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61.发明授权27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552, and 65577 molecules and uses therefor 失效27877,18080,14081,32140,50352,16658,14223,16002,50566,655552和65577分子及其用途公开(公告)号：US07351566B2
公开(公告)日：2008-04-01
申请号：US11429599
申请日：2006-05-05
申请人： Rachel E. Meyers , Joseph M. Carroll , William James Cook , Rosana Kapeller-Libermann , Nadine S. Weich , Rajasekhar Bandaru
发明人： Rachel E. Meyers , Joseph M. Carroll , William James Cook , Rosana Kapeller-Libermann , Nadine S. Weich , Rajasekhar Bandaru
CPC分类号： A61K38/16 , A01K2217/05 , A61K38/4813 , A61K39/00 , A61K2039/53 , C07K14/47 , C07K2319/00 , C12N9/0008 , C12N9/12 , C12N9/16 , C12N9/20 , C12N9/6416 , C12N9/6424 , C12N9/6491 , C12N9/93 , C12Q1/25 , C12Q1/37 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Y603/02019 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/573 , G01N33/68 , G01N2500/10 , Y10T436/143333 , A61K2300/00
摘要： The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 gene has been introduced or disrupted. The invention still further provides isolated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 proteins, fusion proteins, antigenic peptides and anti-27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为27877,18080,14081,32140,50352,16658,14223,16002,50566,65552和65577核酸分子。 本发明还提供反义核酸分子，含有27877,18080,14081,32140,50502,16658,14223,16002,50566,65552和65577核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及 已经引入或破坏了27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577基因的非人类转基因动物。 本发明还进一步提供分离的27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577蛋白，融合蛋白，抗原肽和抗27877,18080,14081,32140,50352,16658,14223 ，16002,50566,65552或65577抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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公开(公告)号：US20070292845A1
公开(公告)日：2007-12-20
申请号：US10165231
申请日：2002-06-06
CPC分类号： C12N9/6472
摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新多肽的分离的核酸分子。 本发明还提供了反义核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及本发明的序列已被引入或破坏的非人类转基因动物。 本发明还进一步提供分离的蛋白质，融合蛋白质，抗原肽和抗体。 还提供了利用本发明组合物的诊断方法。
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63.发明授权Human protein kinase, phosphatase, and protease family members and uses thereof 有权人蛋白激酶，磷酸酶和蛋白酶家族成员及其用途公开(公告)号：US07198930B2
公开(公告)日：2007-04-03
申请号：US11151601
申请日：2005-06-13
CPC分类号： C12N9/1205 , A61K38/00 , C07K16/40 , C12N9/12 , C12N9/16 , C12N9/48 , C12N9/6424 , C12N9/6427 , C12N9/6472 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156
摘要： The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为53070,15985,26583,21953，m32404,14089和23436核酸分子，其编码新的人蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员 ，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。 本发明还提供反义核酸分子，含有53070,15985,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中53070 ，15985,26583,21953，m32404,14089或23436基因已被引入或破坏。 本发明还进一步提供了分离的53070,15985,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗-53070,15985,26583,21953，m32404,14089或23436抗体。 还提供了利用本发明组合物的诊断方法。
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64.发明授权公开(公告)号：US06984502B2
公开(公告)日：2006-01-10
申请号：US10044205
申请日：2001-10-22
IPC分类号： C12N15/00
CPC分类号： C12N9/16 , A61K38/00 , C07K14/4702 , C12N9/12
摘要： The invention provides isolated nucleic acids molecules, including 69087 nucleic acid molecules, which encode a novel G protein coupled receptor kinase. The invention also provides recombinant expression vectors containing 69087, nucleic acid molecules, and host cells into which the expression vectors have been introduced.
