请人： Masayuki Naya ,  Mitsuru Sawano ,  Shu Sato ,  Toshihito Kimura ,  Hitoshi Shimizu

发明人： Masayuki Naya ,  Mitsuru Sawano ,  Shu Sato ,  Toshihito Kimura ,  Hitoshi Shimizu

IPC分类号： G01N21/55

CPC分类号： G01N21/553

摘要： In a measuring method utilizing the phenomenon of attenuation in total internal reflection in which a light beam is caused to enter a dielectric block provided with a film layer to be brought into contact with a sample so that total internal reflection conditions are satisfied at the interface of the dielectric block and the film layer and various angles of incidence of the light beam to the interface of the dielectric block and the film layer can be obtained, and the intensity of the light beam reflected in total internal reflection at the interface is detected, the light beam is caused to intermittently impinge upon the dielectric block.

摘要翻译： 在利用全内反射的衰减现象的测量方法中，使得光束被引入具有与样品接触的膜层的介电块，使得在内部反射条件的界面处满足全内反射条件 可以获得介质块和膜层以及光束到介质块和膜层的界面的各种入射角度，并且检测在界面处的全内反射中反射的光束的强度， 导致光束间歇地撞击介质块。

公开(公告)号：US20060257290A1

公开(公告)日：2006-11-16

申请号：US11402915

申请日：2006-04-13

申请人： Hitoshi Shimizu

发明人： Hitoshi Shimizu

IPC分类号： B01L3/02

CPC分类号： G01N21/553 ,  B01L3/0227 ,  B01L3/0293 ,  B01L3/502 ,  B01L2200/146 ,  B01L2300/027 ,  B01L2300/0877 ,  G01N35/1072

摘要： A multiple pipette assembly is used for the purpose of sample immobilization for surface plasmon resonance (SPR) assay, and dispenses and introduces sample fluid of a sample to a sensing surface of a sensor unit. The sensor unit includes a flow channel having first and second orifices, and the sensing surface, positioned in the flow channel, for detecting the reaction of the sample. First and second pipette devices access the orifices. First and second pumps are connected with respectively the pipette devices, for pressurization to dispense the sample fluid through the pipette devices, or for decompression to aspirate the sample fluid through the pipette devices. The pumps are driven in a manner independent from one another. While the first and second pipette devices move away from the sensor unit, the pumps are caused to decompress a space in the first and second pipette devices and the flow channel.

摘要翻译： 用于表面等离子体共振（SPR）测定的样品固定的多个移液管组件，并且将样品的样品流体分配并引入传感器单元的感测表面。 传感器单元包括具有第一和第二孔的流动通道，以及位于流动通道中的检测表面，用于检测样品的反应。 第一和第二移液器装置进入孔。 第一和第二泵分别与移液管装置连接，用于加压以通过移液管装置分配样品流体，或用于减压以通过移液管装置抽吸样品流体。 泵以彼此独立的方式驱动。 当第一和第二移液管装置远离传感器单元移动时，使泵减压第一和第二移液管装置和流动通道中的空间。

公开(公告)号：US07102754B2

公开(公告)日：2006-09-05

申请号：US10932270

申请日：2004-09-02

申请人： Hisashi Ohtsuka ,  Hitoshi Shimizu ,  Toshihito Kimura

发明人： Hisashi Ohtsuka ,  Hitoshi Shimizu ,  Toshihito Kimura

IPC分类号： G01N21/55

CPC分类号： G01N21/553 ,  G01N21/43

摘要： A state of attenuation in total internal reflection is detected by the use of a measuring apparatus having a measuring unit and a reference unit and a measuring system which corrects result of detection by the measuring unit on the basis of result of detection by the reference unit and measures the change of a state of attenuation in total internal reflection on the basis of the corrected result of detection by the measuring unit. The difference in sensitivity between the measuring unit and the reference unit is detected before initiating the measurement of the change of a state of attenuation in total internal reflection, and result of measurement by the measuring system is calibrated on the basis of the difference in sensitivity between the measuring unit and the reference unit.

公开(公告)号：US20060153742A1

公开(公告)日：2006-07-13

申请号：US11329129

申请日：2006-01-11

申请人： Hitoshi Shimizu

发明人： Hitoshi Shimizu

IPC分类号： B01L3/00

CPC分类号： G01N21/05 ,  B01L3/502 ,  B01L3/5025 ,  B01L3/50853 ,  B01L2200/026 ,  B01L2300/0654 ,  B01L2300/0809 ,  B01L2300/0877 ,  G01N21/553 ,  Y10T436/2575

摘要： A sensor unit for use in a surface plasmon resonance (SPR) assay includes a flow channel device, which causes a sample fluid of a sample to flow on a sensing surface lying on a prism. The flow channel device includes a rigid device body part having an opposing surface positioned opposite to the sensing surface. A flow recess is formed in the opposing surface, closed by the prism to constitute a flow channel, for covering the sensing surface. A sealant portion is overlaid on an edge portion of the opposing surface and the flow recess in the device body part. The sealant portion tightens closing between the device body part and the prism. Also, the sealant portion projects over the opposing surface of the device body part in a state before contacting the prism. In addition, the sealant portion is formed from material having a small non-specific adsorption.