摘要翻译： 本发明提供分离的核酸分子，包括编码新型G蛋白偶联受体激酶的69087核酸分子。 本发明还提供了含有表达载体的69087，核酸分子和宿主细胞的重组表达载体。
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公开(公告)号：US20050233375A1
公开(公告)日：2005-10-20
申请号：US11158218
申请日：2005-06-21
CPC分类号： C12N9/1205 , A01K2217/05 , A61K38/00 , C12N9/12
摘要： The invention provides isolated nucleic acids molecules, designated 13245 nucleic acid molecules, which encode a novel myotonic dystrophy type protein kinase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13245 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 13245 gene has been introduced or disrupted. The invention still further provides isolated 13245 proteins, fusion proteins, antigenic peptides and anti-13245 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
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66.发明授权13245, a novel human myotonic dystrophy type protein kinase and uses therefor 失效13245，一种新型人类强直性营养不良型蛋白激酶，并用于此公开(公告)号：US06946274B2
公开(公告)日：2005-09-20
申请号：US10017216
申请日：2001-10-23
CPC分类号： C12N9/1205 , A01K2217/05 , A61K38/00 , C12N9/12
摘要： The invention provides isolated nucleic acids molecules, designated 13245 nucleic acid molecules, which encode a novel myotonic dystrophy type protein kinase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13245 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 13245 gene has been introduced or disrupted. The invention still further provides isolated 13245 proteins, fusion proteins, antigenic peptides and anti-13245 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新型强直性营养不良型蛋白激酶的分离的核酸分子，命名为13245核酸分子。 本发明还提供了反义核酸分子，含有13245个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏13245基因的非人转基因动物。 本发明还进一步提供分离的13245蛋白，融合蛋白，抗原肽和抗-13245抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US06620592B2
公开(公告)日：2003-09-16
申请号：US09794960
申请日：2001-02-26
IPC分类号： C12N950
CPC分类号： C12N9/6472
摘要： Novel calpain-like protease polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length calpain-like protease proteins, the invention further provides isolated calpain-like protease fusion proteins, antigenic peptides, and anti-calpain-like protease antibodies. The invention also provides calpain-like protease nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a calpain-like protease gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 公开了新的钙蛋白酶样蛋白酶多肽，蛋白质和核酸分子。 除了分离的全长钙蛋白酶样蛋白酶蛋白，本发明还提供了分离的钙蛋白酶样蛋白酶融合蛋白，抗原肽和抗钙蛋白酶样蛋白酶抗体。 本发明还提供了钙蛋白酶样蛋白酶核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中已经引入了钙蛋白酶样蛋白酶基因的非人类转基因动物 或中断。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US06451994B1
公开(公告)日：2002-09-17
申请号：US09406045
申请日：1999-09-27
IPC分类号： C07H2102
CPC分类号： C12N9/6472 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： The present invention relates to a newly identified human ubiquitin protease belonging to the family of mammalian deubiquitinating enzymes. The invention also relates to polynucleotides encoding the ubiquitin protease. The invention further relates to methods using the ubiquitin protease polypeptides and polynucleotides as a target for diagnosis and treatment in ubiquitin-mediated or -related disorders. The invention further relates to drug-screening methods using the ubiquitin protease polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the ubiquitin protease polypeptides and polynucleotides. The invention further relates to procedures for producing the ubiquitin protease polypeptides and polynucleotides.
摘要翻译： 本发明涉及属于哺乳动物脱蛋白酶家族的新鉴定的人泛素蛋白酶。 本发明还涉及编码泛素蛋白酶的多核苷酸。 本发明还涉及使用泛素蛋白酶多肽和多核苷酸作为在泛素介导的或相关疾病中进行诊断和治疗的靶标的方法。 本发明还涉及使用泛素蛋白酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于泛素蛋白酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及生产泛素蛋白酶多肽和多核苷酸的方法。
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69.发明授权Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor 有权人二酰基甘油酰基转移酶2（DGAT2）家族成员及其用途公开(公告)号：US08334111B2
公开(公告)日：2012-12-18
申请号：US13015635
申请日：2011-01-28
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
摘要翻译： 本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。 本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。 本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。 本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。 还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。
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公开(公告)号：US20120149648A1
公开(公告)日：2012-06-14
申请号：US13352223
申请日：2012-01-17
申请人： Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Jiawen Han
发明人： Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Jiawen Han
CPC分类号： C07K7/64 , A61K38/12 , A61K38/1761 , A61K45/06
摘要： The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
摘要翻译： 本发明提供用于治疗细胞增殖性疾病如癌症和免疫增殖性疾病的生物活性的拟肽大环化合物。
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