摘要翻译： 用于表面等离子体共振（SPR）测定的传感器单元包括流动通道装置，其使得样品的样品流体在位于棱镜上的感测表面上流动。 流动通道装置包括具有与感测表面相对定位的相对表面的刚性装置主体部分。 流动凹槽形成在相对的表面中，由棱镜封闭以构成用于覆盖传感表面的流动通道。 密封剂部分重叠在相对表面的边缘部分和装置主体部分中的流动凹部中。 密封部分将装置主体部分和棱镜之间的关闭拉紧。 此外，密封剂部分在与棱镜接触之前的状态下突出到装置主体部分的相对表面上方。 此外，密封剂部分由具有小的非特异性吸附的材料形成。

公开(公告)号：US20050275959A1

公开(公告)日：2005-12-15

申请号：US11147266

申请日：2005-06-08

申请人： Satoru Kawaai ,  Hitoshi Shimizu

发明人： Satoru Kawaai ,  Hitoshi Shimizu

IPC分类号： G02B5/04 ,  G03B21/00

CPC分类号： G02B5/04

摘要： A total reflection prism includes two prisms having a shape of a triangular prism of a first prism and a second prism. The first prism includes an illuminating light incident face, a total reflection face and a panel reference face. The second prism includes an image light incident face on which image light is incident from the first prism, an image light emitting face from which image light is emitted, and a side end face. An edge line portion of a sharp edge is formed between the image light emitting face and the side end face and therefore, a light amount of OFF light reflected by the edge line portion and projected to a screen becomes extremely smaller than a light amount of ON light and does not effect an influence on quality of a projected image.

摘要翻译： 全反射棱镜包括具有第一棱镜和第二棱镜的三角形棱镜形状的两个棱镜。 第一棱镜包括照明光入射面，全反射面和面板基准面。 第二棱镜包括图像光从第一棱镜入射的图像光入射面，发射图像光的图像发光面和侧端面。 在图像发光面和侧端面之间形成锐边缘的边缘线部分，因此边缘线部分反射并投射到屏幕的OFF光的光量比ON的光量极小 并且不影响投影图像的质量。

公开(公告)号：US20050237498A1

公开(公告)日：2005-10-27

申请号：US10867728

申请日：2004-06-16

申请人： Hitoshi Shimizu

发明人： Hitoshi Shimizu

IPC分类号： G02F1/13 ,  G02F1/1335 ,  G03B21/00 ,  G03B21/10 ,  G03B21/14 ,  G03B21/20 ,  G03B21/28

CPC分类号： H04N9/3105 ,  G03B21/006 ,  G03B21/20 ,  G03B21/28 ,  H04N9/317

摘要： A liquid crystal projector of three-color type has three liquid crystal elements for modulating three primary color light bundles into three color optical images respectively. A recombination prism combines modulated three color optical images, and a projection lens system projects the combined full-color image on a screen. The projection lens system is constituted of the front lens group and the first and second rear lens groups. The front lens group and the rear lens groups are mounted to frames that are formed integrally on a prism base plate to which the recombination prism is fixed.

摘要翻译： 三色液晶投影仪具有三个用于将三原色光束分别调制为三色光学图像的液晶元件。 复合棱镜组合调制的三色光学图像，并且投影透镜系统将组合的全色图像投影在屏幕上。 投影透镜系统由前透镜组和第一和第二后透镜组构成。 前透镜组和后透镜组安装到整体形成在复合棱镜固定到的棱镜基板上的框架上。

公开(公告)号：US06912236B2

公开(公告)日：2005-06-28

申请号：US09918018

申请日：2001-07-30

申请人： Hitoshi Shimizu ,  Koji Kumada

发明人： Hitoshi Shimizu ,  Koji Kumada

IPC分类号： H01S5/183 ,  H01S5/323 ,  H01S5/343 ,  H01S5/00

CPC分类号： B82Y20/00 ,  H01S5/18311 ,  H01S5/32358 ,  H01S5/32366 ,  H01S5/343 ,  H01S5/34306

摘要： A semiconductor laser device includes a QW active layer structure including a GaxIn1−xAs1−ySby layer wherein 0.3≦1−x and 0.003≦y≦0.008, or a QW active layer structure including a GaxIn1−xAs1−y1−y2Ny1Sby2 layer wherein 0.3≦1−x, 0

摘要翻译： 半导体激光器件包括QW有源层结构，该QW有源层结构包括Ga x In 1-x As 1 y y Sb y y 其中0.3 <= 1-x和0.003 <= y <= 0.008的QW有源层结构，或包括Ga x In 1-x A A >其中0.3 <= 1-x，0 。 半导体激光器件抑制三维外延生长，具有优异的包括低阈值电流的光学特性。

公开(公告)号：US06678053B2

公开(公告)日：2004-01-13

申请号：US10026604

申请日：2001-12-27

申请人： Hitoshi Shimizu

发明人： Hitoshi Shimizu

IPC分类号： G01N2155

CPC分类号： G01N21/553

摘要： A sensor utilizing attenuated total reflection is equipped with a dielectric block, a thin film layer formed on a surface of the dielectric block, an optical system for making a light beam enter the dielectric block at various angles of incidence so that the condition for total internal reflection is satisfied at an interface between the dielectric block and the thin film layer, a photodetector for detecting the light beam satisfying total internal reflection at the interface, and a differential amplifier array for differentiating a signal output from each of the light-receiving elements of the photodetector, in the juxtaposed direction of the light-receiving elements. Every time a measurement is made, a quantity change &Dgr;I′ in the differentiated value I′ is found by subtracting an initial value from the differentiated value I′. The quantity change &Dgr;I′ is amplified, so that measurements can be made without saturating subsequent electric circuits.

摘要翻译： 使用衰减全反射的传感器配备有介质块，形成在介质块的表面上的薄膜层，用于使光束以各种入射角进入介质块的光学系统，使得总内部的条件 在介质块和薄膜层之间的界面处满足反射，用于检测满足界面处的全内反射的光束的光检测器，以及差分放大器阵列，用于将从每个光接收元件输出的信号 光检测器沿光接收元件的并列方向。 每次进行测量时，通过从微分值I'中减去初始值来发现微分值I'中的量变化ΔI'。 数量变化ΔI'被放大，从而可以在不后续电路饱和的情况下进行测量。